Journal
VIRUSES-BASEL
Volume 13, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/v13050877
Keywords
non-small cell lung cancer; NSCLC; small cell lung cancer; SCLC; Epstein-Barr virus; EBV; next-generation sequencing; NGS
Categories
Funding
- National Cancer Institute of the National Institutes of Health [R01CA261258]
- National Institutes of Health COBRE grant [P20GM121288]
- U.S. -Japan Cooperative Medical Sciences Program Collaborative Award from the National Institute of Allergy and Infectious Diseases [DAA3-19-65602-1]
- Tulane school of medicine faculty research pilot grant
- Japan Society for the Promotion of Science [JP17K4567]
- CRDF Global [DAA3-19-65602-1]
- Carol Lavin Bernick faculty grant
- Takeda Science Foundation
- Shiseido Female Researcher Science
- Japanese Initiative for Progress of Research on Infectious Disease for global Epidemic (J-PRIDE) grant from Japan Agency for Medical Research and Development [20fm0208101j0004]
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Human oncogenic viruses, particularly Epstein-Barr virus, play a significant role in lung cancer. Previous research has established a causal link between EBV and lung cancer, emphasizing the importance of further investigation for clinical diagnosis and treatment of lung cancer patients.
Human oncogenic viruses account for at least 12% of total cancer cases worldwide. Epstein-Barr virus (EBV) is the first identified human oncogenic virus and it alone causes similar to 200,000 cancer cases and similar to 1.8% of total cancer-related death annually. Over the past 40 years, increasing lines of evidence have supported a causal link between EBV infection and a subgroup of lung cancers (LCs). In this article, we review the current understanding of the EBV-LC association and the etiological role of EBV in lung carcinogenesis. We also discuss the clinical impact of the knowledge gained from previous research, challenges, and future directions in this field. Given the high clinical relevance of EBV-LC association, there is an urgent need for further investigation on this topic.
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