Article
Medicine, General & Internal
Yuanting Ye, Naibin Yang, Jingying Zhou, Guoqing Qian, Jinguo Chu
Summary: This case report describes a rare occurrence of disseminated tuberculosis in an immunocompetent male, involving multiple organ systems. The patient initially presented with a hepatic mass detected during a health examination, which led to further imaging and biopsy for diagnosis. The use of metagenomic next-generation sequencing (mNGS) was crucial in confirming the diagnosis, highlighting the importance of considering disseminated TB even in immunocompetent patients.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Abay Atnafu, Kassu Desta, Selfu Girma, Dawit Hailu, Gebeyehu Assefa, Shambel Araya, Dinksira Bekele, Liya Wassie, Kidist Bobosha
Summary: In this study, different methods for diagnosing tuberculosis lymphadenitis (TBLN) in suspected patients were evaluated. The results showed that FNA cytology and RT-PCR were able to identify TBLN cases better than other detection methods, and the combination of FNA cytology and GeneXpert MTB/RIF further improved the diagnostic sensitivity.
Review
Public, Environmental & Occupational Health
Sayyed Gholamreza Mortazavi-Moghaddam, Abdol Sattar Pagheh, Ehsan Ahmadpour, Alacsandra Barac, Azadeh Ebrahimzadeh
Summary: The number of extrapulmonary tuberculosis cases has increased in recent years in Iran. This study aimed to determine the epidemiological status, clinical symptoms, diagnostic methods, and treatment strategies of extrapulmonary tuberculosis, specifically focusing on tuberculosis meningitis and miliary tuberculosis. The study found a higher prevalence of tuberculosis meningitis in certain provinces and identified the common symptoms and diagnostic procedures for both tuberculosis meningitis and miliary tuberculosis. The conventional 6-month treatment approach was used for all participants in the investigations.
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Sabira Tahseen, Atiqa Ambreen, Sheeba Ishtiaq, Faisal M. Khanzada, Nauman Safdar, Lisbet Sviland, Tehmina Mustafa
Summary: This study assessed the value of histological examination in diagnosing tuberculous lymphadenitis (LNTB) and found that combining histology with Xpert can improve the diagnostic rate of LNTB compared to using Xpert alone.
SCIENTIFIC REPORTS
(2022)
Article
Pediatrics
Yellanthoor Ramesh Bhat, Sandesh Kini, Lakshmikanth Halegubbi Karegowda
Summary: The infant likely had congenital tuberculosis, confirmed through CBNAAT testing and ultrasound evaluation, and showed improvement after 12 months of anti-tuberculous treatment.
PAEDIATRICS AND INTERNATIONAL CHILD HEALTH
(2021)
Article
Infectious Diseases
Renata Spener-Gomes, Allyson Guimaraes Costa, Hilda Ferreira de Melo, Alexandra Brito de Souza, Francisco Beraldi-Magalhaes, Jaquelane Silva Jesus, Maria B. Arriaga, Afranio Kritski, Izabella Safe, Bruno B. Andrade, Anete Trajman, Marcelo Cordeiro-Santos
Summary: The study evaluated the diagnostic role of respiratory specimen examination in patients with presumptive EPTB, and found that examining respiratory samples can significantly increase the likelihood of bacteriological confirmation of TB. It is recommended that respiratory samples be examined in patients with presumptive EPTB for better diagnosis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Yunzhen Shi, Wanru Guo, Wenjuan Hu, Xiaomeng Li, Yanwan Shangguan, Xuewen Feng, Ming Hu, Jiafeng Xia, Shuting Wang, Jingnan Li, Li Hong, Bin Lu, Kaijin Xu
Summary: Tuberculous aortitis is a rare but high-mortality disease characterized by aortic pseudoaneurysm and arterial wall thickening and stenosis. We report two cases that showed clinical improvement after treatment.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Primary Health Care
Smriti Agrawal, Surya Kant, Vinita Das, Amita Jain, Shambhavi Mishra
Summary: The study found that GeneXpert test in peritoneal fluid did not detect Mycobacterium in infertile women with confirmed genital tuberculosis, indicating it is not a sensitive tool for diagnosis.
JOURNAL OF FAMILY MEDICINE AND PRIMARY CARE
(2021)
Article
Microbiology
Andrea Monserrat Negrete-Paz, Gerardo Vazquez-Marrufo, Ana Gutierrez-Moraga, Ma Soledad Vazquez-Garciduenas
Summary: This study constructed the pangenome of Mycobacterium tuberculosis and identified genes associated with different clinical presentations of tuberculosis. The analysis revealed gene deletions that could lead to metabolic and stress response changes associated with pulmonary or extrapulmonary tuberculosis.
Review
Immunology
Gail B. Cross, Jim O' Doherty, Christina C. Chang, Anthony D. Kelleher, Nicholas Paton
Summary: PET-CT has the potential to revolutionize research in infectious diseases, particularly in tuberculosis clinical trials. It provides real-time information about the spatial distribution and nature of tuberculosis lesions in the lungs, which can aid in drug development and regimen selection. However, there are challenges in using PET-CT as a predictive biomarker of relapse-free cure in phase 2 clinical trials.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Ali H. Baykan, Hakan S. Sayiner, Ibrahim Inan, Elcin Aydin, Sukru M. Erturk
Summary: Breast tuberculosis primarily affects females of reproductive age, with males, postmenopausal women, and pre-pubescent girls being much less affected. The diagnosis of breast tuberculosis relies on clinical examination, radiological evaluations, and histopathological sampling, with other possible diagnoses needing to be ruled out first.
INSIGHTS INTO IMAGING
(2021)
Article
Gastroenterology & Hepatology
Dae-Weung Kim, Soon-Ah Park, Myoung Hyoun Kim
Summary: A 77-year-old woman underwent F-18 FDG PET/CT for evaluation of fever focus. Diffuse and intense hepatosplenic uptake was noted, suggesting lymphoma or tuberculosis. Liver biopsy revealed chronic granulomatous inflammation with Langerhans-type giant cells and necrosis. A follow-up PET/CT after anti-tuberculosis treatment showed resolution of hepatosplenic uptake.
LIVER INTERNATIONAL
(2023)
Review
Multidisciplinary Sciences
Chunnian Ren, Jie Tang, Liangfeng Xia
Summary: This study searched PubMed, Embase, and Cochran databases to obtain literature on the diagnosis of osteoarticular tuberculosis (OATB) by Interferon Gamma Release Assays (IGRA) from database establishment to June 2021. The bivariate random effect model was used to summarize the sensitivity, specificity, and accuracy of IGRA in diagnosing OATB, and forest plots and receiver operating characteristic (ROC) curves were used for testing.
Article
Multidisciplinary Sciences
Awraris Hailu Bilchut, Alemayehu Gonie Mekonnen, Tigist Abetew Assen
Summary: This study found that diagnostic delays among EPTB patients remain high, with both patient and health system delays equally contributing to the overall diagnosis delay. Improving community awareness of EPTB and enhancing diagnostic efficiency in healthcare facilities could help reduce delays.
Article
Immunology
Jin-Chuan Xu, Xia Shi, Xin Ma, Wen-fei Gu, Zhi-xiong Fang, Hui Zhang, Xiao-Yong Fan
Summary: This study aims to compare the diagnostic performance of laboratory assays on ultrasound-guided core needle biopsy samples for the diagnosis of extra-pulmonary tuberculosis (EPTB) in HIV-positive and HIV-negative patients. The results showed that GeneXpert (Xpert) had higher sensitivity in biopsy samples, while T-SPOT.TB (T-SPOT) had higher sensitivity in non-biopsy samples. Regardless of HIV status, Xpert had the highest sensitivity and specificity. Biopsy samples significantly facilitated the accurate diagnosis of extra-pulmonary tuberculosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)