Article
Multidisciplinary Sciences
Michael C. Sneller, Jana Blazkova, J. Shawn Justement, Victoria Shi, Brooke D. Kennedy, Kathleen Gittens, Jekaterina Tolstenko, Genevieve McCormack, Emily J. Whitehead, Rachel F. Schneck, Michael A. Proschan, Erika Benko, Colin Kovacs, Cihan Oguz, Michael S. Seaman, Marina Caskey, Michel C. Nussenzweig, Anthony S. Fauci, Susan Moir, Tae-Wook Chun
Summary: The combination therapy with broadly neutralizing monoclonal antibodies can provide long-term virological suppression without antiretroviral therapy in individuals with HIV. This study offers guidance for future clinical trials involving next-generation antibodies with long half-lives.
Article
Clinical Neurology
Robert H. Paul, Cecilia M. Shikuma, Nguyen Van Vinh Chau, Lishomwa C. Ndhlovu, Nguyen Tat Thanh, Andrew C. Belden, Dominic C. Chow, Glen M. Chew, Thomas A. Premeaux, Vo Trieu Ly, Joseph A. D. McBride, Jacob D. Bolzenius, Thuy Le
Summary: The study investigated the neurocognitive outcomes of individuals with HIV and hepatitis C co-infection undergoing first-line ART. Findings showed that while most co-infected individuals experienced improved neurocognitive performance after 48 weeks of ART, a subgroup continued to exhibit motor impairment. Baseline HIV disease severity was predictive of persistent motor dysfunction, while liver indices and ART regimen did not affect neurocognitive outcomes in HIV-HCV co-infected individuals.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cell Biology
Amarendra Pegu, Ling Xu, Megan E. DeMouth, Giulia Fabozzi, Kylie March, Cassandra G. Almasri, Michelle D. Cully, Keyun Wang, Eun Sung Yang, Joana Dias, Christine M. Fennessey, Jason Hataye, Ronnie R. Wei, Ercole Rao, Joseph P. Casazza, Wanwisa Promsote, Mangaiarkarasi Asokan, Krisha McKee, Stephen D. Schmidt, Xuejun Chen, Cuiping Liu, Wei Shi, Hui Geng, Kathryn E. Foulds, Shing-Fen Kao, Amy Noe, Hui Li, George M. Shaw, Tongqing Zhou, Constantinos Petrovas, John-Paul Todd, Brandon F. Keele, Jeffrey D. Lifson, Nicole A. Doria-Rose, Richard A. Koup, Zhi-Yong Yang, Gary J. Nabel, John R. Mascola
Summary: The use of trispecific bNAbs can effectively reduce viremia and maintain low levels of virus in the body through immune control. Compared to single bNAbs, trispecific bNAbs can suppress the emergence of resistance and minimize the potential for immune escape.
Article
Cell Biology
Ines Frank, Mariasole Cigoli, Muhammad S. Arif, Marissa D. Fahlberg, Stephanie Maldonado, Giulia Calenda, Amarendra Pegu, Eun Sung Yang, Reda Rawi, Gwo-Yu Chuang, Hui Geng, Cuiping Liu, Tongqing Zhou, Peter D. Kwong, James Arthos, Claudia Cicala, Brooke F. Grasperge, James L. Blanchard, Agegnehu Gettie, Christine M. Fennessey, Brandon F. Keele, Monica Vaccari, Thomas J. Hope, Anthony S. Fauci, John R. Mascola, Elena Martinelli
Summary: In this study, it was found that combining bNAbs with Rh-α(4)β(7) integrin blockade delayed viral rebound in SHIVSF162P3-infected macaques compared to treatment with bNAbs alone. The combination therapy showed a modest prolongation of virologic control in some macaques, indicating the potential benefit of targeting both bNAbs and integrin alpha(4)beta(7) in antiviral therapy.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Review
Integrative & Complementary Medicine
Tao Zhuang, Huang Xiaojie, Liu Ying, Wang Ru, Dong Jipeng, Liang Biyan, Zou Wen, Gao Guojian, Wang Zhuo, Zhang Ke, Wu Hao, Zhang Tong, Wang Jian
Summary: The study found that the integrated treatment strategy of combining traditional Chinese medicine and Western medicine can improve the immune response in HIV-infected patients, especially with better results at 6 and 12 months, and clinical efficacy higher than the control group.
JOURNAL OF TRADITIONAL CHINESE MEDICINE
(2021)
Article
Microbiology
Jennillee Wallace, Hemil Gonzalez, Reshma Rajan, Srinivas D. Narasipura, Amber K. Virdi, Arnold Z. Olali, Ankur Naqib, Zarema Arbieva, Mark Maienschein-Cline, Lena Al-Harthi
Summary: Combination antiretroviral therapy (cART) has significantly improved the treatment of HIV/AIDS, but it may also affect cell dysregulation and increase susceptibility to comorbidities in persons living with HIV (PLWH).
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Miriam Rosas-Umbert, Jesper D. Gunst, Marie H. Pahus, Rikke Olesen, Mariane Schleimann, Paul W. Denton, Victor Ramos, Adam Ward, Natalie N. Kinloch, Dennis C. Copertino, Tuixent Escriba, Anuska Llano, Zabrina L. Brumme, R. Brad Jones, Beatriz Mothe, Christian Brander, Julie Fox, Michel C. Nussenzweig, Sarah Fidler, Marina Caskey, Martin Tolstrup, Ole S. Sogaard
Summary: The study shows that broadly neutralizing antibodies against the virus stimulate T cell immunity in simian-human immunodeficiency virus-infected non-human primates. In humans, adjunctive bNAb treatment may enhance HIV-1-specific cellular immunity, contributing to the suppression of viral replication.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Elmira Esmaeilzadeh, Behzad Etemad, Christy L. Lavine, Lauren Garneau, Yijia Li, James Regan, Colline Wong, Radwa Sharaf, Elizabeth Connick, Paul Volberding, Manish Sagar, Michael S. Seaman, Jonathan Z. Li
Summary: Early initiation of antiretroviral therapy (ART) can alter viral rebound kinetics after analytic treatment interruption (ATI) and may promote HIV-1 remission. Autologous neutralizing antibodies (aNAbs) play a key role in the immune response to HIV-1. In this study, we investigated the role of aNAbs in shaping post-ATI HIV-1 rebound variants. Our findings suggest that aNAbs matured during suppressive ART and exerted selective pressure on rebounding viruses. Certain pre-ATI features, such as HIV-1 sequence similarity to consensus subtype B, restricted proviral diversity, and a strong aNAbs response, were associated with post-treatment control.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Immunology
Dalton Wamalwa, Irene Njuguna, Elizabeth Maleche-Obimbo, Emily Begnel, Daisy J. Chebet, Judith A. Onyango, Lisa Marie Cranmer, Meei-Li Huang, Barbra A. Richardson, Michael Boeckh, Grace John-Stewart, Jennifer Slyker
Summary: CMV viremia is common in hospitalized children with HIV and CMV DNA levels >= 1000 IU/mL are associated with increased risk of mortality and longer hospitalization.
CLINICAL INFECTIOUS DISEASES
(2022)
Editorial Material
Microbiology
Cynthia L. Monaco
Summary: This article discusses the discovery of alterations in gut bacterial and viral populations in HIV-associated AIDS in 2016, and explores how these findings have advanced the field and influenced the author's current research endeavors.
CELL HOST & MICROBE
(2022)
Article
Multidisciplinary Sciences
Nicholas Nii-Trebi, Saori Matsuoka, Ai Kawana-Tachikawa, Evelyn Y. Bonney, Christopher Z. Abana, Sampson B. Ofori, Taketoshi Mizutani, Aya Ishizaka, Teiichiro Shiino, Jun Ohashi, Taeko K. Naruse, Akinori Kimura, Hiroshi Kiyono, Koichi Ishikawa, William K. Ampofo, Tetsuro Matano
Summary: Polymorphisms in HLA class I loci have a significant impact on disease progression in HIV-1 infection. This study analyzed the HLA typing data in a West African population using a super high-resolution single-molecule sequence-based typing (SS-SBT) technique. Several HLA alleles were associated with clinical markers and viral load, but the impact of protective alleles against specific HIV-1 subtypes was not observed in this cohort.
Article
Hematology
James H. Stein, Noah Kime, Claudia E. Korcarz, Heather Ribaudo, Judith S. Currier, Joseph C. Delaney
Summary: The study found that HIV serostatus has a significant impact on endothelial function, especially influenced by kidney function. Factors like HIV RNA viremia, CD4+ T-cell count, and use of antiretroviral therapy were not found to be meaningfully associated with endothelial function, but HIV-infected individuals are at increased cardiovascular disease risk.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Fatima M. Mussa, Higgins P. Massawe, Hussein Bhalloo, Sibtain Moledina, Evelyne Assenga
Summary: The ART adherence among children in Dar es Salaam was found to be relatively low. Factors associated with poor adherence included younger caregivers, child intercurrent illness, while factors associated with good adherence were belief in ART effectiveness and lower HIV clinical stage. More attention and support should be given to younger caregivers, children with concomitant illness, and advanced HIV clinical stages.
Article
Immunology
Trevor A. Crowell, Brook Danboise, Ajay Parikh, Allahna Esber, Nicole Dear, Peter Coakley, Alex Kasembeli, Jonah Maswai, Samoel Khamadi, Emmanuel Bahemana, Michael Iroezindu, Francis Kiweewa, John Owuoth, Joanna Freeman, Linda L. Jagodzinski, Jennifer A. Malia, Leigh Ann Eller, Sodsai Tovanabutra, Sheila A. Peel, Julie A. Ake, Christina S. Polyak
Summary: The study investigated HIV drug resistance among ART-naive and ART-experienced individuals in Africa, revealing a high burden of HIV drug resistance among those on failing ART regimens, potentially limiting the efficacy of standard first- and second-line regimens. Management strategies emphasizing adherence counseling while delaying ART switch may promote drug resistance and should be reconsidered.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Christine M. Durand, Sander Florman, Jennifer D. Motter, Diane Brown, Darin Ostrander, Sile Yu, Tao Liang, William A. Werbel, Andrew Cameron, Shane Ottmann, James P. Hamilton, Andrew D. Redd, Mary G. Bowring, Yolanda Eby, Reinaldo E. Fernandez, Brianna Doby, Nazzarena Labo, Denise Whitby, Wendell Miley, Rachel Friedman-Moraco, Nicole Turgeon, Jennifer C. Price, Peter Chin-Hong, Peter Stock, Valentina Stosor, Varvara A. Kirchner, Timothy Pruett, David Wojciechowski, Nahel Elias, Cameron Wolfe, Thomas C. Quinn, Jonah Odim, Megan Morsheimer, Sapna A. Mehta, Meenakshi M. Rana, Shirish Huprikar, Allan Massie, Aaron A. R. Tobian, Dorry L. Segev
Summary: In this multicenter pilot study of HIV D+/R+ LT, patient and graft survival were better than historical cohorts, however, a potential increase in infections and cancer merits further investigation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Immunology
James H. McMahon, Vanessa A. Evans, Jillian S. Y. Lau, Jori Symons, Jennifer M. Zerbato, Judy Chang, Ajantha Solomon, Surekha Tennakoon, Ashanti Dantanarayana, Michelle Hagenauer, Sulggi Lee, Sarah Palmer, Katie Fisher, Namandje Bumpus, Carley J. S. Heck, David Burger, Guoxin Wu, Paul Zuck, Bonnie J. Howell, Henrik H. Zetterberg, Kaj Blennow, Magnus Gisslen, Thomas A. Rasmussen, Sharon R. Lewin
Summary: The combination of vorinostat and disulfiram in HIV patients on ART was found to be poorly tolerated and showed limited efficacy in enhancing HIV latency reversal.
Review
Clinical Neurology
Lars Hagberg, Arvid Eden, Henrik Zetterberg, Richard W. Price, Magnus Gisslen
Summary: Besides clinical examinations and neuroimaging, blood biomarkers and tests for opportunistic infections can provide important information for evaluating the impact of HIV infection on the brain and in diagnosis.
ACTA NEUROLOGICA SCANDINAVICA
(2022)
Correction
Clinical Neurology
Birgitta Anesten, Henrik Zetterberg, Staffan Nilsson, Bruce J. Brew, Dietmar Fuchs, Richard W. Price, Magnus Gisslen, Aylin Yilmaz
Article
Medicine, General & Internal
Annika Rosengren, Christina E. Lundberg, Mia Soderberg, Ailiana Santosa, Jon Edqvist, Martin Lindgren, Maria Aberg, Magnus Gisslen, Josefina Robertson, Ottmar Cronie, Naveed Sattar, Jesper Lagergren, Maria Branden, Jonas Bjork, Martin Adiels
Summary: Among Swedish residents aged 55 years and above, those receiving home care or long-term care had a significantly increased risk of COVID-19 death during the first year of the pandemic, with over 50% of deaths attributable to these factors.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Josefine Persson, Bjorn Andersson, Suzanne van Veen, Marielle C. Haks, Ogonna Obudulu, Sara Torkzadeh, Tom H. M. Ottenhoff, Nelly Kanberg, Magnus Gisslen, Lars-Magnus Andersson, Ali M. Harandi
Summary: This study identified blood-specific markers of disease severity in COVID-19 patients, which can guide treatment and intervention strategies by analyzing whole blood samples obtained from individuals infected with SARS-CoV-2.
MOLECULAR IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Hanna Brattgard, Per Bjoerkman, Piotr Nowak, Carl Johan Treutiger, Magnus Gisslen, Olof Elvstam
Summary: Among Swedish PWH, low-level viremia (LLV) during antiretroviral therapy (ART) was associated with markers of HIV disease severity before starting ART, male sex, injecting drug use, and use of protease inhibitor (PI)-based or non-standard ART regimens.
Article
Medicine, General & Internal
Arvid Eden, Anna Grahn, Daniel Bremell, Anahit Aghvanyan, Pradeepthi Bathala, Dietmar Fuchs, Johanna Gostner, Lars Hagberg, Nelly Kanberg, Sunsanee Kanjananimmanont, Magnus Lindh, Salvia Misaghian, Staffan Nilsson, Michael Scholl, George Sigal, Erika Stentoft, Marie Studahl, Aylin Yilmaz, Mingyue Wang, Martin Stengelin, Henrik Zetterberg, Magnus Gisslen
Summary: In this study, viral antigen was detected in cerebrospinal fluid (CSF) of COVID-19 patients with neurological symptoms, indicating a correlation between viral antigen and central nervous system (CNS) immune activation. COVID-19 patients showed signs of neuroaxonal injury, with neurosymptomatic patients exhibiting a more pronounced inflammatory profile unrelated to disease severity.
Article
Immunology
Olof Elvstam, Kasper Malmborn, Sixten Elen, Gaetano Marrone, Federico Garcia, Maurizio Zazzi, Anders Sonnerborg, Michael Boehm, Carole Seguin-Devaux, Per Bjorkman
Summary: Retrospective analysis of 22,523 people with HIV-1 receiving antiretroviral therapy indicates that both viral blips and low-level viremia of 51 to 199 copies/mL in repeated measurements are independent predictors of subsequent virologic failure.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Daniel Brodin, Per Tornhammar, Peter Ueda, Anders Krifors, Eli Westerlund, Simon Athlin, Sandra Wojt, Olof Elvstam, Anca Neumann, Arsim Elshani, Julia Giesecke, Jens Edvardsson-Kaellkvist, Sayam Bunpuckdee, Christian Unge, Martin Larsson, Bjorn Johansson, Johan Ljungberg, Jonas Lindell, Johan Hansson, Ola Blennow, Daniel Peter Andersson
Summary: This study aimed to evaluate the efficacy of inhaled ciclesonide in reducing the duration of oxygen therapy among adults hospitalized with COVID-19. The results of a multicenter, randomized, controlled, open-label trial showed no significant advantage of inhaled ciclesonide compared to standard care in shortening the duration of oxygen therapy. The trial was prematurely terminated due to slow enrollment.
Article
Medicine, General & Internal
Christina Carlander, Johanna Brannstrom, Fredrik Mansson, Olof Elvstam, Pernilla Albinsson, Simon Blom, Lena Mattsson, Sanne Hovmoller, Hans Norrgren, Asa Mellgren, Veronica Svedhem, Magnus Gisslen, Anders Sonnerborg
Summary: The Swedish InfCareHIV cohort was established in 2003 to ensure equal and effective care for people living with HIV and enable long-term follow-up. It functions as both a decision support system and a quality registry, providing up-to-date data in real time. The cohort includes data on >99% of diagnosed HIV cases in Sweden and covers various aspects such as biomarkers, antiretroviral therapies, demographics, and patient-reported outcomes.
Letter
Medicine, General & Internal
Rickard Ljung, YiYi Xu, Anders Sundstrom, Susannah Leach, Ebba Hallberg, Maria Bygdell, Maria Larsson, Veronica Arthurson, Magnus Gisslen, Rolf Gedeborg, Fredrik Nyberg
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Lisa Lundberg-Morris, Susannah Leach, Yiyi Xu, Jari Martikainen, Ailiana Santosa, Magnus Gisslen, Huiqi Li, Fredrik Nyberg, Maria Bygdell
Summary: The study suggests that primary covid-19 vaccination before infection is strongly associated with a reduced risk of receiving a diagnosis of post-covid-19 condition (PCC). The findings highlight the importance of primary vaccination against covid-19 to reduce the population burden of PCC.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Health Care Sciences & Services
Malin Spetz, Lisa Lundberg, Chioma Nwaru, Huiqi Li, Ailiana Santosa, Susannah Leach, Magnus Gisslen, Niklas Hammar, Maria Rosvall, Fredrik Nyberg
Summary: This study found that among Swedish adults aged 60 years and older as of May 17, 2021, factors such as younger age, male sex, lower income, living alone, and being born outside Sweden were associated with lower Covid-19 vaccination uptake. Intersectional analysis revealed significant differences in vaccination rates within different sociodemographic subgroups.
LANCET REGIONAL HEALTH-EUROPE
(2022)
Article
Critical Care Medicine
Mans Eeg-Olofsson, Nina Pauli, Louise Hafsten, Josephine Jacobsson, Christopher Lundborg, Magnus Brink, Helen Larsson, Ellen Lindell, Karin Lowhagen, Magnus Gisslen, Henrik Bergquist
Summary: This study aimed to evaluate the optimal timing of tracheotomy for critically ill COVID-19 patients. The results showed a significantly reduced number of mechanical ventilation days in the early tracheotomy group in the per-protocol analysis, but no significant difference was found between the two groups in the intention-to-treat analysis. The overall death rate during intensive care was 32.7%, with no significant differences in survival, complications, or adverse events between the groups.
Article
Microbiology
Da Cheng, Zhenwu Luo, Xiaoyu Fu, Sophie Stephenson, Clara Di Germanio, Philip J. Norris, Dietmar Fuchs, Lishomwa C. Ndhlovu, Quan-zhen Li, Henrik Zetterberg, Magnus Gisslen, Richard W. Price, Shifang Peng, Wei Jiang
Summary: This study reveals the presence of an autoantibody in the central nervous system of HIV patients, and its levels in the cerebrospinal fluid are correlated with markers of neuroinflammation.
MICROBIOLOGY SPECTRUM
(2022)