Article
Medicine, General & Internal
Hina Faisal, Syeda T. Ali, Jiaqiong Xu, Tariq Nisar, Mahmoud Sabawi, Eric Salazar, Faisal N. Masud
Summary: Carboxyhemoglobinemia in COVID-19 patients may be due to sepsis, hemolysis, and cytokine storm triggered by the virus, rather than directly from the virulence of novel coronavirus. The study found a high incidence of carboxyhemoglobinemia in critically ill COVID-19 patients, suggesting routine monitoring of COHb levels for more effective treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Critical Care Medicine
Alexandre Tran, Shannon M. Fernando, Bram Rochwerg, Deborah J. Cook, Mark A. Crowther, Robert A. Fowler, Waleed Alhazzani, Deborah M. Siegal, Lana A. Castellucci, Ryan Zarychanski, Shane W. English, Kwadwo Kyeremanteng, Marc Carrier
Summary: This study aims to identify prognostic factors for the development of venous thromboembolism in the ICU. The results show that factors associated with an increased risk of venous thromboembolism include older age, obesity, active malignancy, history of venous thromboembolism, history of recent surgery, sepsis, lack of pharmacologic prophylaxis, central venous catheter, invasive mechanical ventilation, and use of vasoactive medication.
CRITICAL CARE MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Mouhand F. H. Mohamed, Shaikha D. Al-Shokri, Khaled M. Shunnar, Sara F. Mohamed, Mostafa S. Najim, Shahd I. Ibrahim, Hazem Elewa, Lina O. Abdalla, Ahmed El-Bardissy, Mohamed Nabil Elshafei, Ibrahim Y. Abubeker, Mohammed Danjuma, Khalid M. Dousa, Mohamed A. Yassin
Summary: Recent studies have shown a high prevalence of VTE in critically ill COVID-19 patients, with nearly 50% of patients detected with VTE through systematic screening. Initial analysis suggests that prophylactic anticoagulation may significantly increase the risk of VTE compared to therapeutic anticoagulation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Li Huang, Che Zhang, Xihui Zhou, Zhou Zhao, Weiping Wang, Weidong Leng, Xiao Su, Qizhou Lian
Summary: This study analyzed the characteristics and outcomes of patients with or without convalescent plasma (CP) transfusion for coronavirus disease-2019. The results showed that while CP transfusion was clinically safe, it did not provide significant clinical benefits for critically ill patients with more comorbidities at the late stage of disease during a 28-day observation.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Hematology
Tsai-Wing Ow, Evangelia Fatourou, Liane Rabinowich, Bente van den Boom, Shrijit Nair, Vishal C. Patel, Brian Hogan, Mark McPhail, Lara N. Roberts, William Bernal
Summary: Bleeding and venous thromboembolism (VTE) are common complications in critically ill patients with chronic liver disease (CLD). Bleeding is associated with disease severity and increased mortality, while the occurrence of VTE is linked to hepatocellular carcinoma and specific etiologies of CLD.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Critical Care Medicine
Samuel A. P. Short, Shruti Gupta, Samantha K. Brenner, Salim S. Hayek, Anand Srivastava, Shahzad Shaefi, Harkarandeep Singh, Benjamin Wu, Aranya Bagchi, Hanny Al-Samkari, Rajany Dy, Katherine Wilkinson, Neil A. Zakai, David E. Leaf
Summary: In critically ill patients with severe coronavirus disease 2019, higher levels of d-dimer were independently associated with a greater risk of death, even after multivariable adjustment. Therapeutic anticoagulation did not significantly affect this relationship.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Cecile Payet, Stephanie Polazzi, Thomas Rimmele, Antoine Duclos
Summary: This study investigated whether the risk of death among noncoronavirus disease 2019 critically ill patients increased when numerous coronavirus disease 2019 cases were admitted concomitantly to the same hospital units. The results showed that in hospital units with moderate or high levels of coronavirus disease 2019 critically ill patients, noncoronavirus disease deaths were at higher levels.
CRITICAL CARE MEDICINE
(2022)
Review
Medicine, General & Internal
Johannes Gratz, Marion Wiegele, Mathias Maleczek, Harald Herkner, Herbert Schoechl, Eva Chwala, Paul Knoebl, Eva Schaden
Summary: This study aimed to summarize the incidence of clinically relevant venous thromboembolism (VTE) in critically ill patients with COVID-19. The results showed lower incidence rates than previously reported, providing important clinical information for individual risk-benefit assessments.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Zhimei Zhong, Hongyuan Li, Jieyun Zhu, Pan Ji, Bocheng Li, Jielong Pang, Jianfeng Zhang, Xiangdong Liang
Summary: The main symptoms of severe or critically ill COVID-19 patients are fever and cough with a large percentage showing lymphopenia and elevated levels of C-reactive protein and D-dimer. Many patients progress to acute respiratory distress syndrome, acute cardiac injury, acute kidney injury, and shock.
Review
Medicine, General & Internal
Xiaoyu Gao, Liangnan Zeng, Haorun Wang, Shan Zeng, Junjie Tian, Ligang Chen, Tangming Peng
Summary: This study pooled the prevalence of venous thromboembolism (VTE) in intensive care patients worldwide and identified several risk factors. The results showed a high prevalence of VTE in critically ill patients, emphasizing the need for attention to high-risk populations.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Denise Battaglini, Lavienraj Premraj, Samuel Huth, Jonathon Fanning, Glenn Whitman, Rakesh C. Arora, Judith Bellapart, Diego Bastos Porto, Fabio Silvio Taccone, Jacky Y. Suen, Gianluigi Li Bassi, John F. Fraser, Rafael Badenes, Sung-Min Cho, Chiara Robba
Summary: This study investigates the use of non-invasive multimodal neuromonitoring in COVID-19 patients and finds that these tools have great potential for diagnosing and monitoring patients at risk of brain injury. However, the use of these technologies outside critical care settings is rare.
FRONTIERS IN NEUROLOGY
(2022)
Article
Critical Care Medicine
Paloma Ferrando-Vivas, James Doidge, Karen Thomas, Doug W. Gould, Paul Mouncey, Manu Shankar-Hari, J. Duncan Young, Kathryn M. Rowan, David A. Harrison
Summary: A total of 9,990 patients critically ill with COVID-19 were studied to identify characteristics that predict 30-day mortality. Factors such as age, ethnicity, deprivation, body mass index, prior dependency, and immunocompromise were found to impact the likelihood of death within 30 days of critical care initiation.
CRITICAL CARE MEDICINE
(2021)
Article
Critical Care Medicine
Alice G. Vassiliou, Nikolaos Athanasiou, Chrysi Keskinidou, Edison Jahaj, Stamatios Tsipilis, Alexandros Zacharis, Efthimia Botoula, Aristidis Diamantopoulos, Ioannis Ilias, Dimitra A. Vassiliadi, Stylianos Tsagarakis, Anastasia Kotanidou, Ioanna Dimopoulou
Summary: This study investigated the difference in glucocorticoid receptor alpha expression and cortisol levels between 2019 coronavirus disease patients and non-patients, revealing that coronavirus patients admitted to the ICU exhibited upregulated glucocorticoid receptor alpha and induced leucine zipper expression, along with higher cortisol levels.
CRITICAL CARE MEDICINE
(2021)
Review
Medicine, General & Internal
Do Hyeon Park, Chang Kyung Kang, Pyoeng Gyun Choe, Nam Joong Kim, Wan Beom Park, Myoung-don Oh
Summary: Since 2019, the Republic of Korea has released and revised evidence-based guidelines for the treatment of severe to critically ill patients with COVID-19, which have been widely practiced by medical staff. Dexamethasone is currently used as the main treatment drug, with additional medicines such as remdesivir, baricitinib, and tocilizumab depending on the patient's condition. Venous thromboembolism prophylaxis is also an important adjunctive therapy for severe COVID-19 patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)
Letter
Cardiac & Cardiovascular Systems
Salwa A. Koubaissi, Michella Abi Zeid Daou, Rayan Mohamad, Ahmad Husari
Summary: The management of critically ill COVID-19 patients presents challenges due to the increased risk of serious thrombotic events and major life-threatening bleeds. This study observed a high rate of major bleeding in 25 critically ill patients, with six cases experiencing major bleeds, including unusual sites like gluteal and abdominal wall muscles. Further studies are needed to identify predisposing risk factors and mechanisms behind major bleeding in this population.
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)