Comprehensive Virtual Screening of the Antiviral Potentialities of Marine Polycyclic Guanidine Alkaloids against SARS-CoV-2 (COVID-19)

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Identification of a novel coronavirus causing severe pneumonia in human

(2020) Li-Li Ren et al.   CHINESE MEDICAL JOURNAL

A hundred days into the coronavirus disease (COVID-19) pandemic

(2020) Ines Steffens   Eurosurveillance

Marine natural compounds as potents inhibitors against the main protease of SARS-CoV-2—a molecular dynamic study

(2020) Muhammad Tahir Khan et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Screening Marine Natural Products for New Drug Leads against Trypanosomatids and Malaria

(2020) María Álvarez-Bardón et al.   Marine Drugs

Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors

(2020) Linlin Zhang et al.   SCIENCE

Molecular immune pathogenesis and diagnosis of COVID-19

(2020) Xiaowei Li et al.   Journal of Pharmaceutical Analysis

Short-Cut Bio-Inspired Synthesis of Tricyclic Guanidinic Motifs of Crambescidins and Batzelladines Marine Alkaloids

(2020) Amr El-Demerdash et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Screening of Some Sulfonamide and Sulfonylurea Derivatives as Anti-Alzheimer’s Agents Targeting BACE1 and PPARγ

(2020) Ning Li et al.   Journal of Chemistry

Recent progress and challenges in drug development against COVID-19 coronavirus (SARS-CoV-2) - an update on the status

(2020) Tarek Mohamed Abd El-Aziz et al.   INFECTION GENETICS AND EVOLUTION

Have marine natural product drug discovery efforts been productive and how can we improve their efficiency?

(2019) Florbela Pereira   Expert Opinion on Drug Discovery

Design, synthesis and anticancer evaluation of thieno[2,3-d]pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers

(2019) Souad A. Elmetwally et al.   BIOORGANIC CHEMISTRY

Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of phthalimide-sulfonylurea hybrids as PPARγ and SUR agonists

(2019) Mohamed Ayman El-Zahabi et al.   BIOORGANIC CHEMISTRY

Design, synthesis, molecular modeling, in vivo studies and anticancer evaluation of quinazolin-4(3H)-one derivatives as potential VEGFR-2 inhibitors and apoptosis inducers

(2019) Hazem A. Mahdy et al.   BIOORGANIC CHEMISTRY

Synthesis, docking, QSAR, ADMET and antimicrobial evaluation of new quinoline-3-carbonitrile derivatives as potential DNA-gyrase inhibitors

(2018) Kamal M. El-Gamal et al.   JOURNAL OF MOLECULAR STRUCTURE

Crambescidin 800, Isolated from the Marine Sponge Monanchora viridis, Induces Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells

(2018) Sumi Shrestha et al.   Marine Drugs

New Crambescidin-Type Alkaloids from the Indonesian Marine Sponge Clathria bulbotoxa

(2018) Kasmiati Kasmiati et al.   Marine Drugs

Chemistry and Biological Activities of the Marine Sponges of the Genera Mycale (Arenochalina), Biemna and Clathria

(2018) Amr El-Demerdash et al.   Marine Drugs

Batzella, Crambe and Monanchora: Highly Prolific Marine Sponge Genera Yielding Compounds with Potential Applications for Cancer and Other Therapeutic Areas

(2018) Amr El-Demerdash et al.   Nutrients

Marine Natural Products in Medicinal Chemistry

(2018) Carlos Jiménez   ACS Medicinal Chemistry Letters

Unguiculin A and Ptilomycalins E–H, Antimalarial Guanidine Alkaloids from the Marine Sponge Monanchora unguiculata

(2017) Pierre-Eric Campos et al.   JOURNAL OF NATURAL PRODUCTS

Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp

(2017) Amr El-Demerdash et al.   NATURAL PRODUCT RESEARCH

Monanchoxymycalin C with anticancer properties, new analogue of crambescidin 800 from the marine sponge Monanchora pulchra

(2017) Larisa Kimovna Shubina et al.   NATURAL PRODUCT RESEARCH

Molecular Evolution of Human Coronavirus Genomes

(2017) Diego Forni et al.   TRENDS IN MICROBIOLOGY

Cytotoxic Guanidine Alkaloids from a French Polynesian Monanchora n. sp. Sponge

(2016) Amr El-Demerdash et al.   JOURNAL OF NATURAL PRODUCTS

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges

(2016) Estelle Sfecci et al.   Marine Drugs

Coronaviruses — drug discovery and therapeutic options

(2016) Alimuddin Zumla et al.   NATURE REVIEWS DRUG DISCOVERY

SARS and MERS: recent insights into emerging coronaviruses

(2016) Emmie de Wit et al.   NATURE REVIEWS MICROBIOLOGY

Isolation and identification of new secondary metabolites from the marine sponge Monanchora unguiculata

(2016) PE Campos et al.   PLANTA MEDICA

Epidemiology, Genetic Recombination, and Pathogenesis of Coronaviruses

(2016) Shuo Su et al.   TRENDS IN MICROBIOLOGY

A potent antimicrobial compound isolated from Clathria cervicornis

(2015) Xiuxiu Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Role of Marine Natural Products in the Genesis of Antiviral Agents

(2015) Vedanjali Gogineni et al.   CHEMICAL REVIEWS

Human Coronavirus HKU1 Spike Protein UsesO-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme

(2015) Xingchuan Huang et al.   JOURNAL OF VIROLOGY

Comparison ofin silicotools for evaluating rat oral acute toxicity

(2015) R. Gonella Diaza et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH

CoronavirusNsp10, a Critical Co-factor for Activation of Multiple Replicative Enzymes

(2014) Mickaël Bouvet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells

(2013) J A Rubiolo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Crambescidin-816 Acts as a Fungicidal with More Potency than Crambescidin-800 and -830, Inducing Cell Cycle Arrest, Increased Cell Size and Apoptosis in Saccharomyces cerevisiae

(2013) Juan Rubiolo et al.   Marine Drugs

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Structure of viruses: a short history

(2013) Michael G. Rossmann   QUARTERLY REVIEWS OF BIOPHYSICS

Marine natural products: a new wave of drugs?

(2011) Rana Montaser et al.   Future Medicinal Chemistry

Marine compounds and their antiviral activities

(2010) Jarred Yasuhara-Bell et al.   ANTIVIRAL RESEARCH

The odyssey of marine pharmaceuticals: a current pipeline perspective

(2010) Alejandro M.S. Mayer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

QSAR Studies of CYP2D6 Inhibitor Aryloxypropanolamines Using 2D and 3D Descriptors

(2009) Partha Pratim Roy et al.   Chemical Biology & Drug Design

Merobatzelladines A and B, Anti-Infective Tricyclic Guanidines from a Marine SpongeMonanchorasp.

(2009) Shunsuke Takishima et al.   ORGANIC LETTERS