Synaptic and behavioral effects of chronic stress are linked to dynamic and sex-specific changes in microglia function and astrocyte dystrophy

Neuroendocrine-Immune Crosstalk Shapes Sex-Specific Brain Development

(2020) Sheryl E Arambula et al.   ENDOCRINOLOGY

The critical importance of basic animal research for neuropsychiatric disorders

(2019) Tracy L. Bale et al.   NEUROPSYCHOPHARMACOLOGY

Glucocorticoid receptor antagonism prevents microglia-mediated neuronal remodeling and behavioral despair following chronic unpredictable stress

(2019) Matthew J. Horchar et al.   BRAIN BEHAVIOR AND IMMUNITY

The formative role of microglia in stress-induced synaptic deficits and associated behavioral consequences

(2019) J.L. Bollinger et al.   NEUROSCIENCE LETTERS

Prior stress followed by a novel stress challenge results in sex-specific deficits in behavioral flexibility and changes in gene expression in rat medial prefrontal cortex

(2019) Kelly M. Moench et al.   HORMONES AND BEHAVIOR

Opposite Molecular Signatures of Depression in Men and Women

(2018) Marianne L. Seney et al.   BIOLOGICAL PSYCHIATRY

Stress-Induced Neuronal Colony Stimulating Factor 1 Provokes Microglia-Mediated Neuronal Remodeling and Depressive-like Behavior

(2018) Eric S. Wohleb et al.   BIOLOGICAL PSYCHIATRY

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

(2018) Laetitia Weinhard et al.   Nature Communications

Sex-Specific Features of Microglia from Adult Mice

(2018) Alessandro Villa et al.   Cell Reports

Transcriptional and Translational Differences of Microglia from Male and Female Brains

(2018) Dilansu Guneykaya et al.   Cell Reports

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

Behavioral stress alters corticolimbic microglia in a sex- and brain region-specific manner

(2017) Justin L. Bollinger et al.   PLoS One

Differential effects of stress on microglial cell activation in male and female medial prefrontal cortex

(2016) Justin L. Bollinger et al.   BRAIN BEHAVIOR AND IMMUNITY

Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress

(2016) Giampaolo Milior et al.   BRAIN BEHAVIOR AND IMMUNITY

Gamma frequency entrainment attenuates amyloid load and modifies microglia

(2016) Hannah F. Iaccarino et al.   NATURE

Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants

(2016) Ronald S Duman et al.   NATURE MEDICINE

Neuron–Microglia Interactions in Mental Health Disorders: “For Better, and For Worse”

(2016) Eric S. Wohleb   Frontiers in Immunology

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(2016) Christian Otte et al.   Nature Reviews Disease Primers

Stress weakens prefrontal networks: molecular insults to higher cognition

(2015) Amy F T Arnsten   NATURE NEUROSCIENCE

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

(2015) Robert E Sorge et al.   NATURE NEUROSCIENCE

Chronic stress alters the dendritic morphology of callosal neurons and the acute glutamate stress response in the rat medial prefrontal cortex

(2015) Pauline Luczynski et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

REDD1 is essential for stress-induced synaptic loss and depressive behavior

(2014) Kristie T Ota et al.   NATURE MEDICINE

Microglial phagocytosis of live neurons

(2014) Guy C. Brown et al.   NATURE REVIEWS NEUROSCIENCE

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival

(2013) Jian Luo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition

(2013) J Wei et al.   MOLECULAR PSYCHIATRY

Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis

(2013) T Kreisel et al.   MOLECULAR PSYCHIATRY

Neural control of chronic stress adaptation

(2013) James P. Herman   Frontiers in Behavioral Neuroscience

Bidirectional Microglia-Neuron Communication in the Healthy Brain

(2013) Ukpong B. Eyo et al.   NEURAL PLASTICITY

Variant Brain-Derived Neurotrophic Factor Val66Met Polymorphism Alters Vulnerability to Stress and Response to Antidepressants

(2012) H. Yu et al.   JOURNAL OF NEUROSCIENCE

Decreased expression of synapse-related genes and loss of synapses in major depressive disorder

(2012) Hyo Jung Kang et al.   NATURE MEDICINE

Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex

(2012) Eunice Y. Yuen et al.   NEURON

Psychosocial stressors and the prognosis of major depression: a test of Axis IV

(2012) S. E. Gilman et al.   PSYCHOLOGICAL MEDICINE

Evidence that Microglia Mediate the Neurobiological Effects of Chronic Psychological Stress on the Medial Prefrontal Cortex

(2011) M. Hinwood et al.   CEREBRAL CORTEX

The stressed synapse: the impact of stress and glucocorticoids on glutamate transmission

(2011) Maurizio Popoli et al.   NATURE REVIEWS NEUROSCIENCE

Sex differences in synaptic plasticity in stress-responsive brain regions following chronic variable stress

(2011) Eduardo F. Carvalho-Netto et al.   PHYSIOLOGY & BEHAVIOR

The Mouse Forced Swim Test

(2011) Adem Can et al.   Jove-Journal of Visualized Experiments

Linking Molecules to Mood: New Insight Into the Biology of Depression

(2010) Vaishnav Krishnan et al.   AMERICAN JOURNAL OF PSYCHIATRY

Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions

(2010) Ross J. Tynan et al.   BRAIN BEHAVIOR AND IMMUNITY

A negative regulator of MAP kinase causes depressive behavior

(2010) Vanja Duric et al.   NATURE MEDICINE

Stress-induced dendritic remodeling in the medial prefrontal cortex: Effects of circuit, hormones and rest

(2009) Rebecca M. Shansky et al.   BRAIN RESEARCH

Neural regulation of endocrine and autonomic stress responses

(2009) Yvonne M. Ulrich-Lai et al.   NATURE REVIEWS NEUROSCIENCE

Chronic stress effects on dendritic morphology in medial prefrontal cortex: sex differences and estrogen dependence

(2009) J.E. Garrett et al.   NEUROSCIENCE

Structural and functional alterations to rat medial prefrontal cortex following chronic restraint stress and recovery

(2009) D.S. Goldwater et al.   NEUROSCIENCE

Acute stress enhances glutamatergic transmission in prefrontal cortex and facilitates working memory

(2009) E. Y. Yuen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: a test of the stress sensitization hypothesis in a population-based sample of adults

(2009) K. A. McLaughlin et al.   PSYCHOLOGICAL MEDICINE

Glial Loss in the Prefrontal Cortex Is Sufficient to Induce Depressive-like Behaviors

(2008) Mounira Banasr et al.   BIOLOGICAL PSYCHIATRY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE