Journal
ADVANCED DRUG DELIVERY REVIEWS
Volume 179, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.addr.2021.113913
Keywords
Immunomodulation; Wound healing; Growth factors; Biomimetic materials; Exosomes; Exosome mimetics; Regeneration; Tissue engineering; Cytokines; Immune system; Functional regeneration; Macrophages; M1 macrophages; M2 macrophages; Immune response
Categories
Funding
- CONACYT [859295]
- Ser Cymru II scheme - European Union's Horizon 2020 Research and Innovation Program under the Marie Sklodowska-Curie grant [663830]
- Welsh European Funding Office (WEFO) under the European Regional Development Fund (ERDF)
- Angelina Kostas Research Center for Cardiovascular Medicine and Houston Methodist Research Institute
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Inflammation plays a crucial role in wound healing, with chronic inflammation affecting tissue function. Developing therapeutics based on knowledge of the native tissue microenvironment can modulate immune response and promote tissue repair.
Inflammation plays a central role in wound healing following injury or disease and is mediated by a precise cascade of cellular and molecular events. Unresolved inflammatory processes lead to chronic inflammation and fibrosis, which can result in prolonged wound healing lasting months or years that hampers tissue function. Therapeutic interventions mediated by immunomodulatory drugs, cells, or biomaterials, are therefore most effective during the inflammatory phase of wound healing when a pro-regenerative environment is essential. In this review, we discuss the advantages of exploiting knowledge of the native tissue microenvironment to develop therapeutics capable of modulating the immune response and promoting functional tissue repair. In particular, we provide examples of the most recent biomimetic platforms proposed to accomplish this goal, with an emphasis on those able to induce macrophage polarization towards a pro-regenerative phenotype. (C) 2021 Elsevier B.V. All rights reserved.
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