Journal
CELLS
Volume 10, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/cells10051252
Keywords
N-glycans; O-glycans; receptors; signaling; tyrosine kinase; TGFR
Categories
Funding
- Natural Science and Engineering Research Council of Canada
- GlycoNet fund
- Department of Science and Technology of Jilin Province [20200801066GH]
- Education Department of Jilin Province [JJKH20211060KJ]
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Glycosylation plays crucial roles in receptor functions, affecting receptor conformation, ligand binding, and other functions. Understanding these roles can help control cell survival and death in diseases like cancer and immune responses.
Cells undergo proliferation and apoptosis, migration and differentiation via a number of cell surface receptors, most of which are heavily glycosylated. This review discusses receptor glycosylation and the known roles of glycans on the functions of receptors expressed in diverse cell types. We included growth factor receptors that have an intracellular tyrosine kinase domain, growth factor receptors that have a serine/threonine kinase domain, and cell-death-inducing receptors. N- and O-glycans have a wide range of functions including roles in receptor conformation, ligand binding, oligomerization, and activation of signaling cascades. A better understanding of these functions will enable control of cell survival and cell death in diseases such as cancer and in immune responses.
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