Article
Medicine, General & Internal
Mengqi Song, Bin Zhou, Bilu Li, Lantian Tian
Summary: The study revealed that high expression of PMEPA1 mRNA in pancreatic cancer patients is associated with poor prognosis; PMEPA1 promotes proliferation and viability of pancreatic cancer cells by activating the MAPK signaling pathway; Therefore, the PMEPA1/MAPK axis may be a potential therapeutic target in pancreatic cancer.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Article
Multidisciplinary Sciences
Balakrishnan Solaimuthu, Arata Hayashi, Anees Khatib, Yoav D. Shaul
Summary: A stable breast cancer cell line expressing luciferase and green fluorescent protein was established for real-time monitoring of tumor growth and metastatic colonization. The study successfully evaluated and validated breast cancer metastasis using noninvasive bioluminescence imaging system and fluorescence microscopy.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Reproductive Biology
Ran Lee, Hyun Jung Park, Won Young Lee, Youngsok Choi, Hyuk Song
Summary: This study investigated the effect of gelatin topography on culture plates on the proliferation and colony formation of porcine spermatogonial germ cells. The optimal topography was obtained at 40°C, which promoted the proliferation of feeder cells and the formation of pSGC colonies.
Article
Biochemistry & Molecular Biology
Zihao Liu, Yu Shi, Qun Lin, Wenqian Yang, Qing Luo, Yinghuan Cen, Juanmei Li, Xiaolin Fang, Wen G. Jiang, Chang Gong
Summary: PITPNM1 plays a crucial role in the progression of breast cancer, with its high expression associated with poor prognosis and involvement in carcinogenesis and cell signaling.
Article
Cell Biology
Yi-Hsiang Wang, Chia-Yi Shen, Sheng-Chieh Lin, Wen-Hung Kuo, Yuan-Ting Kuo, Yu-Ling Hsu, Wen-Ching Wang, Kai-Ti Lin, Lu-Hai Wang
Summary: This study identified an important immune cytokine, CXCL7, secreted by tumor infiltrating monocytes, to stimulate cancer cell migration, invasion, and metastasis, contributing to the promotion of breast cancer progression.
CELL DEATH & DISEASE
(2021)
Article
Medicine, Research & Experimental
Catarina Alves-Vale, Ana Maria Capela, Carlota Tavares-Marcos, Beatriz Domingues-Silva, Bruno Pereira, Francisco Santos, Carla Pereira Gomes, Guadalupe Espadas, Rui Vitorino, Eduard Sabido, Paula Borralho, Sandrina Nobrega-Pereira, Bruno Bernardes de Jesuse
Summary: The recently discovered lncRNA NORAD is induced after DNA damage in a p53-dependent manner and it plays a critical role in maintaining genomic stability. NORAD is upregulated in several types of cancer, including breast cancer, and high NORAD expression levels are associated with poor prognosis. In this study, it was found that downregulation of NORAD sensitizes triple-negative breast cancer cells to chemotherapy.
MOLECULAR THERAPY NUCLEIC ACIDS
(2023)
Article
Multidisciplinary Sciences
Mao Li, Markus W. Schweiger, Daniel J. Ryan, Ichiro Nakano, Litia A. Carvalho, Bakhos A. Tannous
Summary: The study found that in breast cancer metastasis, OR5B21 showed increased transcript abundance in distant metastatic sites, and its knockdown significantly reduced invasion and migration of cancer cells. OR5B21 expression was associated with epithelial to mesenchymal transition through the STAT3/NF-kappa B/CEBPb signaling axis.
Article
Medicine, Research & Experimental
Mohammad A. Y. Alqudah, Raneem Al-Samman, Marwah Azaizeh, Karem H. Alzoubi
Summary: Amlodipine has been shown to inhibit the growth, colony formation, and invasion of breast cancer cells, possibly through inducing apoptosis, modulating the ERK1/2 signaling pathway, and regulating integrin beta 1.
BIOMEDICAL REPORTS
(2022)
Article
Multidisciplinary Sciences
Sepehr Behtaji, Soudeh Ghafouri-Fard, Arezou Sayad, Ali Sattari, Mathieu Rederstorff, Mohammad Taheri
Summary: The study identified dysregulation of oxytocin-associated genes in breast cancer tissues, with correlations between these genes linked to the presence of cancer.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Zhe-yuan Xu, Jun Peng, Zhi-zhou Shi, Xin-long Chen, Hong-zhong Cheng, Han Wang, Yang Wang, Guo-ping Wang, Wen Jiang, Hao Peng
Summary: Research shows that in lung cancer, linc00662 overexpression is associated with regulation of miR-145-5p, which in turn affects the expression of PAFAH1B2 to regulate the proliferation and colony formation of lung cancer cells.
BIOCHEMISTRY AND CELL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
S. Sun, Z. Wang, F. Yao, K. Sun, Z. Li, C. Li
Summary: The study found that microRNA-155 loaded by breast cancer cell-derived exosomes inhibits the generation of white adipose tissue and promotes the formation of brown adipose tissue, leading to cachexia. It was also discovered that this effect is associated with miR-155 targeting UBQLN1.
HUMAN MOLECULAR GENETICS
(2023)
Article
Respiratory System
Xuejun Dou, Zhiyuan Wang, Weiqiang Lu, Libin Miao, Yuefeng Zhao
Summary: This study reveals that METTL3-FRAS1 plays a crucial role in NSCLC cell proliferation, colony formation, and tumor growth through the regulation of CDON by cooperating YTHDF1.
BMC PULMONARY MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Fangfang Gao, Xiufeng Hu, Wenjing Liu, Hongbo Wu, Yu Mu, Yanqiu Zhao
Summary: High amplification of CANT1 in lung cancer promotes cell proliferation and viability, and researchers have elucidated the role of the CANT1-NF-kappa B signaling axis in lung cancer.
Article
Multidisciplinary Sciences
Jia-hao Wu, Tian-cheng Cheng, Bei Zhu, Hai-yan Gao, Lin Zheng, Wei-xian Chen
Summary: This study analyzed the expressions, functions, and regulatory network of cuproptosis-related genes in breast cancer using the TCGA database. SLC31A1 was significantly upregulated in breast cancer and was negatively associated with favorable outcomes. LINC01614 and miR-204-5p were potential upstream regulators of SLC31A1. SLC31A1 was also positively correlated with immune infiltration in breast cancer and could predict diagnosis, prognosis, chemosensitivity, and immune infiltration.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Martin C. Abba, Maria Laura Fabre, Jaeho Lee, Pradeep Tatineni, Hyunsuk Kil, C. Marcelo Aldaz
Summary: The long-non-coding HOX transcript antisense intergenic RNA (HOTAIR) is significantly upregulated in breast ductal carcinoma in situ (DCIS), promoting the progression of early-stage breast cancer by modulating multiple signaling pathways to induce premalignant phenotypic changes.
FRONTIERS IN ONCOLOGY
(2021)
Article
Clinical Neurology
Yunju Yang, Maria J. Knol, Ruiqi Wang, Aniket Mishra, Dan Liu, Michelle Luciano, Alexander Teumer, Nicola Armstrong, Joshua C. Bis, Min A. Jhun, Shuo Li, Hieab H. H. Adams, Nasir Ahmad Aziz, Mark E. Bastin, Mathieu Bourgey, Jennifer A. Smith, Stefan Frenzel, Rebecca F. Gottesman, Norbert Hosten, Lifang Hou, Sharon L. R. Kardia, Valerie Lohner, Pascale Marquis, Susana Munoz Maniega, Claudia L. Satizabal, Farzaneh A. Sorond, Maria C. Valdes Hernandez, Cornelia M. van Duijn, Meike W. Vernooij, Katharina Wittfeld, Qiong Yang, Wei Zhao, Eric Boerwinkle, Daniel Levy, Ian J. Deary, Jiyang Jiang, Karen A. Mather, Thomas H. Mosley, Bruce M. Psaty, Perminder S. Sachdev, Jennifer A. Smith, Nona Sotoodehnia, Charles S. DeCarli, Monique M. B. Breteler, M. Arfan Ikram, Hans J. Grabe, Joanna Wardlaw, W. T. Longstreth, Lenore J. Launer, Sudha Seshadri, Stephanie Debette, Myriam Fornage
Summary: This study investigates the association between epigenetic changes and white matter hyperintensities in adults. The findings suggest that blood-brain barrier dysfunction and the immune response are related to white matter hyperintensity burden, and antihyperlipidemic agents might be a potential treatment.
Article
Chemistry, Medicinal
Xiaobao Gong, Zhenwei Gui, Xiaoli Ye, Xuegang Li
Summary: This study discovered that jatrorrhizine, an active constituent of Rhizoma Coptidis, significantly improved diabetic peripheral neuropathy. The findings showed that jatrorrhizine treatment reduced the sensitivity threshold for thermal and mechanical stimuli and increased nerve conduction velocity. Moreover, jatrorrhizine increased the number of nerve fibers and axons, myelin thickness, and axonal diameters. The study also revealed that jatrorrhizine enhanced Schwann cells' myelination by regulating the NRG1-ErbB2-PI3K-AKT pathway.
PHYTOTHERAPY RESEARCH
(2023)
Article
Plant Sciences
Xiaxiang Zhang, Rui Xing, Yunjia Ding, Jingjin Yu, Ruying Wang, Xiaohui Li, Zhimin Yang, Lili Zhuang
Summary: This study identified FaGA2ox4 as a gene with the highest expression level in tall fescue under drought stress. Transgenic rice plants overexpressing FaGA2ox4 exhibited a dwarf and high-tillering phenotype, and also showed improved drought stress tolerance.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2023)
Article
Environmental Sciences
Baocai Lu, Xiao Li, Wenjie Miao, Qi Liu, Ruixue Li, Can Cui, Qingzu Gao, Rong Lian
Summary: ZFAS1 is highly expressed in laryngeal cancer and associated with lymph node metastasis and clinical stages. It promotes proliferation, invasion, and expression of N-cadherin and Vimentin, while suppressing E-cadherin expression in LC cells. ZFAS1 stabilizes RBFOX2 protein expression by binding to it and regulates alternative splicing of MENA, affecting cell functions and malignant progression of laryngeal cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Engineering, Environmental
Songwei Wu, Kongjie Wu, Libiao Shi, Xuecheng Sun, Qiling Tan, Chengxiao Hu
Summary: The exploration of cadmium activation mechanisms mediated by the rhizosphere process is crucial for understanding the accumulation of cadmium in plants. This study investigated the responses of two oilseed rape cultivars with different cadmium accumulation traits to cadmium stress using metabolome and microbiome analyses. The results revealed that the differences in shoot cadmium accumulation between the two cultivars were attributed to the rhizosphere processes, which were influenced by pH, cadmium mobility, and the secretion of certain organic acids. Bacterial taxa with cadmium-resistant and activation capacities were also found to be enriched in the rhizosphere of one of the cultivars. These findings provide important insights into the cultivar response to cadmium accumulation and can contribute to the cleaner production of oilseed rape.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Chemistry, Organic
Mingqin Zhao, Jingyi Hu, Xiaoming Ji, Lu Han, Mengxiao Li, Miao Lai
Summary: A transition-metal and ligand free base-mediated radical condensation reaction to form N-substituted pyrrolyl ketones with water as a side product has been developed. The reaction tolerates a wide range of N-substituted acetylpyrroles and alcohols. The key intermediate is proposed to be the radical anion of the benzylic alcohol, which undergoes coupling with the enolate of the acetylpyrrole to form the new C-C bond. The corresponding pyrrolyl chalcones are obtained by elimination, and the enone intermediate is reduced to afford N-substituted pyrrolyl ketones.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2023)
Article
Materials Science, Multidisciplinary
Zixin Rao, Yu Chen, Kehui Qiu, Junfeng Li, Yu Jiao, Chengxiao Hu, Peicong Zhang, Yi Huang
Summary: In this study, a NaY molecular sieve was synthesized using a low-temperature ultrasonic gelling method and utilized as an adsorbent for the recovery and enrichment of La3+ and Eu3+ from synthetic rare earth liquids. The NaY molecular sieve showed high adsorption capacity and efficiency for the target ions, and maintained good adsorption performance even after multiple cycles, making it a promising candidate for rare earth recycling and enrichment from wastewater.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Oncology
Shuwen Han, Yangyanqiu Wang, Jian Chu, Boyang Hu, Gong Gong, Jing Zhuang
Summary: This study found that sodium butyrate (NaB) is a metabolite that affects the efficacy of oxaliplatin (OXA). NaB and OXA can synergistically inhibit the proliferation, migration, and invasion of colorectal cancer cells and promote cell apoptosis. This suggests that NaB has the potential to become a new clinical adjuvant in colorectal cancer chemotherapy.
TRANSLATIONAL ONCOLOGY
(2023)
Review
Virology
Mengqi Yuan, Xiaoke Yang, Xin Zhang, Xiaotian Zhao, Muhammad Abid, Hua-Ji Qiu, Yongfeng Li
Summary: The Pestivirus genus, part of the Flaviviridae family, includes classical swine fever virus (CSFV), bovine viral diarrhea virus 1 (BVDV-1), BVDV-2, border disease virus (BDV), and other new species such as atypical porcine pestivirus (APPV), giraffe pestivirus, and antelope pestivirus. Pestiviruses cause significant economic losses in animal husbandry. Various types of pestivirus vaccines have been developed to control and prevent these diseases, and recent studies have explored the potential of using pestiviruses as viral vectors for multivalent vaccines. This review analyzes the advantages and disadvantages of different pestivirus vaccines and provides insights into the development of novel vaccines against emerging pestiviruses, including APPV and ovine pestivirus.
Article
Immunology
Zhichen Zhu, Xiaofang Xie, Hua Yu, Wei Jia, Bin Shan, Bin Huang, Fen Qu, Siqiang Niu, Jinnan Lv, Qizhao Gao, Feinan Qian, Xiangxiang Tian, Yaxuan Zhai, Yicheng Wen, Chengcheng Yang, Jie Zhu, Yiwei Tang, Liang Chen, Hong Du
Summary: This study conducted a genomic analysis on 92 isolates of Enterobacter-caused infections from multiple tertiary health centres in China, revealing that the most common CR-Ent species in China was E. xiangfangensis and the major lineages were ST171 and ST116 E. xiangfangensis. Additionally, the prevalent carbapenemase-encoding plasmid carried by CR-Ent strains was identified as bla(NDM)-harbouring IncX3-type plasmid. This study provides the first detailed genomic and clinical characteristics of CR-Ent in China.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Biochemistry & Molecular Biology
Yujie Ning, Sijie Chen, Feiyu Zhang, Yanli Liu, Feihong Chen, Shujin Li, Chaowei Wang, Yifan Wu, Yi Gong, Minhan Hu, Ruitian Huang, Xiong Guo, Lei Yang, Xi Wang
Summary: Using an untargeted metabolomics approach, this study investigated the urinary metabolomic profiles of Kashin-Beck disease (KBD) patients. The results revealed significant differences in metabolites and metabolic pathways between KBD patients and healthy controls. These findings provide new insights into the underlying mechanisms of KBD and suggest the importance of small-molecule metabolites and metabolic pathways in the environmental etiology and pathogenesis of KBD.
Article
Engineering, Electrical & Electronic
Junjia Zhang, Pengcheng Gong, Yuntao Wu, Lirong Li, Liang Yu
Summary: Frequency-invariant (FI) beamformers are important in suppressing speech waveform distortions. Differential microphone arrays (DMAs) with perfect FI beampattern (FIB) are widely used in voice communication and human-machine interface systems. However, superdirective beamforming generated by DMAs amplifies white noise. To overcome this drawback, we propose a least squares broadband FI problem under white noise output power constraints, improving the robustness of superdirective beamformers. We develop a broadband beampattern synthesis algorithm based on the alternating direction penalty method (ADPM) to solve the challenging optimization problem, demonstrating fast convergence through numerical simulations. (c) 2022 Elsevier B.V. All rights reserved.
Article
Chemistry, Multidisciplinary
Liang Yu, Qixin Guo, Rui Wang, Minyan Shi, Fucheng Yan, Ran Wang
Summary: This paper proposes a novel intelligent fault diagnosis system framework that effectively addresses the problems of task processing delays and enhanced computational complexity. Reasonable resource allocation optimization improves the performance, especially in multi-terminals offloading systems. Deep reinforcement learning strategies, specifically the deep Q-learning network (DQN) and deep deterministic policy gradient (DDPG), are used to adaptively and efficiently learn the computational offloading policies. Numerical results demonstrate that both strategies outperform traditional non-learning schemes.
APPLIED SCIENCES-BASEL
(2023)
Article
Pharmacology & Pharmacy
Meirong Li, Jingyu Yang, Xinhuang Yao, Xiang Li, Zhourui Xu, Shiqi Tang, Bangxu Sun, Suxia Lin, Chengbin Yang, Jia Liu
Summary: Colorectal cancer (CRC) is a common and deadly cancer, and there is an urgent need for safe and effective therapies. siRNA-based RNA interference targeting PD-L1 shows potential in CRC treatment but lacks efficient delivery vectors. In this study, a novel co-delivery vector named ASCP was successfully developed for delivering CpG ODNs and siPD-L1. ASCP promoted dendritic cells maturation and exhibited good biosafety. Mild photothermal therapy mediated by ASCP killed tumor cells and released tumor-associated antigens, enhancing the anti-tumor immune response. The combination of MPTT and mild photothermal heating-enhanced gene/immunotherapy effectively inhibited CRC. This study provides new insights into the design of synergistic therapies for tumor treatment and may contribute to nanomedicine in CRC treatment.
Review
Chemistry, Physical
Xiaohui Li, Xiaodong Li, Quanhu Sun, Jianjiang He, Ze Yang, Jinchong Xiao, Changshui Huang
Summary: Graphdiyne (GDY) is a two-dimensional material with various morphologies and structures, exhibiting excellent electronic, chemical, magnetic, and mechanical properties, making it suitable for applications in energy storage, catalysis, and field emission. By replacing hexaethylbenzene, different GDY derivatives with specific structures and controllable sizes can be synthesized.
ACTA PHYSICO-CHIMICA SINICA
(2023)
