Article
Immunology
Guanheng Chen, Leiguang Feng
Summary: This study aimed to provide preventive and prognostic parameters associated with diabetes mellitus and benign prostatic enlargement (BPE). Retrospective data of diabetic patients revealed higher age and prostate volume in those with BPE, while lymphocytes and platelet levels were significantly lower. Multivariable logistic regression analysis identified age as a risk factor and platelet as a protective factor for BPE. In the overall population, prostate volume was positively correlated with age and negatively correlated with lymphocytes and platelet levels.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Giorgio Ivan Russo, Giuseppe Broggi, Andrea Cocci, Paolo Capogrosso, Marco Falcone, Ioannis Sokolakis, Murat Gul, Rosario Caltabiano, Marina Di Mauro
Summary: Interest in the role of dietary patterns in the context of erectile dysfunction and benign prostatic hyperplasia has been growing. Certain dietary patterns, such as the Mediterranean diet, may have a beneficial impact on erectile function and BPH symptoms. Further studies are needed to confirm these findings and explore the potential translational implications.
Article
Polymer Science
Soad A. Mohamed, Remon Roshdy Rofaeil, Hesham Salem, Mahmoud Elrehany, Yahya I. Asiri, Adel Al Fatease, Hamdy Abdelkader
Summary: Oral phosphodiesterase inhibitors have revolutionized the treatment of erectile dysfunction, and topical penile therapy could be a potential replacement for oral medication. This study focuses on developing proniosomal gels for selected members and evaluating their effectiveness on a rodent model. The results show that tadalafil-loaded proniosomal gel has superior skin permeability and improvement in sexual performance compared to the untreated control.
Article
Urology & Nephrology
Andrea Tubaro, Mark Speakman, Alexandre de la Taille, Louis Martinez-Pineiro, Richard Berges, Anup Patel, Anders Bjartell, Christien Caris, Wim Witjes
Summary: This study evaluated the effectiveness of pharmacological treatment for lower urinary tract symptoms-benign prostatic enlargement in a real-world setting, showing that 70% of previously untreated and 42% of previously treated patients experienced symptom improvement after 24 months. Patients with persistent symptoms (IPSS >= 8) remained in both untreated and treated groups at 59% and 61% respectively, with higher rates of symptom deterioration in the previously treated group compared to the previously untreated group.
JOURNAL OF UROLOGY
(2021)
Article
Health Care Sciences & Services
Ioannis-Erineos Zisis, Georgios Georgiadis, Anca Oana Docea, Daniela Calina, Liliana Cercelaru, John Tsiaoussis, Georgios Lazopoulos, Nikolaos Sofikitis, Aristidis Tsatsakis, Charalampos Mamoulakis
Summary: This study evaluated the potential renoprotective effects of vardenafil (VAR) and avanafil (AVA) in a rat model of contrast-induced nephropathy (CIN). The results showed that both VAR and AVA had a protective effect on the kidneys, with improvements in kidney appearance and decreased levels of serum creatinine and renal injury markers.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Urology & Nephrology
Christopher D. Gaffney, Spyridon P. Basourakos, Bashir Al Hussein Al Awamlh, Xian Wu, Peter Y. Cai, Adonis Hijaz, Irina Jaeger, Richard K. Lee, Jonathan E. Shoag
Summary: A retrospective study on the endoscopic treatment of BPE/LUTS revealed that the prostatic urethral lift has rapidly gained popularity, accounting for over 10% of procedures in 2018. Compared to traditional procedures like transurethral resection of the prostate and prostate photovaporization, the prostatic urethral lift showed lower readmission rates within 30 and 90 days but had a higher likelihood of retreatment within 2 years.
JOURNAL OF UROLOGY
(2021)
Review
Urology & Nephrology
Alexander Light, Dost Jabarkhyl, Peter Gilling, Gincy George, Mieke Van Hemelrijck, Ben Challacombe, Sachin Malde, Rick Popert, Prokar Dasgupta, Oussama Elhage
Summary: A comparison of various surgical interventions for benign prostatic obstruction (BPO) showed that prostatic urethral lift (PUL) resulted in better erectile function scores at 24 months compared to monopolar transurethral resection (mTURP). However, there were no significant differences in erectile function following other interventions up to 60 months. Further randomized controlled trials comparing sexual function outcomes are recommended for future research.
Review
Gastroenterology & Hepatology
Arman Shafiee, Razman Arabzadeh Bahri, Mohammad Mobin Teymouri Athar, Fatemeh Afsharrezaei, Mostafa Gholami
Summary: Esophageal motility disorders are associated with impaired neuromuscular coordination, and phosphodiesterase 5 (PDE-5) inhibitors have been proposed as a treatment option. This study found that PDE-5 inhibitors significantly reduce lower esophageal sphincter pressure and the amplitude of contractions, without significantly affecting residual pressure. In addition, these inhibitors also have an impact on esophageal contractility and contraction reserve. Therefore, they may potentially improve symptoms and prevent complications in patients with esophageal motility disorders.
BMC GASTROENTEROLOGY
(2023)
Article
Cell Biology
Silvia Limoncella, Clara Lazzaretti, Elia Paradiso, Sara D'Alessandro, Federica Barbagallo, Salvatore Pacifico, Remo Guerrini, Simonetta Tagliavini, Tommaso Trenti, Daniele Santi, Manuela Simoni, Marco Sola, Giulia Di Rocco, Livio Casarini
Summary: Type 5 phosphodiesterase (PDE5) inhibitors (PDE5i) are commonly used for the treatment of erectile dysfunction. This study suggests that PDE5i may also interact with cAMP-specific PDEs, leading to an increase in cAMP and testosterone levels, which could have a positive impact on male reproductive parameters.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Soad A. Mohamad, Wesam W. Mustafa, Hesham Salem, Mahmoud Elrehany, Remon Roshdy Rofaeil, Hamdy Abdelkader
Summary: Efficient topical drug delivery using phosphodiesterase inhibitors (PDE inhibitors) could potentially revolutionize the treatment of erectile dysfunction. This study investigated the preformulation characteristics and skin permeation of three selected PDE 5 inhibitors. Results showed that the drugs had pH-dependent solubility and lipid solubility. The penetration enhancer Pluronic F127 significantly enhanced the skin permeability of sildenafil. Overall, tadalafil and vardenafil were found to be more viable options for topical penile therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Plant Sciences
A. Anand Ganapathy, V. M. Hari Priya, Alaganandam Kumaran
Summary: This paper reviewed 97 medicinal plants with PDE5 inhibitory effect, of which 77 were selected based on their traditional use as aphrodisiacs. Isoflavones and biflavones were identified as the major active constituents responsible for action, while Icariin and Icariside II were found to be the most effective inhibitors from natural sources. Traditional medicines containing extracts of Ginkgo biloba, Kaempferia parviflora, Clerodendrum colebrookianum, Eurycoma longifolia, and Vitis vinifera were also found to inhibit the PDE5 enzyme.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kai-Yen Tsai, Deng-Chyang Wu, Wen-Jeng Wu, Jiunn-Wei Wang, Yung-Shun Juan, Ching-Chia Li, Chung-Jung Liu, Hsiang-Ying Lee
Summary: This study investigates the potential relationship between human microbiota and prostatic disease by analyzing stool and urine samples from patients. The results suggest that the microbiota composition in urine samples is different among different patient populations, indicating a potential link between microbiota and prostatic disease.
Article
Urology & Nephrology
Dean Elterman, Naeem Bhojani, Christopher Vannabouathong, Bilal Chughtai, Kevin C. Zorn
Summary: This study demonstrates the safety and efficacy of Rezum therapy in patients with large prostate glands (>80 mL) in improving urinary flow rate, prostate symptoms, quality of life, and erectile function.
Article
Biochemistry & Molecular Biology
Bo-Ram Jin, Chae-Young Lim, Hyo-Jung Kim, Minho Lee, Hyo-Jin An
Summary: The study shows that MitoQ, a mitochondria-targeted antioxidant, has therapeutic effects in benign prostatic hyperplasia (BPH) models by inhibiting androgen receptor (AR) and NOD-like receptor family pyrin domain-containing 3 (NLRP3) signaling. Molecular modeling reveals the interaction between DHT, AR, NLRP3, and the inhibitory effects of MitoQ on AR and NLRP3. MitoQ administration alleviates prostate enlargement and exerts anti-proliferative and antioxidant effects in BPH rats by suppressing the AR and NLRP3 signaling pathways.
Article
Engineering, Chemical
Wael Abu Dayyih, Ammar A. Rasras, Mohammad Hailat, Rawan Karaki, Ahmad A. Deeb, Israa Al-Ani, Lina N. Altamimi, Zainab Zakaraya, Sina M. Matalqah, Basim Mareekh, Enas Alkhader, Eyad S. M. Abu-Nameh
Summary: This study developed and verified a simple HPLC-based method for quantitatively analyzing sildenafil, vardenafil, udenafil, avanafil, and tadalafil in a tablet dosage form mixed with honey obtained from the Jordanian market in rat plasma. The method showed linearity and selectivity, and can be used to routinely detect the combination of these drugs.
Article
Environmental Sciences
Costanza Calamai, Oumaima Ammar, Sara Marchiani, Selene Degl'Innocenti, Marisa Fino, Lorenzo Righi, Sara Dabizzi, Mario Maggi, Elisabetta Baldi, Linda Vignozzi, Monica Muratori
Summary: In March 2020, the Italian government implemented a national lockdown, which resulted in a significant reduction in air pollutants and an improvement in sperm motility and DNA quality of male infertility patients after the lockdown period.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2023)
Article
Environmental Sciences
Giulia Guarnieri, Matteo Becatti, Roberta Squecco, Paolo Comeglio, Rachele Garella, Lara Tamburrino, Sara Marchiani, Linda Vignozzi, Gabriella Barbara Vannelli, Mario Maggi, Annamaria Morelli
Summary: The neuroendocrine control of reproduction is regulated by the pulsatile release of GnRH by hypothalamic neurons. BaP, a pollutant, can disrupt endocrine function and affect gonadal function and gamete maturation. This study found that BaP alters the phenotype and function of GnRH neurons by interfering with KISS1R signaling and GnRH secretion, highlighting its importance in the central neuroendocrine control of reproduction.
ENVIRONMENTAL POLLUTION
(2023)
Article
Urology & Nephrology
Giovanni Castellini, Eleonora Rossi, Emanuele Cassioli, Giulia Sanfilippo, Jiska Ristori, Linda Vignozzi, Mario Maggi, Valdo Ricca, Alessandra Daphne Fisher
Summary: This study aimed to evaluate the relationship between internalized transphobia and body uneasiness in individuals with gender dysphoria, as well as the role of internalized transphobia in moderating the improvement of body image after gender affirming hormone therapy. The results showed a correlation between the level of transphobia and education, gender dysphoria, and body uneasiness. Moreover, participants with more transphobic attitudes showed less improvement in body uneasiness after hormone therapy.
JOURNAL OF SEXUAL MEDICINE
(2023)
Article
Urology & Nephrology
Ilaria Cellai, Paolo Comeglio, Sandra Filippi, Serena Martinelli, Fabio Villanelli, Francesca Amore, Elena Rapizzi, Elisa Maseroli, Sarah Cipriani, Chiara Raddi, Giulia Guarnieri, Erica Sarchielli, Giovanna Danza, Annamaria Morelli, Giulia Rastrelli, Mario Maggi, Linda Vignozzi
Summary: This study investigated the role of sex steroids in regulating the RhoA/ROCK pathway in vaginal smooth muscle. The findings suggest that androgens can inhibit this pathway, leading to smooth muscle relaxation in the vagina, which may contribute to sexual intercourse.
JOURNAL OF SEXUAL MEDICINE
(2023)
Article
Andrology
Arcangelo Barbonetti, Giulia Rastrelli, Clotilde Sparano, Chiara Castellini, Linda Vignozzi, Mario Maggi, Giovanni Corona
Summary: A study found that male cannabis users are younger, have fewer comorbidities, and have better sexual performance compared to non-users. Cannabis use is associated with a more unstable relationship and a higher frequency of masturbation. Cannabis use may improve anthropometric and lipid profiles as well as penile arterial response in patients with sexual dysfunction.
Review
Andrology
Giovanni Corona, Walter Vena, Alessandro Pizzocaro, Linda Vignozzi, Alessandra Sforza, Mario Maggi
Summary: Type 2 diabetes mellitus and pre-diabetes are associated with reduced levels of circulating testosterone, but the role of testosterone replacement therapy in these patients is still uncertain.
Article
Andrology
Dimitri Yannas, Elena Zago, Elena Cavallini, Tommaso Todisco, Linda Vignozzi, Giovanni Corona, Mario Maggi, Giulia Rastrelli
Summary: This study found that the level of education is closely associated with erectile dysfunction and cardiovascular risk in men. Men with lower education level are more likely to have erectile dysfunction and metabolic syndrome, as well as a higher risk of cardiovascular events.
Review
Andrology
Francesco Lotti, Mario Maggi
Summary: Diabetes mellitus has a negative effect on sperm quality and male/couple fertility, but studies on this topic have been limited and have shown inconsistent results.
Article
Endocrinology & Metabolism
L. Fei, G. Cantini, A. Nocentini, P. Nardini, S. Catarinicchia, L. Canu, T. Ercolino, G. Quartararo, G. Nesi, M. Gacci, M. Maggi, C. Hantel, M. Mannelli, C. T. Supuran, M. Luconi
Summary: This study found that the expression of carbonic anhydrase (CA) enzymes III and IX is altered in obesity and adrenocortical carcinoma (ACC). Specifically, CAIX is upregulated in ACC, while CAIII is downregulated. In vitro coculture experiments showed that CAIX is significantly upregulated in the interaction between ACC and adipose tissue, while CAIII is downregulated. These findings suggest that CA could be a potential target for novel anticancer therapies.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
G. Corona, D. Cucinotta, G. Di Lorenzo, A. Ferlin, V. A. Giagulli, L. Gnessi, A. M. Isidori, M. I. Maiorino, P. Miserendino, A. Murrone, R. Pivonello, V. Rochira, G. M. Sangiorgi, G. Stagno, C. Foresta, A. Lenzi, M. Maggi, E. A. Jannini
Summary: Erectile dysfunction (ED) is a common male sexual dysfunction that has been mistakenly considered mainly a psychological symptom. However, growing evidence shows the role of organic factors in the pathophysiology of ED.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
G. Marroncini, C. Anceschi, L. Naldi, B. Fibbi, M. Brogi, L. Lanzilao, A. Fanelli, M. Maggi, A. Peri
Summary: This study developed an in vivo model of hyponatremia and found that besides neurological symptoms, hyponatremia may also lead to liver fibrosis and testis alterations. These findings bring new insights into the potential consequences of chronic hyponatremia and emphasize the importance of thorough evaluation of hyponatremic patients.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Cell & Tissue Engineering
Sarah Shafaat, Sabiniano Roman Regueros, Christopher Chapple, Sheila MacNeil, Vanessa Hearnden
Summary: Childbirth can lead to common pelvic floor problems in postmenopausal women, necessitating reconstructive surgery. In this study, a tissue-engineered vaginal wound model was developed to investigate wound healing and the role of estradiol in pelvic tissue repair. The results showed that estradiol significantly improved wound healing and epithelial maturation, as well as promoted collagen reorganization and downregulated α-SMA expression. This model provides a valuable tool for studying vaginal wound healing and developing therapies for improved tissue healing after reconstructive pelvic floor surgery.
JOURNAL OF TISSUE ENGINEERING
(2023)
Review
Public, Environmental & Occupational Health
Livio Tarchi, Giuseppe Pierpaolo Merola, Ottone Baccaredda-Boy, Francesca Arganini, Emanuele Cassioli, Eleonora Rossi, Mario Maggi, David S. Baldwin, Valdo Ricca, Giovanni Castellini
Summary: The purpose of this systematic review was to investigate the adverse effects of SSRIs on sexual function and determine if these effects persist after discontinuation. The review found limited evidence of sexual dysfunction following SSRI discontinuation and was unable to establish a cause-effect relationship. However, it highlighted the need for further research to explore the relationship between SSRI exposure and persistent sexual dysfunction and to develop new treatment options.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Review
Andrology
Daniele Santi, Francesco Lotti, Clotilde Sparano, Giulia Rastrelli, Andrea M. Isidori, Rosario Pivonello, Arcangelo Barbonetti, Andrea Salonia, Suks Minhas, Csilla Krausz, Linda Vignozzi, Mario Maggi, Giovanni Corona
Summary: Obesity has a negative impact on sex hormone metabolism, leading to reduced testosterone levels and potentially affecting male fertility. This study conducted a meta-analysis of observational studies and found that overweight and obese men had lower sperm count and motility compared to normal weight men. The results suggest that increased body weight is a risk factor for male infertility.
Article
Geriatrics & Gerontology
Nadjia Amini, Jolan Dupont, Laurence Lapauw, Laura Vercauteren, Leen Antonio, Terence W. W. O'Neill, Dirk Vanderschueren, Neil Pendleton, Giulia Rastrelli, Mario Maggi, Felipe F. F. Casanueva, Jolanta Slowikowska-Hilczer, Margus Punab, Ilpo T. T. Huhtaniemi, Frederick C. W. Wu, Sabine Verschueren, Jos Tournoy, Evelien Gielen
Summary: This study aimed to investigate the cross-sectional and longitudinal associations between sarcopenia and cognitive performance in middle-aged and older men. The study found that several components of sarcopenia were associated with domain-specific cognitive performance. Longitudinally, baseline and change in subdomains of cognition predicted change in muscle function in specific subgroups.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
