Article
Cell Biology
Hengtao Xie, Yingying Chen, Wei Wu, Xiaobo Feng, Kairong Du
Summary: The study found that GBP treatment enhanced paw withdrawal latency and threshold in rats, restored Vin-induced sciatic nerve damage, and attenuated the increase of proinflammatory cytokine levels. GBP also downregulated the mRNA levels of inflammatory cytokines in the nerves and enhanced SIRT1 activity. This suggests that GBP has a potential protective effect against chemotherapy-induced neuropathic pain through inhibition of neuroinflammation.
MEDIATORS OF INFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Arthur Neuberger, Kirill D. Nadezhdin, Alexander I. Sobolevsky
Summary: TRPV6 is a calcium-selective ion channel with potential as a drug target. The study presents cryo-EM structures of TRPV6 with inhibitors ruthenium red and econazole, revealing their mechanisms of inhibition. Both inhibitors induce conformational changes in TRPV6, guiding the design of new inhibitors.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Rajdeep Chakraborty, Karen Vickery, Charbel Darido, Shoba Ranganathan, Honghua Hu
Summary: Oral cancer is a global health issue with low survival rates, and bacterial antigens may interfere with the effectiveness of capsaicin in treating oral cancer cells. Capsaicin's anti-cancer effects on oral cancer cells are significantly reduced by bacterial antigens, suggesting a need for clinical consideration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jose Ignacio Veytia-Bucheli, Den Alejandro Alvarado-Velazquez, Lourival Domingos Possani, Roberto Gonzalez-Amaro, Yvonne Rosenstein
Summary: Verapamil, a Ca2+ channel blocker, inhibits T cell activation and reduces cytokine production, suggesting its potential relevance in patients receiving CCBs.
Article
Biochemistry & Molecular Biology
Lu Feng, Chen Li, Lin-Wen Zeng, Deng Gao, Yu-Hao Sun, Li Zhong, Heng Lin, Hong-Bing Shu, Shu Li
Summary: This study reveals that the plasma membrane-associated E3 ubiquitin ligase MARCH3 negatively regulates IL-3-triggered signaling. MARCH3 is associated with IL-3R alpha, promoting its degradation and inhibiting IL-3-induced physiological functions and inflammatory diseases. MARCH3 deficiency aggravates IL-3-amplified expression of inflammatory cytokines, organ damage, and inflammatory death in sepsis.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Article
Oncology
Jianru Chen, Weinan Guo, Pengran Du, Tingting Cui, Yuqi Yang, Yinghan Wang, Pan Kang, Zhe Zhang, Qi Wang, Zhubiao Ye, Ling Liu, Zhe Jian, Tianwen Gao, Huijie Bian, Shuli Li, Chunying Li
Summary: This study found that MIF is overabundant in vitiligo patients and a mouse model for human vitiligo. Inhibiting MIF can ameliorate vitiligo progression by suppressing the infiltration of CD8(+) T cells and protecting epidermal melanocytes. This suggests that MIF may be a potential target for vitiligo treatment.
JOURNAL OF PATHOLOGY
(2023)
Article
Oncology
Rui Li, Ramin Salehi-Rad, William Crosson, Milica Momcilovic, Raymond J. Lim, Stephanie L. Ong, Zi Ling Huang, Tianhao Zhang, Jensen Abascal, Camelia Dumitras, Zhe Jing, Stacy J. Park, Kostyantyn Krysan, David B. Shackelford, Linh M. Tran, Bin Liu, Steven M. Dubinett
Summary: Loss of LKB1 leads to increased secretion of ELR+ CXC chemokines in NSCLC, promoting the enrichment of G-MDSCs and immunosuppression. Treatment with ATRA enhances tumor sensitivity to PD-1 blockade, suggesting a potential strategy for overcoming immunotherapy resistance in LKB1-deficient NSCLC.
Article
Biochemistry & Molecular Biology
Tristen Hewitt, Beguem Alural, Manali Tilak, Jennifer Wang, Natalina Becke, Ellis Chartley, Melissa Perreault, Stephen J. Haggarty, Steven D. Sheridan, Roy H. Perlis, Nina Jones, Nikolaos Mellios, Jasmin Lalonde
Summary: Research has found abnormal calcium signaling and neural development in bipolar disorder (BD) patient induced pluripotent stem cell-derived neural progenitor cells (BD-NPCs) and neurons. BD-NPCs showed attenuated store-operated calcium entry (SOCE) and accelerated neurodifferentiation. They also exhibited slower proliferation, increased neurite outgrowth, and decreased neurosphere formation, as well as decreased subventricular areas in developing BD cerebral organoids. BD-NPCs had high expression of the let-7 family and BD neurons had increased miR-34a, both of which are microRNAs implicated in neurodevelopment and BD etiology.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Zhaowei Chen, Binjie Li, Ren-Zhi Zhan, Lingjun Rao, Nenad Bursac
Summary: In this study, the effects of exercise-mimetic electrical stimulation (E-stim) on interferon-gamma (IFN-γ)-induced muscle weakness were investigated using an in vitro tissue-engineered model of human skeletal muscle (myobundle). The results showed that E-stim attenuated IFN-γ-induced muscle wasting and weakness, in part by down-regulating the JAK/STAT signaling pathway amplified by IFN-γ. These findings reveal a previously unknown mechanism of the cell-autonomous anti-inflammatory effects of muscle exercise.
Article
Psychiatry
Rasmon Kalayasiri, Kanokwan Dadwat, Supaksorn Thika, Sunee Sirivichayakul, Michael Maes
Summary: There are only a few studies on the immunological profiles of methamphetamine use, dependence, and induced psychosis. This study found that long-term methamphetamine use has a strong immunosuppressive impact on all immunological profiles. Methamphetamine use is associated with a combination of suppressed immune response and increased pro-inflammatory cytokines. Methamphetamine dependence is linked to increased immunosuppression and decreased stem cell factor levels. Methamphetamine-induced psychosis is related to significant decreases in all immunological profiles and increased pro-inflammatory cytokine signaling. The widespread immunosuppression caused by methamphetamine use may increase the risk of infectious and immune-related diseases.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Cell Biology
Shridhar Sanghvi, Kalina Szteyn, Devasena Ponnalagu, Divya Sridharan, Alexender Lam, Inderjot Hansra, Ankur Chaudhury, Uddalak Majumdar, Andrew R. Kohut, Shubha Gururaja Rao, Mahmood Khan, Vidu Garg, Harpreet Singh
Summary: This study reveals the presence of BKCa channels in the plasma membrane and mitochondria of neonatal murine and rodent cardiomyocytes, and demonstrates their protective effect on the heart. Inhibition of plasma membrane BKCa channels can protect the neonatal heart from ischemia-reperfusion injury.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Maurish Bukhari, Han Deng, Darren Sipes, Marisa Ruane-Foster, Kayla Purdy, Craig D. Woodworth, Shantanu Sur, Damien S. K. Samways
Summary: This study reveals that elevated cytosolic Ca2+ levels stimulate rapid uptake and nuclear accumulation of a DNA-binding fluorescent dye in cervical cancer cells, dependent on activation of intermediate conductance Ca2+-activated K+ channels. Comparisons between cancerous and healthy cervical epithelial cells show significant differences in functional K+ channel activity, which correlates with the incidence of dye uptake. Activation of these channels sensitizes cancer cells to growth suppressant effects, suggesting potential use of channel activators to enhance penetration of toxins into cancer cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Takashi Takeda, Yuhki Yokoyama, Hidekazu Takahashi, Daisuke Okuzaki, Kaho Asai, Hiroaki Itakura, Norikatsu Miyoshi, Shogo Kobayashi, Mamoru Uemura, Toshitsugu Fujita, Hiroo Ueno, Masaki Mori, Yuichiro Doki, Hodaka Fujii, Hidetoshi Eguchi, Hirofumi Yamamoto
Summary: The study aimed to unravel the regulatory mechanism of the KLF5 gene product in CRC through in vitro methods, revealing that KLF5 protein constructs a core-regulatory circuitry with co-factors in the three-dimensional genome structure and coordinately regulates KLF5 and CCAT1 expression in CRC.
BRITISH JOURNAL OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Yixi Liu, Qun Shao, Heng-Jie Cheng, Tiankai Li, Xiaowei Zhang, Michael F. Callahan, David Herrington, Dalane Kitzman, David Zhao, Che-Ping Cheng
Summary: CaMKII inhibition can improve cardiomyocyte function and [Ca2+](i) regulation in patients with CHF, thereby enhancing the cardiac beta-adrenergic reserve.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2021)
Article
Microbiology
Nathan Klopfenstein, Stephanie L. Brandt, Sydney Castellanos, Matthias Gunzer, Amondrea Blackman, C. Henrique Serezani
Summary: SOCS-1 plays a role in controlling Staphylococcus aureus skin infection and is associated with decreased host defense under hyperglycemic conditions. Blocking SOCS-1 may enhance skin host defense. Furthermore, SOCS-1 inhibition promotes skin host defense by increasing levels of type I interferon.
Review
Biochemistry & Molecular Biology
Szilvia Lukacsi, Bernadett Macsik-Valent, Zsuzsa Nagy-Balo, Kristof G. Kovacs, Kristof Kliment, Zsuzsa Bajtay, Anna Erdei
Review
Immunology
Anna Erdei, Kristof G. Kovacs, Zsuzsa Nagy-Balo, Szilvia Lukacsi, Bernadett Macsik-Valent, Istvan Kurucz, Zsuzsa Bajtay
Summary: Complement is known to regulate antibody responses and additional B cell functions such as cytokine production and antigen presentation. These activities are mediated by receptors interacting with activation fragments of C3, attached to antigens and immune complexes. This review focuses on human B lymphocytes and highlights important differences between human and mouse systems.
IMMUNOLOGY LETTERS
(2021)
