Reactive astrocyte-driven epileptogenesis is induced by microglia initially activated following status epilepticus

Aberrant astrocyte Ca2+ signals “AxCa signals” exacerbate pathological alterations in an Alexander disease model

(2018) Kozo Saito et al.   GLIA

Peripherally derived T regulatory and γδ T cells have opposing roles in the pathogenesis of intractable pediatric epilepsy

(2018) Dan Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of Purinergic Receptor P2Y1 in Spatiotemporal Ca2+Dynamics in Astrocytes

(2018) Eiji Shigetomi et al.   JOURNAL OF NEUROSCIENCE

Ca2+ Signals in Astrocytes Facilitate Spread of Epileptiform Activity

(2018) Kjell Heuser et al.   CEREBRAL CORTEX

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Cell Biology of Astrocyte-Synapse Interactions

(2017) Nicola J. Allen et al.   NEURON

Author Correction: Reactive astrocytes function as phagocytes after brain ischemia via ABCA1-mediated pathway

(2017) Yosuke M. Morizawa et al.   Nature Communications

Transformation of Astrocytes to a Neuroprotective Phenotype by Microglia via P2Y 1 Receptor Downregulation

(2017) Youichi Shinozaki et al.   Cell Reports

Microglia-Neuron Communication in Epilepsy

(2016) Ukpong B. Eyo et al.   GLIA

Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain

(2016) Sun Kwang Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Animal models of temporal lobe epilepsy following systemic chemoconvulsant administration

(2016) Maxime Lévesque et al.   JOURNAL OF NEUROSCIENCE METHODS

Astrocyte calcium signaling: the third wave

(2016) Narges Bazargani et al.   NATURE NEUROSCIENCE

Crucial role of astrocytes in temporal lobe epilepsy

(2016) C. Steinhäuser et al.   NEUROSCIENCE

Astrocyte uncoupling as a cause of human temporal lobe epilepsy

(2015) Peter Bedner et al.   BRAIN

Complex alterations in microglial M1/M2 markers during the development of epilepsy in two mouse models

(2015) Melissa J. Benson et al.   EPILEPSIA

Enhanced astroglial Ca2+signaling increases excitatory synaptic strength in the epileptic brain

(2015) Carla Álvarez-Ferradas et al.   GLIA

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

(2015) Nabil N. Dagher et al.   Journal of Neuroinflammation

Astrocyte-Mediated Ischemic Tolerance

(2015) Y. Hirayama et al.   JOURNAL OF NEUROSCIENCE

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

(2015) Itai Weissberg et al.   NEUROBIOLOGY OF DISEASE

Augmentation of Ca2+ signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy

(2015) Karolina Szokol et al.   Frontiers in Cellular Neuroscience

TLR9 signalling in microglia attenuates seizure-induced aberrant neurogenesis in the adult hippocampus

(2015) Taito Matsuda et al.   Nature Communications

Role of Astrocytes in Epilepsy

(2015) D. A. Coulter et al.   Cold Spring Harbor Perspectives in Medicine

Epilepsies associated with hippocampal sclerosis

(2014) Fernando Cendes et al.   ACTA NEUROPATHOLOGICA

Gliotransmitters Travel in Time and Space

(2014) Alfonso Araque et al.   NEURON

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Microglia release ATP by exocytosis

(2013) Yoshio Imura et al.   GLIA

Astrocyte control of synaptic NMDA receptors contributes to the progressive development of temporal lobe epilepsy

(2013) J. Clasadonte et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Astrocyte dysfunction in temporal lobe epilepsy: K+ channels and gap junction coupling

(2012) Christian Steinhäuser et al.   GLIA

A Cre-Dependent GCaMP3 Reporter Mouse for Neuronal Imaging In Vivo

(2012) H. A. Zariwala et al.   JOURNAL OF NEUROSCIENCE

Microglia in early disease stages

(2012) Katie Kingwell   Nature Reviews Neurology

Minocycline attenuates microglia activation and blocks the long-term epileptogenic effects of early-life seizures

(2012) Jayne Abraham et al.   NEUROBIOLOGY OF DISEASE

Neuron–astrocyte signaling and epilepsy

(2011) Gerald Seifert et al.   EXPERIMENTAL NEUROLOGY

Evidence that compromised K+ spatial buffering contributes to the epileptogenic effect of mutations in the human kir4.1 gene (KCNJ10)

(2011) Nadia Nabil Haj-Yasein et al.   GLIA

Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

(2011) M. Zattoni et al.   JOURNAL OF NEUROSCIENCE

Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats

(2010) Lee A. Shapiro et al.   EPILEPSIA

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold

(2010) Marta Gómez-Gonzalo et al.   PLOS BIOLOGY

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Astrocyte dysfunction in epilepsy

(2009) Gerald Seifert et al.   BRAIN RESEARCH REVIEWS

Colony-Stimulating Factor-1 Receptor Inhibitors for the Treatment of Cancer and Inflammatory Disease

(2009) Sharmila Patel et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Epileptogenesis in the immature brain: emerging mechanisms

(2009) Sanjay N. Rakhade et al.   Nature Reviews Neurology

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Behavioral alterations in a mouse model of temporal lobe epilepsy induced by intrahippocampal injection of kainate

(2008) Ina Gröticke et al.   EXPERIMENTAL NEUROLOGY

Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice

(2008) Tianfu Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Status Epilepticus Induces a Particular Microglial Activation State Characterized by Enhanced Purinergic Signaling

(2008) E. Avignone et al.   JOURNAL OF NEUROSCIENCE

The pilocarpine model of temporal lobe epilepsy

(2008) Giulia Curia et al.   JOURNAL OF NEUROSCIENCE METHODS

A role for leukocyte-endothelial adhesion mechanisms in epilepsy

(2008) Paolo F Fabene et al.   NATURE MEDICINE

Microglial activation and TNF  production mediate altered CNS excitability following peripheral inflammation

(2008) K. Riazi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The adenosine kinase hypothesis of epileptogenesis

(2007) Detlev Boison   PROGRESS IN NEUROBIOLOGY