MiR-21 in the Cancers of the Digestive System and Its Potential Role as a Diagnostic, Predictive, and Therapeutic Biomarker
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
MiR-21 in the Cancers of the Digestive System and Its Potential Role as a Diagnostic, Predictive, and Therapeutic Biomarker
Authors
Keywords
-
Journal
Biology-Basel
Volume 10, Issue 5, Pages 417
Publisher
MDPI AG
Online
2021-05-10
DOI
10.3390/biology10050417
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Circulating miR-21 as a Potential Biomarker in Human Digestive System Carcinoma: A Systematic Review and Diagnostic Meta-Analysis
- (2021) Amir Hossein Aalami et al. BIOMARKERS
- MicroRNA 21 Elicits a Pro-inflammatory Response in Macrophages, with Exosomes Functioning as Delivery Vehicles
- (2021) Radha Madhyastha et al. INFLAMMATION
- miR-21 Plays a Dual Role in Tumor Formation and Cytotoxic Response in Breast Tumors
- (2021) Tu Dan et al. Cancers
- Targeted therapy for advanced salivary gland carcinoma based on molecular profiling: results from MyPathway, a phase IIa multiple basket study
- (2020) R. Kurzrock et al. ANNALS OF ONCOLOGY
- Microbiome and Gastric Cancer
- (2020) Lars Engstrand et al. DIGESTIVE DISEASES AND SCIENCES
- Circular RNA circHIAT1 inhibits proliferation and epithelial‐mesenchymal transition of gastric cancer cell lines through downregulation of miR‐21
- (2020) Jingzi Quan et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer
- (2020) Gaofeng Liang et al. JOURNAL OF NANOBIOTECHNOLOGY
- miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis
- (2020) Carmen Elena Condrat et al. Cells
- Exosomal miR-21 promotes proliferation, invasion and therapy resistance of colon adenocarcinoma cells through its target PDCD4
- (2020) Li-Hua Sun et al. Scientific Reports
- Interactions between the MicroRNAs and Microbiota in Cancer Development: Roles and Therapeutic Opportunities
- (2020) Alessandro Allegra et al. Cancers
- Ratios of miRNAs in Peritoneal Exosomes are Useful Biomarkers to Predict Tumor Response to Intraperitoneal Chemotherapy in Patients with Peritoneal Metastases from Gastric Cancer
- (2020) Hideyuki Ohzawa et al. ANNALS OF SURGICAL ONCOLOGY
- Expression and clinical correlation of Survivin and PTEN in gastric cancer patients
- (2020) Aikeremu Yusufu et al. Oncology Letters
- LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells
- (2019) Weidong Li et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential
- (2019) Ester Saus et al. MOLECULAR ASPECTS OF MEDICINE
- Role of the brain-gut axis in gastrointestinal cancer
- (2019) Yang-Zi Di et al. World Journal of Clinical Cases
- Pleiotropic microRNA-21 in pulmonary remodeling: novel insights for molecular mechanism and present advancements
- (2019) Congshan Jiang et al. Allergy Asthma and Clinical Immunology
- Downregulation of miR-21 inhibits the malignant phenotype of pancreatic cancer cells by targeting VHL
- (2019) Jinjin Sun et al. OncoTargets and Therapy
- Plasma exosome‑encapsulated microRNA‑21 and microRNA‑92a are promising biomarkers for the prediction of peritoneal recurrence in patients with gastric cancer
- (2019) Naruyoshi Soeda et al. Oncology Letters
- In Vitro and In Silico Mechanistic Insights into miR-21-5p-Mediated Topoisomerase Drug Resistance in Human Colorectal Cancer Cells
- (2019) Chen et al. Biomolecules
- Microbial regulation of microRNA expression in the brain–gut axis
- (2019) Gerard M Moloney et al. CURRENT OPINION IN PHARMACOLOGY
- Circular RNA circC3P1 restrains kidney cancer cell activity by regulating miR‐21/PTEN axis and inactivating PI3K/AKT and NF‐ k B pathways
- (2019) Tao Chen et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Suppressing miR-21 activity in tumor-associated macrophages promotes an antitumor immune response
- (2019) Mahnaz Sahraei et al. JOURNAL OF CLINICAL INVESTIGATION
- Research Progress in microRNA-Based Therapy for Gastric Cancer
- (2019) Xu Zhao et al. OncoTargets and Therapy
- Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma
- (2018) Chao Wang et al. BIOMEDICINE & PHARMACOTHERAPY
- Downregulation of microRNA-21 inhibited radiation-resistance of esophageal squamous cell carcinoma
- (2018) Fang Li et al. Cancer Cell International
- Overview upon miR-21 in lung cancer: focus on NSCLC
- (2018) Cecilia Bica-Pop et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- miR‑21‑5p confers doxorubicin resistance in gastric cancer cells by targeting PTEN and TIMP3
- (2018) Jun Chen et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Loss of MicroRNA-21 Influences the Gut Microbiota, Causing Reduced Susceptibility in a Murine Model of Colitis
- (2018) Daniel G W Johnston et al. Journal of Crohns & Colitis
- Role of miR-21 in the growth and metastasis of human salivary adenoid cystic carcinoma
- (2018) Fei Yan et al. Molecular Medicine Reports
- Circulating plasma microRNAs in the detection of esophageal squamous cell carcinoma
- (2018) Lu Zhang et al. Oncology Letters
- Human salivary microRNAs in Cancer
- (2018) Óscar Rapado-González et al. Journal of Cancer
- MicroRNA Roles in the Nuclear Factor Kappa B Signaling Pathway in Cancer
- (2018) Jin’en Wu et al. Frontiers in Immunology
- Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
- (2018) Freddie Bray et al. CA-A CANCER JOURNAL FOR CLINICIANS
- Ado-trastuzumab emtansine (T-DM1) in patients (pts) with HER2 amplified (amp) tumors excluding breast and gastric/gastro-esophageal junction (GEJ) adenocarcinomas: Results from the National Cancer Institute (NCI) Molecular Analysis for Therapy Choice (MATCH) trial.
- (2018) Komal L. Jhaveri et al. JOURNAL OF CLINICAL ONCOLOGY
- microRNAs in cancer stem cells: Biology, pathways, and therapeutic opportunities
- (2018) Zahra Asadzadeh et al. JOURNAL OF CELLULAR PHYSIOLOGY
- miR-21 promotes EGF-induced pancreatic cancer cell proliferation by targeting Spry2
- (2018) Qiuyan Zhao et al. Cell Death & Disease
- miR-21 promotes cell migration and invasion of hepatocellular carcinoma by targeting KLF5
- (2018) Jian Wang et al. Oncology Letters
- Prognostic significance of circulating microRNA-21 expression in esophageal, pancreatic and colorectal cancers; a systematic review and meta-analysis
- (2018) Salman Guraya International Journal of Surgery
- Commensal microbiota-induced microRNA modulates intestinal epithelial permeability through the small GTPase ARF4
- (2017) Kazuaki Nakata et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells
- (2017) Peiming Zheng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Mcl-1 stabilization confers resistance to taxol in human gastric cancer
- (2017) Wu Shuang et al. Oncotarget
- Gastric cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†
- (2016) E. C. Smyth et al. ANNALS OF ONCOLOGY
- Epidemiologic studies of the human microbiome and cancer
- (2016) Emily Vogtmann et al. BRITISH JOURNAL OF CANCER
- OncomiR or Tumor Suppressor? The Duplicity of MicroRNAs in Cancer
- (2016) Alexander A. Svoronos et al. CANCER RESEARCH
- Comprehensive Molecular Characterization of Salivary Duct Carcinoma Reveals Actionable Targets and Similarity to Apocrine Breast Cancer
- (2016) M. G. Dalin et al. CLINICAL CANCER RESEARCH
- MiR 21-5p as a predictor of recurrence in young gastric cancer patients
- (2016) Soo-Kyung Park et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- HBx-induced miR-21 suppresses cell apoptosis in hepatocellular carcinoma by targeting interleukin-12
- (2016) Dian Yin et al. ONCOLOGY REPORTS
- MicroRNA-21 promotes cell proliferation, migration, and resistance to apoptosis through PTEN/PI3K/AKT signaling pathway in esophageal cancer
- (2016) Yan-Ran Wu et al. TUMOR BIOLOGY
- microRNA Therapeutics in Cancer — An Emerging Concept
- (2016) Maitri Y. Shah et al. EBioMedicine
- Considering Exosomal miR-21 as a Biomarker for Cancer
- (2016) Jian Shi Journal of Clinical Medicine
- High-Mobility Group Box 1 Promotes Hepatocellular Carcinoma Progression through miR-21-Mediated Matrix Metalloproteinase Activity
- (2015) M. Chen et al. CANCER RESEARCH
- Hsa-miR-21 and Hsa-miR-29 in Tissue as Potential Diagnostic and Prognostic Biomarkers for Gastric Cancer
- (2015) Dahu Wang et al. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
- Targeting Kruppel-Like Factor 5 (KLF5) for Cancer Therapy
- (2015) Yu Gao et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Circulating MicroRNA-21 Is a Potential Diagnostic Biomarker in Gastric Cancer
- (2015) Jianhong Wu et al. DISEASE MARKERS
- MicroRNA-494 sensitizes colon cancer cells to fluorouracil through regulation of DPYD
- (2015) Jie Chai et al. IUBMB LIFE
- MiR-21: an environmental driver of malignant melanoma?
- (2015) Bodo C Melnik Journal of Translational Medicine
- miR-21 regulates tumor progression through the miR-21-PDCD4-Stat3 pathway in human salivary adenoid cystic carcinoma
- (2015) Lie-Hao Jiang et al. LABORATORY INVESTIGATION
- Anti-miR-21 Suppresses Hepatocellular Carcinoma Growth via Broad Transcriptional Network Deregulation
- (2015) T. R. Wagenaar et al. MOLECULAR CANCER RESEARCH
- High frequency of loss of PTEN expression in human solid salivary adenoid cystic carcinoma and its implication for targeted therapy
- (2015) Han Liu et al. Oncotarget
- MiR-21 mediates sorafenib resistance of hepatocellular carcinoma cells by inhibiting autophagy via the PTEN/Akt pathway
- (2015) Changjun He et al. Oncotarget
- Cardamonin Regulates miR-21 Expression and Suppresses Angiogenesis Induced by Vascular Endothelial Growth Factor
- (2015) Fu-Sheng Jiang et al. Biomed Research International
- MicroRNAs as Potential Biomarkers in Cancer: Opportunities and Challenges
- (2015) Huiyin Lan et al. Biomed Research International
- Exosomal miRNAs from Peritoneum Lavage Fluid as Potential Prognostic Biomarkers of Peritoneal Metastasis in Gastric Cancer
- (2015) Motohiko Tokuhisa et al. PLoS One
- miR-21 is a negative modulator of T-cell activation
- (2014) Claudia Carissimi et al. BIOCHIMIE
- Comparison of long non-coding RNAs, microRNAs and messenger RNAs involved in initiation and progression of esophageal squamous cell carcinoma
- (2014) SU-QING LI et al. Molecular Medicine Reports
- A Critical Evaluation of microRNA Biomarkers in Non-Neoplastic Disease
- (2014) Baqer A. Haider et al. PLoS One
- Circulating microRNA-21 as a biomarker for the detection of various carcinomas: an updated meta-analysis based on 36 studies
- (2014) Kailiu Wu et al. TUMOR BIOLOGY
- Prognostic Role of MicroRNA-21 in Gastric Cancer: a Meta-Analysis
- (2014) Chen Li MEDICAL SCIENCE MONITOR
- Targeting miR-21 enhances the sensitivity of human colon cancer HT-29 cells to chemoradiotherapy in vitro
- (2013) Jun Deng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways
- (2013) Longlong Bao et al. CANCER LETTERS
- Down-Regulation of PTEN Expression Modulated by Dysregulated miR-21 Contributes to the Progression of Esophageal Cancer
- (2013) Pei Li et al. DIGESTIVE DISEASES AND SCIENCES
- miR-21 Down-Regulation Suppresses Cell Growth, Invasion and Induces Cell Apoptosis by Targeting FASL, TIMP3, and RECK Genes in Esophageal Carcinoma
- (2013) Na Wang et al. DIGESTIVE DISEASES AND SCIENCES
- Epigenetic regulation of miR-21 in colorectal cancer
- (2013) Angelo Ferraro et al. Epigenetics
- MicroRNA-21: a therapeutic target for reversing drug resistance in cancer
- (2013) Liu Hong et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- SERPINA3K induces apoptosis in human colorectal cancer cells via activating the Fas/FasL/caspase-8 signaling pathway
- (2013) Yachao Yao et al. FEBS Journal
- MicroRNA-21 mediates the rapamycin-induced suppression of endothelial proliferation and migration
- (2013) Chongying Jin et al. FEBS LETTERS
- Diagnostic and prognostic value of circulating miR-21 for cancer: A systematic review and meta-analysis
- (2013) Yang Wang et al. GENE
- MicroRNA-21 regulates the migration and invasion of a stem-like population in hepatocellular carcinoma
- (2013) LIANG ZHOU et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Validation of Circulating miRNA Biomarkers for Predicting Lymph Node Metastasis in Gastric Cancer
- (2013) Shine Young Kim et al. JOURNAL OF MOLECULAR DIAGNOSTICS
- Serum miR-21 as a Diagnostic and Prognostic Biomarker in Colorectal Cancer
- (2013) Yuji Toiyama et al. JNCI-Journal of the National Cancer Institute
- Oesophageal carcinoma
- (2013) Arjun Pennathur et al. LANCET
- Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis
- (2013) Jia-Xing Zhang et al. LANCET ONCOLOGY
- Curcumin induces FasL-related apoptosis through p38 activation in human hepatocellular carcinoma Huh7 cells
- (2013) Wei-Zhang Wang et al. LIFE SCIENCES
- Targeting miR-21 for the Therapy of Pancreatic Cancer
- (2013) Flavie Sicard et al. MOLECULAR THERAPY
- Potential Role of microRNA-21 in the Diagnosis of Gastric Cancer: A Meta-Analysis
- (2013) Zongyue Zeng et al. PLoS One
- Prognostic Role of microRNA-21 in Colorectal Cancer: a Meta-Analysis
- (2013) Xiaochun Xia et al. PLoS One
- Role of microRNAs in the immune system, inflammation and cancer
- (2013) Jennifer Raisch WORLD JOURNAL OF GASTROENTEROLOGY
- Serum microRNA-21 levels are related to tumor size in gastric cancer patients but cannot predict prognosis
- (2013) JIANNING SONG et al. Oncology Letters
- Regarding Article ‘Bcl-2 Upregulation Induced by miR-21 Via a Direct Interaction Is Associated with Apoptosis and Chemoresistance in MIA PaCa-2 Pancreatic Cancer Cells’
- (2012) Tian-Hong Pan et al. ARCHIVES OF MEDICAL RESEARCH
- MicroRNA-21 inhibits Serpini1, a gene with novel tumour suppressive effects in gastric cancer
- (2012) Sumitaka Yamanaka et al. DIGESTIVE AND LIVER DISEASE
- Burden of Gastrointestinal Disease in the United States: 2012 Update
- (2012) Anne F. Peery et al. GASTROENTEROLOGY
- MicroRNA-21 gene and cancer
- (2012) Yong Huang et al. MEDICAL ONCOLOGY
- DIANA miRPath v.2.0: investigating the combinatorial effect of microRNAs in pathways
- (2012) Ioannis S. Vlachos et al. NUCLEIC ACIDS RESEARCH
- Identification of Serum MicroRNAs as Novel Non-Invasive Biomarkers for Early Detection of Gastric Cancer
- (2012) Ming-yang Song et al. PLoS One
- Antagonism of miR-21 Reverses Epithelial-Mesenchymal Transition and Cancer Stem Cell Phenotype through AKT/ERK1/2 Inactivation by Targeting PTEN
- (2012) Mingli Han et al. PLoS One
- miR-21 Is a Promising Novel Biomarker for Lymph Node Metastasis in Patients with Gastric Cancer
- (2012) Yuejuan Xu et al. Gastroenterology Research and Practice
- Bcl-2 Upregulation Induced by miR-21 Via a Direct Interaction Is Associated with Apoptosis and Chemoresistance in MIA PaCa-2 Pancreatic Cancer Cells
- (2011) Jie Dong et al. ARCHIVES OF MEDICAL RESEARCH
- MicroRNA dysregulation in colorectal cancer: a clinical perspective
- (2011) Y Dong et al. BRITISH JOURNAL OF CANCER
- MicroRNA-21: A novel therapeutic target in human cancer
- (2011) Xuan Pan et al. CANCER BIOLOGY & THERAPY
- MicroRNA-21 induces stemness by downregulating transforming growth factor beta receptor 2 (TGF R2) in colon cancer cells
- (2011) Y. Yu et al. CARCINOGENESIS
- Prognostic role of microRNA-21 in various carcinomas: a systematic review and meta-analysis
- (2011) Xiaonan Fu et al. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
- miR-21 targets the tumor suppressor RhoB and regulates proliferation, invasion and apoptosis in colorectal cancer cells
- (2011) Ming Liu et al. FEBS LETTERS
- Loss of E-cadherin expression and outcome among patients with resectable pancreatic adenocarcinomas
- (2011) Seung-Mo Hong et al. MODERN PATHOLOGY
- MicroRNA-21 Exhibits Antiangiogenic Function by Targeting RhoB Expression in Endothelial Cells
- (2011) Céline Sabatel et al. PLoS One
- MiR-21 Induced Angiogenesis through AKT and ERK Activation and HIF-1α Expression
- (2011) Ling-Zhi Liu et al. PLoS One
- Prognostic Significance of miR-181b and miR-21 in Gastric Cancer Patients Treated with S-1/Oxaliplatin or Doxifluridine/Oxaliplatin
- (2011) Jingting Jiang et al. PLoS One
- Regulation and function of miRNA-21 in health and disease
- (2011) Regalla Kumarswamy et al. RNA Biology
- MicroRNAs in NF- B signaling
- (2011) X. Ma et al. Journal of Molecular Cell Biology
- Circulating microRNAs in plasma of patients with gastric cancers
- (2010) M Tsujiura et al. BRITISH JOURNAL OF CANCER
- MicroRNA-21 induces resistance to the anti-tumour effect of interferon-α/5-fluorouracil in hepatocellular carcinoma cells
- (2010) Y Tomimaru et al. BRITISH JOURNAL OF CANCER
- A resource for analysis of microRNA expression and function in pancreatic ductal adenocarcinoma cells
- (2010) Oliver A. Kent et al. CANCER BIOLOGY & THERAPY
- MicroRNA-21 in Pancreatic Cancer: Correlation with Clinical Outcome and Pharmacologic Aspects Underlying Its Role in the Modulation of Gemcitabine Activity
- (2010) Elisa Giovannetti et al. CANCER RESEARCH
- High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients
- (2010) Boye Schnack Nielsen et al. CLINICAL & EXPERIMENTAL METASTASIS
- MicroRNA-21 Is Induced Early in Pancreatic Ductal Adenocarcinoma Precursor Lesions
- (2010) M. C. du Rieu et al. CLINICAL CHEMISTRY
- Overexpression of miR-21 Promotes an In vitro Metastatic Phenotype by Targeting the Tumor Suppressor RHOB
- (2010) Erin C. Connolly et al. MOLECULAR CANCER RESEARCH
- OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
- (2010) Pedro P. Medina et al. NATURE
- MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)
- (2010) N. Valeri et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MicroRNAs: Target Recognition and Regulatory Functions
- (2009) David P. Bartel CELL
- MicroRNA-21 Regulates the Proliferation and Invasion in Esophageal Squamous Cell Carcinoma
- (2009) Y. Hiyoshi et al. CLINICAL CANCER RESEARCH
- MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance
- (2009) T. Moriyama et al. MOLECULAR CANCER THERAPEUTICS
- Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21
- (2009) Frederick J Sheedy et al. NATURE IMMUNOLOGY
- Antisense Inhibition of microRNA-21 or -221 Arrests Cell Cycle, Induces Apoptosis, and Sensitizes the Effects of Gemcitabine in Pancreatic Adenocarcinoma
- (2009) Jong-Kook Park et al. PANCREAS
- Detection of Cancer with Serum miRNAs on an Oligonucleotide Microarray
- (2009) Michael J. Lodes et al. PLoS One
- MiR-21 is an EGFR-regulated anti-apoptotic factor in lung cancer in never-smokers
- (2009) M. Seike et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A truth serum for cancer — microRNAs have major potential as cancer biomarkers
- (2008) Lena J Chin et al. CELL RESEARCH
- MicroRNA Expression Profiles Associated With Prognosis and Therapeutic Outcome in Colon Adenocarcinoma
- (2008) Aaron J. Schetter et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- miR-21: a small multi-faceted RNA
- (2008) Anna M. Krichevsky et al. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
- MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene
- (2008) Z Lu et al. ONCOGENE
- Circulating microRNAs as stable blood-based markers for cancer detection
- (2008) P. S. Mitchell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now