Bromelain a Potential Bioactive Compound: A Comprehensive Overview from a Pharmacological Perspective

Chemical Profiles and Pharmacological Properties with in Silico Studies on Elatostema papillosum Wedd

(2021) Md. Zia Uddin et al.   MOLECULES

The Combination of Bromelain and Acetylcysteine (BromAc) Synergistically Inactivates SARS-CoV-2

(2021) Javed Akhter et al.   Viruses-Basel

Current State and Promising Opportunities on Pharmaceutical Approaches in the Treatment of Polymicrobial Diseases

(2021) Sartini Sartini et al.   Pathogens

Antioxidant-Rich Woodfordia fruticosa Leaf Extract Alleviates Depressive-Like Behaviors and Impede Hyperglycemia

(2021) Mohammed Abu Tayab et al.   Plants-Basel

Investigation of the Pharmacological Properties of Lepidagathis hyalina Nees through Experimental Approaches

(2021) Fowzul Islam Fahad et al.   Life-Basel

Pharmacological studies on the antinociceptive, anxiolytic and antidepressant activity of Tinospora crispa

(2020) Ahmed Rakib et al.   PHYTOTHERAPY RESEARCH

Combined anthocyanins and bromelain supplement improves endothelial function and skeletal muscle oxygenation status in adults: a double-blind placebo-controlled randomized crossover clinical trial

(2020) Elizabeth J. Pekas et al.   BRITISH JOURNAL OF NUTRITION

GC-MS Phytochemical Profiling, Pharmacological Properties, and In Silico Studies of Chukrasia velutina Leaves: A Novel Source for Bioactive Agents

(2020) Israt Jahan et al.   MOLECULES

Deciphering the Pharmacological Properties of Methanol Extract of Psychotria calocarpa Leaves by In Vivo, In Vitro and In Silico Approaches

(2020) Tahmina Akter Bristy et al.   Pharmaceuticals

Unravelling the Biological Activities of the Byttneria pilosa Leaves Using Experimental and Computational Approaches

(2020) Mifta Ahmed Jyoti et al.   MOLECULES

Unveiling pharmacological studies provide new insights on Mangifera longipes and Quercus gomeziana

(2020) Bishwajit Guha et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Biological Evaluation, DFT Calculations and Molecular Docking Studies on the Antidepressant and Cytotoxicity Activities of Cycas pectinata Buch.-Ham. Compounds

(2020) Jinnat Rahman et al.   Pharmaceuticals

The Genus Curcuma and Inflammation: Overview of the Pharmacological Perspectives

(2020) Md. Moshiur Rahaman et al.   Plants-Basel

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy

(2019) Tung-Cheng Chang et al.   PLoS One

BROMELAIN SEPARATION AND PURIFICATION PROCESSES FROM PINEAPPLE EXTRACT

(2019) Danielly C. A. Abreu et al.   BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING

Bromelain reversed electrolyte imbalance in the chronically constricted sciatic nerve of Wistar rats

(2019) Ahmed Olalekan Bakare et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain–Chitosan Nanoparticles

(2019) Janaína Artem Ataide et al.   Polymers

Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches

(2019) Ahmed Rakib et al.   Food Science & Nutrition

Bromelain-loaded nanoparticles: A comprehensive review of the state of the art

(2018) Janaína Artem Ataide et al.   ADVANCES IN COLLOID AND INTERFACE SCIENCE

Are Colon and Rectal Cancer Two Different Tumor Entities? A Proposal to Abandon the Term Colorectal Cancer

(2018) Stephan Paschke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effects on fibrinogen, fibrin, and blood coagulation of proteolytic extracts from fruits of Pseudananas macrodontes, Bromelia balansae, and B. hieronymi (Bromeliaceae) in comparison with bromelain

(2016) María E. Errasti et al.   BLOOD COAGULATION & FIBRINOLYSIS

Bromelain: Methods of Extraction, Purification and Therapeutic Applications

(2016) Zoya Manzoor et al.   BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY

Gold nanoparticles and bioconjugation: a pathway for proteomic applications

(2016) Cláudia Couto et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Anti-rheumatic activity ofAnanas comosusfruit peel extract in a complete Freund’s adjuvant rat model

(2016) Samira Kargutkar et al.   PHARMACEUTICAL BIOLOGY

Combination of cisplatin and bromelain exerts synergistic cytotoxic effects against breast cancer cell line MDA-MB-231 in vitro

(2016) Ahmad Zaim Mat Pauzi et al.   Chinese Medicine

Ananas comosus Effect on Perineal Pain and Wound Healing After Episiotomy: A Randomized Double-Blind Placebo-Controlled Clinical Trial

(2016) Samira Golezar   Iranian Red Crescent Medical Journal

Effects of organic extracts and their different fractions of five Bangladeshi plants on in vitro thrombolysis

(2015) Talha Bin Emran et al.   BMC Complementary and Alternative Medicine

Nanoparticles decorated with proteolytic enzymes, a promising strategy to overcome the mucus barrier

(2015) Irene Pereira de Sousa et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

A novel process for size controlled biosynthesis of gold nanoparticles using bromelain

(2015) Salman Khan et al.   MATERIALS LETTERS

Molecular docking and inhibition studies on the interactions of Bacopa monnieri’s potent phytochemicals against pathogenic Staphylococcus aureus

(2015) Talha Bin Emran et al.   DARU-Journal of Pharmaceutical Sciences

Bromelain Surface Modification Increases the Diffusion of Silica Nanoparticles in the Tumor Extracellular Matrix

(2014) Alessandro Parodi et al.   ACS Nano

Perioperative Bromelain Reduces Pain and Swelling and Improves Quality of Life Measures After Mandibular Third Molar Surgery: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2014) Omer Waleed Majid et al.   JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

An in vitro antibacterial and antifungal effects of cadmium(II) complexes of hexamethyltetraazacyclotetradecadiene and isomers of its saturated analogue

(2014) Foni Bushon Biswas et al.   Asian Pacific Journal of Tropical Medicine

Effects of organic extracts of six Bangladeshi plants on in vitro thrombolysis and cytotoxicity

(2013) M Atiar Rahman et al.   BMC Complementary and Alternative Medicine

Pineapple fruit bromelain recovery using recyclable functionalized ordered mesoporous silica synthesized from sugarcane leaf ash

(2013) A. Arumugam et al.   BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING

Bromelain Inhibits Allergic Sensitization and Murine Asthma via Modulation of Dendritic Cells

(2013) Eric R. Secor et al.   Evidence-based Complementary and Alternative Medicine

Bromelain Enzyme from Pineapple: In Vitro Activity Study under Different Micropropagation Conditions

(2012) Jaci Lima Vilanova Neta et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Pityriasis lichenoides

(2012) Shylaja Someshwar et al.   INDIAN PEDIATRICS

Antioxidative, antimicrobial and cytotoxic effects of the phenolics of Leea indica leaf extract

(2012) Md. Atiar Rahman et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Recombinant bromelain production in Escherichia coli: process optimization in shake flask culture by response surface methodology

(2012) Bala Muntari et al.   AMB Express

Preparative purification of bromelain (EC 3.4.22.33) from pineapple fruit by high-speed counter-current chromatography using a reverse-micelle solvent system

(2011) Lianhong Yin et al.   FOOD CHEMISTRY

Pineapple fruit bromelain affinity to different protein substrates

(2011) Carlos A. Corzo et al.   FOOD CHEMISTRY

Aqueous two-phase extraction of bromelain from pineapple peels (‘Phu Lae’ cultv.) and its biochemical properties

(2011) Sunantha Ketnawa et al.   FOOD SCIENCE AND BIOTECHNOLOGY

Facile synthesis of 3D cubic mesoporous silica microspheres with a controllable pore size and their application for improved delivery of a water-insoluble drug

(2011) Yanchen Hu et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Bromelain-Induced Apoptosis in GI-101A Breast Cancer Cells

(2011) Sivanesan Dhandayuthapani et al.   JOURNAL OF MEDICINAL FOOD

Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G2/M arrest to apoptosis

(2011) Kulpreet Bhui et al.   MOLECULAR CARCINOGENESIS

Pineapple bromelain induces autophagy, facilitating apoptotic response in mammary carcinoma cells

(2010) Kulpreet Bhui et al.   BIOFACTORS

Chitosan Nanoparticles: A Promising System in Novel Drug Delivery

(2010) Kalpana Nagpal et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Separation and Purification of Bromelain by Reverse Micellar Extraction Coupled Ultrafiltration and Comparative Studies with Other Methods

(2010) Umesh H. Hebbar et al.   Food and Bioprocess Technology

Analysis of pineapple [Ananas comosus (L.) Merr.] fruit proteinases by 2-D zymography and direct identification of the major zymographic spots by mass spectrometry

(2010) Marilena Larocca et al.   FOOD CHEMISTRY

Bromelain from pineapple stem in alcoholic–acidic buffers for wine application

(2010) Ilaria Benucci et al.   FOOD CHEMISTRY

Rapid and Selective Enzymatic Debridement of Porcine Comb Burns With Bromelain-Derived Debrase®: Acute-Phase Preservation of Noninjured Tissue and Zone of Stasis

(2010) Adam J. Singer et al.   Journal of Burn Care & Research

Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway

(2009) Kulpreet Bhui et al.   CANCER LETTERS

Bromelain’s activity and potential as an anti-cancer agent: Current evidence and perspectives

(2009) Katya Chobotova et al.   CANCER LETTERS

Preparation and characterization of poly(acrylic acid)-based nanoparticles

(2009) Reka Melinda Molnar et al.   COLLOID AND POLYMER SCIENCE

Scleroderma

(2009) Armando Gabrielli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bromelain induces cardioprotection against ischemia-reperfusion injury through Akt/FOXO pathway in rat myocardium

(2008) Bela Juhasz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Bromelain Inhibits Lipopolysaccharide-Induced Cytokine Production in Human THP-1 Monocytes via the Removal of CD14

(2008) Jing-Rong Huang et al.   IMMUNOLOGICAL INVESTIGATIONS

Purification and drying of bromelain

(2008) R.V. Devakate et al.   SEPARATION AND PURIFICATION TECHNOLOGY

Use of reverse micellar systems for the extraction and purification of bromelain from pineapple wastes

(2007) H. Umesh Hebbar et al.   BIORESOURCE TECHNOLOGY

Liquid–liquid extraction of bromelain and polyphenol oxidase using aqueous two-phase system

(2007) B. Ravindra Babu et al.   CHEMICAL ENGINEERING AND PROCESSING

Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro

(2007) Jane E. Onken et al.   CLINICAL IMMUNOLOGY