Article
Immunology
Wei Yuan, Teng Liu, Yuan-yi Wang, Shuang He, Feng Zhang, Xiao-bian Wang, Shi-hua Deng, Ting Zhang, Dong-ming Wu, Ying Xu
Summary: Acute gouty arthritis (AGA) is an inflammatory condition caused by the deposition of monosodium urate (MSU) crystals in joints and periarticular tissues of hyperuricemia patients. This study investigates the therapeutic potential of PP121, a pyroptosis-related compound, on AGA. Treatment with PP121 significantly reduces tissue damage, pro-inflammatory cytokine release, and inflammatory cell infiltration caused by MSU crystals. The study suggests that PP121 promotes degradation of the NLRR3 inflammasome through autophagy, indicating its therapeutic benefits for AGA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Dong-ming Wu, Jing Li, Rong Shen, Jin Li, Ye Yu, Li Li, Shi-hua Deng, Teng Liu, Ting Zhang, Ying Xu, De-gui Wang
Summary: Pyroptosis plays a vital role in radiation-induced inflammation, and micheliolide (MCL) has shown anti-radiation effects in vitro. This study found that MCL can ameliorate radiation-induced enteropathy (RIE) by inducing autophagy and degrading the NLR pyrin domain three inflammasome. MCL may be a novel therapeutic target for RIE.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Mahsa Dolatshahi, Mohammadmahdi Sabahi, Mohammad Hadi Aarabi
Summary: The emergence of COVID-19 has led to an increased risk of neurodegenerative diseases in survivors due to various mechanisms, including direct brain invasion, inflammation, and hypoxia-induced cerebral vascular issues. However, the severity of infection, neurological symptoms, and viral persistence are critical determinants in this association.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Youngpyo Nam, Gyeong Joon Moon, Sang Ryong Kim
Summary: Neurotrophic factors play a crucial role in neurodegenerative diseases, and Rheb, as a regulator of NTFs expression, is an important therapeutic target for treating these diseases. AAV transduction can effectively promote neuroprotection by upregulating NTFs in conditions like AD and PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Ziying Jiang, Xi Yin, Miao Wang, Yuanyuan Wang, Fengzhu Li, Yang Gao, Gencheng Han, Zhongbao Gao, Zhenfu Wang
Summary: The study found that beta-hydroxybutyrate (BHB) has anti-inflammatory effects on Parkinson's disease (PD) and inhibits the inflammatory response by regulating the STAT3/NLRP3/GSDMD signaling pathway, providing new interventions and therapeutic targets.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Hua Bai, Qifang Zhang
Summary: NLRP3 inflammasome activation plays a crucial role in the pathogenesis of Alzheimer's disease, through mechanisms involving cytokine production and protein deposition. Studying the activation mechanisms of NLRP3 may offer new insights into the pathogenesis of AD and provide novel approaches for its prevention and treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
John P. Seibyl
Summary: Diseases of the central nervous system, such as Alzheimer's and Parkinson's, are common and chronic conditions with significant morbidity. Abnormal protein accumulation and spread in the brain are found to be the primary factors in neurotoxicity and disruption of functional networks. Clinical trials are currently investigating various therapies to target these proteinopathies, although they face challenges in accurate diagnosis, variable rates of progression, and efficacy measures.
JOURNAL OF NUCLEAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Noemi Sola-Sevilla, Ana Ricobaraza, Ruben Hernandez-Alcoceba, Maria S. Aymerich, Rosa M. Tordera, Elena Puerta
Summary: The age-related increase of SIRT2.3 found in the brain is not responsible for induction or prevention of senescence, but potentially contributes to the progression of age-related processes in combination with other risk factors. Understanding the specific role of SIRT2 on aging and the underlying molecular mechanisms is crucial for designing new and more successful therapies for age-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Su Yang, Xingxing Zhang, Hengli Zhang, Xiangxiang Lin, Xijun Chen, Ying Zhang, Xiao Lin, Lijie Huang, Qichuan Zhuge
Summary: The study revealed that DI inhibited NLRP3 assembly, LDH release, and GSDMD cleavage. Co-treatment with DI, LPS, and ATP promoted the transition from M1 to M2, reduced inflammatory mediator expression, and inhibited NF-kappa B phosphorylation. Additionally, DI reduced reactive oxygen species production through the Nrf-2/HO-1 pathway and induced cellular autophagy, playing a key role in microglia inflammation and NLRP3 inflammasome-mediated pyroptosis.
MOLECULAR MEDICINE REPORTS
(2021)
Review
Food Science & Technology
Maria Wallert, Lisa Boermel, Stefan Lorkowski
Summary: Inflammation-driven diseases such as metabolic syndrome and cardiovascular diseases have significant global burden. Nutrients can play a crucial role in treating these diseases, with vitamin E showing promising potential as a therapeutic approach for inflammatory diseases.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Medicine, Research & Experimental
Nan Xiang, Ting Yin, Tao Chen
Summary: The study suggests that Gardnerella vaginalis can induce bacterial vaginosis by promoting NLRP3 inflammasome-mediated pyroptosis, providing insights into one of the molecular mechanisms through which G. vaginalis induces BV.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Neurosciences
Meng Ling, Chunxia Huang, Tianfeng Hua, Hui Li, Wenyan Xiao, Zongqing Lu, Di Jia, Wuming Zhou, Linlin Zhang, Min Yang
Summary: ALDH2 activation attenuates sepsis-induced brain injury possibly through regulation of the NLRP3/caspase-1 signaling pathway. ALDH2 could potentially be considered as a new therapeutic target for the treatment of sepsis-induced brain injury.
BRAIN RESEARCH BULLETIN
(2023)
Review
Neurosciences
Jovana Drljaca, Natasa Milosevic, Maja Milanovic, Ludovico Abenavoli, Natasa Milic
Summary: The gut microbiota-brain axis is a communication network between gut microflora and the central and autonomic nervous system. Alterations in gut microbiota have been targeted for therapy in neurodegenerative and psychiatric diseases. Psychobiotics, through interaction with commensal gut bacteria, have beneficial effects on brain function and mental health, although their mechanism of action is not fully understood. This review summarizes the potential therapeutic effects of psychobiotics alone or in combination with conventional medicine in neurodegenerative diseases such as Alzheimer's and Parkinson's, as well as in psychiatric disorders such as depression, schizophrenia, and bipolar disorder, providing evidence from preclinical and clinical trials.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Runfeng Miao, Jian Huang
Summary: The study aimed to investigate the efficacy of MCC950 in lipopolysaccharide (LPS)-induced inflammation and elucidate the underlying mechanisms. Results showed that MCC950 can alleviate the inflammatory response and prevent organ damage by reducing inflammatory cytokine levels in the blood. Furthermore, MCC950 inhibited neutrophil pyroptosis through mechanisms such as reducing oxidative stress and programmed death induced by LPS. The findings suggest that MCC950 may be an effective treatment for sepsis by targeting neutrophil pyroptosis.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Review
Geriatrics & Gerontology
Jing Yang, Wei Zhang, Shugeng Zhang, Ashok Iyaswamy, Jichao Sun, Jigang Wang, Chuanbin Yang
Summary: A key feature of neurodegenerative diseases (NDs) like Alzheimer's disease (AD) and Parkinson's disease (PD) is the accumulation of misfolded protein aggregates, which have limited effective therapeutic agents. TFEB, a regulator of lysosomal biogenesis and autophagy, plays a crucial role in protein aggregate degradation and is regarded as a promising therapeutic target for these NDs.