Article
Biochemistry & Molecular Biology
Kirti Parwani, Farhin Patel, Dhara Patel, Palash Mandal
Summary: This study discovers the strong antiglycative potential of Swertiamarin (SM), showcasing its ability to reduce oxidative stress, prevent epithelial mesenchymal transition, and decrease the pathogenesis of diabetic nephropathy caused by methylglyoxal (MG) in kidney cells. Additionally, SM downregulates the expression of interleukin-6, tumor necrosis factor-alpha, and interleukin-1 beta in this process.
Review
Biochemistry & Molecular Biology
Qing Yue, Yu Song, Zi Liu, Lin Zhang, Ling Yang, Jinlong Li
Summary: RAGE, as a critical molecule in inflammatory response, binds to various ligands and initiates intracellular signal cascade. It plays a vital role in the occurrence and development of immune-related diseases and has crucial functions in different aspects of life activities. Therefore, targeted intervention in the RAGE signaling pathway may have significant therapeutic potential.
Article
Food Science & Technology
Hee-Weon Lee, Min Ji Gu, Jee-Young Lee, Seungju Lee, Yoonsook Kim, Sang Keun Ha
Summary: The study found that MOLD significantly increases RAGE expression in mouse mesangial cells, leading to ROS production and mitochondrial dysfunction. MOLD activates PI3KB and NF-kappa B signaling pathways, triggering inflammatory responses.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Nutrition & Dietetics
Marco Mouanness, Zaher Merhi
Summary: Advanced glycation end products (AGEs), formed by the reaction between protein and reducing sugars, can impact reproductive health and fertility through inducing inflammation and oxidative stress. This review summarizes the recent data on the pathogenesis of dietary AGEs and their potential impact on female reproductive health and offspring reproduction.
Article
Biochemistry & Molecular Biology
Hee-Weon Lee, Min Ji Gu, Yoonsook Kim, Jee-Young Lee, Seungju Lee, In-Wook Choi, Sang Keun Ha
Summary: This study evaluated the impact of glyoxal-lysine dimer (GOLD) on oxidative damage and inflammatory response in SV40 MES 13 mesangial cells. GOLD increased RAGE expression, reactive oxygen species production, and regulated NRF2 and GLO1 expression. Additionally, GOLD induced mitochondrial deterioration and inflammation through oxidative stress, and regulated MAPK and proinflammatory cytokines release. Inhibition of RAGE using RAGE siRNA suppressed the oxidative stress and inflammatory responses triggered by GOLD, highlighting the importance of the interaction between GOLD and RAGE in mesangial cell function.
Article
Cell Biology
Kalliopi Tzavlaki, Yae Ohata, Anita Moren, Yukihide Watanabe, Jens Eriksson, Maiko Tsuchiya, Yuki Kubo, Kouhei Yamamoto, Mikael E. Sellin, Mitsuyasu Kato, Laia Caja, Carl-Henrik Heldin, Aristidis Moustakas
Summary: LKB1 pathway limits TGF beta-induced epithelial-mesenchymal transition, maintaining mammary epithelial morphogenesis. Downregulation of LKB1 expression in breast cancer is predicted to lead to increased epithelial-mesenchymal transition induced by SNAI1 and TGF beta family members.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Article
Cell Biology
Lei Yang, Baozhu Liang, Jingxin Li, Xiaoyan Zhang, Hong Chen, Jia Sun, Zhen Zhang
Summary: Excessive accumulation of AGEs can impair autophagy on podocytes, while the SGLT2 inhibitor dapagliflozin effectively mitigates AGE-induced podocyte injury by promoting autophagy and regulating the AMPK-mTOR signal pathway.
CELLULAR SIGNALLING
(2022)
Article
Food Science & Technology
Qin Li, Leibing Li, Hanjian Zhu, Fan Yang, Ke Xiao, Lin Zhang, Menglin Zhang, Yongsheng Peng, Chao Wang, Dongsheng Li, Qian Wu, Mengzhou Zhou
Summary: This study investigated the inhibitory activity of lactic acid bacteria (LAB) on advanced glycation end-products (AGEs) during vinegar fermentation. The results showed that LAB strains can inhibit the formation of AGEs by accelerating substrate consumption, improving antioxidant activities, and inhibiting enzyme activities. Moreover, there was a negative correlation between fluorescent AGEs and carboxymethyl lysine (CML)/carboxyethyl lysine (CEL) with antioxidant activities, while enzyme activities were positively correlated with total phenolic content and total flavonoids.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Medicine, Research & Experimental
Omer Faruk Hatipoglu, Eyyup Uctepe, Gabriel Opoku, Hidenori Wake, Kentaro Ikemura, Takashi Ohtsuki, Junko Inagaki, Mehmet Gunduz, Esra Gunduz, Shogo Watanabe, Takashi Nishinaka, Hideo Takahashi, Satoshi Hirohata
Summary: The study demonstrated that knocking down osteopontin (OPN) using small interfering RNA (siRNA) effectively reduced fibrotic areas in a mouse model of pulmonary fibrosis. OPN siRNA treatment also led to a decrease in inflammatory cell count in bronchoalveolar lavage fluid. Furthermore, both in vitro and in vivo experiments showed that OPN downregulation effectively reduced pulmonary fibrosis and epithelial-mesenchymal transition.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Sauradipta Banerjee
Summary: The study characterized MG-modified myoglobin in a time-dependent manner, with mass spectrometric studies indicating modifications at Lys-87 and Lys-133. Far-UV CD studies revealed alterations in protein structure and surface hydrophobicity as a result of MG modification. These findings suggest that MG-derived AGE adducts significantly impact the structure of Mb.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Hyun Hee L. Lee, Sang Keun Ha, Yoonsook Kim, Jinyoung Hur
Summary: A new pre-column derivatization method based on dansylation is proposed to overcome the analytical challenges in identifying and quantifying advanced glycation end products (AGEs). The method allows for the separation of different structural isomers of AGEs with low detection limits and wide linear ranges. The developed method shows potential applicability in various fields of food chemistry and biochemistry.
Article
Biotechnology & Applied Microbiology
Liuyang Ren, Ying Lou, Mingyu Sun
Summary: Evodiamine (EVO) is a novel anti-tumor drug that inhibits cell proliferation and invasion in oral squamous cell carcinoma (OSCC). EVO targets the downstream signaling pathways of AGE/RAGE by affecting RAGE, leading to inhibition of proliferation, invasion, and angiogenesis in OSCC cells.
Article
Biochemistry & Molecular Biology
Pei-Shan Tsai, Chen-Yuan Chiu, Meei-Ling Sheu, Ching-Yao Yang, Kuo-Cheng Lan, Shing-Hwa Liu
Summary: The study found that AGEs can induce EndMT in islet endothelial cells and lead to islet fibrosis in diabetic mice. This suggests that AGE-induced EndMT may contribute to islet fibrosis in diabetes.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Caspar Schiffers, Cheryl van de Wetering, Robert A. Bauer, Aida Habibovic, Milena Hristova, Christopher M. Dustin, Sara Lambrichts, Pamela M. Vacek, Emiel F. M. Wouters, Niki L. Reynaert, Albert van der Vliet
Summary: The downregulation of DUOX1 in the airways of patients with Chronic Obstructive Pulmonary Disease (COPD) may contribute to the pathogenesis of COPD, leading to airway remodeling and emphysema. Animal studies also demonstrate that Duox1 deficiency exacerbates lung pathology induced by smoke exposure.
Article
Obstetrics & Gynecology
Jennifer C. Hutchison, Jemma Evans, Tracey A. Edgell, Guiying Nie, David K. Gardner, Lois A. Salamonsen
Summary: The study found that obese infertile women have elevated levels of advanced glycation end-products (AGE) in their uterine environment. The detrimental effects of AGE on endometrial epithelial cells can be reduced with therapeutics and replicated in a more physiologically relevant primary model (organoids).
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)