Article
Toxicology
Samikshya Poudel, Diego Paine Cabrera, Bharat Bhushan, Michael W. Manley, Sumedha Gunewardena, Hartmut Jaeschke, Udayan Apte
Summary: Hepatocyte-specific deletion of Yes-associated protein (Yap) leads to faster recovery from acetaminophen (APAP) overdose-induced acute liver injury, characterized by accelerated hepatocyte proliferation and earlier pro-regenerative inflammatory response.
TOXICOLOGICAL SCIENCES
(2021)
Article
Oncology
Qian Chen, Xiao-Wei Zhou, Ai-Jun Zhang, Kang He
Summary: ACTN1 is significantly upregulated in HCC tissues and acts as a tumor promoter by suppressing Hippo signaling through physical interaction with MOB1. Therefore, ACTN1 may serve as a potential prognostic marker and therapeutic target for HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Tongqing Chen, Dongdong Sun, Qijuan Wang, Tingting Zhou, Jiani Tan, Changliang Xu, Haibo Cheng, Weixing Shen
Summary: The study reveals that alpha-hederin can induce apoptosis and inhibit cell proliferation in hepatocellular carcinoma cells by inhibiting YAP activity, highlighting its potential as an anti-cancer drug for liver cancer.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Jessica Elderkin, Najeeb Al Hallak, Asfar S. Azmi, Hussein Aoun, Jeffrey Critchfield, Miguel Tobon, Eliza W. Beal
Summary: Hepatocellular carcinoma is the most common primary liver cancer. High-risk patients should be monitored semi-annually. The management of HCC is complex and requires a multidisciplinary team evaluation. Early-stage cancer is best treated with curative-intent treatment methods, while intermediate-stage and advanced-stage require different approaches.
Review
Oncology
Chenbin Liu, Han Wu, Yinqi Mao, Wei Chen, Shuying Chen
Summary: Exosomal microRNAs play a crucial role in hepatocellular carcinoma, holding significant value in the early diagnosis and treatment of this disease.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Biyu Liu, Qi Wang, Tingting Mei, Jiasheng Zheng, Wenfeng Gao, Chunwang Yuan, Kang Li, Yonghong Zhang
Summary: This study investigated the association between pathologic markers and prognosis in patients with hepatocellular carcinoma. The expression of HBsAg in liver tissue was correlated with the prognosis of patients, with those negative for HBsAg having better survival rates than those positive for HBsAg. The expression of liver HBsAg before combined therapy can be used as a prognostic indicator for overall survival and recurrence-free survival in hepatocellular carcinoma patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jean-Philippe Guegan, Marjorie Lapouge, Laure Voisin, Marc K. Saba-El-Leil, Pierre-Luc Tanguay, Kim Levesque, Jeremy Bregeon, Anne-Marie Mes-Masson, Daniel Lamarre, Benjamin Haibe-Kains, Vincent Q. Trinh, Genevieve Soucy, Marc Bilodeau, Sylvain Meloche
Summary: Most patients with hepatocellular carcinoma (HCC) are diagnosed at a late stage with limited therapeutic options and poor prognosis. A previously uncharacterized oncogenic signaling pathway mediated by the tyrosine kinase Yes has been identified in HCC, providing a potential therapeutic target in this type of cancer. Yes activity was shown to be necessary for HCC cell proliferation, and its high activity predicted shorter overall survival in HCC patients.
Article
Oncology
Hiroshi Maeda, Kouichi Miura, Naoki Morimoto, Shunji Watanabe, Mamiko Tsukui, Yoshinari Takaoka, Hiroaki Nomoto, Rie Goka, Naoto Sato, Kazue Morishima, Yasunaru Sakuma, Naohiro Sata, Noriyoshi Fukushima, Norio Isoda, Hironori Yamamoto
Summary: Retrospective study finds that tyrosine kinase inhibitors (TKIs) promote longer overall survival in hepatocellular carcinoma (HCC) patients with extrahepatic metastases compared to conventional therapies. However, TKI plus conventional therapies do not improve prognosis in these patients.
Review
Chemistry, Multidisciplinary
Han Wu, Ming-Da Wang, Lei Liang, Hao Xing, Cheng-Wu Zhang, Feng Shen, Dong-Sheng Huang, Tian Yang
Summary: Nanotechnology has gained extensive attention in surveillance, imaging, and treatment of hepatocellular carcinoma. Nanomedicines focus on early diagnosis and precise treatment of HCC, offering promising potential applications in future clinical practice.
Review
Oncology
Suliman Khan, De-Yu Zhang, Ji-Yu Zhang, Mian Khizar Hayat, Jingli Ren, Safyan Nasir, Muhammad Fawad, Qian Bai
Summary: The expression and function of miRNAs play a crucial role in the development of HCC, affecting the biological behavior and clinical pathological features of liver cancer. Despite the unclear regulatory mechanisms, the potential of miRNA-based therapy for HCC warrants further exploration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Su Jong Yu, Jeong-Ju Yoo, Dong Ho Lee, Su Jin Kim, Eun Ju Cho, Se Hyung Kim, Jeong-Hoon Lee, Yoon Jun Kim, Jeong Min Lee, Jae Young Lee, Jung-Hwan Yoon
Summary: Gadoxetic acid disodium (Gd-EOB-DTPA)-enhanced MRI can detect early stages of hepatocellular carcinoma (HCC) in patients with cirrhosis, but its survival benefit is unknown. This retrospective cohort study found that intermittent replacement of ultrasonography (USG) with Gd-EOB-DTPA-enhanced MRI improved the clinical outcomes of cirrhosis patients, including overall survival and time to progression.
Article
Oncology
Jiang Li, Hai-su Tao, Jian Li, Wen-qiang Wang, Wei-wei Sheng, Zhi-yong Huang, Er-lei Zhang
Summary: This study compared the efficacy of liver resection (LR) and percutaneous microwave coagulation therapy (PMCT) for small hepatocellular carcinoma (HCC) with different degrees of liver cirrhosis. LR provided better surgical outcomes but PMCT had similar long-term results and lower surgical complications in HCC patients with severe cirrhosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yingxi Du, Yarui Ma, Qing Zhu, Tongzheng Liu, Yuchen Jiao, Peng Yuan, Xiaobing Wang
Summary: This study constructed a survival prediction model using m6A-associated genes to investigate the molecular and immune characteristics of HCC. It was found that m6A RNA methylation regulators were differentially expressed and associated with immune checkpoint expression in HCC. Additionally, two distinct HCC clusters were identified with different clinical features and immune characteristics.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Jingjing Zhang, Yangliu Tong, Xun Lu, Fangming Dong, Xiaoxuan Ma, Shiyu Yin, Ying He, Yonghong Liu, Qingchao Liu, Daidi Fan
Summary: This study demonstrates the antitumor effects of a new derivative of ginsenoside CK on hepatocellular carcinoma (HCC), which can inhibit HCC progression by regulating the Hippo-YAP1-TEAD2 signaling pathway. This research provides a new direction for the use of traditional Chinese medicine in tumor therapy.
Article
Oncology
Jina Kim, Hwa Kyung Byun, Tae Hyung Kim, Sun Il Kim, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Do Young Kim, Jinsil Seong
Summary: This study investigated the efficacy of liver-directed concurrent chemoradiotherapy (LD-CCRT) compared to sorafenib in hepatocellular carcinoma patients with portal vein tumor thrombosis (PVTT). The results showed that LD-CCRT led to significantly improved survival compared to sorafenib, and patients who underwent surgical treatment after LD-CCRT had even longer overall survival.
Article
Medicine, Research & Experimental
Jeongeun Hyun, Zhaoli Sun, Ali Reza Ahmadi, Sushant Bangru, Ullas Chembazhi, Kuo Du, Tianyi Chen, Hidekazu Tsukamoto, Ivan Rusyn, Auinash Kalsotra, Anna Mae Diehl
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Engineering, Biomedical
Jung Ju Seo, Nandin Mandakhbayar, Min Sil Kang, Ji-Young Yoon, Na-Hyun Lee, Junyong Ahn, Hae-Hyoung Lee, Jung-Hwan Lee, Hae-Won Kim
Summary: The study introduces a nanoglass paste for promoting bone tissue regeneration, antibacterial effects, and enhancing angiogenesis. The paste releases multiple ions, acting as a therapeutic ions reservoir in surrounding cells. Experimentally, the nanoglass paste showed significant effects on promoting osteogenic differentiation, angiogenesis, and bactericidal properties.
Article
Chemistry, Multidisciplinary
Sang-Cheol Lee, Na-Hyun Lee, Kapil D. Patel, Tae-Su Jang, Jonathan Campbell Knowles, Hae-Won Kim, Hae-Hyoung Lee, Jung-Hwan Lee
Summary: Selenium nanoparticles have a significant promoting effect on the differentiation of osteoblastic cells by regulating ROS and serving as antioxidants in cells. The study demonstrates that selenium nanoparticles can enhance osteogenic gene expression and bone formation, suggesting potential therapeutic applications in bone treatment.
Article
Engineering, Biomedical
Na-Hyun Lee, Min Sil Kang, Tae-Hyun Kim, Dong Suk Yoon, Nandin Mandakhbayar, Seung Bin Jo, Hye Sung Kim, Jonathan C. Knowles, Jung-Hwan Lee, Hae-Won Kim
Summary: The strontium-releasing nanoscale cement provides dual therapeutic actions for the regeneration of osteoporotic bone defect, with potential for effective treatment due to its osteogenic-stimulation and osteoclastic-inhibition effects.
Article
Engineering, Biomedical
Tae-Hyun Kim, Won-Yong Jeon, Yunseong Ji, Eun Ju Park, Dong Suk Yoon, Na-Hyun Lee, Sung-Min Park, Nandin Mandakhbayar, Jung-Hwan Lee, Hae-Hyoung Lee, Hae-Won Kim
Summary: Electricity plays a significant role in wound healing by activating mechanosensitive ion channels and calcium influx to promote key functions in the wound healing process. This study demonstrates that the electricity auto-generating EBC skin patch can accelerate wound healing by modulating inflammation, stimulating angiogenesis, enhancing fibroblast functionality, and promoting matrix synthesis.
Review
Biochemistry & Molecular Biology
Jeongeun Hyun, Jinsol Han, Chanbin Lee, Myunghee Yoon, Youngmi Jung
Summary: Alcoholic liver disease (ALD) is a chronic liver disease caused by chronic or binge alcohol consumption, leading to liver damage and inflammatory reactions. However, the lack of animal models that fully mimic human ALD has posed challenges for the development of novel treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Dong Suk Yoon, Kyoung-Mi Lee, Yoorim Choi, Eun Ae Ko, Na-Hyun Lee, Sehee Cho, Kwang Hwan Park, Jung-Hwan Lee, Hae-Won Kim, Jin Woo Lee
Summary: This study found that PUM1 is associated with the self-renewal capacity and aging process of human mesenchymal stem cells (MSC). PUM1 acts by suppressing TLR4-mediated NF-kappa B activity to protect MSCs against cellular senescence and inflammation. Furthermore, the PUM1-TLR4 regulatory axis represents a potential therapeutic target for osteoarthritis.
CELL DEATH AND DIFFERENTIATION
(2022)
Correction
Biochemistry & Molecular Biology
Dong Suk Yoon, Kyoung-Mi Lee, Yoorim Choi, Eun Ae Ko, Na-Hyun Lee, Sehee Cho, Kwang Hwan Park, Jung-Hwan Lee, Hae-Won Kim, Jin Woo Lee
CELL DEATH AND DIFFERENTIATION
(2022)
Review
Biochemistry & Molecular Biology
Na-Hyun Lee, Sumin You, Ali Taghizadeh, Mohsen Taghizadeh, Hye Sung Kim
Summary: The cell membrane cloaking technique, which utilizes natural design cues, is a promising bioinspired nanotechnology for surface modification of nanoparticles. This technique can replicate complex physicochemical properties and biomimetic functions, thereby enhancing nanotherapeutic platforms. However, there are challenges to be addressed for clinical translation and further research is needed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sang-Cheol Lee, Na-Hyun Lee, Kapil D. Patel, Soo-Kyung Jun, Jeong-Hui Park, Jonathan Campbell Knowles, Hae-Won Kim, Hae-Hyoung Lee, Jung-Hwan Lee
Summary: In this study, nano-sized antioxidative biomaterials using selenium were developed to protect and accelerate the differentiation of C2C12 myoblasts in an oxidative stress environment. The selenium nanoparticles showed antioxidant effects, reduced apoptosis and intracellular ROS levels, and up-regulated genes associated with myoblast differentiation. These results suggest that SeNPs can be used for the treatment of skeletal muscle in a cellular redox environment.
Article
Engineering, Biomedical
Ji-Young Yoon, Nandin Mandakhbayar, Jeongeun Hyun, Dong Suk Yoon, Kapil D. Patel, Keunsoo Kang, Ho-Shup Shim, Hae-Hyoung Lee, Jung-Hwan Lee, Kam W. Leong, Hae-Won Kim
Summary: Cell reprogramming can transform fibroblasts into osteogenic cells, providing a potential source of specialized cells for bone tissue engineering and disease modeling. A chemical cocktail was used to induce osteogenic differentiation, and the resulting cells showed characteristics of osteoblasts. The reprogrammed cells were able to form mineralized nodules and contributed to bone tissue formation in vivo.
Article
Biochemistry & Molecular Biology
Yong -Jae Kim, Jeongeun Hyun
Summary: Mechanosensitive ion channels can detect mechanical stimuli directly applied to cellular membranes or indirectly through tethered components, leading to cellular mechanoresponses. Among these channels, Piezo1 is a relatively new Ca2+-permeable channel primarily found in non-sensory tissues. Recent studies have shown that Piezo1 plays a crucial role in Ca2+-dependent cell death, including apoptosis and ferroptosis, in the presence of mechanical stimuli. Cancer cells are also sensitive to mechanical stresses due to higher levels of Piezo1 expression compared to normal cells. This review discusses Piezo1-mediated cell death mechanisms and therapeutic strategies to modulate Piezo1 activity using pharmacological drugs or mechanical perturbations induced by stretch and ultrasound.
Review
Biochemistry & Molecular Biology
Na-Hyun Lee, Oyunchimeg Bayaraa, Zhou Zechu, Hye Sung Kim
Summary: Cell spheroids combined with biomaterials show promising prospects in regenerative medicine, significantly enhancing the therapeutic effect of cell transplantation. The precise control of cell spheroid formation and function with various biomaterials has been widely applied in tissue regeneration therapy for bones, cartilage, and heart.