Review
Pharmacology & Pharmacy
Yaqun Li, Wenjie Zhao, Jinhua Liu, Zichao Chen, Qingtao Lv, Zhen Zhang
Summary: COVID-19 pneumonia, caused by SARS-CoV-2, has disrupted the pro-inflammatory/anti-inflammatory response, leading to a need to neutralize cytokine storm. Current treatments focus on vaccines for prevention and immunomodulatory therapies to alleviate immune imbalance, with antiviral drugs and respiratory support as clinical options.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Jianxiong Zeng, Xiaochun Xie, Xiao-Li Feng, Ling Xu, Jian-Bao Han, Dandan Yu, Qing-Cui Zou, Qianjin Liu, Xiaohong Li, Guanqin Ma, Ming-Hua Li, Yong-Gang Yao
Summary: The study found that the NLRP3 inflammasome plays a crucial role in the lungs during SARS-CoV-2 infection, and inhibiting this inflammasome can reduce the release of pro-inflammatory cytokines related to COVID-19 in cells and mice. Therefore, targeting the NLRP3 inflammasome could be a promising immune intervention against severe COVID-19 disease.
Review
Biochemistry & Molecular Biology
Lucrezia Mondini, Francesco Salton, Liliana Trotta, Chiara Bozzi, Riccardo Pozzan, Mariangela Barbieri, Stefano Tavano, Selene Lerda, Michael Hughes, Marco Confalonieri, Paola Confalonieri, Barbara Ruaro
Summary: COVID-19 has become a global health problem since 2020, with varying degrees of manifestation and therapeutic options depending on the severity and molecular mechanism of the disease. This review analyzes the main therapeutic options available to date for severe and critical cases by modulating the host inflammatory response. More research is needed to identify biomarkers that can predict disease progression and guide personalized interventions.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Nazanin Aghamohamadi, Faezeh Shahba, Ali Zarezadeh Mehrabadi, Hossein Khorramdelazad, Milad Karimi, Reza Falak, Reza Zolfaghari Emameh
Summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause severe symptoms and complications in various organs, including the liver. Liver injury in COVID-19 patients is associated with abnormal liver function, immune dysfunction, cytokine storm, and therapeutic regimens. The impact of age and immune-mediated responses on liver injury in different age groups is still unclear. This review focuses on cytokine alterations and discusses the association between immune system responses and liver injury in COVID-19 patients of different ages.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Zarrilli, Valentina Angerilli, Gianluca Businello, Marta Sbaraglia, Giulia Traverso, Francesco Fortarezza, Stefania Rizzo, Monica De Gaspari, Cristina Basso, Fiorella Calabrese, Angelo Paolo Dei Tos, Matteo Fassan
Summary: The histopathologic alterations in COVID-19 patients primarily occur in the lungs and blood vessels, with the highest clinical impact. However, many of the collected morphological data so far are nonspecific, erratic, and possibly associated with other co-existing factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tzuriel Sapir, Zaelig Averch, Brian Lerman, Abraham Bodzin, Yeshaya Fishman, Radhashree Maitra
Summary: This systematic review aims to explore the immune mechanisms and pathological features of COVID-19, and propose different treatment approaches based on the stages of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jiayu Zhang, Xuejing Ma, Fuwei Liu, Deju Zhang, Jitao Ling, Zicheng Zhu, Yixuan Chen, Pingping Yang, Yanlin Yang, Xiao Liu, Jing Zhang, Jianping Liu, Peng Yu
Summary: 2019 Coronavirus Disease (COVID-19) is a global pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Severe cases of COVID-19 are associated with a cytokine storm, characterized by elevated levels of pro-inflammatory cytokines in the bloodstream. Recent studies have shown a higher severity of necrobiosis infection in diabetic patients, as well as higher morbidity and mortality in people with chronic metabolic diseases such as diabetes. Additionally, COVID-19 may result in hyperglycemia in infected individuals. This review explores the potential relationship between NLRP3 inflammatory vesicles in diabetes and COVID-19, and discusses the cellular/molecular mechanisms by which SARS-CoV-2 infection activates NLRP3 inflammatory vesicles. Finally, several promising targeted NLRP3 inflammatory vesicle inhibitors are proposed as a basis for clinical management of patients with diabetes combined with noncoronary pneumonia.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Charles Ochieng' Olwal, Nora Nghuchuzie Nganyewo, Kesego Tapela, Alexandra Lindsey Djomkam Zune, Oloche Owoicho, Yaw Bediako, Samuel Duodu
Summary: Sepsis and COVID-19 share many pathophysiological and clinical features, both leading to consumptive thrombocytopenia, coagulopathy, multi-organ dysfunction syndrome, respiratory failure, among other complications. Therefore, lessons learned from sepsis care could potentially inform on COVID-19 management.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Li Yin Tan, Thamil Vaani Komarasamy, Vinod R. M. T. Balasubramaniam
Summary: COVID-19 caused by SARS-CoV-2 can lead to severe health consequences, including acute respiratory distress syndrome and multi-organ failure, through activation of inflammatory pathways and cytokine storm. Long-term effects, particularly on the brain, are of concern.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Virology
Biying Hu, Shaoying Huang, Lianghong Yin
Summary: COVID-19, caused by SARS-CoV-2, has become a global pandemic since its emergence in Wuhan, China, in December 2019, posing a serious threat to public health. Close contact and respiratory droplets are the main modes of transmission. The cytokine storm is closely associated with disease severity and mortality, emphasizing the importance of studying and treating the cytokine storm in COVID-19.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiang-Na Zhao, Yue You, Xiao-Ming Cui, Hui-Xia Gao, Guo-Lin Wang, Sheng-Bo Zhang, Lin Yao, Li-Jun Duan, Ka-Li Zhu, Yu-Ling Wang, Li Li, Jian-Hua Lu, Hai-Bin Wang, Jing-Fang Fan, Huan-Wei Zheng, Er-Hei Dai, Lu-Yi Tian, Mai-Juan Ma
Summary: By comparing the immune responses of asymptomatic and moderate patients, it was found that asymptomatic patients have specific immune characteristics in NK cells and effector T cells, with stronger TCR clonal expansion compared to moderate patients. Moderate patients exhibit varied magnitude and temporal dynamics of ISG expression across multiple cell populations but lower compared to patients with severe disease.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Review
Geriatrics & Gerontology
Shilpi Jain, Eden Abrham, M. Nadeem Khan, Ramkumar Mathur
Summary: The worldwide COVID-19 infection poses a huge risk to public health and the global economy. The impact on elderly people and individuals with underlying health conditions is extensive, and effective strategies are needed to understand the disease mechanisms.
Review
Biochemistry & Molecular Biology
Yixin Liu, Xinsheng Zhou, Xuan Liu, Xiaotao Jiang
Summary: The ongoing global pandemic of COVID-19, caused by SARS-CoV-2, has severe impacts with no specific treatment available. Immunotherapy, essential for boosting host immunity and reducing inflammation, has attracted significant attention in the fight against the disease.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2021)
Article
Chemistry, Multidisciplinary
Qian-Fang Meng, Rui Tian, Haiyi Long, Xianjia Wu, Jialin Lai, Olga Zharkova, Jiong-Wei Wang, Xiaoyuan Chen, Lang Rao
Summary: The COVID-19 pandemic, caused by SARS-CoV-2, has had a significant impact on the global economy and daily life. Some patients develop severe symptoms and complications due to a cytokine storm induced by the virus. While neutralizing antibodies targeting inflammatory cytokines show promise, challenges remain in their application, sparking interest in new biomaterials and nanotechnology for potential therapeutic advancements. Researchers are working towards developing novel treatments to effectively manage COVID-19 and other inflammatory diseases.
ADVANCED MATERIALS
(2021)
Article
Immunology
Job J. Engel, Caspar I. van der Made, Nick Keur, Todia Setiabudiawan, Rutger J. Roering, Georgia Damoraki, Helga Dijkstra, Heidi Lemmers, Sofia Ioannou, Garyfallia Poulakou, Jos W. M. van der Meer, Evangelos J. Giamarellos-Bourboulis, Vinod Kumar, Frank L. van de Veerdonk, Mihai G. Netea, Athanasios Ziogas
Summary: Dexamethasone has anti-inflammatory effects in COVID-19 patients by inhibiting cytokine responses and interferon signaling pathways, which is beneficial for patients with severe symptoms but may have adverse effects on those with mild symptoms.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Sayed Hamid Mousavi, Mohammad Hossein Delshad, Cecilia Acuti Martellucci, Divya Bhandari, Akihiko Ozaki, Fatemeh Pourhaji, Fahimeh Pourhaji, Sayed Mohammad Reza Hosseini, Rohullah Roien, Abass Ali Ramozi, Marzia Wafaee, Shohra Qaderi, Mohammad Delsoz, Shailendra Sigdel, Yasuhiro Kotera, Toyoaki Sawano, Kuldeep Dhama, Alfonso J. Rodriguez-Morales, Jiwei Wang, Tetsuya Tanimoto, Ali Ahmad Yousefi, Ranjit Sah
Summary: This study investigated the perceived susceptibility and severity of COVID-19, as well as the practice of nonpharmaceutical interventions, among people living in Afghanistan. The findings suggest that the psychological and behavioral responses of communities in Afghanistan, particularly among young Internet users, were influenced by the early phase of the COVID-19 pandemic.
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2023)
Article
Energy & Fuels
Tehmina Sharif, Haq Nawaz Bhatti, Ian D. Bull, Muhammad Bilal
Summary: This study optimized the extraction of bioactive molecules from mango peel waste using enzyme-assisted ultrasound extraction (EAUE). The results showed that EAUE could effectively extract high levels of total phenolics, exhibit strong antioxidant capacity, and possess high DPPH scavenging ability. This demonstrates the potential of EAUE as an efficient technique for extracting and recovering bioactive compounds from natural resources.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Review
Food Science & Technology
Chuqi Wang, Minhao Li, Xinyu Duan, Tareq Abu-Izneid, Abdur Rauf, Zidan Khan, Saikat Mitra, Talha Bin Emran, Abdullah S. M. Aljohani, Fahad A. Alhumaydhi, Muthu Thiruvengadam, Hafiz A. R. Suleria
Summary: Tomatoes are widely consumed worldwide and are rich in nutritional and bioactive compounds. However, the processing of tomatoes into various products may affect the bioavailability of these compounds. This review discusses the nutritional and anti-nutritional compounds in tomatoes and their effects on human health, as well as the impact of different food processing techniques on the bioavailability of tomato antioxidants.
FOOD REVIEWS INTERNATIONAL
(2023)
Article
Environmental Sciences
Umme Kalsoom, Nasira Khalid, Affaf Ibrahim, Syed Salman Ashraf, Haq Nawaz Bhatti, Zainab Ahsan, Jakub Zdarta, Muhammad Bilal
Summary: This study investigates the biodegradation of direct blue (DB) 297 and reactive blue (RB) 221 using immobilized horseradish peroxidase (HRP) on iron oxide nanoparticles. The nanoparticles were synthesized by co-precipitation and showed an immobilization efficiency of 87%. The immobilized HRP exhibited higher thermal stability, pH stability, and dye degradation efficiency compared to free HRP.
Review
Pharmacology & Pharmacy
Hardeep Singh Tuli, Vivek Kumar Garg, Ajay Kumar, Diwakar Aggarwal, Uttpal Anand, Nidarshana Chaturvedi Parashar, Adesh K. Saini, Ranjan K. Mohapatra, Kuldeep Dhama, Manoj Kumar, Tejveer Singh, Jagjit Kaur, Katrin Sak
Summary: This review article provides a comprehensive description of the potential applications of Oroxylin A (OA), a constituent of Scutellariae plants, in the treatment of malignant tumors. It discusses the various mechanisms of action, including antiproliferative, anti-inflammatory, and proapoptotic effects, and explores the synergistic effects with conventional anticancer agents as well as the advantages of nanotechnological methods in OA application.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Environmental Sciences
Hamza Rafeeq, Nadia Afsheen, Sadia Rafique, Arooj Arshad, Maham Intisar, Asim Hussain, Muhammad Bilal, Hafiz M. N. Iqbal
Summary: In the recent era, the persistence of hazardous contaminants has had a severe impact on the world. Conventional approaches to remediation have failed to effectively remove these contaminants, leading to an increase in the use of genetically engineered microbes (GEMs) for bioremediation. GEMs are more powerful and cost-effective in degrading various pollutants, making genetic engineering a worthwhile process for environmental improvement and human health.
Review
Immunology
Sunita Panda, Puneet Kumar Singh, Snehasish Mishra, Sagnik Mitra, Priyabrata Pattnaik, Sanjib Das Adhikary, Ranjan K. K. Mohapatra
Summary: India is a leading player in the production of biologics and biosimilars, which can reduce treatment costs and improve healthcare. However, there are gaps in university-industry collaboration, intellectual property rights, and innovation in India. It is necessary to strengthen collaboration, cultivate technopreneurs, and develop business models.
Review
Agriculture, Dairy & Animal Science
Rana Muhammad Bilal, Muhammad Ali Tahir, Asim Shahzad, Mayada R. Farag, Abdelmonem Siddiq, Nahed A. El-Shall, Kuldeep Dhama, Shaaban S. Elnesr, Mahmoud Alagawany
Summary: Poultry is an important source of human protein, but the feed used for poultry is often contaminated with mycotoxins, toxic secondary metabolites produced by fungi. This review focuses on the use of yeast and its derived products to overcome these mycotoxins in poultry diets. Yeast has been found to promote the growth of broilers, enhance immunity, improve gut immunity, and reduce the proportion of harmful microorganisms. Therefore, the inclusion of yeast as a feed additive is considered promising in mitigating the effects of mycotoxins in poultry.
WORLDS POULTRY SCIENCE JOURNAL
(2023)
Letter
Surgery
Hitesh Chopra, Sandip Chakraborty, Shopnil Akash, Chiranjib Chakraborty, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Biotechnology & Applied Microbiology
S. V. Praveen, Rosemol Boby, Roshan Shaji, Deepak Chandran, Nawfal R. Hussein, Sirwan Khalid Ahmed, Shopnil Akash, Kuldeep Dhama
Summary: Concerns about the Omicron subvariant XBB.1.5 and previously reported BF.7 have been raised due to the continuous rise in COVID-19 cases. This study analyzed the perceptions of Indian citizens regarding these variants using natural language processing techniques. The sentiment analysis revealed that a significant number of tweets had neutral sentiments, followed by positive and negative sentiments. The study highlights the importance of addressing concerns about the future and vaccine immunity to tackle the ongoing pandemic.
JOURNAL OF PURE AND APPLIED MICROBIOLOGY
(2023)
Review
Chemistry, Medicinal
Hitesh Chopra, Yugal Kishore Mohanta, Pradipta Ranjan Rauta, Ramzan Ahmed, Saurov Mahanta, Piyush Kumar Mishra, Paramjot Panda, Ali A. Rabaan, Ahmad A. Alshehri, Basim Othman, Mohammed Abdulrahman Alshahrani, Ali S. Alqahtani, Baneen Ali AL Basha, Kuldeep Dhama
Summary: Tuberculosis is a global concern, with the rise of multidrug-resistant strains posing a threat to control efforts. Nanotechnology offers the potential for improved identification of mycobacterial strains and medication delivery systems.
Article
Computer Science, Hardware & Architecture
Md. Monirul Islam, Mohammod Abul Kashem, Salem A. Alyami, Mohammad Ali Moni
Summary: This paper presents an IoT framework for aquaculture that allows real-time monitoring and effective control of water-related parameters. The proposed system utilizes sensors and an Arduino microcontroller to collect and store data in an IoT cloud platform. The collected data is then analyzed using various machine learning algorithms, with Random Forest achieving the highest performance scores. The study also includes hardware details of the IoT system and calculates biochemical and chemical oxygen demands.
MICROPROCESSORS AND MICROSYSTEMS
(2023)
Editorial Material
Medicine, Research & Experimental
Chiranjib Chakraborty, Manojit Bhattacharya, Kuldeep Dhama, Sang-Soo Lee
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Editorial Material
Medicine, General & Internal
Ruhul Amin, Faruk Alam, Kuldeep Dhama, Sandip Chakraborty, Talha B. Emran
ANNALS OF MEDICINE AND SURGERY
(2023)
Letter
Surgery
Hitesh Chopra, Talha B. Emran, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)