The Role of CD276 in Cancers

PBK phosphorylates MSL1 to elicit epigenetic modulation of CD276 in nasopharyngeal carcinoma

(2021) Meng-Yao Wang et al.   Oncogenesis

The B7-H3-targeting antibody-drug conjugate m276-SL-PBD is potently effective against pediatric cancer preclinical solid tumor models

(2021) Nathan M. Kendsersky et al.   CLINICAL CANCER RESEARCH

Clinicopathological and Prognostic Characteristics of CD276 (B7-H3) Expression in Adrenocortical Carcinoma

(2020) Jiayu Liang et al.   DISEASE MARKERS

Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors

(2020) Johanna Theruvath et al.   NATURE MEDICINE

Preclinical Development of MGC018, a Duocarmycin-based Antibody-drug Conjugate Targeting B7-H3 for Solid Cancer

(2020) Juniper A Scribner et al.   MOLECULAR CANCER THERAPEUTICS

CAR T cells targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors

(2019) Robbie G. Majzner et al.   CLINICAL CANCER RESEARCH

B7H3 regulates differentiation and serves as a potential biomarker and theranostic target for human glioblastoma

(2019) Jingwen Zhang et al.   LABORATORY INVESTIGATION

Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells

(2019) Hongwei Du et al.   CANCER CELL

B7-H3 immune checkpoint protein in human cancer

(2019) Karine Flem-Karlsen et al.   CURRENT MEDICINAL CHEMISTRY

B7-H3 modulates endothelial cell angiogenesis through the VEGF cytokine

(2019) Huijun Lai et al.   IMMUNOLOGIC RESEARCH

A platform for extracellular interactome discovery identifies novel functional binding partners for the immune receptors B7-H3/CD276 and PVR/CD155

(2019) Bushra Husain et al.   MOLECULAR & CELLULAR PROTEOMICS

B7-H3 expression and its correlation with clinicopathologic features, angiogenesis, and prognosis in intrahepatic cholangiocarcinoma

(2018) Rui Cheng et al.   APMIS

B7-H3 in tumors: friend or foe for tumor immunity?

(2018) Gen Li et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

B7H3 As a Promoter of Metastasis and Promising Therapeutic Target

(2018) Peixin Dong et al.   Frontiers in Oncology

Enhancing Anti-PD-1/PD-L1 Immune Checkpoint Inhibitory Cancer Therapy by CD276-Targeted Photodynamic Ablation of Tumor Cells and Tumor Vasculature

(2018) Rui Bao et al.   MOLECULAR PHARMACEUTICS

Immunoregulatory Protein B7-H3 Reprograms Glucose Metabolism in Cancer Cells by ROS-Mediated Stabilization of HIF1α

(2016) Sangbin Lim et al.   CANCER RESEARCH

Molecular Pathways: Targeting B7-H3 (CD276) for Human Cancer Immunotherapy

(2016) E. Picarda et al.   CLINICAL CANCER RESEARCH

WITHDRAWN: Tumor B7-H3 (CD276) expression and smoking history in relation to lung adenocarcinoma prognosis

(2016) Kentaro Inamura et al.   JOURNAL OF CONTROLLED RELEASE

B7-H3, B7-H4, Foxp3 and IL-2 expression in cervical cancer: Associations with patient outcome and clinical significance

(2016) CHENGLIN HUANG et al.   ONCOLOGY REPORTS

Correlation of B7-H3 with androgen receptor, immune pathways and poor outcome in prostate cancer: an expression-based analysis

(2016) B Benzon et al.   PROSTATE CANCER AND PROSTATIC DISEASES

B7-H3 as a promising target for cytotoxicity T cell in human cancer therapy

(2016) Juan Ma et al.   Oncotarget

Soluble B7-H3 promotes the invasion and metastasis of pancreatic carcinoma cells through the TLR4/NF-κB pathway

(2016) Chao Xie et al.   Scientific Reports

B7-H3 promotes aggression and invasion of hepatocellular carcinoma by targeting epithelial-to-mesenchymal transition via JAK2/STAT3/Slug signaling pathway

(2015) Fu-biao Kang et al.   Cancer Cell International

ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer

(2015) Pei Zhang et al.   FEBS LETTERS

Glycoprotein B7-H3 overexpression and aberrant glycosylation in oral cancer and immune response

(2015) Jung-Tsu Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and Cancer: What Can We Therapeutically Expect from Checkpoint Inhibitors?

(2015) Johannes Mischinger et al.   Current Urology Reports

Expression of B7-H3, a Potential Factor of Tumor Immune Evasion in Combination with the Number of Regulatory T Cells, Affects Against Recurrence-Free Survival in Breast Cancer Patients

(2014) N. Maeda et al.   ANNALS OF SURGICAL ONCOLOGY

Aberrant expression of B7-H3 in gastric adenocarcinoma promotes cancer cell metastasis

(2014) WEI DAI et al.   ONCOLOGY REPORTS

Association of T-cell co-regulatory protein expression with clinical outcomes following radical cystectomy for urothelial carcinoma of the bladder

(2013) E. Xylinas et al.   EJSO

Monoclonal antibody-based immunotherapy of ovarian cancer: Targeting ovarian cancer cells with the B7-H3-specific mAb 376.96

(2013) Janelle M. Fauci et al.   GYNECOLOGIC ONCOLOGY

T-cell co-stimulation by CD28–CD80/86 and its negative regulator CTLA-4 strongly influence accelerated atherosclerosis development

(2013) M.M. Ewing et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

B7-H3 Associated with Tumor Progression and Epigenetic Regulatory Activity in Cutaneous Melanoma

(2013) Jinhua Wang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Structure and T Cell Inhibition Properties of B7 Family Member, B7-H3

(2013) Vladimir Vigdorovich et al.   STRUCTURE

B7-H3 is expressed in human hepatocellular carcinoma and is associated with tumor aggressiveness and postoperative recurrence

(2012) Tai-Wei Sun et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Development of an Fc-Enhanced Anti-B7-H3 Monoclonal Antibody with Potent Antitumor Activity

(2012) D. Loo et al.   CLINICAL CANCER RESEARCH

B7-H3 expression in colorectal cancer: Nuclear localization strongly predicts poor outcome in colon cancer

(2012) Vibeke Anett Ingebrigtsen et al.   INTERNATIONAL JOURNAL OF CANCER

B7-H3 overexpression in pancreatic cancer promotes tumor progression

(2012) XIN ZHAO et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

B7-H3, a potential therapeutic target, is expressed in diffuse intrinsic pontine glioma

(2012) Zhiping Zhou et al.   JOURNAL OF NEURO-ONCOLOGY

Immunoexpression of B7-H3 in endometrial cancer: Relation to tumor T-cell infiltration and prognosis

(2011) Andreas Brunner et al.   GYNECOLOGIC ONCOLOGY

B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-associated genes

(2011) Christina Tekle et al.   INTERNATIONAL JOURNAL OF CANCER

B7–H3 Ligand Expression by Primary Breast Cancer and Associated With Regional Nodal Metastasis

(2010) Takaaki Arigami et al.   ANNALS OF SURGERY

B7-H3 and Its Role in Antitumor Immunity

(2010) Martin Loos et al.   Clinical & Developmental Immunology

Tumor associated endothelial expression of B7-H3 predicts survival in ovarian carcinomas

(2010) Xingxing Zang et al.   MODERN PATHOLOGY

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer

(2009) Martin Loos et al.   BMC CANCER

Clinical importance of B7-H3 expression in human pancreatic cancer

(2009) I Yamato et al.   BRITISH JOURNAL OF CANCER

MicroRNA miR-29 Modulates Expression of Immunoinhibitory Molecule B7-H3: Potential Implications for Immune Based Therapy of Human Solid Tumors

(2009) H. Xu et al.   CANCER RESEARCH

B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction

(2009) Judith Leitner et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Fine tuning the immune response through B7-H3 and B7-H4

(2009) Kyung H. Yi et al.   IMMUNOLOGICAL REVIEWS

The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans

(2009) Cameron S. Brandt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor Cell and Tumor Vasculature Expression of B7-H3 Predict Survival in Clear Cell Renal Cell Carcinoma

(2008) P. L. Crispen et al.   CLINICAL CANCER RESEARCH

Transgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro study

(2008) Hong Y. Yang et al.   ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS

The contrasting role of B7-H3

(2008) K. A. Hofmeyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses

(2008) M. Hashiguchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell co-stimulatory pathways in autoimmunity

(2008) Jörg J Goronzy et al.   ARTHRITIS RESEARCH & THERAPY