Article
Multidisciplinary Sciences
Allison N. Grossberg, Lilia A. Koza, Aurelie Ledreux, Chad Prusmack, Hari Krishnan Krishnamurthy, Vasanth Jayaraman, Ann-Charlotte Granholm, Daniel A. Linseman
Summary: This study presents results from a multiplex serology test for assessing COVID-19 antibody responses, showing distinct dynamics of IgG, IgM, and IgA responses in patients with different disease severity. It suggests that antibody responses to SARS-CoV-2 may serve as important biomarkers for assessing the risk of viral transmission.
NATURE COMMUNICATIONS
(2021)
Article
Virology
Francisco J. Berguido, Peter D. Burbelo, Alessio Bortolami, Francesco Bonfante, Kerstin Wernike, Donata Hoffmann, Anne Balkema-Buschmann, Martin Beer, William G. Dundon, Charles E. Lamien, Giovanni Cattoli
Summary: The study utilized luciferase immunoprecipitation systems (LIPS) to detect antibodies against SARS-CoV-2 virus in different animal species, demonstrating that the method is suitable for sero-surveillance in a range of animal species, with better performance in the detection of antibodies against the S protein.
Article
Virology
Serge Ouoba, Mafumi Okimoto, Shintaro Nagashima, Yoshihiro Kitahara, Kei Miwata, Ko Ko, E. Bunthen, Aya Sugiyama, Kazuaki Takahashi, Takemasa Sakaguchi, Toshiro Takafuta, Junko Tanaka
Summary: This study investigated the dynamics of SARS-CoV-2 viral load and antibody response in sequential serum samples of COVID-19 patients. It found that patients with moderate symptoms had a faster and stronger antibody response compared to those with mild symptoms, and the viral load gradually decreased to undetectable levels in patients with mild symptoms while fluctuating and persisting in moderate cases. The study sheds light on the immune response, viremia, and antibody acquisition pattern in relation to the severity of infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Clinical Neurology
Katarzyna Krzywicka, Anita van de Munckhof, Mayte Sanchez van Kammen, Mirjam R. Heldner, Katarina Jood, Erik Lindgren, Turgut Tatlisumak, Jukka Putaala, Johanna A. Kremer Hovinga, Saskia Middeldorp, Marcel M. Levi, Charlotte Cordonnier, Marcel Arnold, Aeilko H. Zwinderman, Jose M. Ferro, Jonathan M. Coutinho, Diana Aguiar de Sousa
Summary: This study assessed the age-stratified risk of cerebral venous sinus thrombosis (CVST) with and without thrombocytopenia after SARS-CoV-2 vaccination. The absolute risk of CVST within 28 days of vaccination was highest in the 18-24-year-old age group, and the risk of CVST with thrombocytopenia was slightly increased in patients receiving the Ad26.COV2.S vaccine compared to the estimated background risk. However, there was no increased risk of CVST with thrombocytopenia in recipients of SARS-CoV-2 mRNA vaccines.
Article
Medicine, General & Internal
Marek Wojczyk, Ewa Niewiadomska, Malgorzata Kowalska
Summary: This study aims to present the scale of the spread of SARS-CoV-2 infection and the vaccination coverage among healthcare workers in Poland. The incidence proportion of SARS-CoV-2 infections among HCWs was 16.48%, with laboratory scientists and paramedics being the most affected. There were significant territorial differences in the frequency of infections, deaths, and vaccination coverage among HCWs in different administrative areas.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Hongming Wang, Yoko Ibuka, Ryota Nakamura
Summary: The study shows that targeting low-risk young adults together with high-risk individuals and the elderly can optimally reduce deaths, cases, and severe cases under high virus transmissibility. Optimal group mix outperforms targeting individual groups separately, leading to a reduction of over 60% in deaths and severe cases compared to targeting the elderly or high-risk population only. High-efficacy vaccines can mitigate health loss under suboptimal targeting during the rollout.
Article
Microbiology
Lene H. Harritshoj, Mikkel Gybel-Brask, Shoaib Afzal, Pia R. Kamstrup, Charlotte S. Jorgensen, Marianne Kragh Thomsen, Linda Hilsted, Lennart Friis-Hansen, Pal B. Szecsi, Lise Pedersen, Lene Nielsen, Cecilie B. Hansen, Peter Garred, Trine-Line Korsholm, Susan Mikkelsen, Kirstine O. Nielsen, Bjarne K. Moller, Anne T. Hansen, Kasper K. Iversen, Pernille B. Nielsen, Rasmus B. Hasselbalch, Kamille Fogh, Jakob B. Norsk, Jonas Henrik Kristensen, Kristian Schonning, Nikolai S. Kirkby, Alex C. Y. Nielsen, Lone H. Landsy, Mette Loftager, Dorte K. Holm, Anna C. Nilsson, Susanne G. Saekmose, Birgitte Grum-Schwensen, Bitten Aagaard, Thoger G. Jensen, Dorte M. Nielsen, Henrik Ullum, Ram B. Dessau
Summary: This study evaluated the diagnostic accuracy of 15 commercial and one in-house anti-SARS-CoV-2 assays in Danish laboratories. Most total antibody and IgG assays showed high sensitivity and specificity, with some overlap in confidence intervals. IgM results were more variable, with one assay demonstrating higher sensitivity and specificity.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Environmental Sciences
Christopher S. McMahan, Stella Self, Lior Rennert, Corey Kalbaugh, David Kriebel, Duane Graves, Cameron Colby, Jessica A. Deaver, Sudeep C. Popat, Tanju Karanfil, David L. Freedman
Summary: Wastewater-based epidemiology offers an opportunity for real-time monitoring of SARS-CoV-2 transmission. The SEIR model based on wastewater RNA concentrations provides a robust method to estimate the total number of infected individuals in a community, supplementing individual testing and informing policy decisions.
LANCET PLANETARY HEALTH
(2021)
Article
Multidisciplinary Sciences
Zengmiao Wang, Peiyi Wu, Jingyuan Wang, Jose Lourenco, Bingying Li, Benjamin Rader, Marko Laine, Hui Miao, Ligui Wang, Hongbin Song, Nita Bharti, John S. Brownstein, Ottar N. Bjornstad, Christopher Dye, Huaiyu Tian
Summary: The proportion of asymptomatic infections decreases with age, with children and young adults more likely to have asymptomatic infections. Surveillance strategies for SARS-CoV-2 should take age into account.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Medicine, General & Internal
David N. Fisman, Amy L. Greer, Gabrielle Brankston, Michael Hillmer, Sheila F. O'Brien, Steven J. Drews, Ashleigh R. Tuite
Summary: The study found that disease incidence and testing rates were highest in the oldest age group and lowest in those younger than 20 years, with no differences in incidence by sex. After adjusting for testing frequency, SIRs were lowest in children and adults aged 70 or older, but significantly higher in adolescents and males aged 20 to 49 compared to the overall population.
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Matthew Whitaker, Bethan Davies, Christina Atchison, Wendy Barclay, Deborah Ashby, Ara Darzi, Steven Riley, Graham Cooke, Christl A. Donnelly, Marc Chadeau-Hyam, Paul Elliott, Helen Ward
Summary: The value of SARS-CoV-2 lateral flow immunoassay tests for estimating individual disease risk is unclear. The authors linked testing data from the REACT-2 study in England to hospital and death records and found that vaccinated individuals with a negative LFIA test were at a higher risk of hospitalisation and death.
NATURE COMMUNICATIONS
(2023)
Article
Microbiology
Wayne Dimech, Shannon Curley, Lorenzo Subissi, Ute Stroher, Mark D. D. Perkins, Jane Cunningham
Summary: The markets are flooded with various SARS-CoV-2 serology tests, but there are limited comparative reports on their performance. This study compared 35 rapid diagnostic tests and enzyme immunoassays using samples from individuals with mild to moderate COVID-19 and other coronavirus infections. The results show that independent comparative assessments are important for selecting appropriate test kits, especially during a pandemic.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Sameed M. Siddiqui, Kathryn A. Bowman, Alex L. Zhu, Stephanie Fischinger, Samuel Beger, Jenny S. Maron, Yannic C. Bartsch, Caroline Atyeo, Matthew J. Gorman, Ahmad Yanis, Judd F. Hultquist, Ramon Lorenzo-Redondo, Egon A. Ozer, Lacy M. Simons, Rana Talj, Danielle A. Rankin, Lindsay Chapman, Kyle Meade, Jordan Steinhart, Sean Mullane, Suzanne Siebert, Hendrik Streeck, Pardis Sabeti, Natasha Halasa, Elon R. Musk, Dan H. Barouch, Anil S. Menon, Eric J. Nilles, Douglas A. Lauffenburger, Galit Alter
Summary: As public health guidelines have relaxed, SARS-CoV-2 is likely to remain endemic due to the rise of more infectious variants. Reexposure and reinfection cases have been observed globally, highlighting the need for detecting and monitoring reinfection to prevent vaccine escape mutations. This study identifies simple immune biomarkers of reinfection in rhesus macaques and demonstrates their potential utility in human reinfection cases, providing a cost-effective and scalable marker for targeted pandemic response.
Article
Microbiology
Sameed M. Siddiqui, Kathryn A. Bowman, Alex L. Zhu, Stephanie Fischinger, Samuel Beger, Jenny S. Maron, Yannic C. Bartsch, Caroline Atyeo, Matthew J. Gorman, Ahmad Yanis, Judd F. Hultquist, Ramon Lorenzo-Redondo, Egon A. Ozer, Lacy M. Simons, Rana Talj, Danielle A. Rankin, Lindsay Chapman, Kyle Meade, Jordan Steinhart, Sean Mullane, Suzanne Siebert, Hendrik Streeck, Pardis Sabeti, Natasha Halasa, Elon R. Musk, Dan H. Barouch, Anil S. Menon, Eric J. Nilles, Douglas A. Lauffenburger, Galit Alter
Summary: This study emphasizes the importance of detecting SARS-CoV-2 reinfection and suggests that simple antibody titers and function can serve as markers of reinfection, providing increased resolution and resilience against new outbreaks.
Article
Multidisciplinary Sciences
Ludek Berec, Martin Smid, Lenka Pribylova, Ondrej Majek, Tomas Pavlik, Jiri Jarkovsky, Milan Zajicek, Jakub Weiner, Tamara Barusova, Jan Trnka
Summary: Studies in Czech Republic show that the effectiveness of COVID-19 vaccines declines after 7-8 months, with a decrease in protection against infection, hospitalization, and death. Boosters are found to restore the original vaccine effectiveness, and post-infection immunity also diminishes over time.
Article
Food Science & Technology
Loic Mervant, Marie Tremblay-Franco, Maiwenn Olier, Emilien Jamin, Jean-Francois Martin, Lidwine Trouilh, Charline Buisson, Nathalie Naud, Claire Maslo, Cecile Helies-Toussaint, Edwin Fouche, Emmanuelle Kesse-Guyot, Serge Hercberg, Pilar Galan, Melanie Deschasaux-Tanguy, Mathilde Touvier, Fabrice Pierre, Laurent Debrauwer, Francoise Gueraud
Summary: High consumption of red and processed meat is associated with adverse outcomes such as colorectal cancer and overall global mortality. This study analyzed metabolomics data and conducted preclinical experiments to investigate the underlying mechanisms. The results suggest that microbiota-derived metabolites, such as indoxyl sulfate and cinnamoylglycine, are impacted by a high red meat diet, indicating a modification of the gut microbiota. These findings provide potential biomarkers for red meat consumption and help explain the adverse effects associated with high red and processed meat consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Review
Nutrition & Dietetics
Junko Kose, Pauline Duquenne, Bernard Srour, Charlotte Debras, Damien Leger, Sandrine Peneau, Pilar Galan, Serge Hercberg, Mathilde Touvier, Valentina A. Andreeva
Summary: This narrative review aims to synthesize current knowledge and discuss the results of studies on the link between carbohydrate intake and mental health. The findings suggest a positive association between carbohydrate intake and anxiety disorders and insomnia. Future prospective observational and interventional studies are needed to establish causality.
CAHIERS DE NUTRITION ET DE DIETETIQUE
(2023)
Article
Nutrition & Dietetics
Florine Berthy, Josephine Brunin, Benjamin Alles, Anouk Reuze, Mathilde Touvier, Serge Hercberg, Denis Lairon, Philippe Pointereau, Francois Mariotti, Julia Baudry, Emmanuelle Kesse-Guyot
Summary: The nutritional quality of the EAT-Lancet reference diet has been rarely evaluated. This study examined the food and nutritional intakes of the French population and investigated the consistency between the French national recommendations and the EAT-Lancet reference diet. The results showed that adherence to the EAT-Lancet diet was associated with a decrease in nutrient inadequacy, but certain nutrients remained inadequate in all adherence levels.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Olivia Branche, Camille Buscail, Sandrine Peneau, Julia Baudry, Christine Poitou, Jean-Michel Oppert, Sebastien Czernichow, Emmanuelle Kesse-Guyot, Mathilde Touvier, Chantal Julia, Alice Bellicha
Summary: This study aimed to assess explicit weight bias in French adults and explore the associations with weight status and sociodemographic characteristics. The results showed that fear of fat and belief in weight controllability were higher than dislike towards people with obesity. Fear of fat was higher among women, whereas dislike and belief in weight controllability were higher among men. Obesity was associated with greater fear of fat and lower dislike and belief in weight controllability. Lower income and lower education were associated with lower scores of dislike, fear of fat, and belief in weight controllability. This study provides valuable insights for interventions targeting the reduction of explicit weight bias.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Infectious Diseases
Julien Ramillon, Xavier de Lamballerie, Olivier Robineau, Helene Blanche, Gianluca Severi, Mathilde Touvier, Marie Zins, Fabrice Carrat, Nathanael Lapidus
Summary: This study investigated the association between taste or smell disorders and subject characteristics, symptom associations, and antibody response intensity in COVID-19 patients. The results showed that women, smokers, and people who consume more than 2 alcoholic drinks a day are more likely to develop taste or smell disorders. This symptom is strongly associated with antibody response and most patients also experience other symptoms.
BMC INFECTIOUS DISEASES
(2023)
Correction
Multidisciplinary Sciences
Nathanael Hoze, Henrik Salje, Dominique Rousset, Camille Fritzell, Jessica Vanhomwegen, Sarah Bailly, Matthieu Najm, Antoine Enfissi, Jean-Claude Manuguerra, Claude Flamand, Simon Cauchemez
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Melanie Deschasaux-Tanguy, Fabien Szabo de Edelenyi, Nathalie Druesne-Pecollo, Younes Esseddik, Julien Allegre, Bernard Srour, Pilar Galan, Serge Hercberg, Gianluca Severi, Marie Zins, Emmanuel Wiernik, SAPRIS SERO Study Grp, Xavier de Lamballerie, Fabrice Carrat, Mathilde Touvier
Summary: ABO blood type may influence SARS-CoV-2 infection. Our study used large-scale seroprevalence data to assess the association between ABO blood types and SARS-CoV-2 infection. The study found that non-O individuals, especially those with type A and AB, were more likely to bear anti-SARS-CoV-2 antibodies, while individuals with blood type O had a lower risk of infection.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Maeva Monnier, Flore Moulin, Marion Bailhache, Xavier Thierry, Stephanie Vandentorren, Sylvana Cote, Bruno Falissard, Thierry Simeon, Bertrand Geay, Laetitia Marchand-Martin, Marie-Noelle Dufourg, Marie-Aline Charles, Pierre-Yves Ancel, Maria Melchior, Alexandra Rouquette, Cedric Galera, Nathalie Bajos, Fabrice Carrat, Pierre-Yves Ancel, Marie-Aline Charles, Florence Jusot, Claude Martin, Laurence Meyer, Ariane Pailhe, Alexandra Rouquette, Gianluca Severi, Alexis Spire, Mathilde Touvier, Marie Zins, Xavier Thierry, Thierry Simeon, Bertrand Geay, Laetitia Marie-Noelle Dufourg, Marie-Aline Charles
Summary: This study aims to fill the knowledge gap regarding the association between parents' and children's mental health issues during the COVID-19 school closure in France. The study found that parental anxiety and depression symptoms were associated with children's hyperactivity/inattention and emotional symptoms during the pandemic.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Omar Deraz, Thomas Van Sloten, Rachel Climie, Charlotte Debras, Leopold K. Fezeu, Melanie Deschasaux-Tanguy, Xavier Jouven, Emmanuelle Kesse-Guyot, Pilar Galan, Serge Hercberg, Mathilde Touvier, Jean-Philippe Empana
Summary: Person-centered cardiovascular health (CVH) may serve as a reliable alternative to measured CVH in preventing cardiovascular disease in low resources settings. The study found a high concordance between person-centered and measured CVH, and identified a significant reduction in cardiovascular disease risk associated with person-centered ideal metrics.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Omar Deraz, Billy Caceres, Carl G. Streed, Lauren B. Beach, Xavier Jouven, Mathilde Touvier, Marcel Goldberg, Marie Zins, Jean-Philippe Empana
Summary: This study examined the association between cardiovascular health scores and sexual minority status, finding disparities in cardiovascular health among sexual minority adults. Lesbian and bisexual women had lower cardiovascular health scores compared to heterosexual women, while gay and bisexual men had higher cardiovascular health scores compared to heterosexual men. Primordial prevention targeted at sexual minority populations may be necessary.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Correction
Nutrition & Dietetics
Inge Huybrechts, Fernanda Rauber, Genevieve Nicolas, Corinne Casagrande, Nathalie Kliemann, Roland Wedekind, Carine Biessy, Augustin Scalbert, Mathilde Touvier, Krasimira Aleksandrova, Paula Jakszyn, Guri Skeie, Rashmita Bajracharya, Jolanda M. A. Boer, Yan Borne, Veronique Chajes, Christina C. Dahm, Lucia Dansero, Marcela Guevara, Alicia K. Heath, Daniel B. Ibsen, Keren Papier, Verena Katzke, Cecilie Kyro, Giovanna Masala, Esther Molina-Montes, Oliver J. K. Robinson, Carmen Santiuste de Pablos, Matthias B. Schulze, Vittorio Simeon, Emily Sonestedt, Anne Tjonneland, Rosario Tumino, Yvonne T. van der Schouw, W. M. Monique Verschuren, Beatrice Vozar, Anna Winkvist, Marc J. Gunter, Carlos A. Monteiro, Christopher Millett, Renata Bertazzi Levy
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Marc Garnier, Jean-Michel Constantin, Raphael Cinotti, Chafia Daoui, Dimitri Margetis, Gregory Destruhaut, Cedric Cirenei, Eric Noll, Christophe Quesnel, Agnes Lecinq, Sigismond Lasocki, Helene Charbonneau, Stanislas Abrard, Cyril Quemeneur, Bruno Pastene, Nathanael Lapidus, Marc Leone
Summary: This study aimed to compare postoperative respiratory morbidity between patients with preoperative COVID-19 within 8 weeks prior to surgery and those without infection. The results showed that vaccination and the predominance of the Omicron variant attenuated the effect of preoperative COVID-19 on postoperative respiratory morbidity.
Correction
Infectious Diseases
Julien Ramillon, Xavier de Lamballerie, Olivier Robineau, Helene Blanche, Gianluca Severi, Mathilde Touvier, Marie Zins, Fabrice Carrat, SAPRIS SERO Study Grp, SAPRIS Study Grp, Nathanael Lapidus
BMC INFECTIOUS DISEASES
(2023)
Article
Nutrition & Dietetics
Julia Baudry, Floriane Neves, Denis Lairon, Benjamin Alles, Brigitte Langevin, Josephine Brunin, Florine Berthy, Ina Danquah, Mathilde Touvier, Serge Hercberg, Marie-Josephe Amiot, Philippe Pointereau, Emmanuelle Kesse-Guyot
Summary: This study aimed to evaluate the associations between adherence to the Mediterranean diet and sustainability domains. The results showed that higher adherence to the Mediterranean diet was associated with higher nutritional quality and reduced environmental impact. However, it also increased monetary cost and pesticide exposure.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Infectious Diseases
Amaury Bailleul, Jean-Pierre Fulgencio, Sophie Vimont, Cecile Mordelet, Benoit Ray, Ludovic Lassel, Nathanael Lapidus, Christophe Quesnel, Marc Garnier
Summary: This study aimed to investigate the risk factors for TIVAP-related infection (TIVAP-RI) and its impact on patient prognosis in adult patients with solid tumors. The results showed that TIVAP insertion was associated with a low infection rate and did not affect one-year mortality. Additionally, young age, impaired health status, TIVAP insertion within one month of initiating chemotherapy, and TIVAP insertion in an irradiated area were identified as newly reported preventable risk factors for TIVAP-RI.
INFECTIOUS DISEASES NOW
(2023)