Tumor-targeting pH/redox dual-responsive nanosystem epigenetically reverses cancer drug resistance by co-delivering doxorubicin and GCN5 siRNA

Two Phase 3 Trials of Inclisiran in Patients with Elevated LDL Cholesterol

(2020) Kausik K. Ray et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria

(2020) Manisha Balwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

TRIM28 protects CARM1 from proteasome-mediated degradation to prevent colorectal cancer metastasis

(2019) Jinyuan Cui et al.   Science Bulletin

A view on drug resistance in cancer

(2019) Neil Vasan et al.   NATURE

Supramolecular Modular Approach toward Conveniently Constructing and Multifunctioning a pH/Redox Dual-Responsive Drug Delivery Nanoplatform for Improved Cancer Chemotherapy

(2018) Jia Liu et al.   ACS Applied Materials & Interfaces

Co-Delivery of Doxorubicin and Anti-BCL-2 siRNA by pH-Responsive Polymeric Vector to Overcome Drug Resistance in In Vitro and In Vivo HepG2 Hepatoma Model

(2018) Weitong Sun et al.   BIOMACROMOLECULES

Targeted iron nanoparticles with platinum-(IV) prodrugs and anti-EZH2 siRNA show great synergy in combating drug resistance in vitro and in vivo

(2018) Chang Yu et al.   BIOMATERIALS

Patisiran, an RNAi Therapeutic, for Hereditary Transthyretin Amyloidosis

(2018) David Adams et al.   NEW ENGLAND JOURNAL OF MEDICINE

Androgen receptor transcriptional activity and chromatin modifications on the ABCB1/MDR gene are critical for taxol resistance in ovarian cancer cells

(2018) Nian-Kang Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibit or Evade Multidrug Resistance P-Glycoprotein in Cancer Treatment

(2017) Deepali Waghray et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cell-Targeting Cationic Gene Delivery System Based on a Modular Design Rationale

(2016) Jia Liu et al.   ACS Applied Materials & Interfaces

Codelivery of an Optimal Drug/siRNA Combination Using Mesoporous Silica Nanoparticles To Overcome Drug Resistance in Breast Cancer in Vitro and in Vivo

(2013) Huan Meng et al.   ACS Nano

FGFR-targeted gene delivery mediated by supramolecular assembly between β-cyclodextrin-crosslinked PEI and redox-sensitive PEG

(2013) Yuan Ping et al.   BIOMATERIALS

Elevated level of lysine 9-acetylated histone H3 at the MDR1 promoter in multidrug-resistant cells

(2012) Monika Toth et al.   CANCER SCIENCE

Identification of CD44 as a Surface Biomarker for Drug Resistance by Surface Proteome Signature Technology

(2011) J. W. Cain et al.   MOLECULAR CANCER RESEARCH

Global Methylation Pattern of Genes in Androgen-Sensitive and Androgen-Independent Prostate Cancer Cells

(2010) D. K. Mishra et al.   MOLECULAR CANCER THERAPEUTICS

A Phase I Study of the P-Glycoprotein Antagonist Tariquidar in Combination with Vinorelbine

(2009) J. Abraham et al.   CLINICAL CANCER RESEARCH

Mucus-penetrating nanoparticles for drug and gene delivery to mucosal tissues

(2008) Samuel K. Lai et al.   ADVANCED DRUG DELIVERY REVIEWS

Polymer-Based Gene Delivery: A Current Review on the Uptake and Intracellular Trafficking of Polyplexes

(2008) Patrick Midoux et al.   CURRENT GENE THERAPY

Hyaluronan-mediated CD44 Interaction with p300 and SIRT1 Regulates β-Catenin Signaling and NFκB-specific Transcription Activity Leading to MDR1 and Bcl-xLGene Expression and Chemoresistance in Breast Tumor Cells

(2008) Lilly Y. W. Bourguignon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biodegradable polymers as non-viral carriers for plasmid DNA delivery

(2007) Jordy Luten et al.   JOURNAL OF CONTROLLED RELEASE