Review
Chemistry, Applied
Na Liu, Xia Li, Ping Zhao, Xueqian Zhang, Ou Qiao, Luqi Huang, Lanping Guo, Wenyuan Gao
Summary: Citrus peels, as the main by-product of citrus processing, have a wide application prospect. Extracting functional components from citrus peels can be used to produce various food products, medicines, and biofuels.
Article
Pharmacology & Pharmacy
Jiyoon Yang, Su-Yeon Lee, Soo-Kyeong Jang, Ki-Joong Kim, Mi-Jin Park
Summary: This study investigated the anti-inflammatory effects of various citrus cultivars and their active anti-inflammatory components. The essential oils from Citrus japonica and Citrus maxima exhibited superior anti-inflammatory activities, and α-terpineol was identified as an active anti-inflammatory compound.
Review
Biochemistry & Molecular Biology
Yunho Jin, Yoo Jin Choi, Kyu Heo, Seong Joon Park
Summary: Breast cancer is the most common type of cancer, with estrogen playing a significant role in its development. Melatonin can suppress aromatase activity, reducing estrogen biosynthesis and potentially inhibiting the progression of breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Energy & Fuels
Gizem Yildizli, Gokhan Coral, Furkan Ayaz
Summary: Wood vinegar demonstrates antimicrobial and antifungal activity, but lacks antibacteriophage activity. Additionally, it exhibits anti-inflammatory properties by reducing the production levels of pro-inflammatory cytokines by mammalian macrophage like cells.
BIOMASS CONVERSION AND BIOREFINERY
(2022)
Article
Crystallography
Tarfah Al-Warhi, Ola A. Abu Ali, Leena S. Alqahtani, Eman Abo-Elabass, Mohammed El Behery, Atef E. Abd El-Baky, Mohamed Samir A. Zaki, Eman Fayad, Eman M. Radwan
Summary: Scientists are interested in hybrid coumarin derivatives for their clinical anticancer use. The structure of novel hybrid coumarin derivatives (Compounds 3-6) synthesized from ethyl 8-methoxycoumarin-3-carboxylate (Compound 1) was determined. The cytotoxic activities of these derivatives against MCF-7 and MDA-MB-231 were evaluated, identifying Compound 6 as a promising candidate due to its activity against TUB polymerization, sulfatase, and aromatase enzymes, as well as its role in inducing cell-cycle arrest and apoptosis.
Article
Food Science & Technology
Ye-Rang Yun, Bo-Yeon Park, Sung-Hyun Kim, Ji-Hye Jung
Summary: Various types of vinegars, including Jeju citrus blended vinegars (CBVs) prepared by mixing premature mandarin vinegar and mandarin vinegar, showed higher antioxidant, anti-obesity, and anti-aging activities compared to traditional mandarin vinegar.
Article
Food Science & Technology
Raffaele Romano, Lucia De Luca, Alessandra Aiello, Danilo Rossi, Fabiana Pizzolongo, Paolo Masi
Summary: This work studied the extraction of bioactive compounds from citrus peels using environmentally friendly solvent CO2 under liquid and supercritical conditions. The addition of ethanol as a cosolvent was also investigated. The results showed that the extraction using a mixture of liquid CO2 and ethanol had the highest yield and antiradical activity.
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Medicinal
Huahui Zeng, Duanjie Xu, Yagang Song, Shuo Tian, Jingyi Qiao, Zhanzhan Li, Lingzhou Zhao, Hui Shi, Yueyue Zhou, Shuo Li, Ying Luo, Jiashi Li, Mingsan Miao, Xiangxiang Wu
Summary: The researchers synthesized and evaluated nine prodrugs, among which SS-12 showed the most promising efficacy against breast cancer, with improved bioavailability and longer retention time compared to stachydrine.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Rashidra R. Walker, Jankiben R. Patel, Akash Gupta, A. Michael Davidson, Christopher C. Williams, Florastina Payton-Stewart, Stephen M. Boue, Matthew E. Burow, Rahul Khupse, Syreeta L. Tilghman
Summary: The combination treatment of glyceollins and lapatinib could reduce the proliferation of hormone-dependent letrozole-resistant breast cancer cells by inducing apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Secil Erden Tayhan, Sema Bilgin, Asli Yildirim, Esra Koc
Summary: This study aimed to investigate the anti-proliferative and anti-migratory effects of two isoeugenol-based polyphenolic compounds 1 and 2 on human breast cancer cells. The results showed that these compounds exhibited anti-proliferative, anti-apoptotic, and anti-migratory effects in MCF-7 breast cancer cells. Importantly, no cytotoxic effect was observed on healthy breast tissue cells, suggesting the potential of these compounds as chemotherapeutic drug active ingredients without side effects.
CHEMISTRY & BIODIVERSITY
(2023)
Article
Plant Sciences
Nina-Nicoleta Condurache (Lazar), Constantin Croitoru, Elena Enachi, Gabriela-Elena Bahrim, Nicoleta Stanciuc, Gabriela Rapeanu
Summary: This study demonstrated that eggplant peels could be a potential source of anthocyanins with biological activities. Solid-liquid extraction method showed the highest anthocyanin concentration at high temperature, while ultrasound-assisted extraction method performed better at lower temperature. The extracts also exhibited inhibitory activity against LOX, lipase, and alpha-amylase, suggesting a possible role in reducing the risk of various disorders.
Review
Oncology
Marie Will, Jackson Liang, Ciara Metcalfe, Sarat Chandarlapaty
Summary: This review discusses the mechanisms of therapeutic resistance targeting the estrogen receptor and strategies to overcome it in breast cancer. Selective antagonism of estrogen receptor signaling is a successful therapeutic approach in oncology, but resistance is a major challenge.
NATURE REVIEWS CANCER
(2023)
Article
Chemistry, Applied
Zhirong Wang, Tao Zhong, Xiaofei Mei, Xuhui Chen, Guangjing Chen, Shengqi Rao, Xiangfeng Zheng, Zhenquan Yang
Summary: This study evaluated the effects of different drying methods on the quality of brocade orange peels (BOPs). Freeze drying (FD), heat pump drying (HPD), microwave drying (MD), and far-infrared drying (FID) were compared. The results showed that FD-BOPs had the best appearance and highest levels of certain compounds, while HPD and MD-BOPs had the highest concentrations of limonene and β-myrcene. MD-BOPs also had the highest bioavailability of phenols and ascorbic acid.
Article
Food Science & Technology
Yanpeng Hao, Zuchen Wei, Zhi Wang, Guiying Li, Yang Yao, Baoqing Dun
Summary: The biotransformation of flavonoids through methylation enhances their antimicrobial activities and antiproliferative effects, laying the groundwork for further research into their potential as drugs and health foods. The sustainable production of bioactive flavonoids through this method represents a promising avenue for exploration.
Review
Chemistry, Medicinal
Ankita Sood, Damanpreet Kaur Lang, Rajwinder Kaur, Balraj Saini, Sandeep Arora
Summary: Treatment for breast cancer remains challenging, with aromatase inhibitors showing significantly improved efficacy and safety compared to other drugs.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Applied
Seham S. El Hawary, Mohammed Abubaker, Essam M. Abd El-Kader, Engy A. Mahrous
Summary: In this study, the ethanolic extract of Macadamia integrifolia leaves was investigated, leading to the identification of 6 compounds. Two functional galactolipids, as well as gallic acid and protocatechuic acid, were discovered in the genus Macadamia for the first time. The extract and its fractions exhibited good tyrosinase inhibitory activity.
NATURAL PRODUCT RESEARCH
(2022)
Review
Chemistry, Applied
Engy A. Mahrous, Mohamed A. Farag
Summary: Molecular distillation is a physical separation method used in petrochemical, food, cosmetics, and pharmaceutical industries. Recent advancements have expanded its applications to include purification and enrichment of bioactive compounds in natural extracts and nutraceutical production. Future development may involve expanding its application areas and refining fixed oils, essential oils, and plant extracts.
SEPARATION AND PURIFICATION REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Shahira M. Ezzat, Mohamed F. Abdel Rahman, Maha M. Salama, Engy A. Mahrous, Amany El Bariary
Summary: This study investigated the antihyperglycemic activity of non-polar and polar fractions extracted from green bean pods. The non-polar fraction showed stronger blood glucose-lowering effect than the polar fraction in diabetic rats. Furthermore, when combined with mesenchymal stem cell injection, the non-polar fraction significantly increased serum insulin levels and reduced blood glucose. It also improved oxidative balance and inhibited pancreatic lipase and alpha-amylase activity. These findings suggest that green bean extract can be beneficial for diabetes treatment.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Chemistry, Applied
Ahmed H. Elosaily, Engy A. Mahrous, Abeer A. Salama, Ahmed M. Salama, Soheir M. Elzalabani
Summary: This study investigated the chemical variability and antioxidant, anti-inflammatory activities of Duke and Fuerte avocado cultivars. Duke cultivar exhibited higher antioxidant properties while Fuerte cultivar showed stronger lipid content. However, both cultivars demonstrated comparable inhibition of inflammation over time. Variability in chemical composition could affect the biological activities of avocados and their oil.
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
(2022)
Article
Plant Sciences
Engy A. Mahrous, Ahmed H. Elosaily, Abeer A. A. Salama, Ahmed M. Salama, Soheir M. El-Zalabani
Summary: This study evaluated the anti-inflammatory activity of Jatropha integerrima leaves extract (JILE) and demonstrated its potential for treating various skin conditions. Both oral and topical administration of the extract reduced edema volume and decreased levels of inflammatory markers. Furthermore, liquid chromatography/mass spectrometry analysis identified numerous metabolites with known anti-inflammatory activity.
Review
Food Science & Technology
Dina M. El Kersh, Ghada Hammad, Marwa S. Donia, Mohamed A. Farag
Summary: This review focuses on the chemistry and functionality of colored grape juices compared to other fruit juices. It discusses the potential contaminants and factors influencing juice quality and health effects. The review also compares analytical methods for juice quality control. The presence of phenolics in the colored grape skin makes it a functional beverage.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nada Fareed, Dina M. El-Kersh, Fadia S. Youssef, Rola M. Labib
Summary: Diospyros species, belonging to the Ebenaceae family, have long been used in traditional medicine for their therapeutic properties. Numerous chemical compounds, including naphthoquinones, flavonoids, tannins, coumarins, and various others, have been identified in these plants, contributing to their pharmacological activities such as antioxidant, antibacterial, and anti-inflammatory effects. Further comparative studies among different species are recommended for drug discovery and clinical application.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Dina M. El-Kersh, Rania F. Abou El-Ezz, Marwa Fouad, Mohamed A. Farag
Summary: Acylated flavonoids are natural metabolites found in medicinal plants and foods, with various health benefits. A wide range of acylated flavonoids with interesting biological effects were identified from different plant species. Among them, 123 compounds with potential antimicrobial, antiparasitic, anti-inflammatory, anti-nociceptive, analgesic, and anti-complementary effects were selected from databases, and their interactions with natural enzymes such as acetylcholinesterase, butyrylcholinesterase, alpha-amylase, alpha-glucosidase, aldose reductase, and HIV integrase were investigated to understand their biological activities.
Article
Chemistry, Applied
Safa Abdelbaset, Dina M. El-Kersh, Iriny M. Ayoub, Omayma A. Eldahshan
Summary: This study analyzed the chemical profile of Vitex pinnata bark lipophilic extract using GC-MS and evaluated its anti-TB and cytotoxic activities. The results revealed that the VP n-hexane extract showed potential as a natural anti-TB agent with low cytotoxicity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biology
Reham F. El-Kased, Dina M. El-Kersh
Summary: The purpose of this study was to investigate the antimicrobial effects and preservative action of natural essential oils. Eight natural essential oils were tested against different types of microbes, and thyme oil showed the highest inhibitory effect. Concentration-dependent inhibition of growth was observed for all tested oils. Lemon grass, thyme, and Mentha virdis essential oils were found to be enriched with monoterpenes, exhibiting the strongest antimicrobial activity in pasteurized apple juice.
Article
Pharmacology & Pharmacy
Khaled Mahmoud, Mahmoud Teaima, Yasmeen Attia, Mohamed El-Nabarawi, Shady Swidan
Summary: This study aimed to improve the effectiveness of SIM in hepatocellular carcinoma (HCC) by using D-alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) modified lipid nanocapsules (LNC). The effect of size-optimized SIM-loaded LNC on epithelial-to-mesenchymal transition (EMT) in HCC, and the implication of phosphatase and tensin homolog (PTEN)/protein kinase B (AKT) axis were investigated.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Chemistry, Applied
Lukasz Pecio, Solomiia Kozachok, Fatema R. Saber, Maria Garcia-Marti, Yasser El-Amier, Engy A. Mahrous, Lukasz Swiatek, Anastazja Boguszewska, Adrianna Skiba, Ahmed H. Elosaily, Krystyna Skalicka-Wozniak, Jesus Simal-Gandara
Summary: In this study, the cytotoxic activity of Ochradenus baccatus Delile, a desert plant native to the Middle East, was evaluated using cell lines and a zebrafish embryo model. The extract exhibited the highest cytotoxicity against human cervical adenocarcinoma cells, with a CC50 of 39.1 μg/mL and a selectivity index of 7.23. Metabolic analysis identified various compounds in the extract, including fatty acids, flavonoids, glucosinolates, nitrile glycosides, and organic acids. These phytochemicals may contribute to the observed cytotoxic activity. O. baccatus has the potential to be a safe food source to help meet the increasing food demand in Saharan countries.
Article
Environmental Sciences
Tamer A. Al-Shafie, Engy A. Mahrous, Mustafa Shukry, Mohammad Y. Alshahrani, Samah F. Ibrahim, Liana Fericean, Afaf Abdelkader, Mennatallah A. Ali
Summary: Increasing cancer cell sensitivity to chemotherapy by amending aberrant metabolism using plant extracts represents a promising strategy to lower chemotherapy doses while retaining the same therapeutic outcome.
Meeting Abstract
Pharmacology & Pharmacy
Basma Alaa, Olfat Hammam, Aiman El-Khatib, Yasmeen Attia
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Seham El-Hawary, Mohammed Abubaker, Engy A. Mahrous
Summary: In this study, we investigated the effects of macadamia nut extract on aging induced by D-galactose. The results showed that macadamia nut extract ameliorated cognitive impairment and oxidative stress, and protected liver and kidney functions. Nut extract was more effective than leaf and shell extracts.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2022)
