Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Review
Cell Biology
Bowen Hu, Hongmei Li, Xiquan Zhang
Summary: Mitochondria play a crucial role in cellular energy homeostasis and metabolism, generating ATP through oxidative phosphorylation among other functions. The GH-GHR-IGF1 axis influences somatic growth processes such as cell proliferation and survival. This axis has a significant impact on mitochondrial biogenesis, mitophagy, and function under various physiological conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Endocrinology & Metabolism
Leonie Rieger, Rosemary O'Connor
Summary: The internalization and localization of the IGF-1 receptor play crucial roles in cell signaling and biological processes, with different cell types and cell adhesion receptors regulating this process. Further study on how IGF-1R intracellular trafficking and compartmentalized signaling is controlled, particularly in cancer, is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Haim Werner, Zvi Laron
Summary: The GH-IGF1 signaling pathway plays a key role in aging and longevity. Patients with LS, a congenital IGF1 deficiency, seem to be protected from cancer. Aging and cancer may be different manifestations of the same underlying processes. Genome-wide screenings have identified genes associated with aging and longevity in LS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Evgenia Gurevich, Yael Segev, Daniel Landau
Summary: GH and IGF-1 have important roles in kidney development and function regulation, with GH excess potentially leading to kidney damage. Chronic kidney disease and its complications in children are associated with alterations in the GH/IGF1 axis, with GH treatment being used to promote growth.
Article
Cell Biology
Charmaine J. Green, Miriam Span, Monique H. Rayhanna, Marisa Perera, Margot L. Day
Summary: The viability of embryos cultured in vitro is poor compared to those that develop in vivo. This study investigated the role of autocrine and exogenous IGFBP3 in mouse preimplantation embryos. Addition of exogenous IGFBP3 to embryo culture media increased the rate of development, and the effect was mediated by IGF1 and EGF receptors. Acute exposure to IGFBP3 activated the PI3-kinase/Akt pathway to promote cell proliferation and survival. Therefore, addition of IGFBP3 to IVF culture media should be considered.
Article
Cell Biology
Rive Sarfstein, Karthik Nagaraj, Shivang Parikh, Carmit Levy, Zvi Laron, Dafna Benayahu, Haim Werner
Summary: Normal growth and development are controlled by genetic and metabolic factors, with the GH-IGF1 hormonal axis playing a key role. LS patients have reduced cancer risk, and the UGT2B15 gene may be a novel target for IGF1 action.
Article
Biology
Jie Li, Jiayi Wu, Catherine Hall, Xiao-chen Bai, Eunhee Choi, Emily J. Gallagher
Summary: The insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) play crucial roles in metabolic homeostasis and cell growth. This study reveals that the structural rigidity of the disulfide-linked alpha CTs is critical for optimal IR and IGF1R signaling activation.
Article
Geriatrics & Gerontology
Silvana Sidhom, Augusto Schneider, Yimin Fang, Samuel McFadden, Justin Darcy, Roshini Sathiaseelan, Allyson K. Palmer, Frederik J. Steyn, Johannes Grillari, John J. Kopchick, Andrzej Bartke, Shadab Siddiqi, Michal M. Masternak, Michael B. Stout
Summary: 17α-estradiol has been shown to promote health benefits in male mice by increasing hepatic insulin-like growth factor 1 (IGF1) production in a growth hormone (GH)-dependent manner. However, this effect was not observed in female mice.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bhumika Rajoria, Xihong Zhang, Douglas Yee
Summary: The Insulin-like Growth Factor (IGF) system has long been studied in breast cancer progression, but targeting it has not been successful due to the complexity and homology of its receptors. This study examined the metabolic phenotype of breast cancer cells upon stimulation with IGF-1 and insulin. The results showed that IGF-1R, but not IR, regulates ATP production, providing evidence of the relationship between metabolic dysfunction, cancer, and the IGF axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Seung Hee Seo, Soo-Yeon Hwang, Seohui Hwang, Sunjung Han, Hyojin Park, Yun-Sil Lee, Seung Bae Rho, Youngjoo Kwon
Summary: Epithelial ovarian cancer (EOC) is closely related to angiogenesis regulated by ELF3, which promotes the secretion of IGF1 and VEGF. ELF3 silencing can inhibit angiogenesis and tumorigenesis in EOC, suggesting that understanding the mechanism of ELF3 can improve EOC therapy.
Article
Endocrinology & Metabolism
Fa Zhang, Emrah Altindis, C. Ronald Kahn, Richard D. DiMarchi, Vasily Gelfanov
Summary: The study identified viral insulin-like peptides with unique biological functions, including one that acts as a potent and full antagonist of the IGF-1R. The results revealed the importance of the internal structure of VILPs in regulating their biological activities and discovered a set of potentially medicinally important antagonists.
MOLECULAR METABOLISM
(2021)
Editorial Material
Cell Biology
Pawel Kordowitzki, Kornelia Krajnik, Agnieszka Skowronska, Mariusz T. Skowronski
Summary: This commentary highlights the pleiotropic effects of IGF1 on physiological processes inside the egg, focusing on the potential clinical application in women with metabolic imbalances. It provides a brief overview of IGF1-related cell signal transduction pathways during oocyte maturation and aging.
Review
Cell Biology
Haim Werner, Lena Lapkina-Gendler, Laris Achlaug, Karthik Nagaraj, Lina Somri, Danielle Yaron-Saminsky, Metsada Pasmanik-Chor, Rive Sarfstein, Zvi Laron, Shoshana Yakar
Article
Cell Biology
Rive Sarfstein, Karthik Nagaraj, Derek LeRoith, Haim Werner
Review
Cell Biology
Sher Bahadur Poudel, Manisha Dixit, Maria Neginskaya, Karthik Nagaraj, Evgeny Pavlov, Haim Werner, Shoshana Yakar
Editorial Material
Cell Biology
Haim Werner
Article
Cell Biology
Rand Shibel, Rive Sarfstein, Karthik Nagaraj, Lena Lapkina-Gendler, Zvi Laron, Manisha Dixit, Shoshana Yakar, Haim Werner
Summary: Endometrial cancer is commonly linked to the insulin-like growth factor-1 (IGF1) axis, while individuals with Laron syndrome (LS) are protected from cancer development due to IGF1 deficiency. The downregulation of OR5H2 gene in LS-derived cells suggests a potential role in endometrial cancer as a target for positive regulation by IGF1.
Article
Biochemistry & Molecular Biology
Danielle Yaron-Saminsky, Karthik Nagaraj, Rive Sarfstein, Zvi Laron, Metsada Pasmanik-Chor, Haim Werner
Summary: The GH-IGF1 hormonal system is important in growth, metabolism, and disease development. LS, caused by a mutation in the GH receptor gene, may be associated with reduced cancer risk due to differential miR expression levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Rive Sarfstein, Karthik Nagaraj, Shivang Parikh, Carmit Levy, Zvi Laron, Dafna Benayahu, Haim Werner
Summary: Normal growth and development are controlled by genetic and metabolic factors, with the GH-IGF1 hormonal axis playing a key role. LS patients have reduced cancer risk, and the UGT2B15 gene may be a novel target for IGF1 action.
Article
Cell Biology
Karthik Nagaraj, Rive Sarfstein, Zvi Laron, Haim Werner
Summary: The GH/IGF1 pathway plays a crucial role in cellular interactions, metabolism, growth, and aging. Patients with LS have a reduced risk of developing cancer, and the discovery of IGF1 and TXNIP provides new insights into cellular redox regulation. The IGF1-TXNIP axis is essential for maintaining cellular homeostasis.
Review
Cell Biology
Haim Werner, Rive Sarfstein, Karthik Nagaraj, Zvi Laron