Review
Biochemistry & Molecular Biology
Yasmine K. Abd El Fattah, Ahmed I. Abulsoud, Sherihan G. AbdelHamid, Nadia M. Hamdy
Summary: The lncRNA CCDC144NL-AS1 is functionally linked to several human cancers and could serve as a promising prognostic biomarker and therapeutic target.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Genetics & Heredity
Huiyuan Xiao, Wen Huang, Yanlei Li, Rongxin Zhang, Long Yang
Summary: The study showed that higher expression of TTN-AS1 was associated with poorer DFS in BC patients, especially in those who underwent Re-TURBT. Knocking down TTN-AS1 could inhibit the proliferation and invasion abilities of BC cells. ATF2 may act as a downstream target of TTN-AS1 in BC, and high expression of ATF2 is also related to adverse DFS in patients.
FRONTIERS IN GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Sophie Wulf, Luisa Mizko, Karl-Heinz Herrmann, Marta Sanchez-Carbonell, Anja Urbach, Cornelius Lemke, Alexander Berndt, Ivonne Loeffler, Gunter Wolf
Summary: MORG1 is a scaffold molecule for the ERK signaling pathway and also interacts with prolyl-hydroxylase 3, modulating the expression of HIF-1α. Knockout mice lacking Morg1 were generated and showed embryonic lethality due to severe developmental defects, particularly in the brain, spinal cord, and chorioallantoic fusion.
Review
Pathology
Khazar Ghasempour Dabbaghi, Noushin Mashatan, Omid Faraz, Aysa Hasanzade Bashkandi, Nematullah Shomoossi, Peyman Tabnak
Summary: Long non-coding RNAs (lncRNAs) play a critical role in human cancers as oncogenes or tumor suppressors. MAFG-AS1, an antisense RNA of MAF BZIP Transcription Factor G (MAFG), is overexpressed in many cancers and associated with poor clinical characteristics and prognosis.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Xuelian Huang, Sicong Zhu, Kelin Zhang, Wenliang Tan, Yajin Chen, Changzhen Shang
Summary: High expression of TMCO1-AS1 is significantly correlated with poor prognosis in HCC. TMCO1-AS1 expression is positively correlated with AFP level, vascular invasion, tumor stage, and tumor differentiation. Survival analysis shows a significant inverse association between TMCO1-AS1 expression and patient survival. Cox analysis confirms TMCO1-AS1 as an independent prognostic factor for HCC. Tissue analysis from our center supports the results of bioinformatics analysis. Risk models incorporating TMCO1-AS1 exhibit better sensitivity and specificity in predicting overall survival and recurrence-free survival compared to clinical characteristics alone.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Review
Neurosciences
Mohammed Almannai, Dana Marafi, Ayman W. W. El-Hattab
Summary: WIPI proteins play important roles in autophagy and pathogenic variants in genes encoding these proteins can cause various neurological disorders. Deficiencies in WIPI2 are associated with intellectual disability, pathogenic variants in WDR45B cause El-Hattab-Alkuraya syndrome, and pathogenic variants in WDR45 lead to BPAN. WIPI1 is linked to neural tube defects.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Medicine, Research & Experimental
Yu-Run Zhu, Kun-Peng Zhu, Jian-Ping Hu, Shuo Tan, Chun-Lin Zhang
Summary: Osteosarcoma is a malignant tumor primarily affecting children and adolescents. Metastasis and chemotherapy resistance are challenging in its treatment. This study investigated the clinical significance of two non-coding RNAs, lncRNA OIP5-AS1 and hsa_circ_0004674, in osteosarcoma.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Biotechnology & Applied Microbiology
Linyong Wu, Wei Liao, Xiaodong Wang, Yujia Zhao, Jinshu Pang, Yuji Chen, Hong Yang, Yun He
Summary: The study investigated the expression, prognostic potential, and relationship with immune infiltration of ASB16-AS1 in cancer. Results showed high expression in tumor tissues, association with poor prognosis in multiple cancer types, and promotion of tumor progression in liver cancer. ASB16-AS1 was found to be positively correlated with some immune cells and negatively correlated with others, while also interacting with molecular features in diverse ways.
Review
Chemistry, Medicinal
Bei Wang, Jinlan Chen, Chen Lin, Ru Liu, Lu Wang, Chengfu Yuan
Summary: This article reviews the pathophysiological functions and molecular mechanisms of MCM3AP-AS1 in various tumors. It found that the abnormal expression of MCM3AP-AS1 is closely related to tumor proliferation, invasion, and migration. MCM3AP-AS1 mediates or participates in related signaling pathways to regulate the expression of targeted miRNAs and proteins, making it a potential tumor marker and therapeutic target.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Review
Cell Biology
Xiao Yu, Qingyuan Zheng, Qiyao Zhang, Shuijun Zhang, Yuting He, Wenzhi Guo
Summary: MCM3AP-AS1, a novel lncRNA aberrantly expressed in human cancers, is significantly associated with clinical characteristics of tumors and modulates tumor progression by controlling cellular functions. It shows promise as a biomarker for cancer diagnosis, prognosis evaluation, and treatment, with potential clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Medicine, General & Internal
Xiaona Xu, Fujiao Duan, Liran Xu, Shiutin Ng, Yongwei Li, Yanan Li, Xiaoge Wang, Tianjian Long, Nana Ding, Erping Xu
Summary: This study systematically evaluated the potential correlation between Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) and the prognosis of digestive system cancers (DSC). The results showed that high expression of AFAP1-AS1 was significantly associated with poor prognosis in DSC.
Review
Cell Biology
Soudeh Ghafouri-Fard, Sajad Najafi, Bashdar Mahmud Hussen, Aryan R. Ganjo, Mohammad Taheri, Mohammad Samadian
Summary: Long non-coding RNAs (lncRNAs) are a heterogeneous group of ncRNAs with a characteristic size of more than 200 nucleotides. DLX6-AS1 is an lncRNA that has been found to be up-regulated in various cancers, and it promotes the oncogenic phenotype of cancer cells by affecting signaling pathways. It is associated with clinicopathological features and shorter survival in cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Fangnan Zhao, Fangshun Tan, Lu Tang, Zhuoying Du, Xiaoya Chen, Yuzhi Yang, Gang Zhou, Chengfu Yuan
Summary: This article elucidates the pathophysiological functions of lncRNA DLGAP1-AS1 and DLGAP1-AS2 in various tumors. The expression of DLGAP1-AS1 and DLGAP1-AS2 is abnormally high in multiple cancers and is closely associated with poor prognosis. They have different malignant impacts on tumor cells, including invasion, apoptosis, proliferation, epithelial-mesenchymal transition, drug resistance, and radioresistance. DLGAP1-AS2 can also predict the prognosis of Wilms tumor and renal cell carcinoma. Therefore, DLGAP1-AS1 and DLGAP1-AS2 may serve as clinical markers for early tumor diagnosis and effective therapeutic targets.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Cell Biology
Jianjun Tan, Weilin Mao, Shuzi Long, Tao Zhang
Summary: A metastasis-related risk model was established in this study to accurately predict the prognosis of LUAD. The metastatic relevance and clinical significance of MRLNRs were validated through various in vitro experiments. The MRRS provided a promising assessing model for clinical decision making and prognosis of LUAD.
Article
Oncology
Cheng Chen, Na Su, Guiying Li, Yanfeng Shen, Xiaoting Duan
Summary: TMCC1-AS1 is significantly upregulated in liver cancer tissues and cell lines, and high expression is associated with advanced tumor stage and lymph node metastasis, as well as predict poor survival in patients. Knockdown of TMCC1-AS1 inhibits cell proliferation, migration, and invasion, while overexpression has the opposite effects in HepG2 and SNU-182 cells.