The Effect of GLT-1 Upregulation on Extracellular Glutamate Dynamics

The relationship between glutamate dynamics and activity-dependent synaptic plasticity

(2020) Jocelyn R. Barnes et al.   JOURNAL OF NEUROSCIENCE

Ceftriaxone Attenuated Anxiety-Like Behavior and Enhanced Brain Glutamate Transport in Zebrafish Subjected to Alcohol Withdrawal

(2020) Jotele Fontana Agostini et al.   NEUROCHEMICAL RESEARCH

Molecular changes evoked by the beta-lactam antibiotic ceftriaxone across rodent models of substance use disorder and neurological disease

(2020) Irena Smaga et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Hippocampal Synaptic Dysfunction in a Mouse Model of Huntington Disease Is Not Alleviated by Ceftriaxone Treatment

(2020) Crystal M. Wilkie et al.   eNeuro

LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia

(2020) Christian Henneberger et al.   NEURON

Local Efficacy of Glutamate Uptake Decreases with Synapse Size

(2020) Michel K. Herde et al.   Cell Reports

Repurposing of the β-Lactam Antibiotic, Ceftriaxone for Neurological Disorders: A Review

(2019) Ebrahim M. Yimer et al.   Frontiers in Neuroscience

Single synapse indicators of impaired glutamate clearance derived from fast iGluu imaging of cortical afferents in the striatum of normal and Huntington (Q175) mice

(2019) Anton Dvorzhak et al.   JOURNAL OF NEUROSCIENCE

Region- and activity-dependent regulation of extracellular glutamate

(2018) Nawrin F. Pinky et al.   JOURNAL OF NEUROSCIENCE

Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes

(2018) Joshua B. Foster et al.   NEUROSCIENCE

Direct assessment of presynaptic modulation of cortico-striatal glutamate release in a Huntington’s disease mouse model

(2018) Ellen T. Koch et al.   JOURNAL OF NEUROPHYSIOLOGY

Defective glutamate and K+clearance by cortical astrocytes in familial hemiplegic migraine type 2

(2016) Clizia Capuani et al.   EMBO Molecular Medicine

Glutamate Clearance Is Locally Modulated by Presynaptic Neuronal Activity in the Cerebral Cortex

(2016) Moritz Armbruster et al.   JOURNAL OF NEUROSCIENCE

Selective Deletion of Astroglial FMRP Dysregulates Glutamate Transporter GLT1 and Contributes to Fragile X Syndrome Phenotypes In Vivo

(2016) H. Higashimori et al.   JOURNAL OF NEUROSCIENCE

Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2

(2016) Atul Kumar et al.   Frontiers in Cellular Neuroscience

Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models

(2016) Matthew P. Parsons et al.   Nature Communications

Astrocytes gate Hebbian synaptic plasticity in the striatum

(2016) Silvana Valtcheva et al.   Nature Communications

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

(2016) J. K. Hefendehl et al.   Nature Communications

Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer’s disease

(2015) Kou Takahashi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conditional Deletion of the Glutamate Transporter GLT-1 Reveals That Astrocytic GLT-1 Protects against Fatal Epilepsy While Neuronal GLT-1 Contributes Significantly to Glutamate Uptake into Synaptosomes

(2015) G. T. Petr et al.   JOURNAL OF NEUROSCIENCE

Surface diffusion of astrocytic glutamate transporters shapes synaptic transmission

(2015) Ciaran Murphy-Royal et al.   NATURE NEUROSCIENCE

Ceftriaxone ameliorates tau pathology and cognitive decline via restoration of glial glutamate transporter in a mouse model of Alzheimer's disease

(2015) Joannee Zumkehr et al.   NEUROBIOLOGY OF AGING

Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection

(2014) Qiongman Kong et al.   JOURNAL OF CLINICAL INVESTIGATION

Ceftriaxone modulates uptake activity of glial glutamate transporter-1 against global brain ischemia in rats

(2014) Yu-Yan Hu et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic Glutamate Spillover Due to Impaired Glutamate Uptake Mediates Heroin Relapse

(2014) H.-w. Shen et al.   JOURNAL OF NEUROSCIENCE

Ceftriaxone Protects Astrocytes from MPP+ via Suppression of NF-κB/JNK/c-Jun Signaling

(2014) Yunlong Zhang et al.   MOLECULAR NEUROBIOLOGY

Extrasynaptic NMDA Receptor Involvement in Central Nervous System Disorders

(2014) Matthew P. Parsons et al.   NEURON

Up-regulated GLT-1 Resists Glutamate Toxicity and Attenuates Glutamate-induced Calcium Loading in Cultured Neurocytes

(2013) Chun-hua Liu et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Upregulation of GLT-1 by treatment with ceftriaxone alleviates radicular pain by reducing spinal astrocyte activation and neuronal hyperexcitability

(2013) K.J. Nicholson et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Ceftriaxone increases glutamate uptake and reduces striatal tyrosine hydroxylase loss in 6-OHDA Parkinson's model

(2013) Tanya Chotibut et al.   MOLECULAR NEUROBIOLOGY

An optimized fluorescent probe for visualizing glutamate neurotransmission

(2013) Jonathan S Marvin et al.   NATURE METHODS

Neuroprotective effect of ceftriaxone in a rat model of traumatic brain injury

(2013) Changmeng Cui et al.   NEUROLOGICAL SCIENCES

Ceftriaxone Normalizes Nucleus Accumbens Synaptic Transmission, Glutamate Transport, and Export following Cocaine Self-Administration and Extinction Training

(2012) H. Trantham-Davidson et al.   JOURNAL OF NEUROSCIENCE

Riluzole elevates GLT-1 activity and levels in striatal astrocytes

(2011) Marica Carbone et al.   NEUROCHEMISTRY INTERNATIONAL

Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated neuroprotection following cerebral ischemia/reperfusion injury

(2010) Rajkumar Verma et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

(2010) Giles E. Hardingham et al.   NATURE REVIEWS NEUROSCIENCE

Palmitoylation and function of glial glutamate transporter-1 is reduced in the YAC128 mouse model of Huntington disease

(2010) Kun Huang et al.   NEUROBIOLOGY OF DISEASE

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxonein vitro

(2009) Jan Lewerenz et al.   JOURNAL OF NEUROCHEMISTRY

Mechanism of Ceftriaxone Induction of Excitatory Amino Acid Transporter-2 Expression and Glutamate Uptake in Primary Human Astrocytes

(2008) Seok-Geun Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The β-lactam antibiotic, ceftriaxone, dramatically improves survival, increases glutamate uptake and induces neurotrophins in stroke

(2008) Christa Thöne-Reineke et al.   JOURNAL OF HYPERTENSION

Up-regulation of GLT1 expression increases glutamate uptake and attenuates the Huntington's disease phenotype in the R6/2 mouse

(2008) B.R. Miller et al.   NEUROSCIENCE

A quantitative assessment of glutamate uptake into hippocampal synaptic terminals and astrocytes: New insights into a neuronal role for excitatory amino acid transporter 2 (EAAT2)

(2008) D.N. Furness et al.   NEUROSCIENCE

A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis

(2008) Nico Melzer et al.   PLoS One