Exosomal miR-155 from M1-polarized macrophages promotes EndoMT and impairs mitochondrial function via activating NF-κB signaling pathway in vascular endothelial cells after traumatic spinal cord injury

Exosome-shuttled miR-216a-5p from hypoxic preconditioned mesenchymal stem cells repair traumatic spinal cord injury by shifting microglial M1/M2 polarization

(2020) Wei Liu et al.   Journal of Neuroinflammation

Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

(2020) Xiang Zhou et al.   NATURE NEUROSCIENCE

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

The Stroke-Induced Blood-Brain Barrier Disruption: Current Progress of Inspection Technique, Mechanism, and Therapeutic Target

(2020) Takeshi Okada et al.   Current Neuropharmacology

Angiopoietin-2 blockade ameliorates autoimmune neuroinflammation by inhibiting leukocyte recruitment into the CNS

(2020) Zhilin Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

MicroRNA-421-3p-abundant small extracellular vesicles derived from M2 bone marrow-derived macrophages attenuate apoptosis and promote motor function recovery via inhibition of mTOR in spinal cord injury

(2020) Jiaxing Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Zeb2 Is a Regulator of Astrogliosis and Functional Recovery after CNS Injury

(2020) Ana L. Vivinetto et al.   Cell Reports

Neuron-derived exosomes-transmitted miR-124-3p protect traumatically injured spinal cord by suppressing the activation of neurotoxic microglia and astrocytes

(2020) Dongdong Jiang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury

(2019) Tian Zhou et al.   NATURE NEUROSCIENCE

Microglia are an essential component of the neuroprotective scar that forms after spinal cord injury

(2019) Victor Bellver-Landete et al.   Nature Communications

The origin, fate, and contribution of macrophages to spinal cord injury pathology

(2019) Lindsay M. Milich et al.   ACTA NEUROPATHOLOGICA

Endothelial-to-Mesenchymal Transition

(2019) Joyce Bischoff   CIRCULATION RESEARCH

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

(2019) Kazu Kobayakawa et al.   Science Advances

RNA binding protein HuD contributes to β-cell dysfunction by impairing mitochondria dynamics

(2019) Youlim Hong et al.   CELL DEATH AND DIFFERENTIATION

Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease

(2019) Marcelo A. Mori et al.   Cell Metabolism

Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

(2019) Koichiro Haruwaka et al.   Nature Communications

Simultaneous Blood–Brain Barrier Crossing and Protection for Stroke Treatment Based on Edaravone-Loaded Ceria Nanoparticles

(2018) Qunqun Bao et al.   ACS Nano

Exosomes derived from bone mesenchymal stem cells repair traumatic spinal cord injury via suppressing the activation of A1 neurotoxic reactive astrocytes

(2018) Wei Liu et al.   JOURNAL OF NEUROTRAUMA

A Metabolic Basis for Endothelial-to-Mesenchymal Transition

(2018) Jianhua Xiong et al.   MOLECULAR CELL

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons

(2018) Arnau Hervera et al.   NATURE CELL BIOLOGY

Distinct myeloid cell subsets promote meningeal remodeling and vascular repair after mild traumatic brain injury

(2018) Matthew V. Russo et al.   NATURE IMMUNOLOGY

Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury

(2018) Yi Yang et al.   NEUROBIOLOGY OF DISEASE

The Biology of Regeneration Failure and Success After Spinal Cord Injury

(2018) Amanda Phuong Tran et al.   PHYSIOLOGICAL REVIEWS

Endothelial pyruvate kinase M2 maintains vascular integrity

(2018) Boa Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Increased macrophages and changed brain endothelial cell gene expression in the frontal cortex of people with schizophrenia displaying inflammation

(2018) Helen Q. Cai et al.   MOLECULAR PSYCHIATRY

Insights into the Evolution of the Suppressors of Cytokine Signaling (SOCS) Gene Family in Vertebrates

(2018) Bei Wang et al.   MOLECULAR BIOLOGY AND EVOLUTION

Macrophage-Derived mir-155-Containing Exosomes Suppress Fibroblast Proliferation and Promote Fibroblast Inflammation during Cardiac Injury

(2017) Chunxiao Wang et al.   MOLECULAR THERAPY

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

(2016) Mireille Khacho et al.   Cell Stem Cell

Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells

(2016) Anitha K. Shenoy et al.   JOURNAL OF CLINICAL INVESTIGATION

c-Met–mediated endothelial plasticity drives aberrant vascularization and chemoresistance in glioblastoma

(2016) Menggui Huang et al.   JOURNAL OF CLINICAL INVESTIGATION

Perivascular macrophages mediate the neurovascular and cognitive dysfunction associated with hypertension

(2016) Giuseppe Faraco et al.   JOURNAL OF CLINICAL INVESTIGATION

The pro-inflammatory effects of miR-155 promote liver fibrosis and alcohol-induced steatohepatitis

(2016) Shashi Bala et al.   JOURNAL OF HEPATOLOGY

miR-155 Deletion in Mice Overcomes Neuron-Intrinsic and Neuron-Extrinsic Barriers to Spinal Cord Repair

(2016) A. D. Gaudet et al.   JOURNAL OF NEUROSCIENCE

The ubiquitin-proteasome system regulates focal adhesions at the leading edge of migrating cells

(2016) Anjali Teckchandani et al.   eLife

TNF and Increased Intracellular Iron Alter Macrophage Polarization to a Detrimental M1 Phenotype in the Injured Spinal Cord

(2015) Antje Kroner et al.   NEURON

Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

(2015) J. Ruschel et al.   SCIENCE

Melatonin attenuates inflammatory response-induced brain edema in early brain injury following a subarachnoid hemorrhage: a possible role for the regulation of pro-inflammatory cytokines

(2014) Jingyin Chen et al.   JOURNAL OF PINEAL RESEARCH

Fluoxetine inhibits matrix metalloprotease activation and prevents disruption of blood–spinal cord barrier after spinal cord injury

(2012) Jee Y. Lee et al.   BRAIN

FGF Regulates TGF-β Signaling and Endothelial-to-Mesenchymal Transition via Control of let-7 miRNA Expression

(2012) Pei-Yu Chen et al.   Cell Reports

The blood-spinal cord barrier: Morphology and Clinical Implications

(2011) Viktor Bartanusz et al.   ANNALS OF NEUROLOGY

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Particulate matter air pollution causes oxidant-mediated increase in gut permeability in mice

(2011) Ece A Mutlu et al.   Particle and Fibre Toxicology

Animal Models in Spinal Cord Injury: A Review

(2011) A.Z. Akhtar et al.   REVIEWS IN THE NEUROSCIENCES

Quantitative analysis of cellular inflammation after traumatic spinal cord injury: evidence for a multiphasic inflammatory response in the acute to chronic environment

(2010) Kevin D. Beck et al.   BRAIN

Suppressor of cytokine signaling 1 (SOCS1) limits NFκB signaling by decreasing p65 stability within the cell nucleus

(2010) Julia Strebovsky et al.   FASEB JOURNAL

Identification of Two Distinct Macrophage Subsets with Divergent Effects Causing either Neurotoxicity or Regeneration in the Injured Mouse Spinal Cord

(2009) K. A. Kigerl et al.   JOURNAL OF NEUROSCIENCE

Decreased junctional adhesion molecule-A expression during blood–brain barrier breakdown

(2008) Dennis Yeung et al.   ACTA NEUROPATHOLOGICA