4.5 Review

Neuropsychological and neurophysiological predictors and consequences of cannabis and illicit substance use during neurodevelopment: a systematic review of longitudinal studies

Journal

LANCET CHILD & ADOLESCENT HEALTH
Volume 5, Issue 8, Pages 589-604

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/S2352-4642(21)00051-1

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Funding

  1. Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, NSW, Australia
  2. Australian Rotary Health Bruce Edwards Postdoctoral Fellowship
  3. Australian National Health and Medical Research Council Early Career Fellowship
  4. National Health and Medical Research Council [GNT1169377]
  5. Australian National Health and Medical Research Council Principal Research Fellowship
  6. Australian National Health and Medical Research Council Career Development Fellowship

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Adolescence and early adulthood are crucial periods of neurodevelopment, with delayed or irregular neurodevelopment potentially predisposing young people to substance use, which can lead to functional, structural, and cognitive deficits. Identifying aberrant neurodevelopment is essential for preventing substance use-related harm.
Adolescence and early adulthood are crucial periods of neurodevelopment characterised by functional, structural, and cognitive maturation, which helps prepare young people for adulthood. This systematic review of longitudinal studies aims to delineate neural predictors from neural consequences of cannabis and illicit substance use, as well as investigate the potential for the developing brain (at ages 10-25 years) to recover after damage. Five databases were searched to yield a total of 38 eligible studies, with some assessing multiple outcome techniques, including 22 neuroimaging, two neurophysiological, and 22 neuropsychological findings. High-quality evidence suggested that delayed or irregular neurodevelopment in executive functioning, particularly emotional perception, might predispose young people to higher frequency substance use. There was evidence of functional, structural, and cognitive deficits proceeding substance use, with harm potentially dependent on the frequency of use and recovery potentially dependent on the duration of use. Identifying aberrant neurodevelopment in young people is crucial for preventing substance use-related harm.

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