Article
Engineering, Industrial
Mohamad Ali Morshedi, Hamed Kashani
Summary: This study proposes a new decision-making model to explain homeowners' behavior when presented with various alternatives for mitigating seismic risk, and integrates it into an agent-based model to evaluate owners' responses to hazard mitigation policies. The model considers building characteristics, owners' attitudes, and their response to proposed incentives, providing insights for policymakers to select appropriate policies to enhance community resilience.
RELIABILITY ENGINEERING & SYSTEM SAFETY
(2022)
Article
Health Care Sciences & Services
Jing Hao, Dina Hassen, James M. Gudgeon, Susan R. Snyder, Heather Hampel, Marc S. Williams, Ravi N. Sharaf, Christine Y. Lu, Janet L. Williams, Victoria Schlieder, Alanna Kulchak Rahm
Summary: An updated economic evaluation compared eight different Lynch syndrome screening protocols for newly diagnosed colorectal cancer patients. The study found that the DGS and TSGS protocols performed best in identifying LS cases, while the IHC protocol was the most efficient in terms of cost per LS case identified.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Computer Science, Interdisciplinary Applications
Mariia Kozlova, Robert J. Moss, Julian Scott Yeomans, Jef Caers
Summary: This paper introduces a framework for quantitative sensitivity analysis using the SimDec visualization method, and tests its effectiveness on decision-making problems. The framework captures critical information in the presence of heterogeneous effects, and enhances its practicality by introducing a formal definition and classification of heterogeneous effects.
ENVIRONMENTAL MODELLING & SOFTWARE
(2024)
Article
Biology
Jan Boelts, Jan-Matthis Lueckmann, Richard Gao, Jakob H. Macke
Summary: Inferring parameters of computational models is crucial in cognitive neuroscience. Simulation-based inference (SBI) using neural density estimators provides a more efficient way to capture decision-making data. Compared to traditional methods, this approach demonstrates higher accuracy and training efficiency.
Article
Psychology, Biological
Damon Tomlin
Summary: Consensus decision-making is essential in human social interactions, where individual decision-makers need to balance the trade-offs between payoffs and time. Socially minded agents are more likely to exhibit evolutionarily stable strategies in reaching consensus.
EVOLUTION AND HUMAN BEHAVIOR
(2021)
Article
Public, Environmental & Occupational Health
Shacara N. N. Blake, Jacqueline G. G. Hugtenburg, Manon van der Vlugt, Evelien Dekker, Mirjam P. P. Fransen
Summary: During the first year of the CRC screening program on Curacao, only 20% of invitees participated. The study revealed that the target population had limited awareness of CRC screening and the procedure involved. Most respondents viewed the provision of the screening program positively and preferred to make independent decisions about participation. Personalized approaches, visual aids, and media were the preferred sources of information.
Article
Health Care Sciences & Services
Justine P. Enns, Craig E. Pollack, Cynthia M. Boyd, Jacqueline Massare, Nancy L. Schoenborn
Summary: The study found that clinicians have different perspectives on discontinuing breast, prostate, and colorectal cancer screenings in older adults, with varying decisions on screening continuation, benefits/harms considerations, and involvement of specialists. There is a need for more explicit guidance on weighing competing considerations in cancer screening, with future decision support tools and clinician education materials addressing these complexities.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Environmental Sciences
Ying Pei, Baohong Lu, Yang Song, Yan Yang, Xinyue Feng, Wenlong Shen
Summary: This study focused on the downstream area of Bengbu Sluice in the Huai River Basin of China. By using habitat simulation and hydrological approaches, ecological flow thresholds were determined to address the degradation of the ecosystem. A multi-objective synergistic decision model was developed to coordinate economic and ecological water use conflicts. The results showed that the coordinated solution could meet the ecological and economic water demands of the basin.
Article
Critical Care Medicine
Shawn P. E. Nishi, Lisa M. Lowenstein, Tito R. Mendoza, Maria A. Lopez, Laura C. Crocker, Karen Sepucha, Jiangong Niu, Robert J. Volk
Summary: Among patients recently assessed for LCS, the quality of decision-making is highly variable, with patients valuing early cancer detection over concerns about harms. Patients were more likely to receive information on the benefits of LCS than on the risks, and one-third experienced some degree of decisional conflict. However, most patients felt they were adequately involved in the screening decision-making process.
Article
Urban Studies
Fei Ye, Yingying Chen, Lixu Li, Yina Li, Ying Yin
Summary: This study develops a new smart city index system that includes digital infrastructure, smart living, and digital economy dimensions. The objective evaluation process combines the Shannon entropy weighting method with three multi-criteria decision-making methods. Analysis of data from nine cities in the Pearl River Delta region shows that digital infrastructure is the most important indicator, followed by digital economy and smart life. The findings enrich the components and evaluation methods of the smart city index system and provide guidance for decision-makers in formulating smart city construction plans.
Article
Oncology
Stefan Ecker, Christian Kirisits, Maximilian Schmid, Johannes Knoth, Gerd Heilemann, Astrid De Leeuw, Alina Sturdza, Kathrin Kirchheiner, Nina Jensen, Remi Nout, Ina Juergenliemk-Schulz, Richard Poetter, Sofia Spampinato, Kari Tanderup, Nicole Eder-Nesvacil
Summary: This study aims to develop a novel decision-support system in radiation oncology that incorporates clinical, treatment, and outcome data from a clinical trial on magnetic resonance image-guided adaptive brachytherapy for locally advanced cervical cancer. The developed system, EviGUIDE, combines dosimetric information, patient and treatment characteristics, tumor control probability (TCP) and normal tissue complication probability (NTCP) models to predict treatment outcomes. EviGUIDE provides visual representation of the clinical impact of different treatment plans and feedback on achievable doses based on a large reference population.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Nursing
Huanhuan Li, Si Chen, Dongfei Ma, Yingnan Zhao, Xu Zhang, Yijing Li, Guanglong Zhang, Jiao Sun
Summary: This systematic review aimed to identify, characterize, and summarize patient-targeted interventions to improve the uptake of colorectal cancer genetic evaluation for at-risk individuals and to enhance their informed decision making. The findings showed that interventions focusing on risk assessment, education, and decision aids had positive effects on the uptake of colorectal cancer genetic evaluation and informed decision making for at-risk individuals.
INTERNATIONAL JOURNAL OF NURSING STUDIES
(2021)
Article
Construction & Building Technology
Yuan Shi, Rong Wang, Panfeng Chen
Summary: This study proposes a multi-criteria decision-making method to assist investors in selecting the most suitable energy-saving renovation strategy for hospital wards. The results show that green roofs have the highest economic benefits, and the replacement of high-performance windows becomes a viable option when considering other renovation measures and investors' preferences.
ENERGY AND BUILDINGS
(2023)
Article
Agriculture, Dairy & Animal Science
Melina Richardet, Hernan G. Solari, Victor E. Cabrera, Claudina Vissio, Daniel Aguero, Julian A. Bartolome, Gabriel A. Bo, Cristina I. Bogni, Alejandro J. Larriestra
Summary: A simulation model was developed to capture the complexity and dynamics of bovine mastitis, considering its multiple effects. The model allows for customization and supports decision-making of producers and veterinarians.
Article
Materials Science, Multidisciplinary
Ming Zhang, Chong Wang, Lulu Fan, Junyan Yi
Summary: This study establishes an evaluation index system for typical asphalt pavement structures based on the original highway structure in Jilin Province. Key parameters of asphalt pavement structure, design performance, and economy are calculated using the finite element method and pavement economic analysis method. The best solution is determined through the use of analytic hierarchy process and gray relational theory. The proposed decision-making model quickly and conveniently determines the most suitable pavement structure.
Article
Oncology
Wing-Lok Chan, Cheuk-Wai Choi, Ian Yu-Hong Wong, Terence Hon-Ting Tsang, Adrian Tin-Chung Lam, Rosa Pui-Ying Tse, K. K. Chan, Claudia Wong, Betty Tze-Ting Law, Emina Edith Cheung, Siu-Yin Chan, Ka-On Lam, Dora Kwong, Simon Law
Summary: This study reviewed the long-term clinical outcomes and safety data of induction chemotherapy followed by surgery or definitive chemoradiotherapy in patients with locally advanced unresectable esophageal cancer. The results showed that patients who received subsequent surgery had significantly longer median overall survival compared to those who had definitive chemoradiotherapy or no definitive treatment. Induction chemotherapy followed by conversion surgery offered a chance of cure with long-term survival benefit and manageable toxicities in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Venus W. Y. Lee, Alex C. H. Liu, Ken W. Cheng, Chi-Leung Chiang, Victor Ho-Fun Lee
Summary: Radiotherapy with electrons is commonly used after whole-breast radiotherapy for breast cancer patients, but the optimization of dose to adjacent organs and conformity of planning target volume (PTV) is difficult. This study examines the feasibility of using modulated electron bolus (MEB) to improve PTV conformity and reduce dose to adjacent organs.
Article
Oncology
Jiang Zhang, Xinzhi Teng, Saikit Lam, Jiachen Sun, Andy Lai-Yin Cheung, Sherry Chor-Yi Ng, Francis Kar-Ho Lee, Kwok-Hung Au, Celia Wai-Yi Yip, Victor Ho-Fun Lee, Zhongshi Lin, Yongyi Liang, Ruijie Yang, Ying Han, Yuanpeng Zhang, Feng-Ming (Spring) Kong, Jing Cai
Summary: This study explores the feasibility of improving the prognosis stratification of the N staging system for Nasopharyngeal Carcinoma (NPC) by using quantitative spatial characterizations of metastatic lymph node (LN). Independent anatomical prognostic factors were identified and combined with the N stage, leading to superior risk stratification performance. This quantitative approach may help discover new prognostic or predictive factors for other diseases and benefit precision medicine.
Review
Gastroenterology & Hepatology
Rex Wan-Hin Hui, Lung-Yi Mak, Tan -To Cheung, Victor Ho -Fun Lee, Wai-Kay Seto, Man-Fung Yuen
Summary: Hepatocellular carcinoma (HCC) is a significant public health issue in Hong Kong, with chronic hepatitis B being the most common cause. This article provides an overview of local guidelines and real-life practices for managing HCC in Hong Kong. The guidelines recommend regular screening with liver ultrasound and serum alpha-fetoprotein for viral hepatitis or cirrhotic patients, and this is followed in clinical practice. Diagnosis is usually done through imaging, without the need for histology. Treatment options, such as stereotactic body radiation therapy, targeted therapy, and immunotherapy, are outlined in the guidelines. Overall, the guidelines are tailored to the local expertise and patient population, and regular updates are necessary to keep up with advancements in HCC management. (Clin Mol Hepatol 2023;29:217-229)
CLINICAL AND MOLECULAR HEPATOLOGY
(2023)
Article
Medicine, General & Internal
Horace C. W. Choi, Kathy Leung, Karen K. L. Chan, Yuan Bai, Mark Jit, Joseph T. T. Wu
Summary: This study aimed to evaluate the cost-effectiveness of determining the optimal screening strategies for vaccinated and unvaccinated cohorts. It found that HPV testing is a cost-effective alternative to cytology for vaccinated cohorts, and the optimal screening frequency depends on vaccine uptake.
Article
Oncology
S. F. Lee, P. L. Yip, O. L. Chan, V. W. Y. Lee, A. Wong, H. C. W. Choi
Summary: This study analyzed the clinical implications of brain metastasis size change rate on tumor biology and prognosis for patients who received stereotactic radiotherapy (SRT). They developed a prognostic model based on significant predictors of overall survival and found that brain metastasis growth kinetics is a valuable metric for SRT outcomes in patients with brain metastases. This model can be used to identify patients with different overall survival rates.
Article
Clinical Neurology
Julia Chan, Danielle Wing Lam Ng, Qiuyan Liao, Richard Fielding, Inda Soong, Karen Kar Loen Chan, Conrad Lee, Alice Wan Ying Ng, Wing Kin Sze, Wing Lok Chan, Victor Ho Fun Lee, Wendy Wing Tak Lam
Summary: The study aims to examine the trajectories of sleep disturbance in cancer survivors during the first 2 years post-treatment and to investigate whether psychological, cognitive, and physical factors differentiate these trajectories. The findings showed that one in three cancer survivors experienced persistent high sleep disturbance, with higher rates of intrusive thoughts and cancer-related hyperarousal compared to stable good sleepers. Higher depression scores also predicted membership in the persistent high sleep disturbance group.
Article
Oncology
Jina Kim, Jason Chia-Hsien Cheng, Taek-Keun Nam, Jin Hee Kim, Byoung Kuk Jang, Wen-Yen Huang, Hiroshi Aikata, Myungsoo Kim, Jung Hyun Kwon, Jinbo Yue, Victor Ho Fun Lee, Zhaochong Zeng, Jinsil Seong
Summary: This study compared the efficacy of liver-directed combined radiotherapy (LD combined RT) with sorafenib in hepatocellular carcinoma patients presenting portal vein tumor thrombosis. The LD combined RT group showed significantly improved overall survival and a higher conversion rate to curative surgery. Despite the multimodality of the treatment, LD combined RT had comparable toxicity rates to sorafenib.
Review
Gastroenterology & Hepatology
Tan-To Cheung, Simon Chun-Ho Yu, Stephen L. Chan, Ronnie T. P. Poon, Philip Kwok, Ann-Shing Lee, Anna Tai, Derek Tam, Chin-Cheung Cheung, Tak-Wing Lai, Nam-Hung Chia, Ada Law, Tracy Shum, Yim-Kwan Lam, Vince Lau, Victor Lee, Charing Chong, Chung-Ngai Tang, Thomas Yau
Summary: This article summarizes the expertise and latest evidence-based recommendations on the treatment of hepatocellular carcinoma (HCC) by Hong Kong clinicians.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Article
Health Care Sciences & Services
Aya El Helali, Tai-Chung Lam, Elaine Yee-Ling Ko, David J. H. Shih, Chun Kau Chan, Charlene H. L. Wong, Jason W. H. Wong, Lydia W. T. Cheung, Johnny K. S. Lau, Anthony P. Y. Liu, Ann S. Y. Chan, Herbert H. Loong, Stephen Tak Sum Lam, Godfrey Chi-Fung Chan, Victor H. F. Lee, Kwok Keung Yuen, Wai-Tong Ng, Anne W. M. Lee, Edmond S. K. Ma
Summary: This study investigated the feasibility of the HKU-HKSH Multi-disciplinary Molecular Tumour Board (MTB) in determining genome-guided therapy for treatment-refractory solid cancers in Hong Kong. The results showed that MTB-guided treatment positively impacted patients' overall survival, illustrating the applicability of next-generation sequencing comprehensive gene profiling (CGP) in real-world clinical practice.
LANCET REGIONAL HEALTH-WESTERN PACIFIC
(2023)
Article
Infectious Diseases
Victor Ho-Fun Lee, Sik-Kwan Chan, Yiu-Ho Tam, Tin-Ching Chau, Jasper Fuk Woo Chan, Sum-Yin Chan, Chun-Yat Ip, Horace Cheuk-Wai Choi, Sherry Chor-Yi Ng, Kwok Keung Yuen
Summary: This study aimed to identify the predictors of delayed viral clearance in cancer patients with asymptomatic COVID-19 when the SARS-CoV-2 Omicron variants prevailed in Hong Kong. Multiple predictors were evaluated using machine learning algorithms, and it was found that age >65 years, male sex, high Charlson comorbidity index, lung cancer, immune checkpoint inhibitor, and receipt of one or no dose of COVID-19 vaccine were significant predictors. These findings contribute to targeted interventions for patients with delayed viral clearance.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Oncology
Clement Chun-Him Wong, Horace Cheuk-Wai Choi, Victor Ho-Fun Lee
Summary: The study analyzed the complication rates of different CVADs used in palliative care settings, showing that PICCs have higher complications compared to central lines. This information could be beneficial in formulating future guidelines on CVAD choice for palliative cancer care.
Review
Oncology
Ngar-Woon Kam, Cho-Yiu Lau, Chi-Ming Che, Victor Ho-Fun Lee
Summary: This article discusses the relationship between COVID-19 and nasopharyngeal carcinoma (NPC) and emphasizes the role of midkine (MK) in these diseases. It explores the impact of immune cell infiltration and interaction on cancer progression and COVID-19 severity. The exploration of new cancer therapies targeting MK offers hope for personalized treatments.
Article
Oncology
Claire Petit, Anne Lee, Jun Ma, Benjamin Lacas, Wai Tong Ng, Anthony T. C. Chan, Ruey-Long Hong, Ming-Yuan Chen, Lei Chen, Wen-Fei Li, Pei-Yu Huang, Terence Tan, Roger K. C. Ngan, Guopei Zhu, Hai-Qiang Mai, Edwin P. Hui, George Fountzilas, Li Zhang, Alexandra Carmel, Dora L. W. Kwong, James Moon, Jean Bourhis, Anne Auperin, Jean-Pierre Pignon, Pierre Blanchard
Summary: This study updated the evaluation of chemotherapy for nasopharynx carcinoma through a network meta-analysis. The results showed that the addition of induction chemotherapy or adjuvant chemotherapy to chemoradiotherapy improved overall survival for patients with non-metastatic nasopharyngeal carcinoma compared to chemoradiotherapy alone.
Article
Oncology
Victor Chun -Lam Wong, Ming-In Wong, Victor Ho-Fun Lee, Kwan Man, Kevin Tak-Pan Ng, Tan To Cheung
Summary: This study aimed to develop liquid biopsy assays for early HCC diagnosis and prognosis. A panel of 23 microRNAs (HCCseek-23 panel) was consolidated based on their reported functions in HCC development. Serum samples were collected from 103 early-stage HCC patients before and after hepatectomy. Quantitative PCR and machine learning random forest models were applied to develop diagnostic and prognostic models.