Review
Pharmacology & Pharmacy
Fan Feng, Mingying Liu, Lianhong Pan, Jiaqin Wu, Chunli Wang, Li Yang, Wanqian Liu, Wei Xu, Mingxing Lei
Summary: Keloids are a fibroproliferative skin disorder caused by abnormal healing of injured or irritated skin. Mechanical stimulation can lead to excessive fibroblast proliferation, extracellular matrix deposition, and increase of keloid matrix stiffness, while matrix mechanics further activates the fibrotic phenotype. The TGF-beta/Smad signaling pathway, integrin signaling pathway, YAP/TAZ signaling pathway, and calcium ion pathway are involved in keloid formation. Understanding the role of biomechanical factors in keloid formation may facilitate the development of therapeutic interventions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mathias Rath, Alain Pitiot, Michael Kirr, Waltraud Froehlich, Bianca Plosnita, Stefan Schliep, Jurgen Bauerschmitz, Andreas S. Baur, Christian Ostalecki
Summary: This study found that keloids are characterized by a persistent inflammatory process, with monocyte-derived inflammatory dendritic cells and activated CD4+ T lymphocytes dominating immune infiltration. Metalloproteinases were identified as a potential target for therapeutic intervention in keloid formation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Chih-Chun Lee, Chia-Hsuan Tsai, Chih-Hao Chen, Yuan-Chieh Yeh, Wen-Hung Chung, Chun-Bing Chen
Summary: Keloid is a unique type of disfiguring pathological scarring in human skin that is characterized by excessive collagen deposition. Immune cell infiltration is a common feature of normal and pathological tissue repair, but the immunopathological mechanisms of keloid remain unclear. Recent studies have highlighted the crucial role of innate and adaptive immunity in regulating the abnormal behavior of keloid fibroblasts. Novel therapeutics targeting immune pathways have shown varying efficacy in restoring regulation of the immune microenvironment in keloid.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Natasha Barone, Tyler Safran, Joshua Vorstenbosch, Peter G. Davison, Sabrina Cugno, Amanda M. Murphy
Summary: Hypertrophic scars and keloids are caused by excessive tissue response to dermal injury, and treatment remains a challenge, requiring further research.
SEMINARS IN PLASTIC SURGERY
(2021)
Review
Pharmacology & Pharmacy
Dan Zhang, Bo Li, Muxin Zhao
Summary: Hypertrophic scar and keloid are fibroproliferative disorders of the skin caused by aberrant wound healing, with inflammation being recognized as the initiator of their formation. Interleukins, known for their role in inflammatory and immune responses, are being explored as potential therapeutic targets for their treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Chemistry, Multidisciplinary
David M. Dolivo, Adrian E. Rodrigues, Thomas A. Mustoe, Robert D. Galiano, Seok Jong Hong
Summary: Cellular therapies hold promise for fibrosis treatment. A recent article presents a strategy and proof-of-concept for delivering stimulated cells to degrade hepatic collagen in vivo. The discussion highlights the strengths of this approach and its potential to generalize to treat other forms of fibrosis.
Article
Biochemistry & Molecular Biology
Longwei Liu, Hongsheng Yu, Yi Long, Zhifeng You, Rei Ogawa, Yanan Du, Chenyu Huang
Summary: Asporin is highly expressed in keloids, disrupting the orientation, reorganization, and contraction ability of dermal cells, ultimately leading to the formation of disorganized collagen network similar to keloids. This interference with collagen mechanosignaling prevents fibroblast activation and differentiation into mature myofibroblasts, promoting keloid growth and invasion. Asporin may serve as a new diagnostic biomarker and therapeutic target for keloids.
Article
Cell Biology
Yan Gao, Xue Hou, Yuyin Dai, Ting Yang, Kexin Chen
Summary: This study reveals that electron beam therapy leads to an increase in FAP+ cells, promoting cell proliferation and delaying cellular senescence, accompanied by increased ATP production.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Pierre Marty, Brice Chatelain, Thomas Lihoreau, Marion Tissot, Zelie Dirand, Philippe Humbert, Clemence Senez, Eleonora Secomandi, Ciro Isidoro, Gwenael Rolin
Summary: Keloids are characterized by increased fibrous tissue deposition during abnormal wound healing. Halofuginone (HF) has been shown to inhibit fibrotic processes in keloid fibroblasts, offering a potential therapeutic approach for keloid prevention and management.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Polymer Science
Yong-Ji Chen, Hung-Wei Cheng, Wan-Yu Yen, Jen-Hao Tsai, Chin-Yi Yeh, Ching-Jung Chen, Jen Tsai Liu, San-Yuan Chen, Shwu-Jen Chang
Summary: This study developed a microneedle patch with controlled transdermal dual-drug release for the combinatory treatment of keloid scars. The results showed that the dual-drug system could inhibit the proliferation of fibroblasts and prevent the generation of reactive oxygen species, effectively preventing the formation of keloid scars.
Article
Dermatology
Lingxi Chen, Yingjun Su, Bin Yin, Shu Li, Xialin Cheng, Yan He, Chiyu Jia
Summary: LARP6 plays an important role in the proliferation and invasion process of keloid lesions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Physiology
Yixiu Zhong, Youfan Zhang, Aijiao Yu, Zhiwen Zhang, Zhenjun Deng, Kaifen Xiong, Qi Wang, Jianglin Zhang
Summary: This review mainly discusses the roles of mesenchymal stem cell-derived exosomes in keloid and hypertrophic scar treatment and summarizes possible underlying mechanisms.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Surgery
Wenhao Wu, Yang Zhao, Yuxuan Chen, Aimei Zhong
Summary: According to a network meta-analysis, a combination of TAC and BTA is the most effective treatment for pathological scars. The effectiveness of TAC+BTA is significantly different from that of BTA, TAC, 5-Fu, VER, or BLM monotherapies. TAC+5-Fu is more effective than TAC, 5-Fu, VER, or BLM alone, and BTA is more effective than both TAC and 5-Fu. VER and BLM have similar effectiveness, but both are better than TAC and 5-Fu. There were no significant differences between other local injection therapies.
AESTHETIC PLASTIC SURGERY
(2023)
Review
Cell Biology
Christine Bojanic, Kendrick To, Adam Hatoum, Jessie Shea, K. T. Matthew Seah, Wasim Khan, Charles M. Malata
Summary: Scars resulting from abnormal wound repair processes like hypertrophic and keloid scars can significantly impair quality of life. While existing treatment options are unsatisfactory, there is increasing interest in using MSC therapy to address these abnormal scars, although human clinical trials are still lacking.
CELL AND TISSUE RESEARCH
(2021)
Article
Clinical Neurology
Huiru Li, Lingling Song, Manqiu Cen, Xihang Fu, Xinxin Gao, Qianlin Zuo, Jing Wu
Summary: This study aimed to evaluate the association between oxidative balance score (OBS) and depressive symptoms and the underlying mechanisms. The results showed a significant negative association between OBS and depression risk. Oxidative stress and inflammation partially mediated the association between OBS and depression scores.
JOURNAL OF AFFECTIVE DISORDERS
(2023)