☆ 4.7 Article

Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway

SCIENTIFIC REPORTS (2021)

Journal

SCIENTIFIC REPORTS

Volume 11, Issue 1, Pages -

Publisher

NATURE PORTFOLIO

DOI: 10.1038/s41598-021-85145-1

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Multidisciplinary Sciences

Funding

National Natural Science Foundation of China [81971299, 82071112]
Science and Technology Commission of Shanghai Municipality (STCSM) [20ZR1431800]
Cross-disciplinary Research Fund of Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine [JYJC202005]
Project of Biobank from Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine [YBKB201905]
CAMS Innovation Fund for Medical Sciences (CIFMS) [2019-I2M-5-037]

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Abstract

Psoralen, extracted from a Chinese herb, has anti-inflammatory and estrogen-like effects by activating ER, which may serve as an adjunct therapy for periodontitis.

Psoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the mechanisms underlying these effects. Through the molecule docking assay, psoralen was found to have a better combination with ER alpha than ER beta. In human periodontal ligament cells, psoralen was found to upregulate the estrogen target genes (e.g., CTSD, PGR, TFF1) and down-regulate the expression of inflammatory cytokines (TNF-alpha, IL-1 beta, IL-6 and IL-8) stimulated by P. gingivalis LPS, as well as TLR4-IRAK4-NF-kappa b signaling pathway proteins. These effects were reversed by the ER antagonist ICI 182780. These results indicated that psoralen may exert anti-inflammatory effects as an agonist to ER, which could provide a theoretical basis for the use of psoralen for adjuvant therapy and prevention of periodontitis.

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