Article
Chemistry, Multidisciplinary
Theotim Lucas, Clement Linger, Thomas Naillon, Mahshid Hashemkhani, Lise Abiven, Bruno Viana, Corinne Chaneac, Gautier Laurent, Rana Bazzi, Stephane Roux, Sonia Becharef, Giulio Avveduto, Florence Gazeau, Jerome Gateau
Summary: Photoacoustic spectroscopy provides a precise and robust method of analyzing the photothermal capabilities of nanoagents in aqueous solutions, without the need for models.
Review
Chemistry, Multidisciplinary
Jinwoo Shin, Nayeon Kang, Byungkook Kim, Hyunsik Hong, Le Yu, Jungryun Kim, Heemin Kang, Jong Seung Kim
Summary: One-dimensional (1-D) nanomaterials, classified according to their shape, have unique physicochemical properties and promising applications in nanotechnology. In cancer therapy and diagnosis, the biological characteristics of 1-D nanomaterials have extended their potential, including high drug loading efficiency, prolonged blood circulation, cancer cell capture, unique cellular uptake mechanisms, efficient photothermal conversion, and material tunability. This review presents an overview of emerging 1-D nanomaterials in cancer therapy and diagnosis, discussing their definition, shape-dependent physicochemical properties, biomedical applications, recent advances, and unexplored potential.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Materials Science, Biomaterials
Zhe Yang, Yueqi Zhao, Yang Li, Lei Song, Yangliu Lin, Kaimeng Liu, Yujia Zhang, Andrei V. Zvyagin, Linan Fang, Yuanqing Sun, Bai Yang, Quan Lin
Summary: Surgical resection is the main treatment for oral tongue squamous cell carcinoma (OTSCC), but it can cause significant damage to oral physiological function and aesthetics, with a high risk of recurrence. Therefore, it is important to develop an alternative strategy with precise guidance for OTSCC treatment. In this study, multifunctional Au/Mn nanodots (NDs) were designed and synthesized, which can perform multimodal bioimaging, including computed tomography (CT) and magnetic resonance imaging (MRI), and exhibit bright near-infrared fluorescence imaging (FI) for navigation, as well as integrate photothermal therapy (PTT) property.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Inorganic & Nuclear
Jinwu Liu, Hong Qu, Lifeng Hang, Yiqiang Sun, Wuming Li, Yiyu Chen, Hong Li, Wei Wen, Yanqiu Feng, Guihua Jiang
Summary: Chemodynamic therapy, a therapeutic modality based on reactive oxygen species, has limitations due to the antioxidant system in tumor microenvironment. In this study, a dual-targeting nanotheranostic agent was developed for enhanced chemodynamic therapy of tumors. The agent showed significant therapeutic effects by reducing glutathione levels and targeting tumor tissues using both biological and physical approaches.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Multidisciplinary
Piao Jiang, Bin Liang, Zhen Zhang, Bing Fan, Lin Zeng, Zhiyong Zhou, Zhifang Mao, Quan Xu, Weirong Yao, Qinglin Shen
Summary: Lung cancer is the most rapidly growing malignant tumor with the highest incidence and mortality rates, posing the greatest threat to human health and life. It is currently the leading malignant tumor in males and the second leading malignant tumor in females. In the era of precision medicine, there have been unprecedented changes in the concept and strategy of cancer diagnosis and treatment. Nanotechnology has brought new possibilities for tumor diagnosis and treatment, with nanomaterials playing an important role in tumor imaging, diagnosis, drug delivery, and controlled drug release. This article reviews the advancements in lipid-based nanosystems, polymer-based nanosystems, and inorganic nanosystems in the diagnosis and treatment of non-small-cell lung cancer (NSCLC).
Article
Oncology
Razan Aldahhan, Dana Almohazey, Firdos Alam Khan
Summary: Colorectal cancer is a highly aggressive type of cancer, and the development of nanoparticles, particularly gold nanoparticles, shows promise in the treatment and diagnosis of this disease. However, there is conflicting research on the pharmacokinetics of gold nanoparticles, highlighting the need for a publicly available database for further analysis.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
X. Hai, M. Ji, K. Yu, T. Tian, Z. Cui, S. Bi, X. Zhang
Summary: DNA nanotechnology has been utilized to construct a DNA-Au nanomachine with active/passive dual-targeting capacity for lysosomal acidic microenvironment-activated combinational chemo-photothermal therapy of cervical carcinoma. The nanomachine consists of three-dimensional DNA nanoflowers and BSA-modified gold nanoparticles, allowing for targeted chemotherapy and photothermal therapy. In vitro and in vivo studies demonstrate the potential of this nanomachine for targeted combinational therapy of cancer.
MATERIALS TODAY NANO
(2023)
Review
Biochemistry & Molecular Biology
Rebecca C. Fitzgerald, Antonis C. Antoniou, Ljiljana Fruk, Nitzan Rosenfeld
Summary: Proactively detecting cancer at an early stage is crucial, but distinguishing inconsequential changes from life-threatening lesions can be challenging. Advancements in technology will aid real-time detection of personalized cancer signals. Risk-based detection and prevention should be cost effective and widely accessible.
Article
Chemistry, Multidisciplinary
Ali Tarighatnia, Mohammad Hossein Abdkarimi, Nader D. Nader, Tayebeh Mehdipour, Mohammad Reza Fouladi, Ayuob Aghanejad, Hossein Ghadiri
Summary: Mesoporous silica-coated bismuth nanoparticles conjugated with mucin-16 aptamer were synthesized and used as dual-modal contrast agents for cervical cancer imaging with CT and US modalities. Targeted NPs showed higher accumulation in cancer cells compared to non-targeted NPs, and the bismuth NP concentrations correlated linearly with CT numbers and US image intensity values. These results suggest that the MSBi@MUC16 NPs are high-performance hybrid contrast agents for US/CT dual-modal imaging of cervical cancer.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yanan Xu, Qian Zhang, Runzhi Chen, Haiting Cao, Jie Tang, Yuqi Wu, Xing Lu, Binbin Chu, Bin Song, Houyu Wang, Yao He
Summary: In this study, a novel nanoantenna was designed and synthesized for early diagnosis and smart treatment of acute kidney injury (AKI). The nanoantenna showed kidney retention and could be used for photoacoustic imaging in deep tissues. It also had a high sensitivity for detecting miR-21, which is up-expressed in AKI. In addition, the naked rDON scaffold generated by AKI could capture more reactive oxygen species and alleviate ischemic AKI.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Review
Chemistry, Multidisciplinary
Yiwei Zhang, Xinxin Li, Yajie Zhang, Jun Wei, Wei Wang, Changzhi Dong, Yanan Xue, Min Liu, Renjun Pei
Summary: Fe3O4 nanoparticles, approved by the FDA, have unique properties that make them ideal for cancer diagnosis and therapy. Their potential as theranostic nanoplatforms in individual therapies in the near future is promising.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Myeongsoo Kim, Jinhwan Kim, Don VanderLaan, Kelsey P. P. Kubelick, Anamik Jhunjhunwala, Ayoung Choe, Stanislav Y. Y. Emelianov
Summary: Manipulating the interparticle connectivity between gold nanospheres allows for regulating photoacoustic signal generation in biomedical imaging. This study demonstrates that nanoassemblies with semi-connectivity between gold nanospheres exhibit higher photoacoustic signals compared to assemblies with no connectivity or full connectivity. Additionally, the semi-connected nanoassemblies demonstrate enhanced photostability and have the potential to surpass conventional plasmonic contrast agents for photoacoustic imaging applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Medicine, Research & Experimental
Alessandro Villa, Mariangela Garofalo, Daniela Crescenti, Nicoletta Rizzi, Electra Brunialti, Andrea Vingiani, Paolo Belotti, Carlo Sposito, Silvia Franze, Francesco Cilurzo, Giancarlo Pruneri, Camilla Recordati, Chiara Giudice, Alessia Giordano, Monica Tortoreto, Giangiacomo Beretta, Damiano Stefanello, Giacomo Manenti, Nadia Zaffaroni, Vincenzo Mazzaferro, Paolo Ciana
Summary: Research has shown that nano- and microsized extracellular vesicles (EVs) play a significant role in intercellular communication and can be used for targeted cancer therapy. By labeling EVs with indocyanine green (ICG) and tracking their distribution, it was found that nanoparticles with cancer tropism exist in the blood of colorectal cancer (CRC) patients. In mouse models, it was demonstrated that transplanted EVs were able to recognize tumors and deliver tumor-interfering molecules, indicating the therapeutic potential of autologous EVs for cancer treatment.
Article
Nanoscience & Nanotechnology
Chukwuazam Nwasike, Erin Purr, Jaspreet Singh Nagi, Gretchen J. Mahler, Amber L. Doiron
Summary: Inflammatory diseases account for 3 out of 5 deaths in the world. Current screening and diagnostic methods are not sufficient in accurately identifying high-risk or low-risk stages of these diseases. In this study, we modified interpolymer complexed superparamagnetic iron oxide nanoparticles (IPC-SPIOs) by incorporating mannose as a targeting biomolecule to improve nanoparticle delivery to M2 macrophages at inflammatory sites. The modified nanoparticles showed increased uptake by M2 macrophages without compromising cellular viability.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Le-Le Zhou, Qun Guan, Wei Zhou, Jing-Lan Kan, Yu-Bin Dong
Summary: Metal-free radiosensitizers, particularly iodine, have shown promise in enhancing radiotherapy due to their suitable X-ray absorption capacities and negligible biotoxicities. However, conventional iodine compounds have very short circulating half-lives and are not retained in tumors very well, which significantly limits their applications. In this study, a room-temperature synthesis of an iodide-containing cationic COF was reported, which can serve as a tumor radiosensitizer for enhanced radiotherapy and inhibit colorectal tumor growth. These findings highlight the potential of metal-free COFs as effective radiotherapy sensitizers.
Article
Oncology
Xinning Wang, Aditi Shirke, Ethan Walker, Rongcan Sun, Gopolakrishnan Ramamurthy, Jing Wang, Lingpeng Shan, Joey Mangadlao, Zhipeng Dong, Jing Li, Ziying Wang, Mark Schluchter, Dong Luo, Yu Wang, Shaun Stauffer, Susann Brady-Kalnay, Christopher Hoimes, Zhenghong Lee, James P. Basilion
Summary: Researchers have developed a new PSMA-targeting drug conjugate with potent and selective antitumor activity, showing potential to impact therapeutic management of lethal prostate cancers.
Article
Oncology
E. Walker, S. M. Turaga, X. Wang, R. Gopalakrishnan, S. Shukla, J. P. Basilion, J. D. Lathia
Summary: The study demonstrated the successful non-invasive detection and visualization of prostate and breast cancerous tissues in vivo using a novel JAM-A mAb/IR700 conjugate, showing therapeutic and prognostic potential while being able to image specific receptor expression without post-image processing.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Oncology
Xinning Wang, Dong Luo, James P. Basilion
Summary: Photodynamic therapy (PDT) is an effective treatment modality for cancers that uses harmless light to activate photosensitizers, targeting specific tumor cells to improve treatment efficacy and reduce toxicity to normal tissues. Recent advancements in targeted delivery of photosensitizers to cancer cells have shown promising results in enhancing PDT outcomes.
Article
Endocrinology & Metabolism
Yu Wang, Eric C. Abenojar, Jing Wang, Al C. Leon, Sidhartha Tavri, Xinning Wang, Ramamurthy Gopalakrishnan, Ethan Walker, Gregory T. MacLennan, Anoja Giles, Gregory J. Czarnota, James P. Basilion, Agata A. Exner
Summary: In this study, a prostate cancer model was successfully established in immunosuppressed rabbits, providing a clinically relevant intermediate step for assessing preclinical interventions. The minimally invasive ultrasound-guided tumor cell injection proved to be a better method compared to laparotomy, allowing for shorter recovery time for the rabbits.
Article
Oncology
Ethan Walker, Daan G. J. Linders, Eric Abenojar, Xinning Wang, Hans Marten Hazelbag, Marieke E. Straver, Okker D. Bijlstra, Taryn L. March, Alexander L. Vahrmeijer, Agata Exner, Matthew Bogyo, James P. Basilion, Brian Straight
Summary: A formulation of a fluorescent molecular probe has been developed to enhance the resection quality for solid-tumor cancers. This formulation can be topically applied immediately after surgery and activates in the presence of residual cancer, providing a strong fluorescent signal to precisely delineate any remaining cancer cells. The utilization of this formulation has the potential to reduce re-excisions and improve patient quality of life.
Article
Endocrinology & Metabolism
Dong Luo, Xinning Wang, Gopalakrishnan Ramamurthy, Ethan Walker, Lifang Zhang, Aditi Shirke, Naraen G. Naidu, Clemens Burda, Reena Shakya, Eric T. Hostnik, Mathew Joseph, Lee Ponsky, Vladimir Ponomarev, Thomas J. Rosol, Michael F. Tweedle, James P. Basilion
Summary: Researchers have developed a canine model for studying the effectiveness of PSMA-targeted gold nanoparticles in the imaging and therapy of early stage prostate cancer. The nanoparticles allowed visualization of cancer cells and their destruction when exposed to specific wavelength light.
Article
Chemistry, Multidisciplinary
Dong Luo, Xinning Wang, Sophia Zeng, Gopalakrishnan Ramamurthy, Clemens Burda, James P. Basilion