IL4I1 Is Expressed by Head–Neck Cancer-Derived Mesenchymal Stromal Cells and Contributes to Suppress T Cell Proliferation

Human T cells interacting with HNSCC‐derived mesenchymal stromal cells acquire Tissue‐Resident memory like properties

(2020) Alessio Mazzoni et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression

(2020) Ahmed Sadik et al.   CELL

Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond

(2019) Michael Platten et al.   NATURE REVIEWS DRUG DISCOVERY

DNA methylation of indoleamine 2,3-dioxygenase 1 (IDO1) in head and neck squamous cell carcinomas correlates with IDO1 expression, HPV status, patients’ survival, immune cell infiltrates, mutational load, and interferon γ signature

(2019) Verena Sailer et al.   EBioMedicine

IDO1 in cancer: a Gemini of immune checkpoints

(2018) Lijie Zhai et al.   Cellular & Molecular Immunology

Mesenchymal stem cells are enriched in head neck squamous cell carcinoma, correlates with tumour size and inhibit T-cell proliferation

(2015) F Liotta et al.   BRITISH JOURNAL OF CANCER

Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos+, but not natural Helios+, FOXP3+Treg cells

(2015) Clara-Maria Scarlata et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL4I1 Is a Novel Regulator of M2 Macrophage Polarization That Can Inhibit T Cell Activation via L-Tryptophan and Arginine Depletion and IL-10 Production

(2015) Yinpu Yue et al.   PLoS One

Mechanisms of tumor escape from immune system: Role of mesenchymal stromal cells

(2014) Alessandro Poggi et al.   IMMUNOLOGY LETTERS

IL-4-induced gene 1 maintains high Tob1 expression that contributes to TCR unresponsiveness in human T helper 17 cells

(2013) Veronica Santarlasci et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Rarity of Human T Helper 17 Cells Is due to Retinoic Acid Orphan Receptor-Dependent Mechanisms that Limit Their Expansion

(2012) Veronica Santarlasci et al.   IMMUNITY