Differential methylation EPIC analysis discloses cisplatin-resistance related hypermethylation and tumor-specific heterogeneity within matched primary and metastatic testicular germ cell tumor patient tissue samples

Targeting the Immune system and Epigenetic Landscape of Urological Tumors

(2020) João Lobo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

DNA Methylation-Based Testing in Liquid Biopsies as Detection and Prognostic Biomarkers for the Four Major Cancer Types

(2020) Vera Constâncio et al.   Cells

Genomic landscape of platinum resistant and sensitive testicular cancers

(2020) Chey Loveday et al.   Nature Communications

Testicular cancer: Determinants of cisplatin sensitivity and novel therapeutic opportunities

(2020) Gerda de Vries et al.   CANCER TREATMENT REVIEWS

Hypermethylation and global remodeling of DNA methylation is associated with acquired cisplatin resistance in testicular germ cell tumors

(2020) Zeeshan Fazal et al.   Epigenetics

Differential gene expression in cisplatin-resistant and -sensitive testicular germ cell tumor cell lines

(2020) Jan Roška et al.   Oncotarget

Human Germ Cell Tumors are Developmental Cancers: Impact of Epigenetics on Pathobiology and Clinic

(2019) João Lobo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clonal analyses of refractory testicular germ cell tumors

(2019) Michael T. Barrett et al.   PLoS One

Epigenetic drugs and their molecular targets in testicular germ cell tumours

(2019) Sina Jostes et al.   Nature Reviews Urology

Molecular heterogeneity and early metastatic clone selection in testicular germ cell cancer development

(2019) Lambert C. J. Dorssers et al.   BRITISH JOURNAL OF CANCER

Phase II study of avelumab in multiple relapsed/refractory germ cell cancer

(2019) M. Mego et al.   INVESTIGATIONAL NEW DRUGS

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors

(2019) Ratnakar Singh et al.   Cancers

Molecular Basis of Cisplatin Resistance in Testicular Germ Cell Tumors

(2019) Violeta Bakardjieva-Mihaylova et al.   Cancers

Detailed Characterization of Immune Cell Infiltrate and Expression of Immune Checkpoint Molecules PD-L1/CTLA-4 and MMR Proteins in Testicular Germ Cell Tumors Disclose Novel Disease Biomarkers

(2019) João Lobo et al.   Cancers

OUP accepted manuscript

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Testicular germ cell tumors: revisiting a series in light of the new WHO classification and AJCC staging systems, focusing on challenges for pathologists

(2018) João Lobo et al.   HUMAN PATHOLOGY

Integrated Molecular Characterization of Testicular Germ Cell Tumors

(2018) Hui Shen et al.   Cell Reports

An Open-label Randomized Phase 2 study of Durvalumab Alone or in Combination with Tremelimumab in Patients with Advanced Germ Cell Tumors (APACHE): Results from the First Planned Interim Analysis

(2018) Andrea Necchi et al.   EUROPEAN UROLOGY

Molecular Mechanisms of Cisplatin Chemoresistance and Its Circumventing in Testicular Germ Cell Tumors

(2018) Silvia Schmidtova et al.   Current Oncology Reports

5-Azacitidine Exerts Prolonged Pro-Apoptotic Effects and Overcomes Cisplatin-Resistance in Non-Seminomatous Germ Cell Tumor Cells

(2018) Christoph Oing et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Imprints and DPPA3 are bypassed during pluripotency- and differentiation-coupled methylation reprogramming in testicular germ cell tumors

(2016) J. Keith Killian et al.   GENOME RESEARCH

MGMT and CALCA promoter methylation are associated with poor prognosis in testicular germ cell tumor patients

(2016) Camila Maria da Silva Martinelli et al.   Oncotarget

Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine

(2016) Costantine Albany et al.   Oncotarget

Genome-wide methylation analysis identifies genes silenced in non-seminoma cell lines

(2016) Dzul Azri Mohamed Noor et al.   npj Genomic Medicine

Hypermethylation of genes in testicular embryonal carcinomas

(2015) Hoi-Hung Cheung et al.   BRITISH JOURNAL OF CANCER

Genome Wide DNA Methylation Profiles Provide Clues to the Origin and Pathogenesis of Germ Cell Tumors

(2015) Martin A. Rijlaarsdam et al.   PLoS One

Seminoma and Embryonal Carcinoma Footprints Identified by Analysis of Integrated Genome-Wide Epigenetic and Expression Profiles of Germ Cell Cancer Cell Lines

(2014) Yvonne G. van der Zwan et al.   PLoS One

Cisplatin resistance in germ cell tumours: models and mechanisms

(2014) C. Jacobsen et al.   Andrology

Unravelling mechanisms of cisplatin sensitivity and resistance in testicular cancer

(2013) R. Koster et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Acute Hypersensitivity of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage-Associated p53 Activation, Anti-Pluripotency and DNA Demethylation

(2012) Bijesh K. Biswal et al.   PLoS One

DNA methylation as a universal biomarker

(2010) Victor V Levenson   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Global DNA methylation in fetal human germ cells and germ cell tumours: association with differentiation and cisplatin resistance

(2010) Hendrik Wermann et al.   JOURNAL OF PATHOLOGY

High DNA Methyltransferase 3B Expression Mediates 5-Aza-Deoxycytidine Hypersensitivity in Testicular Germ Cell Tumors

(2009) M. J. Beyrouthy et al.   CANCER RESEARCH