Article
Psychology, Developmental
Patricia Camprodon-Boadas, Elena de la Serna, Inmaculada Baeza, Olga Puig, Daniel Ilzarbe, Gisela Sugranyes, Roger Borras, Josefina Castro-Fornieles
Summary: Cognitive reserve plays a crucial role in long-term clinical, neuropsychological, and psychosocial functioning outcomes for patients diagnosed with first-episode psychosis during childhood or adolescence.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Review
Psychology, Multidisciplinary
Francesco Panico, Laura Sagliano, Alfonso Magliacano, Gabriella Santangelo, Luigi Trojano
Summary: This review explores the relationship between Cognitive Reserve (CR) and cognition in adulthood. The results suggest a positive association between CR and almost all cognitive domains. However, limited studies on constructional abilities prevent a clear conclusion in this area.
CURRENT PSYCHOLOGY
(2023)
Article
Clinical Neurology
Ana M. Sanchez-Torres, Silvia Amoretti, Monica Enguita-German, Gisela Mezquida, Lucia Moreno-Izco, Rocio Panadero-Gomez, Lide Rementeria, Alba Toll, Roberto Rodriguez-Jimenez, Alexandra Roldan, Edith Pomarol-Clotet, Angela Ibanez, Judith Usall, Fernando Contreras, Eduard Vieta, Jose M. Lopez-Ilundain, Jessica Merchan-Naranjo, Ana Gonzalez-Pinto, Esther Berrocoso, Miguel Bernardo, Manuel J. Cuesta
Summary: This study aimed to investigate the relationship between relapse, cognitive function, and cognitive reserve in schizophrenia patients. The results showed that higher personal cognitive reserve mitigated the negative effects of relapse on attention performance, while higher cognitive reserve (both personal and familial) improved processing speed and visual memory in patients who did not relapse. These findings provide evidence for the protective effect of cognitive reserve over the course of the illness.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Clinical
Silvia Amoretti, Adriane R. Rosa, Gisela Mezquida, Bibiana Cabrera, Maria Ribeiro, Mariola Molina, Miquel Bioque, Antonio Lobo, Ana Gonzalez-Pinto, David Fraguas, Iluminada Corripio, Eduard Vieta, Elena de la Serna, Laura Morro, Marina Garriga, Carla Torrent, Manuel J. Cuesta, Miguel Bernardo
Summary: This study explored the mediating effects of cognitive reserve on the relationship between cognitive performance, clinical symptoms, and functioning in first-episode psychosis patients. The results showed that cognitive reserve partially mediated the relationship between attention and negative symptoms at baseline and functioning at follow-up, and fully mediated the relationship between verbal memory and functioning at follow-up. The findings highlight the importance of cognitive reserve in understanding the long-term functioning of patients with first-episode psychosis.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Clinical Neurology
V. Bessi, G. Giacomucci, S. Mazzeo, S. Bagnoli, S. Padiglioni, J. Balestrini, G. Tomaiuolo, I. Piaceri, M. Carraro, L. Bracco, S. Sorbi, B. Nacmias
Summary: The study found that the variant of PER2 could affect cognitive reserve and cognition, with PER2 G carriers showing lower premorbid intelligence, fewer years of education, and a lower frequency of family history of AD. In addition, PER2 G carriers performed worse in baseline tests for MCI.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Laura Zamarian, Elfriede Karner, Thomas Bodner, Atbin Djamshidian, Margarete Delazer
Summary: This study reveals the differential effects of education on cognitive performance in older patients with cognitive decline. Higher education is advantageous for verbal memory, executive functions, object naming, and constructional praxis tests, but less beneficial at lower global mental status levels.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Emmi Pentikainen, Lilli Kimppa, Anni Pitkaniemi, Outi Lahti, Teppo Sarkamo
Summary: This study conducted a 2-year follow-up study and found that older adult choir singers showed sustained enhancement in verbal flexibility, but the effects on other verbal skills and quality of life were unclear.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Review
Neurosciences
Nadja Tschentscher, Christian F. J. Woll, Julia C. Tafelmaier, Dominik Kriesche, Julia C. Bucher, Rolf R. Engel, Susanne Karch
Summary: This study reviewed primary research from 2009 to 2022 and found that cognitive impairment is a significant issue in patients with schizophrenia spectrum disorders, affecting multiple cognitive domains. The impairment persists in patients with chronic psychotic disorders and has implications for various disease outcomes such as relationships, employment, and longevity.
Article
Psychiatry
Tapio Paljarvi, Jari Tiihonen, Markku Lahteenvuo, Antti Tanskanen, Seena Fazel, Heidi Taipale
Summary: This study used routine data from nationwide health registers in Finland to estimate the risk of cause-specific mortality in psychotic depression compared with severe non-psychotic depression while controlling for comorbid psychiatric disorders. The results showed that individuals with psychotic depression had a higher risk of all-cause mortality, suicides, and fatal accidents during the subsequent 5-year period after the index diagnosis compared with those with non-psychotic depression. Prompt treatment and enhanced monitoring for psychotic symptoms are necessary to prevent deaths because of suicides and other external causes in patients with severe depression.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Geriatrics & Gerontology
Schwilk Nora, Kloeppel Stefan, Schmidtke Klaus, Metternich Birgitta
Summary: The study aimed to investigate if patients diagnosed with Functional Cognitive Disorder (FCD) face a higher risk of developing dementia. Results showed that FCD patients' cognitive measures remained stable over time, with the majority performing within 1.5 standard deviations and none showing signs of dementia in the 10-year follow-up.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Neurosciences
Jackie M. Poos, Ineke J. M. van der Ham, Anna E. Leeuwis, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Albert Postma
Summary: In this study, a short digital spatial memory test was able to detect object location memory and navigation impairment in patients with mild AD dementia and MCI, highlighting the value of incorporating such a test battery in standard neuropsychological assessment. The results indicated that scene recognition and route continuation were equally impaired in patients with AD dementia and MCI, while route ordering was only impaired in patients with MCI. Weak to moderate correlations were found between route continuation and memory, and between route ordering and attention, but not for the OLMT.
Article
Clinical Neurology
Erin E. Sundermann, Bin Tang, Michelle Kim, Emily W. Paolillo, Robert K. Heaton, Raeanne C. Moore
Summary: This study examined the impact of depression and anxiety, the most common neuropsychiatric symptoms, on cognitive change in persons with HIV (PWH) and compared it to persons without HIV (PWoH). The results showed that depression and anxiety symptoms were more strongly associated with worse cognitive functioning in PWH, particularly in learning and memory, compared to PWoH. These associations seemed to persist for at least one year.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cardiac & Cardiovascular Systems
Syenna H. J. Schievink, Martin P. J. van Boxtel, Kay Deckers, Robert J. van Oostenbrugge, Frans R. J. Verhey, Sebastian Kohler
Summary: This study investigated the impact of cardiovascular disease on cognitive function and found that both prevalent and incident cardiovascular disease can predict cognitive decline in middle-aged individuals. The study also found that the onset of cognitive decline in patients with incident cardiovascular disease is linked to the timing of the vascular event itself.
EUROPEAN HEART JOURNAL
(2022)
Article
Behavioral Sciences
Dana Pourzinal, Jihyun Yang, Kumareshan Sivakumaran, Katie L. McMahon, Leander Mitchell, John D. O'Sullivan, Gerard J. Byrne, Nadeeka N. Dissanayaka
Summary: The dual syndrome hypothesis suggests that Parkinson's disease (PD) can be divided into two cognitive subtypes: a frontal subtype with executive/attention impairment and gradual cognitive decline, and a posterior-cortical subtype with memory/visuospatial deficits and rapid cognitive decline. This study aimed to compare the rate of global cognitive decline between subtypes and explore their performance in specific cognitive domains over time to better understand the prognosis of each subtype.
BRAIN AND BEHAVIOR
(2023)
Article
Psychiatry
Silvia Amoretti, Francisco Diego Rabelo-da-Ponte, Adriane Ribeiro Rosa, Gisela Mezquida, Ana M. Sanchez-Torres, David Fraguas, Bibiana Cabrera, Antonio Lobo, Ana Gonzalez-Pinto, Laura Pina-Camacho, Iluminada Corripio, Eduard Vieta, Carla Torrent, Elena de la Serna, Daniel Berge, Miquel Bioque, Marina Garriga, Maria Serra, Manuel J. Cuesta, Miguel Bernardo
Summary: This study evaluated 114 patients with first-episode psychosis and identified two distinct cognitive subgroups, with some patients showing cognitive improvement after two years of treatment. Cognitive reserve and age of onset were found to be important predictors of cognitive impairment.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Psychology, Developmental
Isabel Valli, Elena De la Serna, Alex G. Segura, Jose C. Pariente, Angels Calvet-Mirabent, Roger Borras, Daniel Ilzarbe, Dolores Moreno, Nuria Martin-Martinez, Inmaculada Baeza, Mireia Rosa-Justicia, Clemente Garcia-Rizo, Covadonga M. Diaz-Caneja, Nicolas A. Crossley, Allan H. Young, Eduard Vieta, Sergi Mas, Josefina Castro-Fornieles, Gisela Sugranyes
Summary: This study examined cognitive function and its clinical, genetic, and brain imaging correlates in youth at family risk for schizophrenia (SZ) and bipolar disorder (BP). Participants were grouped into intact, intermediate, and impaired clusters based on cognitive performance. The impaired cluster showed lower total brain surface area, particularly in the frontal and temporal cortices, and had poorer psychosocial functioning and worse PRS-COG compared to the other clusters and controls.
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
(2023)
Article
Psychology, Clinical
Alex G. Segura, Gisela Mezquida, Albert Martinez-Pinteno, Patricia Gasso, Natalia Rodriguez, Lucia Moreno-Izco, Silvia Amoretti, Miquel Bioque, Antonio Lobo, Ana Gonzalez-Pinto, Alicia Garcia-Alcon, Alexandra Roldan-Bejarano, Eduard Vieta, Elena de la Serna, Alba Toll, Manuel J. Cuesta, Sergi Mas, Miquel Bernardo
Summary: Early intervention is crucial for preventing the progression of psychotic disorders. This study found that genetic susceptibility related to cognitive performance is associated with an increased risk of first-episode psychosis (FEP) and its clinical and cognitive progression. Additionally, genetic susceptibility for depression is associated with a worsening trajectory of executive function and general cognitive status.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Clinical Neurology
Giovanna Fico, Ulker Isayeva, Michele De Prisco, Vincenzo Oliva, Brisa Sole, Laura Montejo, Iria Grande, Nestor Arbelo, Marta Gomez-Ramiro, Luis Pintor, Bernardo Carpiniello, Mirko Manchia, Eduard Vieta, Andrea Murru
Summary: This systematic review and meta-analysis investigates the repurposing of psychotropic drugs in the treatment of COVID-19. The study finds that antidepressants do not significantly affect the risk and mortality of COVID-19, while fluvoxamine may have potential in reducing mortality risk. Antipsychotics may increase the risk of severe COVID-19 and mortality, but their use in psychiatric patients should be evaluated on a case-by-case basis.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Marco Solmi, Giovanni Croatto, Giada Piva, Stella Rosson, Paolo Fusar-Poli, Jose M. Rubio, Andre F. Carvalho, Eduard Vieta, Celso Arango, Nicole R. DeTore, Elizabeth S. Eberlin, Kim T. Mueser, Christoph U. Correll
Summary: Psychosocial interventions play an important role in schizophrenia and early psychosis. However, the literature on this topic is heterogeneous and contradictory. This umbrella review summarizes the findings from multiple meta-analyses comparing the effectiveness of different psychosocial interventions with standard treatment or other active interventions. The results suggest that early intervention services and cognitive behavioral therapy have significant effects on symptom reduction and functional improvement in early psychosis. For schizophrenia patients, cognitive behavioral therapy, psychoeducation, and any family interventions show positive effects on symptom reduction, relapse prevention, and functional improvement.
MOLECULAR PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Giovanni Croatto, Davy Vancampfort, Alessandro Miola, Miriam Olivola, Jess G. Fiedorowicz, Joseph Firth, Ovidiu Alexinschi, Marcel A. Gaina, Vladimir Makkai, Fernanda Cunha Soares, Leandro Cavaliere, Giorgia Vianello, Brendon Stubbs, Paolo Fusar-Poli, Andre F. Carvalho, Eduard Vieta, Samuele Cortese, Jae Il Shin, Christoph U. Correll, Marco Solmi
Summary: People with mood disorders are at increased risk of comorbid medical diseases. Interventions such as psychological therapies, exercise, and certain medications can improve physical health outcomes in mood disorders, but some medications may have negative effects. It is important to consider evidence from other disorders and individual RCTs when prioritizing effective treatments with beneficial or physically neutral profiles.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Alexandra J. M. Beunders, Federica Klaus, Almar A. L. Kok, Sigfried N. T. M. Schouws, Ralph W. Kupka, Hilary P. Blumberg, Farren Briggs, Lisa T. Eyler, Brent P. Forester, Orestes Forlenza, Ariel Gildengers, Esther Jimenez, Benoit H. Mulsant, Regan E. Patrick, Soham Rej, Martha Sajatovic, Kaylee Sarna, Ashley Sutherland, Joy Yala, Eduard Vieta, Luca M. Villa, Nicole C. M. Korten, Annemieke Dols
Summary: This study compared bipolar I disorder (BD-I) and bipolar II disorder (BD-II) in a large, global sample and found no significant differences between the two in terms of general functioning, cognition, and somatic burden. These findings suggest that the distinction between BD-I and BD-II may not be applicable to geriatric bipolar disorder patients.
Article
Clinical Neurology
Ana M. Sanchez-Torres, Silvia Amoretti, Monica Enguita-German, Gisela Mezquida, Lucia Moreno-Izco, Rocio Panadero-Gomez, Lide Rementeria, Alba Toll, Roberto Rodriguez-Jimenez, Alexandra Roldan, Edith Pomarol-Clotet, Angela Ibanez, Judith Usall, Fernando Contreras, Eduard Vieta, Jose M. Lopez-Ilundain, Jessica Merchan-Naranjo, Ana Gonzalez-Pinto, Esther Berrocoso, Miguel Bernardo, Manuel J. Cuesta
Summary: This study aimed to investigate the relationship between relapse, cognitive function, and cognitive reserve in schizophrenia patients. The results showed that higher personal cognitive reserve mitigated the negative effects of relapse on attention performance, while higher cognitive reserve (both personal and familial) improved processing speed and visual memory in patients who did not relapse. These findings provide evidence for the protective effect of cognitive reserve over the course of the illness.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Cristina Saiz-Masvidal, Fernando Contreras, Carles Soriano-Mas, Gisela Mezquida, Covadonga M. Diaz-Caneja, Eduard Vieta, Silvia Amoretti, Antonio Lobo, Ana Gonzalez-Pinto, Joost Janssen, Maria Sague-Vilavella, Josefina Castro-Fornieles, Daniel Berge, Miquel Bioque, Noemi G. Lois, Mara Parellada, Miguel Bernardo
Summary: The study investigates the relationship between structural brain alterations and clinical improvement in first-episode psychosis (FEP). Using structural covariance analysis, the researchers found increased correlation in brain regions involved in multisensory signal processing and bodily self-consciousness in the group that showed clinical improvement.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Psychiatry
Norma Verdolini, Silvia Alonso-Lana, Pilar Salgado-Pineda, Salvador Sarro, Raymond Salvador, Teresa Maristany, Jose M. Goikolea, Caterina M. Bonnin, Ines Martin, Laura Salo, Ana Romaguera, Elena Rodriguez-Cano, Adriane R. Rosa, Eduard Vieta, Edith Pomarol-Clotet
Summary: This study aimed to assess the brain functional correlates of psychosocial functioning in individuals with bipolar disorder during a working memory task. The results revealed differences in brain activation between bipolar patients and healthy controls, particularly in the medial frontal cortex. In addition, the study found inverse correlations between psychosocial functioning and brain activation in several cortical regions, including the frontal, parietal, and temporo-occipital regions.
PSYCHIATRY RESEARCH
(2023)
Editorial Material
Psychiatry
Eduard Vieta
Article
Psychology, Clinical
Adrian I. Campos, Laura S. Van Velzen, Dick J. Veltman, Elena Pozzi, Sonia Ambrogi, Elizabeth D. Ballard, Nerisa Banaj, Zeynep Basgoeze, Sophie Bellow, Francesco Benedetti, Irene Bollettini, Katharina Brosch, Erick J. Canales-Rodriguez, Emily K. Clarke-Rubright, Lejla Colic, Colm G. Connolly, Philippe Courtet, Kathryn R. Cullen, Udo Dannlowski, Maria R. Dauvermann, Christopher G. Davey, Jeremy Deverdun, Katharina Dohm, Tracy Erwin-Grabner, Roberto Goya-Maldonado, Negar Fani, Lydia Fortea, Paola Fuentes-Claramonte, Ali Saffet Gonul, Ian H. Gotlib, Dominik Grotegerd, Mathew A. Harris, Ben J. Harrison, Courtney C. Haswell, Emma L. Hawkins, Dawson Hill, Yoshiyuki Hirano, Tiffany C. Ho, Fabrice Jollant, Tanja Jovanovic, Tilo Kircher, Bonnie Klimes-Dougan, Emmanuelle le Bars, Christine Lochner, Andrew M. McIntosh, Susanne Meinert, Yara Mekawi, Elisa Melloni, Philip Mitchell, Rajendra A. Morey, Akiko Nakagawa, Igor Nenadic, Emilie Olie, Fabricio Pereira, Rachel D. Phillips, Fabrizio Piras, Sara Poletti, Edith Pomarol-Clotet, Joaquim Radua, Kerry J. Ressler, Gloria Roberts, Elena Rodriguez-Cano, Matthew D. Sacchet, Raymond Salvador, Anca-Larisa Sandu, Eiji Shimizu, Aditya Singh, Gianfranco Spalletta, J. Douglas Steele, Dan J. Stein, Frederike Stein, Jennifer S. Stevens, Giana I. Teresi, Aslihan Uyar-Demir, Nic J. van der Wee, Steven J. van der Werff, Sanne J. H. van Rooij, Daniela Vecchio, Norma Verdolini, Eduard Vieta, Gordon D. Waiter, Heather Whalley, Sarah L. Whittle, Tony T. Yang, Carlos A. Zarate Jr, Paul M. Thompson, Neda Jahanshad, Anne-Laura van Harmelen, Hilary P. Blumberg, Lianne Schmaal, Miguel E. Renteria
Summary: A major limitation of current suicide research is the lack of power to identify robust correlates of suicidal thoughts or behavior. Variation in suicide risk assessment instruments used across cohorts may represent a limitation to pooling data in international consortia. Our findings suggest that multi-item instruments provide valuable information on different aspects of suicidal thoughts or behavior but share a modest core factor with single suicidal ideation items. Retrospective, multisite collaborations including distinct instruments should be feasible provided they harmonize across instruments or focus on specific constructs of suicidality.
Article
Psychiatry
Diego Hidalgo-Mazzei, Tim Mantingh, Xavier Perez de Mendiola, Ludovic Samalin, Juan Undurraga, Sergio Strejilevich, Emanuel Severus, Michael Bauer, Ana Gonzalez-Pinto, Willem A. Nolen, Allan H. Young, Eduard Vieta
Summary: A global survey conducted by the ISBD Task Force on the Role of Lithium in Bipolar Disorders revealed potential factors contributing to the decline in lithium prescriptions in the past two decades. The survey received 886 responses from 43 different countries, showing that lithium remains the preferred treatment option for bipolar disorder maintenance (59%), but negative beliefs, acute side effects, tolerability problems, and intoxication risk are reasons for not choosing lithium.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Review
Biochemistry & Molecular Biology
Sourav Khanra, Preethi Reddy, Anna Gimenez-Palomo, Chun Hui J. Park, Bruna Panizzutti, Madeleine McCallum, Shyam Sundar Arumugham, Shreekantiah Umesh, Monojit Debnath, Basudeb Das, Ganesan Venkatasubramanian, Melanie Ashton, Alyna Turner, Olivia M. Dean, Ken Walder, Eduard Vieta, Lakshmi N. Yatham, Isabella Pacchiarotti, Y. C. Janardhan Reddy, Nishant Goyal, Muralidharan Kesavan, Lluc Colomer, Michael Berk, Jee Hyun Kim
Summary: The core feature of bipolar disorder is pathological disturbances in mood, along with disrupted thinking and behavior. Due to its complex and heterogeneous etiology, a range of genetic and environmental factors are involved. This complexity and poorly understood neurobiology make it challenging to develop drugs, resulting in limited treatment options, especially for bipolar depression. Therefore, novel approaches are needed, such as investigating the potential of trimetazidine as a treatment option for bipolar depression.
MOLECULAR PSYCHIATRY
(2023)