Role of Angiogenesis in the Pathogenesis of NAFLD

Neovascularization is a key feature of liver fibrosis progression: anti-angiogenesis as an innovative way of liver fibrosis treatment

(2020) Mariia Zadorozhna et al.   MOLECULAR BIOLOGY REPORTS

Systemic Therapy for Advanced Hepatocellular Carcinoma: ASCO Guideline

(2020) John D. Gordan et al.   JOURNAL OF CLINICAL ONCOLOGY

Role of liver sinusoidal endothelial cells in nonalcoholic fatty liver disease

(2019) Adel Hammoutene et al.   JOURNAL OF HEPATOLOGY

Resolving the fibrotic niche of human liver cirrhosis at single-cell level

(2019) P. Ramachandran et al.   NATURE

TGF-β in Hepatic Stellate Cell Activation and Liver Fibrogenesis—Updated 2019

(2019) Dewidar et al.   Cells

Animal models of NAFLD from a hepatologist's point of view

(2018) Daniel Jahn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Origins of Portal Hypertension in Nonalcoholic Fatty Liver Disease

(2018) Gyorgy Baffy   DIGESTIVE DISEASES AND SCIENCES

Therapeutic inhibition of inflammatory monocyte recruitment reduces steatohepatitis and liver fibrosis

(2018) Oliver Krenkel et al.   HEPATOLOGY

Systematic review with meta-analysis: risk of hepatocellular carcinoma in non-alcoholic steatohepatitis without cirrhosis compared to other liver diseases

(2018) Jonathan G. Stine et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Angiopoietin-2 promotes pathological angiogenesis and is a novel therapeutic target in murine non-alcoholic fatty liver disease

(2018) Sander Lefere et al.   HEPATOLOGY

Ezetimibe suppresses development of liver tumors by inhibiting angiogenesis in mice fed a high-fat diet

(2018) Kouichi Miura et al.   CANCER SCIENCE

The role of hypoxia-inducible factors in metabolic diseases

(2018) Frank J. Gonzalez et al.   Nature Reviews Endocrinology

Serum vascular cell adhesion molecule-1 predicts significant liver fibrosis in non-alcoholic fatty liver disease

(2017) S Lefere et al.   INTERNATIONAL JOURNAL OF OBESITY

Liver sinusoidal endothelial cells: Physiology and role in liver diseases

(2017) Johanne Poisson et al.   JOURNAL OF HEPATOLOGY

Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets

(2017) Gyongyi Szabo et al.   Nature Reviews Gastroenterology & Hepatology

Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention

(2017) Zobair Younossi et al.   Nature Reviews Gastroenterology & Hepatology

Portal myofibroblasts connect angiogenesis and fibrosis in liver

(2016) Sara Lemoinne et al.   CELL AND TISSUE RESEARCH

Neoangiogenesis-related genes are hallmarks of fast-growing hepatocellular carcinomas and worst survival. Results from a prospective study

(2015) Erica Villa et al.   GUT

Portal myofibroblasts promote vascular remodeling underlying cirrhosis formation through the release of microparticles

(2015) Sara Lemoinne et al.   HEPATOLOGY

Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice

(2014) Liu Yang et al.   GASTROENTEROLOGY

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

(2014) Josef Ehling et al.   GUT

Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis

(2014) Michaela Granzow et al.   HEPATOLOGY

Neovascularization and oxidative stress in the progression of non-alcoholic steatohepatitis

(2014) Mitsuteru Kitade et al.   Molecular Medicine Reports

The emerging roles of microvesicles in liver diseases

(2014) Sara Lemoinne et al.   Nature Reviews Gastroenterology & Hepatology

Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models

(2013) Stephanie Coulon et al.   HEPATOLOGY

Bevacizumab Attenuates Hepatic Fibrosis in Rats by Inhibiting Activation of Hepatic Stellate Cells

(2013) Yangqing Huang et al.   PLoS One

Lipid-Induced Toxicity Stimulates Hepatocytes to Release Angiogenic Microparticles That Require Vanin-1 for Uptake by Endothelial Cells

(2013) D. Povero et al.   Science Signaling

Evaluation of inflammatory and angiogenic factors in patients with non-alcoholic fatty liver disease

(2012) Stephanie Coulon et al.   CYTOKINE

Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis

(2012) Yosui Tamaki et al.   JOURNAL OF GASTROENTEROLOGY

The role of angiotensin II in nonalcoholic steatohepatitis

(2012) E. Matthew Morris et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

TGF-β Receptor Signaling Pathways in Angiogenesis; Emerging Targets for Anti-Angiogenesis Therapy

(2011) Laurens A. van Meeteren et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis

(2011) Dominique Thabut et al.   HEPATOLOGY

Inhibition of placental growth factor activity reduces the severity of fibrosis, inflammation, and portal hypertension in cirrhotic mice

(2011) Christophe Van Steenkiste et al.   HEPATOLOGY

The biphasic nature of hypoxia-induced directional migration of activated human hepatic stellate cells

(2011) Erica Novo et al.   JOURNAL OF PATHOLOGY

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Hepatic and HSC-specific sorafenib effects in rats with established secondary biliary cirrhosis

(2010) Martin Hennenberg et al.   LABORATORY INVESTIGATION

Angiogenesis in chronic liver disease and its complications

(2010) Stephanie Coulon et al.   LIVER INTERNATIONAL

Hepatic Microcirculation in Fatty Liver Disease

(2008) Geoff C. Farrell et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis

(2008) Kojiro Taura et al.   GASTROENTEROLOGY

Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats

(2008) Marc Mejias et al.   HEPATOLOGY