A narrative review of research progress on the relationship between hypoxia-inducible factor-2α and wound angiogenesis

Objective: This article aims to pay attention to the latest research on the expression, activation and function of hypoxia-inducible factor-2 alpha (HIF-2 alpha) under hypoxia and non-hypoxia conditions, and summarizes the current knowledge about the interaction between hypoxia-inducible factor-2 and angiogenesis, hoping to understand its actions in physiology and disease, with the goal of providing a new strategy for the diagnosis and treatment of wounds. Background: Wound healing is a complex and continuous process, involving coagulation, inflammation, angiogenesis, new tissue formation and extracellular matrix remodeling. Of these, angiogenesis is an essential step. One of the main reasons for non-healing or delayed healing of wounds in peripheral vascular diseases and diabetes is the reduced ability to regenerate microvessels through the process of angiogenesis, which has become the focus of new methods for treating chronic wounds. HIF-2 alpha regulates many aspects of angiogenesis, including vascular maturation, cell migration, proliferation and metastasis. Methods: Throughout extensive search of PubMed, summarize the medical research on HIF-2 alpha to 2020. Conclusions: HIF-2 alpha is necessary for normal embryonic development by stimulating the expression of angiogenic factors, such as vascular endothelial growth factor (VEGF). It is essential for the formation of new blood vessels in physiological and pathophysiological environments. Targeting HIF-2 alpha in wound healing has much clinical significance for tissue repair.

Automated summary

This article focuses on the latest research regarding the expression, activation, and function of HIF-2α under hypoxia and non-hypoxia conditions, emphasizing its crucial role in angiogenesis. Targeting HIF-2α in wound healing could be clinically significant for tissue repair, providing a new strategy for diagnosis and treatment.