Article
Health Care Sciences & Services
Malgorzata Galecka, Katarzyna Blizniewska-Kowalska, Agata Orzechowska, Janusz Szemraj, Michael Maes, Michael Berk, Kuan-Pin Su, Piotr Galecki
Summary: This research study found that in depressed patients without coexisting inflammatory diseases, the gene expression levels of specific immune-inflammatory factors such as IL-17, IL-21, IL-23, and IL-35 were higher, while Foxp3 expression was lower. The duration of the disease appears to be more important than the severity of depression in relation to the expression of these genes. These findings suggest that specific inflammatory genes may play a role in the etiopathogenesis of depressive disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Yanbo Wang, Yanling Yu, Wanjing Yu, Xun Bian, Linxia Gong
Summary: IL-35 inhibits cell pyroptosis and reduces asthma injury by suppressing the p38 MAPK pathway.
Review
Biochemistry & Molecular Biology
Kazuki Nagata, Chiharu Nishiyama
Summary: Mast cells play critical roles in immune responses as initiators and suppressors, with IL-10 serving as a key anti-inflammatory cytokine in regulating their functions. IL-10 exerts diverse effects on mast cells in vivo and in vitro, influencing tissue homeostasis and immune-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Chul Hwan Bang, Ji Young Song, Yu Mee Song, Ji Hyun Lee, Young Min Park, Jun Young Lee
Summary: The study revealed that CD45RO(+)CLA(+)H4R(+) T cells are an important source of IL-31 in AD patients. Stimulation with 4-methylhistamine increased IL-31 production in these cells. This suggests that these cells could be a potential target for treating IL-31-induced pruritus.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Plant Sciences
Antonio Tornero-Martinez, Maria Del Carmen Silva-Lucero, Eden Cano Sampedro, Eva Ramon-Gallegos, Claudia Perez-Cruz, Brenda Perez-Grijalva, Rosalva Mora-Escobedo
Summary: The anti-inflammatory effects of Aloe vera and its extracts were evaluated in an astrocyte cell line with a neuro-inflammatory profile. The extracts showed a reduction in inflammatory markers and inhibited the pro-inflammatory pathway.
PLANT FOODS FOR HUMAN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Kuan-Ming Chiu, Yen-Ling Hung, Su-Jane Wang, Yi-Ju Tsai, Nan-Lin Wu, Cher-Wei Liang, Der-Chen Chang, Chi-Feng Hung
Summary: Neferine has anti-allergic and anti-inflammatory effects on mast cells by inhibiting degranulation and cytokine expression, decreasing intracellular calcium levels, and reducing the phosphorylation of the MAPK/NF-kappa B pathway. In vivo studies demonstrate that neferine improves dermatitis appearance, mast cell infiltration, and restores barrier protein expression. Neferine also reduces scratching behavior induced by compound 48/80, suggesting its potential as a natural product for skin allergy and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Hee-Yun Kim, Hanchul Jung, Hyung-Min Kim, Hyun-Ja Jeong
Summary: Surfactin exhibits significant anti-cancer effects on melanoma skin cancer by enhancing immune response and inducing apoptosis of melanoma cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Shixin Duan, Jun Wang, Xinyi Lou, Dongxin Chen, Peiyunfeng Shi, Hongchao Jiang, Zhiming Wang, Wen Li, Feng Qian
Summary: IL-33 is an important member of the IL-1 family and plays a crucial role in modulating inflammatory responses. The researchers developed an effective anti-human IL-33 monoclonal antibody named 5H8, which binds to the FVLHN epitope of IL-33 and inhibits its biological activity. In vitro and in vivo experiments showed that 5H8 suppressed IL-33-induced IL-6 expression and relieved HDM-induced asthma and PR8-induced acute lung injury. The study also demonstrated that 5H8 has good thermal stability and high affinity. These findings suggest that 5H8 has potential as a therapeutic antibody for inflammatory diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Kanan Bando, Yukinori Tanaka, Saka Winias, Shunji Sugawara, Itaru Mizoguchi, Yasuo Endo
Summary: IL-33 is released upon cell injury and induces histamine release and local inflammation. IL-33 directly and indirectly induces histamine release through histidine decarboxylase (HDC), and the newly formed histamine contributes to the negative regulation of IL-33-induced eosinophilia via H4 receptors.
INFLAMMATION RESEARCH
(2023)
Article
Immunology
Ritu Sarin, Ran Gu, Zahra Jalali, Emanual Maverakis, Maria G. Tsokos, Iannis E. Adamopoulos
Summary: Interleukin 27 has both pro-inflammatory and anti-inflammatory properties in autoimmunity. The anti-inflammatory effects of IL-27 are linked with inhibition of Th17 differentiation and IL-27 also inhibits IL-23-induced inflammation associated with myeloid cell infiltration in the joints and spleen. The IL-27 anti-inflammatory response is associated with reduced levels of myeloid cells in the spleen and bone marrow.
CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Cheng-Rong Yu, Manoj Kumar Yadav, Minkyung Kang, Yingyos Jittayasothorn, Lijin Dong, Charles E. Egwuagu
Summary: Interleukin-27 (IL-27) and Interleukin-35 (IL-35) have different roles in neuroinflammation and uveitis. IL-27 can suppress encephalomyelitis and autoimmune uveitis, while IL-35 may have a protective role in the retina by constitutive secretion to counteract persistent low-grade inflammation. Decreased expression of IL-35 leads to increased severity of uveitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Linh Pham, Leonardo Baiocchi, Lindsey Kennedy, Keisaku Sato, Vik Meadows, Fanyin Meng, Chiung-Kuei Huang, Debjyoti Kundu, Tianhao Zhou, Lixian Chen, Gianfranco Alpini, Heather Francis
Summary: The daily rhythmicity in our body is controlled by a circadian clock in the suprachiasmatic nucleus in the hypothalamus. Mast cells play a protective role against pathogens and inflammation and are associated with the circadian rhythm. Melatonin and histamine modulate circadian rhythms by regulating NF-kappa B, offering a promising therapeutic strategy for MC-mediated inflammatory diseases.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Meng Li, Betty C. A. M. van Esch, Paul A. J. Henricks, Johan Garssen, Gert Folkerts
Summary: The inhibitory effects of butyrate and propionate on TNF alpha-induced IL-8 production were mediated by the HDACs/IL-33/NF-kappa B pathway, while their effects on VCAM-1 expression might be associated with the HDACs/MAPK signaling pathway, independently of IL-33.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Jin Kyeong Choi, Charles E. Egwuagu
Summary: B lymphocytes play a central role in host immunity by orchestrating humoral immune responses and producing neutralizing antibodies. Recent recognition shows that B cells also help maintain peripheral tolerance and suppress autoimmune diseases, with rare populations of regulatory B cells producing anti-inflammatory cytokines. The newly discovered i35-Bregs can suppress autoimmune diseases by inducing infectious tolerance in conventional B cells.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Dorina Lauritano, Filiberto Mastrangelo, Cristian D'Ovidio, Gianpaolo Ronconi, Alessandro Caraffa, Carla E. Gallenga, Ilias Frydas, Spyros K. Kritas, Matteo Trimarchi, Francesco Carinci, Pio Conti
Summary: Mast cells (MCs) are tissue cells derived from bone marrow stem cells and play a role in various diseases and disorders. They communicate with microglia in the brain through the production of mediators and can have pathological effects. MCs release preformed chemical mediators and cytokines, and can interact with neuropeptides, leading to inflammation in the central nervous system. This article explores the activation of MCs by neuropeptides and the therapeutic potential of anti-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)