Review
Immunology
Zilong Wang, Chucun Fang, Mengting Yao, Dongwen Wu, Maga Chen, Tianting Guo, Jianwen Mo
Summary: Venous thromboembolism is a common and costly health problem. Deep-vein thrombosis can cause severe consequences. Inflammatory response is considered an important pathway for triggering venous thromboembolism, and regulating it through the NF-kappa B signaling pathway may provide new solutions for prevention and treatment of thrombosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Pharmacology & Pharmacy
Xin Sun, Le Yang, Hui Sun, Ye Sun, Shuyun Wei, Ying Han, Wenkai Wang, Ling Kong, Xijun Wang
Summary: This article compiles key research on the molecular signaling pathways and UA transporters linked to gout under the regulation of TCM. It finds that TCM has the capacity to modulate various signaling pathways and UA transporters, contributing to gout treatment by maintaining a balanced inflammatory interaction and facilitating UA excretion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Flavia Carneiro Mendes, Janine Cerqueira de Paiva, Eloi Quintas Goncalves da Silva, Marcus Reboucas Santos, Graziela Domingues de Almeida Lima, Gabriela Alves Moreira, Lucas Viana Gomes Silva, Joice de Melo Agripino, Ana Paula Martins de Souza, Tiago Antonio de Oliveira Mendes, Mariana Machado-Neves, Robson Ricardo Teixeira, Abelardo Silva-Junior, Juliana Lopes Rangel Fietto, Leandro Licursi de Oliveira, Gustavo Costa Bressan
Summary: The serine/arginine-rich protein kinases (SRPK) can modulate the splicing and expression of gene isoforms related to cancer and infectious diseases. SRPK inhibitors such as SRPIN340 and its derivatives have been found to exhibit immunomodulatory activity and could be used as vaccine adjuvants or in immunotherapies.
Article
Food Science & Technology
Jing Li, Saisai Feng, Leilei Yu, Jianxin Zhao, Fengwei Tian, Wei Chen, Qixiao Zhai
Summary: This study systematically discusses the immunomodulatory activities of cell-surface polysaccharides of lactic acid bacteria (LAB) and Bacteroides, including their mechanisms, synthesis, regulation, structure, and functional links. The research highlights the significant protective properties of these polysaccharides in immunocompromised diseases.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Biochemistry & Molecular Biology
Sheng-Nan Yuan, Cai-Yun Feng, Yao Rong, Xu Guo, Ying-Ying Chen, M. Fraga-Corral, Miguel A. Prieto, Xiao-Yue Zhang, Ning-Yang Li, Chao Liu, Jin-Yue Sun
Summary: This study investigated the immunomodulatory potential of nervonic acid (NA) on murine RAW264.7 macrophages. The effects of NA were evaluated through various assays and techniques, including assessment of nitric oxide levels, cytokine secretion, phagocytic activity, reactive oxygen species generation, and NF-κB signaling pathway. The results showed that NA can promote the production of NO, TNF-α, IL-1β, IL-6, and ROS in RAW264.7 cells, and upregulate the expression of iNOS, TNF-α, IL-1β, and IL-6 mRNA. Additionally, NA increased the expression of TLR4 protein and the phosphorylation level of NF-κB in a concentration-dependent manner. In conclusion, NA has immunomodulatory potential by activating the NF-κB signaling pathway through the TLR4 signaling pathway.
JOURNAL OF FOOD BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Shengwen Calvin Li, Mustafa H. Kabeer
Summary: The study shows that splenocyte reinfusion can improve the defective antibody response to the Pneumovax 23 vaccine. This finding triggered a debate on the mechanisms of primary and secondary immune responses based on humoral antibody responses. The study also proposes a new mechanism, caveolae memory extracellular vesicles, by which polysaccharides mediate prolonged immune response post-vaccination.
Article
Biochemistry & Molecular Biology
Zohreh Khorshidvand, Sadegh Shirian, Hanieh Amiri, Alireza Zamani, Amir Hossein Maghsood
Summary: The study investigated the immunomodulatory effects of propranolol hydrochloride (PRO) in combination with chitosan nanoparticles (CS NPs) as an adjuvant for a vaccine against T. gondii. The results showed that mice immunized with CS-SAG1-PRO NPs had the highest lymphocyte proliferation rate, increased secretion of various cytokines, and elevated levels of protective cytokines. The mice also exhibited a higher level of T. gondii-specific IgG, indicating an immune response biased towards Th1 cells. This approach holds promise for immunostimulation and vaccine delivery against T. gondii infection.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Cheng Wang, Hongqi Shang, Wenping Cui, Fan Zhou, Shuyu Zhang, Xiangkun Wang, PanPan Gao, Kai Wei, Ruiliang Zhu
Summary: Pine pollen polysaccharides (PPPS) was found to promote wound healing by activating the JAK2-STAT3 signaling pathway, accelerating cell proliferation and altering the cell cycle.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Wei Chen, Yang Lu, Dongwen Hu, Jianling Mo, Jingdan Ni
Summary: BP1 polysaccharide fraction isolated from black mulberry shows a better protective effect against lipotoxicity, and it can reduce lipotoxicity by activating the Nrf2 signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Chemistry, Medicinal
Bingjie Yue, Gangfan Zong, Ruizhi Tao, Zhonghong Wei, Yin Lu
Summary: This article discusses the extraction and pharmacological effects of traditional Chinese medicine polysaccharides, the functions of the gut microbiota, and the interactions between polysaccharides and the gut microbiota. It elucidates the mechanisms of how polysaccharides modulate host physiology via the gut microbiota.
PHYTOTHERAPY RESEARCH
(2022)
Article
Multidisciplinary Sciences
Duoli Zhang, Tao Zou, Qingsong Liu, Jie Chen, Mintao Xiao, Anfu Zheng, Zhuo Zhang, Fukuan Du, Yalan Dai, Shixin Xiang, Xu Wu, Mingxing Li, Yu Chen, Yueshui Zhao, Jing Shen, Guiquan Chen, Zhangang Xiao
Summary: METTL7A, a protein-coding gene associated with methylation, has been found to play an important role in tumor progression and tumorigenicity through the p53 signaling pathway.
Article
Biochemistry & Molecular Biology
Jiaping Zhou, Guoqing Wang, Ran Han, Ruhua Wang, Yu Kong, Rui Zhang, Lihua Hou, Meng Meng
Summary: The study investigated the immunomodulatory effect of glycopeptides from Paecilomyces sinensis on ethanol-induced ulcers in mice. Results showed that CPS-II has immunoregulation and anti-ulcer properties, reducing oxidative stress and inflammatory response by regulating the miR-9-5p-MEK/ERK signaling pathway, thus protecting the gastric mucosa and improving stress gastric ulcers.
Article
Plant Sciences
Parvathi Annamalai, Elden Berla Thangam
Summary: The methanolic extract from Vitex trifolia L. leaves demonstrated significant anti-inflammatory effects in a rat model of inflammation, reducing edema and leukocyte infiltration. It also lowered the levels of pro-inflammatory cytokines and increased the concentration of anti-inflammatory cytokines. Additionally, the extract inhibited the nuclear translocation of NF-Kappa B, indicating its potential role in down-regulating the inflammatory signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Tracer Yong, Ko-Keng Chang, Yi-Sheng Wang, Che Ma
Summary: This article introduces the preparation and clinical application of a cancer vaccine targeting IL-17RB. The vaccine is composed of multiple synthesized epitope peptides chemically conjugated onto CRM197, a carrier protein, and has a durable anti-cancer effect.
Article
Chemistry, Applied
Li Ren, Jie Zhang, Tiehua Zhang
Summary: Polysaccharides from Ganoderma, as the most abundant bioactive compounds, exhibit unique biological properties such as anti-tumor, anti-inflammatory, and immunomodulatory activities. They can potentially be applied for the modulation of the host immune system, including innate immunity, cellular immunity, and humoral immunity.