Review
Immunology
Alejandro M. Palma, Mark R. Hanes, Jean S. Marshall
Summary: Mast cells are important immune cells that can greatly influence the generation and activities of B cells through the production of cytokines. They co-localize with B cells in many tissues and regulate the development and antibody production of B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Virology
Thi Thu Phuong Tran, Tuan Hiep Tran, Eric J. Kremer
Summary: Most adults develop long-lived B- and T-cell responses after exposure to various human adenoviruses (HAdVs), protecting them from re-infections by the same HAdV type. However, certain HAdV types may lead to persistent infections, especially when an individual's T-cell response is compromised. Interestingly, patients with B-cell deficiencies do not seem to be at a greater risk of HAdV disease.
Article
Immunology
Luis Felipe Olguin-Contreras, Anna N. Mendler, Grzegorz Popowicz, Bin Hu, Elfriede Noessner
Summary: The study aimed to generate chimeric co-stimulatory switch proteins by fusing intracellular co-stimulatory domains with extracellular protein domains, providing co-stimulation to enhance TCR signaling and facilitate various effects in the tumor environment, showing promising applications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Julio Flores-Gonzalez, Alexia Urban-Solano, Lucero A. Ramon-Luing, Juan Carlos Cancino-Diaz, Araceli Contreras-Rodriguez, Everardo Curiel-Quesada, Rogelio Hernandez-Pando, Leslie Chavez-Galan
Summary: This study evaluated the distribution of circulating B cell subsets in tuberculosis (TB) patients and their response to stimuli from M.tb. The results showed that patients with different types of TB have altered frequencies of circulating B cells. Drug-sensitive and drug-resistant TB patients displayed unique characteristics and produced different levels of cytokines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Marissa Y. Chou, Dan Liu, Jinping An, Ying Xu, Jason G. Cyster
Summary: B cells that bind soluble autoantigens receive chronic signaling via the B cell receptor (signal-1) in the absence of strong costimulatory signals (signal-2), and this leads to their elimination in peripheral tissues. The factors determining the extent of soluble autoantigen-binding B cell elimination are not fully understood. We found that cathepsin B (Ctsb) promotes the elimination of B cells chronically exposed to signal-1. Ctsb acts extracellularly to reduce soluble autoantigen-binding B cell survival and its actions restrain CD40L-dependent pro-survival effects.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Casper Marsman, Dorit Verhoeven, Jana Koers, Theo Rispens, Anja ten Brinke, S. Marieke van Ham, Taco W. Kuijpers
Summary: The present study establishes optimized protocols for B-cell differentiation and Ig secretion in primary human B-cell and PBMC cultures, which require low amounts of cells and are suitable for clinical and research studies on B-cell-mediated diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Stefan Tukaj, Jagoda Mantej, Krzysztof Sitko, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz
Summary: Stress-induced heat shock protein 70 (Hsp70) plays a crucial role in autoimmune processes, with highly immunogenic extracellular Hsp70 activating immune responses and contributing to the development of inflammatory/autoimmune disorders. Anti-Hsp70 autoantibodies are significantly increased in patients with epidermolysis bullosa acquisita (EBA), an autoimmune blistering skin disease, and are positively correlated with pro-inflammatory interferon gamma (IFN-γ) levels. These autoantibodies promote EBA development by enhancing neutrophil infiltration and activating the NF-κB signaling pathway in an IFN-γ-associated manner.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Bingxi Li, Yanjian Yang, Yuan Li, Liting Wu, Siwei Wu, Zijiong Dong, Meng Chen, Fang Liang, Zheng Guo, Bei Wang, Jianmin Ye
Summary: The study identified and characterized the Nile tilapia CD40-like protein, OnCD40, and revealed its important role in the TD immune response, particularly in the expression patterns during B cell activation and differentiation. Furthermore, the study found that the expression level of OnCD40 was higher in IgMhi B cells compared to IgMlo plasma-like B cells.
Article
Immunology
Ran Guo, Wenxuan Wang, Lanzhi Yu, Zhixiang Zhu, Pengfei Tu
Summary: The study showed that CD40L primarily promotes the adaptive immune function of B cells, while BAFF mainly enhances the innate immune function. The differences in regulatory effects were attributed to the modulation of NF-kappa B, ERK1/2, and PI3K-AKT signaling pathways by anti-CD40 and BAFF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Johannes Dirks, Oliver Andres, Luisa Paul, Georgi Manukjan, Harald Schulze, Henner Morbach
Summary: The expression of IgD in human naive B cells has a significant impact on their maturation and Ig selection, shaping the composition of naive B cells and being involved in selecting specific Ig V-H segments for pre-immune Ig repertoire. Naive B cells lacking IgD expression showed decreased responsiveness in vitro to signals from IgM-BCR, TLR7/9, or CD40 pathways. Furthermore, the frequency of IgM(lo/-) B cells lacking IgD was significantly reduced in the mature naive B cell compartment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Sharesta Khoenkhoen, Monika Adori, Dario Solis-Sayago, Juliette Soulier, Jamie Russell, Bruce Beutler, Gabriel K. Pedersen, Gunilla B. Karlsson Hedestam
Summary: Mice lacking the I kappa BNS protein exhibit impaired antibody responses to both T cell-independent and T cell-dependent antigens. Conditional knock-out mice with I kappa BNS ablation specifically in B cells show normal T cell populations and germinal center formation, but still have defective antibody responses to T cell-dependent antigens.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chenqu Suo, Krzysztof Polanski, Emma Dann, Rik G. H. Lindeboom, Roser Vilarrasa-Blasi, Roser Vento-Tormo, Muzlifah Haniffa, Kerstin B. Meyer, Lisa M. Dratva, Zewen Kelvin Tuong, Menna R. Clatworthy, Sarah A. Teichmann
Summary: Dandelion is a computational pipeline for single-cell V(D)J sequence analysis, which improves V(D)J sequence annotation and identifies nonproductive and partially spliced sequences. It enhances the accuracy of predicting human thymic development trajectories and provides insights into the origins of human B1 cells and ILC/NK cell development.
NATURE BIOTECHNOLOGY
(2023)
Article
Allergy
Kimberly A. Dill-McFarland, Justin T. Schwartz, Hongfang Zhao, Baomei Shao, Patricia C. Fulkerson, Matthew C. Altman, Michelle A. Gill
Summary: This study investigated the impact of eosinophils on pDC antiviral interferon responses and found that eosinophils inhibit pDC IFN-alpha secretion and repress basal expression of interferon-stimulated genes. Furthermore, it was observed that pDCs from individuals treated with anti-IL-5/5R alpha therapy exhibited increased IFN-alpha secretion and transcription in response to RV.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Xue Li, Quan Jiang, Guiyu Song, Mahsa Nouri Barkestani, Qianxun Wang, Shaoxun Wang, Matthew Fan, Caodi Fang, Bo Jiang, Justin Johnson, Arnar Geirsson, George Tellides, Jordan S. Pober, Dan Jane-Wit
Summary: The ZFYVE21-Rubicon-RNF34 (ZRR) signaling complex localizes on endosomes and modulates complement-mediated inflammasome activity, promoting the release of IL-1 and tissue injury. The ZRR complex increases the activation of endosome-associated caspase-1, potentially serving as a therapeutic target for attenuating inflammasome-mediated tissue injury.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Franziska Briest, Daniel Noerenberg, Cornelius Hennch, Kenichi Yoshida, Raphael Hablesreiter, Jose Nimo, Daniel Sasca, Marieluise Kirchner, Larry Mansouri, Yoshikage Inoue, Laura Wiegand, Annette M. Staiger, Beatrice Casadei, Penelope Korkolopoulou, January Weiner, Armando Lopez-Guillermo, Arne Warth, Tamas Schneider, Akos Nagy, Wolfram Klapper, Michael Hummel, George Kanellis, Ioannis Anagnostopoulos, Philipp Mertins, Lars Bullinger, Richard Rosenquist, Theodoros P. Vassilakopoulos, German Ott, Seishi Ogawa, Frederik Damm
Summary: Recent exome-wide studies have found frequent somatic mutations in the epigenetic modifier ZNF217 in primary mediastinal B cell lymphoma (PMBCL) and related disorders. The functional consequences of ZNF217 alterations were comprehensively evaluated in PMBCL, and it was found that these alterations led to changes in cytokine and interferon signal transduction, disturbed expression of certain genes, altered cell behavior, and aberrant differentiation. ZNF217 was also discovered to act within a histone modifier complex and interfere with chromatin structure.