Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2021.665159
Keywords
depression; gut microbiota; function prediction; Sophora alopecuroides L; alkaloids; CUMS
Categories
Funding
- Research Foundation of Jilin Provincial Science & Technology Committee [20190304026YY, 20200404124YYGH, 20200201135JC]
- Ministry of Industry and Information Technology of Changchun City [2017342]
- Natural Science Foundation of Jilin Province, P. R. China [20180101242JC]
- Systems Biology Research on Genome and Transcriptome of Stem Cells of Jilin Province Sunbird Regenerative Medical Engineering Co., Ltd. [2017030]
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The study showed that Sophora alopecuroides L.-derived alkaloids can improve depression-like behaviors and related indicators, decrease gut microbiota diversity, and deplete harmful microbiota in mice with depression. There is a correlation between specific gut microbiota and depression-related indicators, suggesting that alkaloids may improve depression by modulating gut microbiota.
It was recently shown that the gut microbiota of both depression patients and depression model animals is significantly altered, suggesting that gut microbes are closely related to depression. Here, we investigated the effects of Sophora alopecuroides L.-derived alkaloids on the gut microbiota of mice with depression-like behaviors. We first established a mouse model of depression via chronic unpredictable mild stress (CUMS) and detected changes in depression-like behaviors and depression-related indicators. Simultaneously, 16S rRNA sequencing was performed to investigate gut microbiota changes. Sophora alopecuroides L.-derived alkaloids improved depression-like behaviors and depression-related indicators in mice. The alkaloids decreased the gut microbiota diversity of CUMS mice and depleted intestinal differentially abundant harmful microbiota genera. Spearman analysis showed that there is a certain correlation between the differential microbiota (Lactobacillus, Helicobacter, Oscillospira, Odoribacter, Mucispirillum, Ruminococcus), depression-like behaviors, and depression-related indicators. Combined with the predictive analysis of gut microbiota function, these results indicate that alkaloids improve depression in mice through modulating gut microbiota.
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