Article
Parasitology
Lingqin Wu, Wenhui Yin, Jutai Wen, Shuying Wang, Huihui Li, Xiaoli Wang, Weixiao Zhang, Shuyao Duan, Qiuyu Zhu, Erhe Gao, Shili Wu, Bin Zhan, Rui Zhou, Xiaodi Yang
Summary: The study showed that treatment with Ts-AES significantly improved cardiac function and ventricular remodeling, reduced pathological damage and mortality in mice with MI. This was associated with decreased pro-inflammatory cytokine levels, increased regulatory cytokine expression, and promotion of macrophage polarization from M1 to M2 type in MI mice.
PARASITES & VECTORS
(2023)
Article
Parasitology
Jing Wang, Bin Tang, Xihuo You, Xuepeng Cai, Wanzhong Jia, Xiaolei Liu, Mingyuan Liu, Xuemin Jin, Jing Ding
Summary: This study investigated the effects of Trichinella spiralis' excretory/secretory products (ESP) on the functions of immune cells. The results revealed the evasion and regulation mechanisms employed by the parasite, providing insights into its strategies to manipulate host immunity.
PARASITES & VECTORS
(2023)
Article
Parasitology
Fabrizio Bruschi, Alisa Gruden-Movesijan, Barbara Pinto, Natasa Ilic, Ljiljana Sofronic-Milosavljevic
Summary: This study investigated the effects of products extracted from Trichinella spiralis muscle larvae on the experimental autoimmune encephalomyelitis (EAE) rat model, finding that treatment with ES L1 could alleviate EAE symptoms. Furthermore, lower levels of serum MMP-9 and NGAL/MMP-9 complex were observed in rats treated with ES L1, indicating a potential mechanism for the amelioration of EAE.
EXPERIMENTAL PARASITOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ge Cheng, Zifang Zhang, Yixuan Wang, Youjiao Zao, Ruoqi Wang, Mengying Gao, Miaomiao Feng, Xi Zhang, Peng Jiang
Summary: Trichinella spiralis infection activates the TGF-beta 1/Smad3 pathway, promoting collagen secretion in muscle cells and playing an important role in the formation of collagen capsules. Further investigation is needed to identify the specific components in the Trichinella spiralis ES products that induce collagen synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Parasitology
Sylwia Grzelak, Anna Stachyra, Justyna Bien-Kalinowska
Summary: This study aimed to identify common and species-specific excretory-secretory proteins of T. spiralis and T. britovi adult worms for early diagnosis of Trichinella infection. Through various analyses, several key proteins were identified that could potentially be used for diagnostic purposes.
VETERINARY PARASITOLOGY
(2021)
Article
Microbiology
Chengyao Li, Xue Bai, Xiaolei Liu, Yuanyuan Zhang, Lei Liu, Lixiao Zhang, Fengyan Xu, Yong Yang, Mingyuan Liu
Summary: Through an in vitro cell monolayer model, it was found that the excretory secretory products of Trichinella spiralis muscle larvae can disrupt the host intestinal barrier by reducing the expression of tight junction proteins. This effect is likely mediated via the MAPK signaling pathway, highlighting serine protease as a key factor for invasion by T. spiralis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Veterinary Sciences
Haoxuan Wang, Yingying Zhu, Meichen Li, Jingdan Pan, Dan Li, Wen-Ping Guo, Guangcheng Xie, Luanying Du
Summary: The expression of 2,860 genes in A549 cells was altered by ML-ESPs, with 1,634 upregulated and 1,226 downregulated. GO and KEGG analysis revealed that the differentially expressed genes were mainly associated with cancer pathways and metabolic processes. Among the downregulated genes in the metabolic process interaction network, genes involved in glucose metabolism such as PFKM, PFKL, ENO2, LDHB, 6PGL, PRE, TKT, and TALDO1 were suppressed by ML-ESPs, while TCA-related genes including PDP1, PDP2, ACO1, and OGDH were upregulated.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jingqian Su, Siyuan Chen, Jianbin Xiao, Zhihua Feng, Shan Hu, Qiaofen Su, Qi Chen, Duo Chen
Summary: This study explores the therapeutic potential of aloe-emodin (AE) in the treatment of CLP-induced sepsis, demonstrating its ability to mitigate systemic inflammation and regulate the gut microbiota. The study provides novel insights into the molecular mechanisms underlying the anti-inflammatory effects of AE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Parasitology
Jian Li, Jing Ding, Xiao-Lei Liu, Bin Tang, Xue Bai, Yang Wang, Wei-Dong Qiao, Ming-Yuan Liu, Xue-Lin Wang
Summary: This study successfully developed a rapid and sensitive diagnostic method named UPT-LF-ES assay for detecting anti-T. spiralis IgG antibodies in pig serum, based on UCNPs-ES/goat anti-rabbit IgG probes. The assay showed high sensitivity and specificity, contributing to preventing human trichinellosis effectively.
PARASITES & VECTORS
(2021)
Article
Immunology
Bin Zhang, Feng Zheng, Anpeng Liu, Zhen Li, Fei Zheng, Qiangsheng Liu, Liu Yang, Kai Chen, Yanlin Wang, Zongze Zhang, Qianwen He, Jia Zhan
Summary: Activation of CB2 receptors plays a protective role in sepsis by inhibiting pyroptosis and reducing the release of inflammatory mediators. The protective effect depends on the presence of endogenous CB2 receptors.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Xinyu Wang, Aizhe Li, Ruizhe Wang, Tianji Hou, Huixin Chen, Jing Wang, Mingyuan Liu, Chen Li, Jing Ding
Summary: Trichinellosis is a food-borne parasitic infection caused by consuming raw or semi-raw pork products infected with Trichinella spiralis. A rapid and sensitive on-site diagnostic method using a novel lateral flow immunoassay strip (ICS) was developed to detect T. spiralis-specific IgG antibody in pig serum and whole blood samples. The method was successfully used to investigate Trichinella infection in five provinces of China, and the results correlated with the standard method of artificial digestion.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Jing -Bo Zhen, Jin-Peng Zhang, Feng Sun, Li-Hao Lin, Yu-Heng Zhang, Rui-Biao Wang, Yang Han, Zhi-Xin Li, Yi-Xin Lu
Summary: Allergic asthma, a chronic, heterogeneous, and inflammatory respiratory disease, has limited treatment options. This study focused on the effects of Trichinella spiralis (T. spiralis) excretory-secretory (ES) antigens on allergic asthma. The study used Ts43, Ts49, and Ts53 proteins, important components of ES antigens, to establish ES antigens intervention models in mice. The results showed that ES antigens could alleviate asthma symptoms, weight loss, and lung inflammation, with better effects observed with combined intervention of Ts43, Ts49, and Ts53. Furthermore, the study investigated the changes in Th1 and Th2 immune responses and the differentiation direction of T lymphocytes in mice. The results indicated a decrease in the ratio of CD4+/CD8+ T cells and an increase in the ratio of Th1/Th2 cells. Overall, this study demonstrated that T. spiralis ES antigens could attenuate allergic asthma in mice by altering the differentiation of CD4+ and CD8+ T cells and regulating the Th1/Th2 cell ratio.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Benjamin Hamid, Friederike Ebner, Lalita Bechtold, Arkadi Kundik, Sebastian Rausch, Susanne Hartmann
Summary: The study found that the relative frequencies of DC subsets in porcine blood differ, with A. suum E/S showing differential modulation on different DC subsets, suppressing pDC and cDC1 while upregulating cDC2.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Natasa Ilic, Zanka Bojic-Trbojevic, Britta Lundstroem-Stadelmann, Danica Cujic, Ivana Mitic, Alisa Gruden-Movsesijan
Summary: This study demonstrates the immunomodulatory potential of Trichinella spiralis muscle larvae excretory-secretory products and suggests their possible use as a treatment for inflammatory disorders. The isolated proteins possess galectin-1 properties and induce tolerogenic dendritic cells and regulatory T cells.
Article
Cell Biology
Ana L. Rios-Lopez, Romel Hernandez-Bello, Gloria M. Gonzalez, Alejandro Sanchez-Gonzalez
Summary: The study reveals that Trichinella spiralis excretory-secretory (ES) antigens inhibit the release of NETs by neutrophils, while other antimicrobial functions remain unchanged. This may offer a novel strategy for treating autoimmune pathologies involving NETs formation.
CELLULAR IMMUNOLOGY
(2022)