Article
Clinical Neurology
Joseph Haynes, Maksim Shapiro, Eytan Raz, Barry Czeisler, Erez Nossek
Summary: Spinal cord infarction is rare but prompt diagnosis and treatment are crucial. The case presented in this study demonstrates successful treatment of anterior spinal artery territory ischemia with ASA intra-arterial thrombolytic therapy, leading to significant neurological improvement.
JOURNAL OF CLINICAL NEUROSCIENCE
(2021)
Article
Clinical Neurology
Vanessa H. E. Chen, Grace K. H. Lee, Choon-Han Tan, Aloysius S. T. Leow, Ying-Kiat Tan, Claire Goh, Anil Gopinathan, Cunli Yang, Bernard P. L. Chan, Vijay K. Sharma, Benjamin Y. Q. Tan, Leonard L. L. Yeo
Summary: This study evaluated the efficacy and safety of concomitant or rescue intra-arterial adjunctive medications in patients with acute ischemic stroke and large vessel occlusion undergoing mechanical thrombectomy. Results showed that patients treated with combination therapy had a higher likelihood of achieving good functional outcome and lower 90-day mortality, with no significant difference in successful recanalization and symptomatic intracranial hemorrhage compared to patients treated with MT alone.
Review
Clinical Neurology
Shima Shahjouei, Reza Bavarsad Shahripour, Oana M. Dumitrascu
Summary: Thrombolytic therapy with tissue plasminogen activator (tPA) can improve visual recovery in non-arteritic central retinal artery occlusion (naCRAO) patients. The efficacy of intravenous thrombolysis (IVT) or intra-arterial thrombolysis (IAT) in naCRAO is still uncertain. Early treatment with tPA is associated with enhanced visual outcomes in naCRAO.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Nanoscience & Nanotechnology
Hannah J. Vaughan, Camila G. Zamboni, Kathryn M. Luly, Ling Li, Kathleen L. Gabrielson, Laboni F. Hassan, Nicholas P. Radant, Pranshu Bhardwaj, Florin M. Selaru, Martin G. Pomper, Jordan J. Green
Summary: This study investigated a new approach of local delivery of polymeric nanoparticles (NPs) via intra-arterial injection for targeted local gene delivery to hepatocellular carcinoma (HCC) tumors. The results showed that this method had a better effect in treating HCC compared to intravenous administration.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Clinical Neurology
Thanh N. Nguyen, Muhammad M. Qureshi, Davide Strambo, Daniel Strbian, Silja Raety, Christian Herweh, Mohamad Abdalkader, Marta Olive-Gadea, Marc Ribo, Marios Psychogios, Urs Fischer, Anh Nguyen, Joji B. Kuramatsu, David Haupenthal, Martin Koehrmann, Cornelius Deuschl, Jordi Kuehne Escola, Shadi Yaghi, Liqi Shu, Volker Puetz, Daniel P. O. Kaiser, Johannes Kaesmacher, Adnan Mujanovic, Dominique Cornelius Marterstock, Tobias Engelhorn, Piers Klein, Diogo C. Haussen, Mahmoud H. Mohammaden, Hend Abdelhamid, Lorena Souza Viana, Bruno Cunha, Isabel Fragata, Michele Romoli, Francesco Diana, Pekka Virtanen, Kimmo Lappalainen, Judith Clark, Stavros Matsoukas, Johanna T. Fifi, Sunil A. Sheth, Sergio Salazar-Marioni, Joao Pedro Marto, Joao Nuno Ramos, Milena Miszczuk, Christoph Riegler, Ashutosh P. Jadhav, Shashvat M. Desai, Volker Maus, Maximilian Kaeder, Adnan H. Siddiqui, Andre Monteiro, Hesham E. Masoud, Neil Suryadevara, Maxim Mokin, Shail Thanki, James E. Siegler, Jane Khalife, Italo Linfante, Guilherme Dabus, Negar Asdaghi, Vasu Saini, Christian H. Nolte, Eberhard Siebert, Thomas R. Meinel, Stefanos Finitsis, Markus A. Moehlenbruch, Peter A. Ringleb, Anne Berberich, Raul G. Nogueira, Uta Hanning, Lukas Meyer, Patrik Michel, Simon Nagel
Summary: This study compared the clinical outcomes of endovascular therapy (EVT) and medical management (MM) in patients with isolated posterior cerebral artery occlusion. The results showed no difference between the two groups in terms of the modified Rankin Scale and National Institutes of Health Stroke Scale at 90 days. However, the EVT group had a higher likelihood of excellent outcome and complete vision recovery, despite higher rates of symptomatic intracranial hemorrhage and mortality.
Article
Biochemistry & Molecular Biology
Being-Chuan Lin, Cheng-Hsien Wu, Yon-Cheong Wong, Sheng-Che Hung, Ming-Che Hsin
Summary: This retrospective study evaluated the outcomes of 13 patients with acute superior mesenteric artery (SMA) occlusion who underwent intra-arterial urokinase thrombolysis. The study found that urokinase therapy restored bowel perfusion and preserved bowel in six patients, but failed in the other seven patients. Significant differences were observed in the degree of SMA occlusion, the degree of recanalisation, and the length of stay between the complete and incomplete occlusion groups. In cases of complete SMA occlusion, surgery was warranted, while urokinase thrombolysis may serve as an adjunctive treatment for cases of incomplete SMA occlusion.
Article
Clinical Neurology
Johannes Kaesmacher, Nuran Abdullayev, Basel Maamari, Tomas Dobrocky, Jan Vynckier, Eike Piechowiak, Raoul Pop, Daniel Behme, Peter B. Sporns, Hanna Styczen, Pekka Virtanen, Lukas Meyer, Thomas R. Meinel, Daniel Cantre, Christoph Kabbasch, Volker Maus, Johanna Pekkola, Sebastian Fischer, Anca Hasiu, Alexander Schwarz, Moritz Wildgruber, David J. Seiffge, Soenke Langner, Nicolas Martinez-Majander, Alexander Radbruch, Marc Schlamann, Dan Mihoc, Remy Beaujeux, Daniel Strbian, Jens Fiehler, Pasquale Mordasini, Jan Gralla, Urs Fischer
Summary: The study found that the administration of intra-arterial fibrinolytics as an adjunct to mechanical thrombectomy is rarely performed but can improve reperfusion, leading to better treatment outcomes. However, there is a possible increased risk of symptomatic intracranial hemorrhage, highlighting the importance of careful patient selection.
Article
Clinical Neurology
S. H. Jang, S. -i. Sohn, H. Park, S. -j. Lee, Y. -w. Kim, J. M. Hong, C-h. Kim, J. W. Choi, D. -h. Kang, Y. -s. Kim, Y. -h. Hwang, J. S. Lee, J. -h. Hong
Summary: This study using a multicenter registry found that intra-arterial tirofiban during endovascular therapy in acute ischemic stroke patients undergoing intravenous thrombolysis with recombinant IV tPA may be safe and not associated with increased postprocedural complications or mortality.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2021)
Article
Biochemical Research Methods
Chengyan Chu, Anna Jablonska, Yue Gao, Xiaoyan Lan, Wojciech G. Lesniak, Yajie Liang, Guanshu Liu, Shen Li, Tim Magnus, Monica Pearl, Miroslaw Janowski, Piotr Walczak
Summary: Using MRI guidance, the variability in BBB manipulation can be greatly reduced or eliminated, leading to improved delivery of therapeutic agents to the brain. This technique is easy to implement and can enhance the efficacy of treatment.
Review
Clinical Neurology
Brian Mac Grory, Matthew Schrag, Valerie Biousse, Karen L. Furie, Marie Gerhard-Herman, Patrick J. Lavin, Lucia Sobrin, Stavropoula I. Tjoumakaris, Cornelia M. Weyand, Shadi Yaghi
Summary: Central retinal artery occlusion (CRAO) is an acute ischemic stroke that lacks scientific information and consistent management strategies, requiring more high-quality clinical trials. Acute CRAO is a medical emergency that necessitates early recognition and triage to emergency care.
Article
Clinical Neurology
Sabine L. Collette, Reinoud P. H. Bokkers, Aryan Mazuri, Geert J. Lycklama A. Nijeholt, Robert J. Van Oostenbrugge, Natalie E. LeCouffe, Faysal Benali, Charles B. L. M. Majoie, Jan Cees De Groot, Gert Jan R. Luijckx, Maarten Uyttenboogaart
Summary: This study analyzed data from the MR CLEAN Registry to explore the use of local intra-arterial thrombolytics during endovascular thrombectomy (EVT) and compared the outcomes with EVT without thrombolytics. It found that the use of intra-arterial thrombolytics did not improve functional outcome and was associated with lower reperfusion success, while the rates of symptomatic intracranial hemorrhage and early neurological recovery were comparable between the two groups.
STROKE AND VASCULAR NEUROLOGY
(2023)
Article
Dermatology
Qian Wu, Qiang Fu, Xiao Xu, Can Zheng, Jie Zhang, Minliang Chen
Summary: Blindness caused by fillers is a rare but serious complication. Intra-arterial thrombolytic therapy with hyaluronidase and papaverine has shown positive effects on hyaluronic acid-induced visual loss and should be promoted clinically.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2022)
Article
Neuroimaging
Jongshin Kim, Seunguk Jung, Kyu Hyung Park, Se Joon Woo, Cheolkyu Jung
Summary: The study found a significant correlation in the severity of steno-occlusive lesions between the OphA and the ipsilateral CA in patients with CRAO. Patients with less severe angiographic features in the CA showed improved retinal reperfusion after IAT. The angiographic findings in the CA may serve as a predictive marker for vessel integrity of the OphA and recanalization outcome after IAT.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Medicine, General & Internal
Chunrong G. Tao, Raul Nogueira, Yuyou Zhu, Jun Sun, Hongxing Han, Guangxiong Yuan, Changming Wen, Peiyang Zhou, Wenhuo Chen, Guoyong Zeng, Yuwen Li, Zhengfei Ma, Chuanqing Yu, Junfeng Su, Zhiming Zhou, Zhongjun Chen, Geng Liao, Yaxuan Sun, Youquan Ren, Hui Zhang, Jie Chen, Xincan Yue, Guodong Xiao, Li Wang, Rui Liu, Wenhua Liu, Yong Liu, Chao Zhang, Tianlong Liu, Jianlong Song, Rui Li, Pengfei Xu, Yamei Yin, Guoping Wang, Blaise Baxter, Adnan I. Qureshi, Xinfeng Liu, Wei Hu, ATTENTION Investigators
Summary: This multicenter, prospective, randomized controlled trial in China compared endovascular thrombectomy to best medical care for basilar-artery occlusion stroke. The results showed that endovascular thrombectomy within 12 hours led to better functional outcomes at 90 days but was associated with procedural complications and intracerebral hemorrhage.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Sanaz Nasoohi, Parsa Alehossein, Masoumeh Jorjani, Candice M. M. Brown, Tauheed Ishrat
Summary: The sudden increase in blood sugar levels after thrombectomy can reduce the effectiveness of the intervention in stroke patients. The interaction between thioredoxin-interacting protein (TXNIP) and hyperglycemic stroke injury has been found to be critical. Verapamil has been shown to alleviate the cerebrovascular toxicity caused by tissue plasminogen activators in hyperglycemic stroke. This study investigates the direct neuroprotective effects of verapamil and its ability to reduce glucose toxicity in a preclinical model of hyperglycemic stroke.
FRONTIERS IN PHARMACOLOGY
(2023)