Article
Oncology
Zhenghao Wu, Zihan Xi, Yunxiao Xiao, Xiangwang Zhao, Jiexiao Li, Nan Feng, Longqing Hu, Renjing Zheng, Ning Zhang, Shuntao Wang, Tao Huang
Summary: This study examines the role of thyroid-stimulating hormone (TSH) in tumor immunity. It finds that TSH promotes tumor growth and invasion in thyroid cancers and glioma through the TSH receptor (TSHR) pathway. TSH also induces the expression of programmed death-ligand 1 (PD-L1) in tumors, contributing to immune evasion. Inhibiting TSHR reverses tumor immune evasion and enhances T effector cell activation. These findings suggest that TSH suppression therapy could be an effective strategy in combination with immune checkpoint blockades.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Monika Graeser, Friedrich Feuerhake, Oleg Gluz, Valery Volk, Michael Hauptmann, Katarzyna Jozwiak, Matthias Christgen, Sherko Kuemmel, Eva-Maria Grischke, Helmut Forstbauer, Michael Braun, Mathias Warm, John Hackmann, Christoph Uleer, Bahriye Aktas, Claudia Schumacher, Cornelia Kolberg-Liedtke, Ronald Kates, Rachel Wuerstlein, Ulrike Nitz, Hans Heinrich Kreipe, Nadia Harbeck
Summary: The study found that changes in immune infiltrate in breast cancer patients before and after NACT treatment can impact the pathological complete response rate, with a transition from "cold" to "hot" immune cell composition potentially increasing the pCR rate of PD1-positive CD4 and CD8 cells, while a transition from "hot" to "cold" may decrease the pCR rate of T cells and PD1-positive CD4 cells. Higher pCR rates were associated with an "altered" distribution of T cells and PD1-positive CD4 cells between the tumor and stroma.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Pengfei Xu, Joy C. Yang, Bo Chen, Christopher Nip, Jonathan E. Van Dyke, Xiong Zhang, Hong-Wu Chen, Christopher P. Evans, William J. Murphy, Chengfei Liu
Summary: This study investigated the mechanisms underlying the failure of atezolizumab and enzalutamide combination treatment in castration-resistant prostate cancer. The researchers found that enzalutamide-resistant prostate cancer cells promote immunosuppressive signaling, which may contribute to the reduced efficacy of immune checkpoint inhibitors in these patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Fatima Ahmetlic, Josia Fauser, Tanja Riedel, Vera Bauer, Carolin Flessner, Nadine Hoemberg, Roman Hennel, Ellen Brenner, Kirsten Lauber, Martin Roecken, Ralph Mocikat
Summary: The study found that in treating lymphoma in mice with immune checkpoint inhibitors, 20% to 30% of mice were long-term protected and did not show clinical signs of tumor growth. The therapeutic effect depended on cytokine-induced senescence in malignant B cells. Therapy with immune checkpoint antibodies improved T cell functions and long-time survivors were only observed in the presence of T cells.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Shin Hye Yoo, Jihui Yun, Bhumsuk Keam, Seung-Pyo Hong, Chan-Young Ock, Jaemoon Koh, Sehui Kim, Yoon Kyung Jeon, Kyeong Cheon Jung, Miso Kim, Tae Min Kim, Dong-Wan Kim, Jong-Il Kim, Dae Seog Heo
Summary: The increase in immunosuppressive markers observed after ICI treatment may contribute to acquired resistance (AR), and APOBEC-mediated PIK3CA mutation could be another mechanism of AR. Further studies with sufficient sample size are needed to validate these mechanisms.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Zongren Wang, Xueling Zhang, Wuguo Li, Qiao Su, Zhaoyang Huang, Xinyao Zhang, Haiqi Chen, Chengqiang Mo, Bin Huang, Wei Ou, Junxing Chen, Guangyin Zhao, Lingwu Chen, Lan Shao
Summary: The study revealed that DTX induces the expression of PD-L1 in prostate cancer cells through the activation of the ATM-NEMO-NF-kappa B axis, leading to increased resistance to chemotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Myrto K. Moutafi, Magdalena Molero, Sandra Martinez Morilla, Javier Baena, Ioannis A. Vathiotis, Niki Gavrielatou, Laura Castro-Labrador, Gorka Ruiz de Garibay, Vera Adradas, Daniel Orive, Karmele Valencia, Alfonso Calvo, Luis M. Montuenga, S. Ponce Aix, Kurt A. Schalper, Roy S. Herbst, Luis Paz-Ares, David L. Rimm, Jon Zugazagoitia
Summary: This study identifies CD44 as a novel biomarker for predicting sensitivity to PD-1 axis blockade in NSCLC, and validates its correlation with prolonged progression-free survival and overall survival.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Feiya Ma, Jensen Vayalil, Grace Lee, Yuqi Wang, Guangyong Peng
Summary: Tumor-derived extracellular vesicles (EVs) are a major factor inducing T cell dysfunction in the tumor microenvironment, playing a crucial role in cancer immunity. By carrying immune suppressive signals, tumor-derived EVs can drive T cell dysfunction and promote tumor immunity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Guangshun Sun, Hanyuan Liu, Jie Zhao, Jinyu Zhang, Tian Huang, Guoqiang Sun, Siqi Zhao, Zihao Zhang, Hengsong Cao, Dawei Rong, Xiangyi Kong, Qinghua Ji, Li Liu, Xuehao Wang, Weiwei Tang, Yongxiang Xia
Summary: This study reveals that macrophage GSK3 beta deficiency can inhibit the development of HCC by inhibiting the M2 phenotype and enhance the sensitivity of anti-PD1 immunotherapy for HCC by decreasing PD-L1 ubiquitination. The expression of CD14(+)GSK3 beta(+) in PBMC can noninvasively predict anti-PD1 sensitivity in HCC patients, providing novel strategies to predict anti-PD1 sensitivity, increase anti-PD1 therapeutic effect, and bring new hope for HCC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Samuel Peter Heilbroner, Reed Few, Judith Mueller, Jitesh Chalwa, Francois Charest, Somasekhar Suryadevara, Christine Kratt, Andres Gomez-Caminero, Brian Dreyfus, Tomas G. Neilan
Summary: The study used a machine learning model to predict cardiac events risk factors in patients receiving immune checkpoint inhibitors therapy, including increased age, corticosteroids, laboratory abnormalities, cardiac history, extremes of weight, decreased lymphocyte percentage, and increased neutrophil percentage.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Minlin Jiang, Chunyan Wu, Liping Zhang, Chenglong Sun, Hao Wang, Yi Xu, Hui Sun, Jun Zhu, Wencheng Zhao, Qiyu Fang, Jia Yu, Peixin Chen, Shengyu Wu, Zixuan Zheng, Yayi He, Caicun Zhou
Summary: The study found that FOXP3 in SCLC is associated with immune biomarkers like PD-L1, PD-1, CD4, CD8, and CD3, and is correlated with longer relapse-free survival. An immune risk score model incorporating FOXP3, TIL PD-L1, and CD8 showed better predictive performance than single or two-indicator-based systems.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Aiqin Gao, Xia Liu, Wenli Lin, Jingnan Wang, Shuyun Wang, Fusheng Si, Lan Huang, Yangjing Zhao, Yuping Sun, Guangyong Peng
Summary: ILT4 is highly expressed in human tumor cells and tissues, negatively associated with clinical outcomes. Tumor-derived ILT4/PIR-B directly induces cell senescence in naive/effector T cells in vitro and in vivo through MAPK ERK1/2 signaling. Blocking tumor-derived PIR-B can reprogram tumor metabolism, prevent senescence development in tumor-specific T cells, and enhance antitumor immunity in both breast cancer and melanoma mouse models.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Seung Joon Lee, Hannah Yang, Woo Ram Kim, Yu Seong Lee, Won Suk Lee, So Jung Kong, Hye Jin Lee, Jeong Hun Kim, Jaekyung Cheon, Beodeul Kang, Hong Jae Chon, Chan Kim
Summary: STING activation can normalize the peritoneal vascular and immune microenvironment, converting immunologically cold peritoneal tumors into T-cell-inflamed tumors and providing a rationale for a novel combination therapeutic strategy for peritoneal carcinomatosis in colon cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Cyrille Coustal, Juliette Vanoverschelde, Xavier Quantin, Candice Lesage, Jean-Marie Michot, Ariane Lappara, Stephane Ederhy, Eric Assenat, Maxime Faure, Nahema Issa, Olivier Lambotte, Mathieu Puyade, Olivier Dereure, Diego Tosi, Patricia Rullier, Isabelle Serre, Romaric Larcher, Kada Klouche, Gerald Chanques, Helene Vernhet-Kovacsik, Jean-Luc Faillie, Audrey Agullo, Francois Roubille, Philippe Guilpain, Alexandre Thibault Jacques Maria
Summary: Immune checkpoint inhibitors (ICI) have revolutionized cancer treatment, but have also led to the emergence of immune-related adverse events (irAEs), including the rare but life-threatening myocarditis.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Alok A. Khorana, Jennell Palaia, Lisa Rosenblatt, Radhika Pisupati, Ning Huang, Chi Nguyen, John Barron, Kerrin Gallagher, T. Christopher Bond
Summary: This study assessed the incidence and risk factors of venous thromboembolism (VTE) in patients with non-small cell lung cancer (NSCLC) treated with immune checkpoint inhibitors (ICI). The study found that ICI-based regimens were associated with lower risk of VTE compared to chemotherapy (chemo), while the risk of VTE with ICI+chemo regimens was similar to chemo. Previous radiation and severe obesity were also associated with VTE.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Cell & Tissue Engineering
Zhu Wang, Youjia Li, Yuliang Wang, Dinglan Wu, Alaster Hang Yung Lau, Pan Zhao, Chang Zou, Yong Dai, Franky Leung Chan
STEM CELL RESEARCH & THERAPY
(2020)
Correction
Biochemistry & Molecular Biology
Zhu Wang, Youjia Li, Dinglan Wu, Shan Yu, Yuliang Wang, Franky Leung Chan
Article
Urology & Nephrology
Zhu Wang, Ming-xing Li, Chang-zhi Xu, Ying Zhang, Qiong Deng, Rui Sun, Qi-yi Hu, Sheng-ping Zhang, Jian-wen Zhang, Hui Liang
Article
Oncology
Rui Sun, Hui Liang, Huan Guo, Zhu Wang, Qiong Deng
Summary: This study investigated the expression of PMCA4 in mouse testis and its regulation by androgens and AR. Results showed that PMCA4 was upregulated during mouse testis development and its expression levels were influenced by testosterone and AR. These findings suggest that PMCA4 may play a role in regulating spermatogenesis.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Andrology
Qiyi Hu, Yongjian Ji, Zhu Wang, Yulin Lai, Qiong Deng, Jianwen Zhang, Hongliang Wang, Hui Liang, Hongjun Zhao
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2020)
Review
Oncology
Zhu Wang, Ying Zhang, Jianwen Zhang, Qiong Deng, Hui Liang
Summary: This review summarizes the critical roles of HNF4 alpha in tumorigenesis and examines its expression profile and alterations through pan-cancer analysis using bioinformatics, aiming to provide a better understanding of the functional roles of this gene in human cancers.
Review
Medicine, Research & Experimental
Zhu Wang, Ying Zhang, Jianwen Zhang, Qiong Deng, Hui Liang
Summary: Kidney stone disease is one of the oldest known diseases in medicine, with unclear mechanisms of formation and development. Recent technological advances have led to the development of various theories and strategies in surgical management of kidney stones. Observations suggest five main mechanisms for kidney stone formation: urinary supersaturation, Randall's plaques, sex hormones, microbiome, and immune response, providing opportunities for novel research and understanding in urology and nephrology.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Jieyan Wang, Yingling Wang, Shihan He, Zhu Wang, Qiong Deng, Hui Liang
Summary: Inhibition of proteasomes by MG132 leads to macrophage apoptosis by promoting ROS production and mitochondrial dysfunction.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
Article
Andrology
Qiong Deng, Zhu Wang, Ye Du, Ying Zhang, Hui Liang
Summary: The study verified that Pebp1 is a target gene regulated by androgens and AR in mouse Sertoli cells, with effective androgen-responsive elements (AREs) in the promotor of the Pepb1 gene. Pebp1 is expressed at all stages of testicular development in mice, showing an increasing trend in expression from 1 to 8 weeks postnatal.
SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Qiong Deng, Zhu Wang, Jieyan Wang, Jianwen Zhang, Ying Zhang, Hui Liang
Summary: This study investigated the association between gut microbiome and renal stone formation, and found that the gut microbiome plays an important role in the occurrence and development of kidney stones. These findings may provide new insights for the prevention, diagnosis and treatment of renal stones.
LETTERS IN APPLIED MICROBIOLOGY
(2022)
Article
Cell & Tissue Engineering
Weijie Gao, Yuliang Wang, Shan Yu, Zhu Wang, Taiyang Ma, Andrew Man-Lok Chan, Peter Ka-Fung Chiu, Chi-Fai Ng, Dinglan Wu, Franky Leung Chan
Summary: The NOS-NO signaling pathway plays a significant role in the growth regulation of prostate cancer stem-like cells and the development of metastatic castration-resistant prostate cancer.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Medicine, Research & Experimental
Zi-Hao Feng, Yan-Ping Liang, Jun-Jie Cen, Hao-Hua Yao, Hai-Shan Lin, Jia-Ying Li, Hui Liang, Zhu Wang, Qiong Deng, Jia-Zheng Cao, Yong Huang, Jin-Huan Wei, Jun-Hang Luo, Wei Chen, Zhen-Hua Chen
Summary: In this study, an m6A-immune-related lncRNA risk model was established, which can be used to predict prognosis, immune landscape, and chemotherapeutic response in bladder cancer.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Zhu Wang, Qiong Deng, Yanli Gu, Min Li, Ying Zhang, Qiyi Hu, Shenping Zhang, Xisheng Wang, Hui Liang
Summary: This study investigated the gene expression changes in the kidney of a rat model with kidney stones. The results showed dysregulated genes related to injury, apoptosis, immune response, solute carriers, transporters, and metabolic factors. These findings contribute to a better understanding of the pathogenesis of nephrolithiasis and could potentially lead to the development of new strategies for prevention and treatment.
Article
Andrology
Zhiping Tan, Zhenhua Chen, Gaoshen Yao, Mukhtar Adan Mumin, Yinghan Wang, Jiangquan Zhu, Quanhui Xu, Wei Chen, Hui Liang, Zhu Wang, Qiong Deng, Junhang Luo, Jinhuan Wei, Jiazheng Cao
Summary: A retrospective cohort study compared the effectiveness of neoadjuvant chemotherapy (NAC) versus adjuvant chemotherapy (AC) in the management of muscle invasive bladder cancer (MIBC). The study found that NAC and AC had similar treatment efficacy. However, further validation from large-scale randomized trials is needed to confirm these findings.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2023)