The pregnane X receptor drives sexually dimorphic hepatic changes in lipid and xenobiotic metabolism in response to gut microbiota in mice

Gut-Resident Lactobacilli Activate Hepatic Nrf2 and Protect Against Oxidative Liver Injury

(2020) Bejan J. Saeedi et al.   Cell Metabolism

Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues

(2020) Camila M. Lopes-Ramos et al.   Cell Reports

DIABLO: an integrative approach for identifying key molecular drivers from multi-omic assays

(2019) Amrit Singh et al.   BIOINFORMATICS

Fructose malabsorption induces cholecystokinin expression in the ileum and cecum by changing microbiota composition and metabolism

(2019) Xufei Zhang et al.   FASEB JOURNAL

Sex-specific association between gut microbiome and fat distribution

(2019) Yan Min et al.   Nature Communications

The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation

(2019) Vivek Krishna Pulakazhi Venu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Microbiota-driven gut vascular barrier disruption is a prerequisite for non-alcoholic steatohepatitis development

(2019) Juliette Mouries et al.   JOURNAL OF HEPATOLOGY

Molecular phenomics and metagenomics of hepatic steatosis in non-diabetic obese women

(2018) Lesley Hoyles et al.   NATURE MEDICINE

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice

(2018) Alida Kindt et al.   Nature Communications

The Mouse Microbiome Is Required for Sex-Specific Diurnal Rhythms of Gene Expression and Metabolism

(2018) Benjamin D. Weger et al.   Cell Metabolism

Mechanisms and Clinical Significance of Pharmacokinetic-Based Drug-Drug Interactions with Drugs Approved by the U.S. Food and Drug Administration in 2017

(2018) Jingjing Yu et al.   DRUG METABOLISM AND DISPOSITION

BioJupies: Automated Generation of Interactive Notebooks for RNA-Seq Data Analysis in the Cloud

(2018) Denis Torre et al.   Cell Systems

Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease

(2017) Chris Estes et al.   HEPATOLOGY

Chemical transformation of xenobiotics by the human gut microbiota

(2017) Nitzan Koppel et al.   SCIENCE

Microbial-Host Co-metabolites Are Prodromal Markers Predicting Phenotypic Heterogeneity in Behavior, Obesity, and Impaired Glucose Tolerance

(2017) Marc-Emmanuel Dumas et al.   Cell Reports

Validation of a microdose probe drug cocktail for clinical drug interaction assessments for drug transporters and CYP3A

(2016) T Prueksaritanont et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

EASL–EASD–EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease

(2016) et al.   DIABETOLOGIA

Gut microbiome and liver diseases

(2016) Herbert Tilg et al.   GUT

Signals from the gut microbiota to distant organs in physiology and disease

(2016) Bjoern O Schroeder et al.   NATURE MEDICINE

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Influence of sex and developmental stage on acute hepatotoxic and inflammatory responses to liver procarcinogens in the mouse

(2016) Daniel Hanna et al.   TOXICOLOGY

Non-alcoholic fatty liver and the gut microbiota

(2016) Stavros Bashiardes et al.   Molecular Metabolism

Hepatic circadian clock oscillators and nuclear receptors integrate microbiome-derived signals

(2016) Alexandra Montagner et al.   Scientific Reports

CrossNorm: a novel normalization strategy for microarray data in cancers

(2016) Lixin Cheng et al.   Scientific Reports

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

(2015) Vishal Singh et al.   Cell Metabolism

Antibiotics promote inflammation through the translocation of native commensal colonic bacteria

(2015) Kathryn A Knoop et al.   GUT

The gut microbiota modulates host amino acid and glutathione metabolism in mice

(2015) A. Mardinoglu et al.   Molecular Systems Biology

Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome

(2015) Benoit Chassaing et al.   NATURE

The Characterization of Novel Tissue Microbiota Using an Optimized 16S Metagenomic Sequencing Pipeline

(2015) Jérôme Lluch et al.   PLoS One

Microbial Determinants of Biochemical Individuality and Their Impact on Toxicology and Pharmacology

(2014) Andrew D. Patterson et al.   Cell Metabolism

Symbiotic Bacterial Metabolites Regulate Gastrointestinal Barrier Function via the Xenobiotic Sensor PXR and Toll-like Receptor 4

(2014) Madhukumar Venkatesh et al.   IMMUNITY

Host-microbial interactions in the metabolism of therapeutic and diet-derived xenobiotics

(2014) Rachel N. Carmody et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Minireview: Gut Microbiota: The Neglected Endocrine Organ

(2014) Gerard Clarke et al.   MOLECULAR ENDOCRINOLOGY

Artificial sweeteners induce glucose intolerance by altering the gut microbiota

(2014) Jotham Suez et al.   NATURE

Sex Differences in the Circadian Variation of Cytochrome P450 Genes and Corresponding Nuclear Receptors in Mouse Liver

(2013) Yuan-Fu Lu et al.   CHRONOBIOLOGY INTERNATIONAL

Intestinal microbiota in patients with nonalcoholic fatty liver disease

(2013) Marialena Mouzaki et al.   HEPATOLOGY

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma

(2012) Hashem B. El-Serag   GASTROENTEROLOGY

Intestinal microbiota determines development of non-alcoholic fatty liver disease in mice

(2012) Tiphaine Le Roy et al.   GUT

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH

(2012) Lixin Zhu et al.   HEPATOLOGY

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88

(2011) Erik Larsson et al.   GUT

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Liganded pregnane X receptor represses the human sulfotransferase SULT1E1 promoter through disrupting its chromatin structure

(2011) Susumu Kodama et al.   NUCLEIC ACIDS RESEARCH

Colonization-Induced Host-Gut Microbial Metabolic Interaction

(2011) S. P. Claus et al.   mBio

Pregnane X Receptor as a Therapeutic Target to Inhibit Androgen Activity

(2010) Bin Zhang et al.   ENDOCRINOLOGY

integrOmics: an R package to unravel relationships between two omics datasets

(2009) Kim-Anh Lê Cao et al.   BIOINFORMATICS

Sumoylated PPARα mediates sex-specific gene repression and protects the liver from estrogen-induced toxicity in mice

(2009) Nicolas Leuenberger et al.   JOURNAL OF CLINICAL INVESTIGATION

Intestinal Microbiota Regulate Xenobiotic Metabolism in the Liver

(2009) Britta Björkholm et al.   PLoS One