Article
Plant Sciences
Vanesa S. Garcia de la Torre, Teodoro Coba de la Pena, M. Mercedes Lucas, Jose J. Pueyo
Summary: This study found that transgenic plants displayed better growth performance and higher Cd tolerance under Cd stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Yao Zheng, Cecile Cabassa-Hourton, Holger Eubel, Guillaume Chevreux, Laurent Lignieres, Emilie Crilat, Hans-Peter Braun, Sandrine Lebreton, Arnould Savoure
Summary: This study reveals evidence of physical proximity and interactions among ProDH, P5CDH, and OAT in the mitochondria of Arabidopsis during dark-induced leaf senescence, suggesting the formation of a complex during P5C metabolism.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Environmental Sciences
Mahmoud R. Sofy, Akram A. Aboseidah, Samia A. Heneidak, Hoda R. Ahmed
Summary: This study focused on the role of isolated bacteria in alleviating the harmful effects of salt stress on plants. Results showed that treatment with endophytic bacteria significantly increased plant resistance to salt stress by enhancing enzymatic and non-enzymatic antioxidant defenses, osmolyte substances, and antioxidant enzyme gene expression. The use of endophytic bacteria also led to decreased Na+ accumulation and increased K+ uptake in plant tissues, ultimately improving salt tolerance in pea plants.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Leslaw Bernard Lahuta, Joanna Szablinska-Piernik, Marcin Horbowicz
Summary: In peas, proline, GABA, branched-chain amino acids, and hydroxyproline accumulated under drought and decreased after re-watering. The first drought/re-watering cycle enhanced the plant's ability to return to a normal metabolic profile after subsequent stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Alexandra N. Bogner, Kyle M. Stiers, John J. Tanner
Summary: Proline metabolism plays a significant role in cancer cells, involving upregulation of proline biosynthetic genes and the dual function of proline catabolic enzyme in promoting cancer and apoptosis. The cycling of proline impacts cellular growth and death pathways. PYCR, the last enzyme in proline biosynthesis, is crucial for the proline metabolic cycle and has been shown to be widely upregulated in various cancer types.
Article
Plant Sciences
Felix Frimpong, Carel W. Windt, Dagmar van Dusschoten, Ali A. Naz, Michael Frei, Fabio Fiorani
Summary: The study found that barley genotypes carrying a wild allele at P5cs1 locus have an advantage in drought resistance at the reproductive stage by accumulating proline, maintaining photosynthetic activity, and intrinsic water use efficiency, ultimately achieving higher seed productivity.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Corentin Dourmap, Anne Marmagne, Sandrine Lebreton, Gilles Clement, Anne Guivarc'h, Arnould Savoure, Celine Masclaux-Daubresse
Summary: This study investigated the phenotypes of Arabidopsis plants with mutations in the p5cdh gene and found that these mutants had lower seed yield and produced lighter seeds, indicating defects in stem-to-seed resource allocation. Furthermore, under high nitrate supply, the defects in carbon, nitrogen, and biomass allocation to seeds in p5cdh mutants were significantly amplified. Interestingly, these defects were not observed in the prodh1 prodh2 double-mutant. This study highlights the essential role of P5CDH in the carbon and nitrogen remobilization for seed development in Arabidopsis.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Chemistry, Multidisciplinary
Oseeyi Daudu, Kaylen R. Meeks, Lu Zhang, Javier Seravalli, John J. Tanner, Donald F. Becker
Summary: This study investigated the Thr171Met variant of PYCR1, which is found in patients with malignant melanoma and lung adenocarcinoma. The variant significantly affects the catalytic activity of PYCR1 but does not affect thermostability. The results suggest that the impact of the T171M variant on PYCR1 function in cancer is not due to increased catalytic activity.
Article
Biochemistry & Molecular Biology
Sagar M. Patel, Javier Seravalli, Xinwen Liang, John J. Tanner, Donald F. Becker
Summary: PYCR is an important enzyme for L-proline biosynthesis, with mutations in the PYCR2 gene linked to postnatal microcephaly and hypomyelination disorders. The disease-related variants R119C and R251C show catalytic impairment and structural defects, contributing to the pathology of these disorders.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Biochemistry & Molecular Biology
Chunhong Cui, Jiaxin Wang, Ling Guo, Chuanyue Wu
Summary: PINCH-1 protein promotes the expression of the key enzyme P5CS involved in proline biosynthesis, affecting cell proliferation and lung adenocarcinoma progression.
Article
Cell Biology
Raju Lama Tamang, Balawant Kumar, Sagar M. M. Patel, Ishwor Thapa, Alshomrani Ahmad, Vikas Kumar, Rizwan Ahmad, Donald F. F. Becker, Dundy (Kiran) Bastola, Punita Dhawan, Amar B. B. Singh
Summary: PYCR2, a terminal enzyme of proline metabolism, is associated with the aggressiveness of colorectal cancer (CRC). PYCR2 overexpression is correlated with poor patient survival. Inhibition of PYCR2 suppresses tumorigenic abilities of CRC cells and tumor growth. PYCR2 regulates MASTL/Wnt/β-catenin signaling to promote cancer stem cell populations and colon carcinogenesis.
Article
Biochemistry & Molecular Biology
Sagar M. Patel, Javier Seravalli, Kyle M. Stiers, John J. Tanner, Donald F. Becker
Summary: L-Thioproline is a cyclic sulfur-containing analog of l-proline found in various organisms, and human PYCR isozymes 1 and 2 show significant dehydrogenase activity towards L-T4C. This suggests a new enzyme function for PYCRs in the metabolism of L-T4C, leading to cysteine formation.
Article
Plant Sciences
Edith Cruzado-Tafur, Aleksandra Orzol, Adrian Golebiowski, Pawel Pomastowski, Mateusz Cichorek, Jacek Olszewski, Justyna Walczak-Skierska, Boguslaw Buszewski, Malgorzata Szultka-Mlynska, Katarzyna Glowacka
Summary: In this study, the effects of cadmium stress and silicon supplementation on pea plants were investigated. It was found that cadmium mainly accumulates in the roots of the plants, and supplementation with silicon reduces oxidative stress and reduces the accumulation of cadmium in the roots and shoots of the plants.
JOURNAL OF PLANT RESEARCH
(2023)
Article
Plant Sciences
Amelie Morin, Laurence Maurousset, Cecile Vriet, Remi Lemoine, Joan Doidy, Nathalie Pourtau
Summary: Grain legumes are important food crops that need to be cultivated in larger quantities to meet the growing concern about food safety and protein autonomy. However, the increase in legume cultivation must also address environmental challenges brought by global temperature increase and drought stress. Carbon allocation and source-sink relationships play a crucial role in crop yield, and understanding these mechanisms is essential in improving yield stability and stress tolerance.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Biotechnology & Applied Microbiology
Mohammed AbdulRahman Almuwayhi
Summary: The study reveals the environmental hazards of Cd on the molecular, morphological and physiological traits of P. sativum.
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
(2021)
Article
Plant Sciences
Agnieszka Grabowska, Edyta Zdunek-Zastocka, Ewa Kutryn, Joanna Kwinta
ACTA PHYSIOLOGIAE PLANTARUM
(2017)
Article
Plant Sciences
Marta Gietler, Malgorzata Nykiel, Slawomir Orzechowski, Joerg Fettke, Barbara Zagdanska
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2017)
Article
Biochemistry & Molecular Biology
Beata Prabucka, Marcin Mielecki, Magdalena Chojnacka, Wieslaw Bielawski, Mariusz Czarnocki-Cieciura, Slawomir Orzechowski
Article
Plant Sciences
Edyta Zdunek-Zastocka, Agnieszka Grabowska, Tomasz Branicki, Beata Michniewska
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2017)
Article
Plant Sciences
Justyna Fidler, Agnieszka Grabowska, Beata Prabucka, Aneta Wiesyk, Anna Gora-Sochacka, Wieslaw Bielawski, Miroslaw Pojmaj, Edyta Zdunek-Zastocka
JOURNAL OF PLANT PHYSIOLOGY
(2018)
Article
Entomology
Katarzyna Michalska, Anna Tomczyk, Barbara Lotocka, Slawomir Orzechowski, Marcin Studnicki
EXPERIMENTAL AND APPLIED ACAROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Edyta Zdunek-Zastocka, Agnieszka Grabowska
Article
Plant Sciences
Irina Malinova, Stella Koessler, Tom Orawetz, Ulrike Matthes, Slawomir Orzechowski, Anke Koch, Joerg Fettke
PLANT AND CELL PHYSIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Henrike Brust, Slawomir Orzechowski, Joerg Fettke
Article
Biochemistry & Molecular Biology
Slawomir Orzechowski, Dorota Sitnicka, Agnieszka Grabowska, Julia Compart, Joerg Fettke, Edyta Zdunek-Zastocka
Summary: Short-term cold treatment alters carbohydrate metabolism in potato leaves, leading to an increase in soluble sugar content.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Slawomir Orzechowski, Julia Compart, Edyta Zdunek-Zastocka, Joerg Fettke
Summary: Climate change can negatively impact starch granule properties due to both long-term and short-term temperature stresses, highlighting the importance of comprehensive research in this area.
JOURNAL OF PLANT PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jan Majdura, Urszula Jankiewicz, Agnieszka Galazka, Slawomir Orzechowski
Summary: Quorum sensing (QS) is a system of communication in bacterial cells through chemical signals, which modulate the behavior of entire populations of bacteria. Recent research has shown that QS molecules play an important role in plant growth stimulation and defense responses. Therefore, using class 1 autoinducers to induce beneficial activity in plants may be a practical solution to improve crop productivity.