A cohesin cancer mutation reveals a role for the hinge domain in genome organization and gene expression

Cryo-EM structure of the human cohesin-NIPBL-DNA complex

(2020) Zhubing Shi et al.   SCIENCE

A WIZ/Cohesin/CTCF Complex Anchors DNA Loops to Define Gene Expression and Cell Identity

(2020) Megan Justice et al.   Cell Reports

Distinct and overlapping roles of STAG1 and STAG2 in cohesin localization and gene expression in embryonic stem cells

(2020) Nicole L. Arruda et al.   Epigenetics & Chromatin

Chromatin topology in development and disease

(2019) Olimpia Bompadre et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Sister DNA Entrapment between Juxtaposed Smc Heads and Kleisin of the Cohesin Complex

(2019) Christophe Chapard et al.   MOLECULAR CELL

Cohesin Members Stag1 and Stag2 Display Distinct Roles in Chromatin Accessibility and Topological Control of HSC Self-Renewal and Differentiation

(2019) Aaron D. Viny et al.   Cell Stem Cell

DNA loop extrusion by human cohesin

(2019) Iain F. Davidson et al.   SCIENCE

Human cohesin compacts DNA by loop extrusion

(2019) Yoori Kim et al.   SCIENCE

The Cohesin Ring Uses Its Hinge to Organize DNA Using Non-topological as well as Topological Mechanisms

(2018) Madhusudhan Srinivasan et al.   CELL

The Energetics and Physiological Impact of Cohesin Extrusion

(2018) Laura Vian et al.   CELL

Scc2 Is a Potent Activator of Cohesin’s ATPase that Promotes Loading by Binding Scc1 without Pds5

(2018) Naomi J. Petela et al.   MOLECULAR CELL

Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA

(2018) Xingya Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A tethered-inchworm model of SMC DNA translocation

(2018) Michael H. Nichols et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Towards a Unified Model of SMC Complex Function

(2018) Markus Hassler et al.   CURRENT BIOLOGY

Invariant TAD Boundaries Constrain Cell-Type-Specific Looping Interactions between Promoters and Distal Elements around the CFTR Locus

(2016) Emily M. Smith et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Insulated Neighborhoods: Structural and Functional Units of Mammalian Gene Control

(2016) Denes Hnisz et al.   CELL

3D Chromosome Regulatory Landscape of Human Pluripotent Cells

(2016) Xiong Ji et al.   Cell Stem Cell

Organization and function of the 3D genome

(2016) Boyan Bonev et al.   NATURE REVIEWS GENETICS

SMC complexes: from DNA to chromosomes

(2016) Frank Uhlmann   NATURE REVIEWS MOLECULAR CELL BIOLOGY

COSMIC: somatic cancer genetics at high-resolution

(2016) Simon A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Genome-wide RNAi Screen Identifies Cohesin Genes as Modifiers of Renewal and Differentiation in Human HSCs

(2016) Roman Galeev et al.   Cell Reports

Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2

(2016) Jung-Sik Kim et al.   PLoS Genetics

Juicer Provides a One-Click System for Analyzing Loop-Resolution Hi-C Experiments

(2016) Neva C. Durand et al.   Cell Systems

Juicebox Provides a Visualization System for Hi-C Contact Maps with Unlimited Zoom

(2016) Neva C. Durand et al.   Cell Systems

Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation

(2015) Claire Mazumdar et al.   Cell Stem Cell

Cohesin and human disease: lessons from mouse models

(2015) Vijay Pratap Singh et al.   CURRENT OPINION IN CELL BIOLOGY

Dose-dependent role of the cohesin complex in normal and malignant hematopoiesis

(2015) Aaron D. Viny et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

(2015) Jasper Mullenders et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Condensin-driven remodelling of X chromosome topology during dosage compensation

(2015) Emily Crane et al.   NATURE

CTCF/cohesin-binding sites are frequently mutated in cancer

(2015) Riku Katainen et al.   NATURE GENETICS

A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping

(2014) Suhas S.P. Rao et al.   CELL

Control of Cell Identity Genes Occurs in Insulated Neighborhoods in Mammalian Chromosomes

(2014) Jill M. Dowen et al.   CELL

How to make a cardiomyocyte

(2014) D. Spater et al.   DEVELOPMENT

Enhancer biology and enhanceropathies

(2014) Edwin Smith et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of a DNA exit gate in the human cohesin ring

(2014) P. J. Huis in 't Veld et al.   SCIENCE

Closing the cohesin ring: Structure and function of its Smc3-kleisin interface

(2014) T. G. Gligoris et al.   SCIENCE

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment

(2013) Jennifer E. Phillips-Cremins et al.   CELL

Cohesin and CTCF differentially affect chromatin architecture and gene expression in human cells

(2013) J. Zuin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Control of RNA Polymerase II Activity by Cohesin

(2013) Cheri A. Schaaf et al.   PLoS Genetics

Multiple Structural Maintenance of Chromosome Complexes at Transcriptional Regulatory Elements

(2013) Jill M. Dowen et al.   Stem Cell Reports

Differential oestrogen receptor binding is associated with clinical outcome in breast cancer

(2012) Caryn S. Ross-Innes et al.   NATURE

Topological domains in mammalian genomes identified by analysis of chromatin interactions

(2012) Jesse R. Dixon et al.   NATURE

Stem cell gene expression programs influence clinical outcome in human leukemia

(2011) Kolja Eppert et al.   NATURE MEDICINE

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Systematic Reduction of Cohesin Differentially Affects Chromosome Segregation, Condensation, and DNA Repair

(2010) Jill M. Heidinger-Pauli et al.   CURRENT BIOLOGY

Both Interaction Surfaces within Cohesin's Hinge Domain Are Essential for Its Stable Chromosomal Association

(2010) Ajay Mishra et al.   CURRENT BIOLOGY

A positively charged channel within the Smc1/Smc3 hinge required for sister chromatid cohesion

(2010) Alexander Kurze et al.   EMBO JOURNAL

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome

(2009) E. Lieberman-Aiden et al.   SCIENCE

Transcriptional Dysregulation in NIPBL and Cohesin Mutant Human Cells

(2009) Jinglan Liu et al.   PLOS BIOLOGY

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

(2008) Derk ten Berge et al.   Cell Stem Cell

Model-based Analysis of ChIP-Seq (MACS)

(2008) Yong Zhang et al.   GENOME BIOLOGY