Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 13, Issue 32, Pages 38647-38655Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c05751
Keywords
aptamers; DNA-templated silver nanoclusters; antibacterial; fluorescent; nanoflim
Funding
- National Natural Science Foundation of China [31871875]
- Major Scientific and Technological Innovation Projects of Shandong [2019JZZY011014]
- 2115 Talent Development Program of China Agricultural University [00109016]
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The combination of DNA-AgNCs with bacterial aptamers has led to a novel approach for visual detection and effective elimination of bacteria. The capture of aptamers not only facilitates visual monitoring of bacteria but also enhances antibacterial effects. Additionally, a fluorescent nanofilm with excellent selectivity and antibacterial activity for detecting and eliminating S. aureus has been developed based on the DNA-AgNCs.
As a new type of nanomaterial, DNA-templated silver nanoclusters (DNA-AgNCs) have been widely studied because of their fluorescence and antibacterial properties. In this study, we combined the DNA-AgNCs with aptamers of bacteria to achieve a novel approach for the visual detection and effective elimination of bacteria. The aptamers of Staphylococcus aureus (S. aureus) were linked to G-rich sequences to achieve fluorescence enhancement when approaching the DNA-AgNCs. The capture of aptamers not only realized the visual monitoring of bacteria but also promoted the antibacterial effects. Additionally, a fluorescent nanofilm with excellent selectivity and antibacterial activity in the detection and elimination of S. aureus was developed based on the DNA-AgNCs. These aptamer-functionalized DNA-AgNCs show significant potential for many applications in food packaging and biomedical engineering.
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