Article
Chemistry, Multidisciplinary
Dongqin Yu, Haochen Zhang, Zhenqi Liu, Chun Liu, Xiubo Du, Jinsong Ren, Xiaogang Qu
Summary: This study encapsulates neural stem cells (NSCs) using porous carbon nanospheres (PCNs) and hydrogen-bonded organic frameworks (HOFs) to resist oxidative stress and enhance viability, demonstrating the promotion of neurogenesis and improvement of cognitive function in an Alzheimer's disease (AD) mouse model.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Jiakang Tang, Ji Liu, Qizhen Zheng, Wenting Li, Jinhan Sheng, Lanqun Mao, Ming Wang
Summary: The self-assembly of nanoscale HOFs to encapsulate proteins for intracellular biocatalysis shows high efficiency and minimal effect on protein activity. The protein@nHOFs can efficiently enter cells and retain enzyme activity, paving new avenues for biomacromolecule delivery and disease treatment using nHOFs.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Yixuan Guo, Chen Wang, Guanglai Mo, Yao Wang, Xiyu Song, Peng Li
Summary: Recent developments in supramolecular materials have led to the rapid advancement of hydrogen-bonded organic frameworks (HOFs) as a family of stable and useful crystalline porous materials. By integrating HOFs with functional materials, new multifunctional composites with superior properties have been achieved, and they have found diverse applications in gas separation, catalysis, sensing, biomedicines, and antibacterial applications. However, there are still unresolved challenges and future research efforts needed in this field.
CRYSTAL GROWTH & DESIGN
(2023)
Article
Chemistry, Multidisciplinary
Peter Wied, Francesco Carraro, Juan M. Bolivar, Christian J. Doonan, Paolo Falcaro, Bernd Nidetzky
Summary: This article explores the method of incorporating enzymes into hydrogen-bonded organic frameworks and finds that genetic engineering can enhance the loading and activity of enzymes, with high stability and versatility.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Materials Science, Multidisciplinary
Yu Hu, Wang-Kang Han, Yong Liu, Ruo-Meng Zhu, Xiaodong Yan, Huan Pang, Zhi-Guo Gu
Summary: In this study, the directed structural transformation of a hydrogen-bonded organic framework (HOF) to covalent organic frameworks (COFs) via mechanochemical drive was reported for the first time. The topological similarity between HOF and the targeted COFs facilitated the transition, resulting in the synthesis of novel large-channel two-dimensional multicomponent COFs. These COFs demonstrated broad light absorption, superior chemical stability, and excellent photocatalytic hydrogen evolution performance. This work provides new guidance for the green and efficient synthesis, as well as the functionalized applications of COFs.
ACS MATERIALS LETTERS
(2023)
Article
Chemistry, Analytical
Jinglong Fang, Li Dai, Ruiqing Feng, Dan Wu, Xiang Ren, Wei Cao, Hongmin Ma, Qin Wei
Summary: In this study, a K-PTC MOF was synthesized and used to formulate an ECL immunosensor. The K-PTC MOF showed more stable ECL emission and analytical applications at a voltage of -1.1 V compared to PTCA. A sandwich sensing platform was constructed using metal-phenolic bioactive nanoparticles (MPNPs) to regulate the ECL emission. The sensor demonstrated good detection performance for neuron-specific enolase (NSE) in the range of 10 pg/mL to 50 ng/mL.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Qian Wang, Pei-Pei You, Guotao Hu, Xiaojian Yang, Peng Chen, Peng Wang, Shuang-Feng Yin
Summary: This study elaborately designs a stabilized hydrogen-bonded organic framework by integrating a micromolecular hydrogen-based triazole unit into a rigid perylene diimide based framework. The experimental and theoretical results show that this design enhances the stability, local polarization, electron delocalization, and built-in electric field of the framework, leading to efficient exciton dissociation and carrier transfer. The designed framework exhibits excellent photocatalytic nitrogen fixation performance.
APPLIED CATALYSIS A-GENERAL
(2023)
Review
Chemistry, Multidisciplinary
Ying Liu, Ganggang Chang, Fang Zheng, Lihang Chen, Qiwei Yang, Qilong Ren, Zongbi Bao
Summary: Hydrogen-bonded organic frameworks (HOFs) are a new class of porous crystalline materials assembled by hydrogen bonds. They offer advantages such as mild synthesis, easy purification, and good recyclability. Enhancing stability, establishing porosity, and functionalization are the main challenges in HOFs development. Recently, more stable and permanently porous HOFs, including hybrid HOFs with stronger charge-assisted hydrogen bonds and coordination bonds, have been reported.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Jianli Wang, Yifan Mao, Runze Zhang, Yanli Zeng, Changsheng Li, Bingjie Zhang, Jianhui Zhu, Jiawen Ji, Desheng Liu, Rumin Gao, Yongqiang Ma
Summary: This study presents a universal scheme for synthesizing core-shell hybrids (MOF@HOF) by using stable HOFs and surface-functionalized MOFs. The newly synthesized NH2-UiO-66@DAT-HOF core-shell nanostructure exhibits excellent stability and superb photocatalytic performance, with an apparent reaction rate constant up to 60.7 and 7.6 times higher than its parent materials NH2-UiO-66 and DAT-HOF for tetracycline degradation. This enhancement is attributed to the broader visible-light utilization range and efficient charge carrier separation supported by the S-scheme heterojunction. Furthermore, the photocatalytic efficiency of the core-shell nanostructure remains high after several-cycle applications.
Article
Chemistry, Multidisciplinary
Linjing Tong, Yuhong Lin, Xiaoxue Kou, Yujian Shen, Yong Shen, Siming Huang, Fang Zhu, Guosheng Chen, Gangfeng Ouyang
Summary: Mimicking bioactivity of native enzymes through synthetic chemistry is an efficient strategy for enhancing biocatalysts in a cell-free environment, but faces persistent challenges. In this study, we demonstrate the use of structurally explicit hydrogen-bonded organic frameworks (HOFs) to mimic photo-responsive oxidase and reveal the significant role of pore environments in mediating oxidase-like activity. Based on the desirable oxidase-like activity, a visual and sensitive HOFs biosensor for detecting phosphatase, an important biomarker of skeletal and hepatobiliary diseases, is established. Our work highlights the influence of pore environments on the activity of nanozymes in addition to the active center.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Qi Lai, Le Pei, Teng Fei, Ping Yin, Siping Pang, Jean'ne M. Shreeve
Summary: Size matching molecular design utilizing host-guest chemistry is a promising strategy for seeking new functional materials. The authors screened different sized nitrogen rich azoles for selective encapsulation into a hydroxylammonium framework to achieve a dense packing and higher energetic performance.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Wei-Kang Qin, Duan-Hui Si, Qi Yin, Xiang-Yu Gao, Qian-Qian Huang, Ya-Nan Feng, Lei Xie, Shuo Zhang, Xin-Song Huang, Tian-Fu Liu, Rong Cao
Summary: This article successfully synthesizes hydrogen-bonded organic frameworks (HOFs) with predicted structure through mechanosynthesis method, and demonstrates the applicability of reticular chemistry to HOF assemblies with different building blocks. The obtained crystalline HOFs have uniform nano-sized morphology, and the one-pot mechanosynthesis generates Pd@HOF composites with different CO oxidation activities. In situ DRIFTS studies reveal the vital role of porous matrix in catalytic performance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Physical
Tao Li, Bai-Tong Liu, Zhi-Bin Fang, Qi Yin, Rui Wang, Tian-Fu Liu
Summary: HOFs provide a platform for self-assembling functional species into ordered structures, with PFC-42-Pt demonstrating outstanding photocatalytic activity in the production of hydrogen under visible light irradiation. The ordered arrangement of PFC-42-Pt significantly enhances its photocatalytic activity, as further evidenced by recrystallization experiments.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Chemistry, Multidisciplinary
Xue Yang, Jian Huang, Shuiying Gao, Yanqi Zhao, Tao Huang, Hongfang Li, Tianfu Liu, Zhiyang Yu, Rong Cao
Summary: This study successfully fabricates high-quality HOF nanofilms with smooth surface, good crystallinity, and high orientation, and employs them in resistive memory devices, demonstrating excellent switching behavior. Furthermore, the scratched HOF film can be easily regenerated through a simple solvent rinsing process, enabling their reuse for the fabrication of new devices.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Caitlin E. Shields, Xue Wang, Thomas Fellowes, Rob Clowes, Linjiang Chen, Graeme M. Day, Anna G. Slater, John W. Ward, Marc A. Little, Andrew I. Cooper
Summary: Designing hydrogen-bonded organic frameworks (HOFs) with low densities and high porosities is challenging due to the preference for close packing in most molecules. Crystal structure prediction (CSP) can rank alternative crystal packings for organic molecules based on their lattice energies. By combining CSP with structure-property predictions, a previously unknown low-energy HOF (TH5-A) with remarkably low density and three-dimensional pores was discovered for triptycene trisquinoxalinedione (TH5). This TH5-A polymorph demonstrates high porosity with a surface area of 3,284 m(2) g(-1), making it one of the most porous HOFs reported.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Austin L. Raithel, William E. Meador, Tea-Yon Kim, Richard J. Staples, Jared H. Delcamp, Thomas W. Hamann
Summary: Strong-field hexadentate ligands coordinated to cobalt metal centers resulted in three new low spin to low-spin Co(III/II) redox couples. The redox potential of the Co(III/II) redox couples could be tuned by modifying the ligand backbone with dimethyl amine groups. Despite the hexadentate ligands, the redox couples showed a reversible molecular switch rearrangement from five-coordinate Co(II) to six-coordinate Co(III).
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Organic
Ajay Kumar Chinnam, Richard J. Staples, Jean'ne M. Shreeve
Summary: A simple synthetic strategy for bridged bis(nitramide)-based N-substituted tetrazoles is described in this study. All new compounds were isolated and fully characterized using sophisticated analytical techniques. The structures of the intermediate derivative and two final compounds were determined by single-crystal X-ray data. The thermostabilities and energetic properties of the new bridged bisnitramide-based N-substituted tetrazoles were discussed and compared with known materials.
Article
Crystallography
Sean Parkin, Jeremy Cunningham, Brian Rawls, John E. Bender, Richard J. Staples, Shannon M. Biros
Summary: This paper compares variations in a structure model derived from a solid solution of chalcogenide derivatives. It presents a sequence of processes to ascertain the composition of the crystal and strategies to inspect various aspects of the model.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Crystallography
Elizabeth N. Sielaff, Richard J. Staples, Shannon M. Biros
Summary: The molecular structure of tert-butyl 3,6-diiodocarbazole-9-carboxylate, C17H15I2NO2, exhibits a planar carbazole ring with C-I bond lengths of 2.092 (4) and 2.104 (4) A degrees. The carbamate group has key bond lengths of 1.404 (6) A degrees (N-C), 1.330 (5) A degrees (O-C), and 1.201 (6) A degrees (C=O). The crystal structure contains intermolecular Pi- Pi interactions and both type I and type II intermolecular I...I interactions.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Fangzhou Li, Errui Li, Krishanu Samanta, Zhaoxi Zheng, Lianqian Wu, Albert D. Chen, Omar K. Farha, Richard J. Staples, Jia Niu, Klaus Schmidt-Rohr, Chenfeng Ke
Summary: In this study, a porous material with high adsorption capacity, stability, and resistance to corrosion was designed and synthesized for BF3 storage and catalysis. The material exhibited a record-high BF3 uptake capacity and was used to reduce undesired chain transfer and termination in polymerization reactions, resulting in higher molecular weights and lower polydispersity of the polymers.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Organic
Sohan Lal, Richard J. Staples, Jean'ne M. Shreeve
Summary: A straightforward synthetic strategy was reported for newly designed nitrogen-rich planar explosives and solid propellants. These materials exhibit high densities (1.69-1.95 g cm(-3)), high positive enthalpies of formation (approaching 1149.21 kJ mol(-1)), promising energetic properties (P = 26.36-33.78 GPa, D = 8258-9518 m s(-1)), acceptable thermal stabilities (T (d) = 132-277°C), good sensitivities (IS = 4-40 J, FS = 60-360 N), and excellent propulsive performance (Isp = 176.80-253.06 s).
Article
Chemistry, Organic
Jatinder Singh, Richard J. J. Staples, Jeanne M. Shreeve
Summary: A strategy for synthesizing nitrogen-rich energetic materials with good properties is reported, taking advantage of the synergetic effects of inter- or intramolecular hydrogen bonds. A new thermostable and insensitive material, 1,2-dihydrazono-1,2-di(1H-tetrazol-5-5-yl)ethane, was obtained from the reaction of dioxime with hydrazinehydrate. The material has reduced acidity, low solubility in water, high nitrogen content (76%), high thermal stability (275°C), and insensitivity to external stimuli.
Article
Crystallography
Faith M. Carlson, Richard J. Staples, Shannon M. Biros
Summary: The title compound crystallizes as the bromide salt of a 50:50 mixture of (triethylazaniumyl)carboxylic acid and the zwitterionic (triethylazaniumyl)carboxylate, with the two organic entities linked by a bridging carboxylic acid hydrogen atom. The tetralkylammonium group adopts a tetrahedral shape and the carboxylic acid/carboxylate group is engaged in intramolecular hydrogen bonds.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sohan Lal, Richard J. Staples, Jean'ne M. Shreeve
Summary: A scalable synthesis of TNMTO can be achieved from commercially available 2-methylpyrimidine-4,6-diol. TNMTO has high density, low thermal stability, and positive oxygen balance. It exhibits excellent detonation properties and propulsive properties, making it a potential green oxidizer in solid rocket propulsion, superior to ADN, TNAA, and AP.
DALTON TRANSACTIONS
(2023)
Review
Chemistry, Physical
Yaxi Wang, Lu Hu, Siping Pang, Jean'ne M. Shreeve
Summary: This article summarizes the importance and construction strategies of nitroamino-based materials and introduces some important nitroamino-substituted explosives. Through comprehensive analysis of structural features, synthesis methods, and performance characteristics, a macroscopic view of nitroamino explosives is provided, including the mechanism of self-stabilizing hydrogen transfer, improved performance, and a blueprint for the future design of high energy density materials based on these characteristics.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Physical
Jatinder Singh, Richard J. J. Staples, Jean'ne M. Shreeve
Summary: In this study, a strategy to maximize donor-acceptor hydrogen bonding sites was used to construct new energetic compounds with improved temperature resistance. Compound 3 exhibited high thermal stability, insensitivity to impact and friction, and had a high heat of formation and detonation velocity. It showed high safety, ultrahigh power, and good compatibility, making it a potential high-energy-density material for practical use.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Inorganic & Nuclear
Sohan Lal, Richard J. Staples, Jean'ne M. Shreeve
Summary: A series of phenylene-bridged isoxazole and tetrazole-1-ol based green energetic materials were successfully synthesized with good to excellent yields. The structures of the newly synthesized compounds were confirmed through spectroscopic techniques, elemental analysis, and single-crystal X-ray analysis. The significance of this work lies in the good thermal stability (167-340 degrees C) and acceptable densities (1.51 g cm(-3) to 1.82 g cm(-3)) exhibited by all the newly synthesized compounds. Detailed computational analysis revealed that these compounds possess excellent energetic properties (propulsive and ballistic) along with impressive thermal and mechanical stabilities, making them promising candidates for solid propulsion systems. Compounds 5, 12, and 14 are identified as superior candidates for melt-castable energetic materials.
DALTON TRANSACTIONS
(2023)