Article
Biochemistry & Molecular Biology
Federica Papaccio, Daniela Kovacs, Barbara Bellei, Silvia Caputo, Emilia Migliano, Carlo Cota, Mauro Picardo
Summary: Research indicates that cancer-associated fibroblasts play significant roles in tumor growth, extracellular matrix remodeling, and inflammatory response. A thorough understanding of the melanoma-fibroblast relationship can expand treatment options.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Nadiah Abu, Nurul Ainaa Adilah Rus Bakarurraini
Summary: The interdependency between cancer cells and immune cells is crucial to understanding cancer pathogenesis. Extracellular vesicles (EVs) released by both cancer and immune cells act as messengers in this process. Tumor-derived EVs have been found to interact with immune cells, especially T cells, while T cell-derived EVs also play immunomodulatory roles. This mini-review aims to explore the impact of tumor-derived EVs and T cell-derived EVs on cancer immunosuppression, highlighting the interplay between different types of EVs and their effects on tumor immunity. The role of EVs in various types of T cells, including CD8(+), CD4(+) Th17, and Treg cells, is also discussed. Furthermore, limitations and future directions regarding this research are addressed, contributing to a better understanding of the functions of these tiny mediators.
Article
Engineering, Biomedical
Hyosuk Kim, Hyun-Ju Park, Hyo Won Chang, Ji Hyun Back, Su Jin Lee, Yae Eun Park, Eun Hye Kim, Yeonsun Hong, Gijung Kwak, Ick Chan Kwon, Ji Eun Lee, Yoon Se Lee, Sang Yoon Kim, Yoosoo Yang, Sun Hwa Kim
Summary: The highly immunosuppressive tumor microenvironment with protumoral immune cells accelerates malignant transformation and treatment resistance. Tumor-associated macrophages (TAMs), as the predominant immune cells in tumors, play a crucial role in regulating the immunosuppressive tumor microenvironment. This study explores an exosome-guided direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type macrophages, potentially enhancing antitumor immunity.
BIOACTIVE MATERIALS
(2023)
Review
Pharmacology & Pharmacy
Srijan Dubey, Sayak Ghosh, Debosmita Goswami, Debapriya Ghatak, Rudranil De
Summary: Macrophages are immune cells that can engulf and destroy target cells, including tumor cells. Some macrophages undergo a change to become polarized M2 macrophages while devouring cancer cells. M2 macrophages play important roles in metastasis, tumor suppression, and angiogenesis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Yuhan Zhang, Yan Chen, Lei Shi, Jie Li, Wenjuan Wan, Bowen Li, Doudou Liu, Xiaoshuang Li, Yuting Chen, Meng Xiang, Hao Chen, Bin Zeng, H. Rosie Xing, Jianyu Wang
Summary: The study demonstrates that extracellular vesicles (EVs) mediate the intercellular communication between melanoma stem cells (MSCs) and melanoma parental cells (MPCs), promoting metastasis through the miR-592/PTPN7/MAPK axis.
CELL DEATH DISCOVERY
(2022)
Review
Cell Biology
Zhengshuo Li, Xiaoyue Zhang, Can Liu, Jian Ma
Summary: Genetic susceptibility factors, immune microenvironment, and microbial factors interact to contribute to gastrointestinal tumorigenesis. The suppressive immune microenvironment reshaped by tumors directly leads to T-cell depletion in tumor immunotherapy. Soluble factors secreted by tumor or stromal cells collectively shape the suppressive immune environment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Jiali Yao, Yingrui Chen, Zhijie Lin
Summary: The tumor microenvironment (TME) plays a critical role in the development and progression of colorectal cancer (CRC), with signaling molecules promoting tumor angiogenesis and immune escape. Exosomes, as messengers between tumor and host cells, are considered key mediators in the tumor-promoting TME. However, the exosome-mediated communication networks in the CRC microenvironment are still unclear.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Biochemistry & Molecular Biology
Andrew E. Massey, Shabnam Malik, Mohammad Sikander, Kyle A. Doxtater, Manish K. Tripathi, Sheema Khan, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan, Bilal B. Hafeez
Summary: This review discusses the common isolation and loading methods of exosomes, their major roles in the tumor microenvironment, as well as recent applications of exosomes as drug delivery vessels and the resulting clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Tanghua Li, Jiapeng Jiao, Haoteng Ke, Wenshan Ouyang, Luobin Wang, Jin Pan, Xin Li
Summary: Despite improved treatment methods, hepatocellular carcinoma (HCC) still has a high mortality rate. Recent studies have shown the potential of immunotherapy in cancer treatment. Exosomes play a role in regulating the immune system in HCC, and understanding their role can improve the effectiveness of immunotherapy. Engineered exosomes can deliver drugs and RNA molecules to regulate the immune microenvironment of HCC, improving the mortality rate. This study aims to declare the role of exosomes in HCC and provide potential treatment options for clinical transformation therapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Nadiah Abu, Nurul Ainaa Adilah Rus Bakarurraini, Siti Nurmi Nasir
Summary: Certain cancer therapies may induce immunogenic cell death that promotes tumor progression. The release of damage-associated molecular patterns (DAMPs) upon cell death induces an inflammatory response, but the mechanisms behind DAMPs release and activity require further investigation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Moran Yang, Jiaqi Lu, Guodong Zhang, Yiying Wang, Mengdi He, Qing Xu, Congjian Xu, Haiou Liu
Summary: This study reveals the critical role of CXCL13 in shaping the antitumor microenvironment by facilitating the maintenance of CXCR5(+)CD8(+) T cells in TLSs, and supports a clinical investigation for a combination of CXCL13 and PD-1 blockade therapy in HGSC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Oncology
Jing Li, Yan Zhang, Bing Luo
Summary: Oncogenic viral infection can affect the tumor microenvironment through exosomes, promoting tumor progression. Exosomes are extracellular membrane vesicles that contain lipids, nucleic acids, and proteins, and they can exchange information between cells. Many studies have shown that various tumor-associated viruses can exert their biological functions through exosomes.
Article
Cell Biology
Qi Lou, Minyi Zhao, Quanhui Xu, Siyu Xie, Yingying Liang, Jian Chen, Lisha Yuan, Lingling Wang, Linjia Jiang, Lisha Mou, Dongjun Lin, Meng Zhao
Summary: This study found that interleukin 17 (IL-17) cooperating with interferon gamma can transform bone marrow mesenchymal stem/stromal cells (BMSCs) into tumor-associated MSCs (TA-MSCs), promoting tumor progression. Retinoic acid inhibits the NF-κB signaling pathway to regulate the function of TA-MSCs and inhibit tumor growth.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
XuLing Ji, Xiaoxia Huang, Chao Li, Ningning Guan, Tingting Pan, Jing Dong, Lin Li
Summary: Macrophages are immune cells that can differentiate and exert either pro-tumor or tumor-suppressive effects in breast tumors by secreting cytokines. Tumor cell pyroptosis can activate anti-tumor immunity, recruit tumor-associated macrophages, and inhibit tumor growth. This paper describes the mechanism of tumor-associated macrophages in affecting breast tumor cell pyroptosis and emphasizes their crucial role in the tumor microenvironment. It provides a basis for further research on using immune cells to impact breast tumors and guide anti-tumor strategies, with important implications for breast tumor prevention and treatment.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Zhengjun Zhou, Pengcheng Wang, Rongqi Sun, Jia Li, Zhiqiang Hu, Haoyang Xin, Chubin Luo, Jian Zhou, Jia Fan, Shaolai Zhou
Summary: The interaction between TANs and TAMs enhances the proliferation and invasion abilities of ICC cells, promoting ICC progression. They can produce Oncostatin M and interleukin-11 in co-culture, activating STAT3 signaling in ICC cells, and silencing STAT3 can disrupt the pro-tumor effect of TANs and TAMs on ICC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)