Journal
CRYSTALS
Volume 11, Issue 4, Pages -Publisher
MDPI
DOI: 10.3390/cryst11040353
Keywords
hydroxyapatite; nanocomposites; 3D printing; polymer; hard tissue engineering
Funding
- National Natural Science Foundation of China [31700840]
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This review discusses the use of 3D printing technologies for preparing porous HA-based nanocomposites and explores the properties of HA-based composites synthesized through 3D printing. The article also delves into the applications of HA-based nanocomposites in tissue engineering and potential future developments.
Hydroxyapatite (HA) and HA-based nanocomposites have been recognized as ideal biomaterials in hard tissue engineering because of their compositional similarity to bioapatite. However, the traditional HA-based nanocomposites fabrication techniques still limit the utilization of HA in bone, cartilage, dental, applications, and other fields. In recent years, three-dimensional (3D) printing has been shown to provide a fast, precise, controllable, and scalable fabrication approach for the synthesis of HA-based scaffolds. This review therefore explores available 3D printing technologies for the preparation of porous HA-based nanocomposites. In the present review, different 3D printed HA-based scaffolds composited with natural polymers and/or synthetic polymers are discussed. Furthermore, the desired properties of HA-based composites via 3D printing such as porosity, mechanical properties, biodegradability, and antibacterial properties are extensively explored. Lastly, the applications and the next generation of HA-based nanocomposites for tissue engineering are discussed.
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